In a rich and thought-provoking paper, Lambros Malafouris argues that taking material culture seriously means to be ‘systematically concerned with figuring out the causal efficacy of materiality in the enactment and constitution of a cognitive system or operation’ (Malafouris 2004, 55). As I understand this view, there are really two intertwined claims to be established. The first is that the things beyond the skin that make up material culture (in other words, the physical objects and artefacts in which cultural networks (...) and systems of human social relations are realized) may be essential to the enactment of, and be partly constitutive of, certain cognitive systems or operations. The consequence of establishing this claim is supposed to be that we have a mandate to recast the boundaries of the mind so as to include, as proper parts of the mind, things located beyond the skin. Thus, in talking about the contribution of the world to cognition, Malafouris (2004, 58) concludes that ‘what we have traditionally construed as an active or passive but always clearly separated external stimulus for setting a cognitive mechanism into motion, may be after all a continuous part of the machinery itself; at least ex hypothesi’. This is the position that, in philosophical circles, is known increasingly as the extended mind hypothesis (Clark & Chalmers 1998; Menary forthcoming). Henceforth I shall refer to this hypothesis as EM. A stock example will help bring the idea into view. Rumelhart et al. (1986) note that most of us solve difficult multiplication problems by using ‘pen and paper’ as an external resource. This environmental prop enables us to transform a difficult cognitive problem into a set of simpler ones, and to temporarily store the results of certain intermediate calculations. For the fan of EM, the distributed combination of this external resource and certain inner psychological processes constitutes a cognitive system in its own right. (shrink)

Cet ouvrage est la thèse de doctorat en médecine présentée en 1943 par Georges Canguilhem, augmentée, lors de sa réédition vingt ans plus tard, de réflexions philosophiques sur la signification du terme « normal » en médecine. La thèse débute par une étude historique sur l’identité des phénomènes normaux et pathologiques, dogme de la pensée médicale au XIXe siècle. La seconde partie est une étude systématique, sous la forme d’une analyse critique, des concepts de normal et de pathologique. Georges Canguilhem (...) (1904-1995), philosophe puis médecin, contribua à rénover l’épistémologie française. (shrink)

Challenging and rewarding in equal measure, _Phenomenology of Perception_ is Merleau-Ponty's most famous work. Impressive in both scope and imagination, it uses the example of perception to return the body to the forefront of philosophy for the first time since Plato. Drawing on case studies such as brain-damaged patients from the First World War, Merleau-Ponty brilliantly shows how the body plays a crucial role not only in perception but in speech, sexuality and our relation to others.

Challenging and rewarding in equal measure, _Phenomenology of Perception_ is Merleau-Ponty's most famous work. Impressive in both scope and imagination, it uses the example of perception to return the _body_ to the forefront of philosophy for the first time since Plato. Drawing on case studies such as brain-damaged patients from the First World War, Merleau-Ponty brilliantly shows how the body plays a crucial role not only in perception but in speech, sexuality and our relation to others. Perhaps above all, Merleau-Ponty's (...) insights about the embodied mind are a bold and refreshing challenge to the new era of virtual reality and artificial intelligence, as scientists and psychologists discover the centrality of the body to mind and intelligence. (shrink)

No student or colleague of Marjorie Grene will miss her incisive presence in these papers on the study and nature of living nature, and we believe the new reader will quickly join the stimulating discussion and critique which Professor Grene steadily provokes. For years she has worked with equally sure knowledge in the classical domain of philosophy and in modern epistemological inquiry, equally philosopher of science and metaphysician. Moreover, she has the deeply sensible notion that she should be a critically (...) intelligent learner as much as an imaginatively original thinker, and as a result she has brought insightful expository readings of other philosophers and scientists to her own work. We were most fortunate that Marjorie Grene was willing to spend a full semester of a recent leave here in Boston, and we have on other occasions sought her participation in our colloquia and elsewhere. Now we have the pleasure of including among the Boston Studies in the Philosophy of Science this generous selection from Grene's philosophical inquiries into the understanding of the natural world, and of the men and women in it. Boston University Center for the R. S. COHEN Philosophy and History of Science M. W. W ARTOFSKY April 1974 PREFACE This collection spans - spottily - years from 1946 ('On Some Distinctions between Men and Brutes') to 1974 ('On the Nature of Natural Necessity'). (shrink)

