Switch to: Citations

Add references

You must login to add references.
  1. Stripe formation in the early fly embryo: principles, models, and networks.Dmitri Papatsenko - 2009 - Bioessays 31 (11):1172-1180.
    Early development of animal embryos begins from spatially distributed products of gene expression, i.e., gradients. While maternal and early zygotic genes form broad and/or terminal gradients, their direct targets appear later on as relatively narrow stripes, which foreshadow presumptive germ layers or future segments. Evidently, stripe expression of the zygotic genes is among the key mechanisms of embryo patterning. In this paper, known qualitative and quantitative models for the stripe formation are considered on the example of early embryogenesis of Drosophila. (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  • Positive feedback in cellular control systems.Alexander Y. Mitrophanov & Eduardo A. Groisman - 2008 - Bioessays 30 (6):542-555.
    Feedback loops have been identified in a variety of regulatory systems and organisms. While feedback loops of the same type (negative or positive) tend to have properties in common, they can play distinctively diverse roles in different regulatory systems, where they can affect virulence in a pathogenic bacterium, maturation patterns of vertebrate oocytes and transitions through cell cycle phases in eukaryotic cells. This review focuses on the properties and functions of positive feedback in biological systems, including bistability, hysteresis and activation (...)
    Direct download (5 more)  
     
    Export citation  
     
    Bookmark   2 citations  
  • The biphasic behavior of incoherent feed‐forward loops in biomolecular regulatory networks.Dongsan Kim, Yung-Keun Kwon & Kwang-Hyun Cho - 2008 - Bioessays 30 (11-12):1204-1211.
    An incoherent feed‐forward loop (FFL) is one of the most‐frequently observed motifs in biomolecular regulatory networks. It has been thought that the incoherent FFL is designed simply to induce a transient response shaped by a ‘fast activation and delayed inhibition’. We find that the dynamics of various incoherent FFLs can be further classified into two types: time‐dependent biphasic responses and dose‐dependent biphasic responses. Why do the structurally identical incoherent FFLs play such different dynamical roles? Through computational studies, we show that (...)
    Direct download (2 more)  
     
    Export citation  
     
    Bookmark   4 citations  
  • Gene networks and liar paradoxes.Mark Isalan - 2009 - Bioessays 31 (10):1110-1115.
    Network motifs are small patterns of connections, found over‐represented in gene regulatory networks. An example is the negative feedback loop (e.g. factor A represses itself). This opposes its own state so that when ‘on’ it tends towards ‘off’ – and vice versa. Here, we argue that such self‐opposition, if considered dimensionlessly, is analogous to the liar paradox: ‘This statement is false’. When ‘true’ it implies ‘false’ – and vice versa. Such logical constructs have provided philosophical consternation for over 2000 years. (...)
    Direct download (7 more)  
     
    Export citation  
     
    Bookmark   4 citations