Penseur singulier et inclassable, auteur de La gnose de -, Raymond Ruyer développa en plein XXe siècle le projet d'une méta-physique panpsychiste contemporaine des dernières avancées de l'embryologie, de la cybernétique et de la physique quantique. Salué par Merleau-Ponty et Deleuze, Ruyer est redécouvert aujourd'hui, notamment grâce aux travaux de Fabrice Colonna qui signe la préface de cette nouvelle édition de Néo-finalisme. Raymond Ruyer y entreprend rien de moins qu'une réhabilitation du thème finaliste que la philosophie et la science modernes (...) semblaient avoir définitivement remisé. Appuyée sur les résultats de la science, la réflexion philosophique conduit à reconnaître qu'une finalité réelle et créatrice est à l'oeuvre dans les replis de la nature partout où se manifeste une activité organisatrice de structures spatio-temporelles. Les questions les plus fondamentales de la métaphysique s'en trouvent transformées : le sens de la vie corporelle, la signification de la liberté, la possibilité d'un Dieu. (shrink)

What makes this work so important is that it returned the body to the forefront of philosophy for the first time since Plato.

At the time of his death in May 1961, Maurice Merleau-Ponty held the chair of Philosophy at the College de France. Together with Jean-Paul Sartre and Simone de Beauvoir, he was cofounder of the successful and influential review Les Temps Modernes. However, after Merleau-Ponty's two studies of Marxist theory and practice (Humanisme et Terreur and Les Aventures de la Dialectique), he alienated both orthodox Marxists and "mandarins of the left" such as Sartre and de Beauvoir. Perhaps his most lasting contribution (...) to the interpretation of human existence was his formulation of a positive philosophical approach to psychology the foundations of which were clearly outlined in The Structure of Behavior and later more fully developed in Phenomenology of Perception. (shrink)

A classic of phenomenology and existentialism and arguably Jonas's greatest work, The Phenomenon of Life sets forth a systematic and comprehensive philosophy -- ...

This paper proposes a basic revision of the understanding of teleology in biological sciences. Since Kant, it has become customary to view purposiveness in organisms as a bias added by the observer; the recent notion of teleonomy expresses well this as-if character of natural purposes. In recent developments in science, however, notions such as self-organization (or complex systems) and the autopoiesis viewpoint, have displaced emergence and circular self-production as central features of life. Contrary to an often superficial reading, Kant gives (...) a multi-faceted account of the living, and anticipates this modern reading of the organism, even introducing the term self-organization for the first time. Our re-reading of Kant in this light is strengthened by a group of philosophers of biology, with Hans Jonas as the central figure, who put back on center stage an organism-centered view of the living, an autonomous center of concern capable of providing an interior perspective. Thus, what is present in nuce in Kant, finds a convergent development from this current of philosophy of biology and the scientific ideas around autopoeisis, two independent but parallel developments culminating in the 1970s. Instead of viewing meaning or value as artifacts or illusions, both agree on a new understanding of a form of immanent teleology as truly biological features, inevitably intertwined with the self-establishment of an identity which is the living process. (shrink)

Theories of health and disease which oppose evaluative and descriptive claims or opt for one or the other in defining fundamental concepts err, it is argued, due to an oversimplified conception of both the science of medicine and the art of clinical judgment. The work of Georges Canguilhem on the biological dimensions of value and subjectivity is explored. I conclude that he avoids the falsehoods of (a) neutral, pure fact-based medical science, and (b) cultural, arbitrary notions of value.

In the 1930s, two concepts excited the European biological community: the organizer phenomenon and organicism. This essay examines the history of and connection between these two phenomena in order to address the conventional ‘rise-and-fall’ narrative that historians have assigned to each. Scholars promoted the ‘rise-and-fall’ narrative in connection with a broader account of the devitalizing of biology through the twentieth century. I argue that while limited evidence exists for the ‘fall of the organizer concept’ by the 1950s, the organicism that (...) often motivated the organizer work had no concomitant fall – even during the mid-century heyday of molecular biology. My argument is based on an examination of shifting social networks of life scientists from the 1920s to the 1970s, many of whom attended or corresponded with members of the Cambridge Theoretical Biology Club . I conclude that the status and cohesion of these social networks at the micro scale was at least as important as macro-scale conceptual factors in determining the relative persuasiveness of organicist philosophy. (shrink)

La description purement génétique de l’embryogenèse a récemment été mise en question. Un intérêt toujours plus ample est accordé aux effets des contraintes mécaniques. Afin de comprendre si ces travaux produisent une authentique intégration de niveaux, cet article propose l analyse d une de ces recherches d’un point de vue transcendantal. C’est-à-dire qu’on se posera la question du processus constitutif par lequel on décrit un objet biologique. Cette analyse révèle un processus d objectivation caractéristique du déterminisme génétique qui ne peut (...) pas représenter une intégration de niveaux. Cela nous conduira à introduire le concept de symétrie épistémologique qui se réfère à une façon équilibrée d’accéder à l’objet biologique. Enfin, on proposera un modèle de symétrie épistémologique explicitement dérivé du concept kantien d organisme. (shrink)

La description purement génétique de l’embryogenèse a récemment été mise en question. Un intérêt toujours plus ample est accordé aux effets des contraintes mécaniques. Afin de comprendre si ces travaux produisent une authentique intégration de niveaux, cet article propose l analyse d une de ces recherches d’un point de vue transcendantal. C’est-à-dire qu’on se posera la question du processus constitutif par lequel on décrit un objet biologique. Cette analyse révèle un processus d objectivation caractéristique du déterminisme génétique qui ne peut (...) pas représenter une intégration de niveaux. Cela nous conduira à introduire le concept de symétrie épistémologique qui se réfère à une façon équilibrée d’accéder à l’objet biologique. Enfin, on proposera un modèle de symétrie épistémologique explicitement dérivé du concept kantien d organisme. (shrink)

La description purement génétique de l’embryogenèse a récemment été mise en question. Un intérêt toujours plus ample est accordé aux effets des contraintes mécaniques. Afin de comprendre si ces travaux produisent une authentique intégration de niveaux, cet article propose l analyse d une de ces recherches d’un point de vue transcendantal. C’est-à-dire qu’on se posera la question du processus constitutif par lequel on décrit un objet biologique. Cette analyse révèle un processus d objectivation caractéristique du déterminisme génétique qui ne peut (...) pas représenter une intégration de niveaux. Cela nous conduira à introduire le concept de symétrie épistémologique qui se réfère à une façon équilibrée d’accéder à l’objet biologique. Enfin, on proposera un modèle de symétrie épistémologique explicitement dérivé du concept kantien d organisme. (shrink)

In several disciplines within science—evolutionary biology, molecular biology, astrobiology, synthetic biology, artificial life—and outside science—primarily ethics—efforts to define life have recently multiplied. However, no consensus has emerged. In this article, I argue that this is no accident. I propose a dilemma showing that the project of defining life is either impossible or pointless. The notion of life at stake in this project is either the folk concept of life or a scientific concept. In the former case, empirical evidence shows that (...) life cannot be defined. In the latter case, I argue that, although defining life may be possible, it is pointless. I conclude that scientists, philosophers, and ethicists should discard the project of defining life. (shrink)

This paper reformulates some of the questions raised by extended mind theorists from an enactive, life/mind continuity perspective. Because of its reliance on concepts such as autopoiesis, the enactive approach has been deemed internalist and thus incompatible with the extended mind hypothesis. This paper answers this criticism by showing (1) that the relation between organism and cogniser is not one of co-extension, (2) that cognition is a relational phenomenon and thereby has no location, and (3) that the individuality of a (...) cogniser is inevitably linked with the question of its autonomy, a question ignored by the extended mind hypothesis but for which the enactive approach proposes a precise, operational, albeit non-functionalist answer. The paper raises a pespective of embedded and intersecting forms of autonomous identity generation, some of which correspond to the canonical cases discussed in the extended mind literature, but on the whole of wider generality. In addressing these issues, this paper proposes unbiased, non-species specific definitions of cognition, agency and mediation, thus filling in gaps in the extended mind debates that have led to paradoxical situations and a problematic over-reliance on intutions about what counts as cognitive. (shrink)

Mind, it is increasingly fashionable to assert, is an intrinsically embodied and environmentally embedded phenomenon. But there is a potential tension between two strands of thought prominent in this recent literature. One of those strands depicts the body as special, and the fine details of a creature’s embodiment as a major constraint on the nature of its mind: a kind of new-wave body-centrism. The other depicts the body as just one element in a kind of equal-partners dance between brain, body (...) and world, with the nature of the mind fixed by the overall balance thus achieved: a kind of extended functionalism (now with an even broader canvas for multiple realizability than ever before). The present paper displays the tension, scouts the space of possible responses, and ends by attempting to specify what the body actually needs to be, given its complex role in these recent debates. (shrink)

Dans cette etude, qui etait a l'origine sa these de doctorat, Canguilhem retrace les etapes historiques de la formation du concept de reflexe au cours des XVIIe et XVIIIe siecles, c'est-a-dire depuis les premieres experimentations sur les relations entre systeme nerveux et systeme musculaire, jusqu'a la formulation theorique du mouvement involontaire animal, a l'epoque moderne. Loin de se reduire au resultat de decouvertes specifiques, et encore moins attribuable a une figure unique de la pensee scientifique, le concept de reflexe s'articule (...) au fil d'une histoire conceptuelle riche et complexe, en opposition a la conception mecaniste du vivant heritee de Descartes. C'est cette histoire que Canguilhem nous livre dans ses mutiples sources et filiations, en explorant les travaux de physiologues et biologistes tels que Willis, Haller, Unzer et Pochaska: un exercice exemplaire - et devenu desormais classique - d'histoire des sciences et d'epistemologie. (shrink)

In _Vibrant Matter_ the political theorist Jane Bennett, renowned for her work on nature, ethics, and affect, shifts her focus from the human experience of things to things themselves. Bennett argues that political theory needs to do a better job of recognizing the active participation of nonhuman forces in events. Toward that end, she theorizes a “vital materiality” that runs through and across bodies, both human and nonhuman. Bennett explores how political analyses of public events might change were we to (...) acknowledge that agency always emerges as the_ _effect of ad hoc configurations of human and nonhuman forces. She suggests that recognizing that agency is distributed this way, and is not solely the province of humans, might spur the cultivation of a more responsible, ecologically sound politics: a politics less devoted to blaming and condemning individuals than to discerning the web of forces affecting situations and events. Bennett examines the political and theoretical implications of vital materialism through extended discussions of commonplace things and physical phenomena including stem cells, fish oils, electricity, metal, and trash. She reflects on the vital power of material formations such as landfills, which generate lively streams of chemicals, and omega-3 fatty acids, which can transform brain chemistry and mood. Along the way, she engages with the concepts and claims of Spinoza, Nietzsche, Thoreau, Darwin, Adorno, and Deleuze, disclosing a long history of thinking about vibrant matter in Western philosophy, including attempts by Kant, Bergson, and the embryologist Hans Driesch to name the “vital force” inherent in material forms. Bennett concludes by sketching the contours of a “green materialist” ecophilosophy. (shrink)

An examination of the Scientific Revolution that shows how the mechanistic world view of modern science has sanctioned the exploitation of nature, unrestrained commercial expansion, and a new socioeconomic order that subordinates women.

- Comment une autre langue se crée dans la langue, de telle manière que le langage tout entier tende vers sa limite ou son propre " dehors "? - Comment la possibilité de la psychose et la réalité du délire s'inscrivent dans ce parcours? - Comment le dehors du langage est fait de visions et d'auditions non-langagières, mais que seul le langage rend possibles? - Pourquoi les écrivains sont dès lors, à travers les mots, des coloristes et des musiciens?

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

« Que l’on étudie donc la nécessité des phénomènes matériels et l’ordre des causes efficientes, on trouvera que rien ne se passe sans une cause qui satisfait l’imagination, que rien n’échappe aux lois mathématiques du mécanisme. Que l’on contemple d’autre part la chaîne d’or des fins et la sphère des formes qui constituent comme un monde intelligible, et l’on reconnaîtra que, grâce à la perfection de l’Auteur suprème, les sommets de l’éthique et de la métaphysique se confondent, de sorte que (...) rien ne se fait sans la plus haute raison. Car le même Dieu est à la fois la forme éminente et la cause efficiente première et la fin ou l’ultime raison des choses. Il sied que nous adorions ses traces dans les choses et que non seulement nous contemplions les moyens par lesquels il agit et le mécanisme des causes matérielles, mais qu’encore nous méditions sur les fins sublimes de cette admirable habileté; que nous reconnaissions en Dieu, en même temps que l’architecte du monde matériel, aussi et surtout le Roi des esprits, dont l’intelligence a tout ordonné pour le mieux et créer l’univers comme l’État le plus parfait possible sous le gouvernement du plus puissant et du plus sage des monarques. ». (shrink)

La philosophie n'est ni contemplation, ni réflexion, ni communication. Elle est l'activité qui crée les concepts. Comment se distingue-t-elle de ses rivales, qui prétendent nous fournir en concepts? La philosophie doit nous dire quelle est la nature créative du concept, et quels en sont les concomitants : la pure immanence, le plan d'immanence, et les personnages conceptuels. Par là, la philosophie se distingue de la science et de la logique. Celles-ci n'opèrent pas par concepts, mais par fonctions, sur un plan (...) de référence et avec des observateurs partiels. L'art opère par percepts et affects, sur un plan de composition avec des figures esthétiques. La philosophie n'est pas interdisciplinaire, elle est elle-même une discipline entière qui entre en résonance avec la science et avec l'art, comme ceux-ci avec elle : trouver le concept d'une fonction, etc. C'est que les trois plans sont les trois manières dont le cerveau recoupe le chaos, et l'affronte. Ce sont les Chaoïdes. La pensée ne se constitue que dans ce rapport où elle risque toujours de sombrer. (shrink)

The study of conscious experience per se has not kept pace with the dramatic advances in PET, fMRI and other brain-scanning technologies. If anything, the standard approaches to examining the 'view from within' involve little more than cataloguing its readily accessible components. Thus the study of lived subjective experience is still at the level of Aristotelian science, leading to a widespread scepticism over the possibility of a truly scientific study of conscious experience. Drawing on a wide range of approaches -- (...) from phenomenology to meditation -- The View From Within examines the possibility of a disciplined approach to the study of subjective states. The focus is on the practical issues involved. (shrink)

Since Darwin, Biology has been framed on the idea of evolution by natural selection, which has profoundly influenced the scientific and philosophical comprehension of biological phenomena and of our place in Nature. This book argues that contemporary biology should progress towards and revolve around an even more fundamental idea, that of autonomy. Biological autonomy describes living organisms as organised systems, which are able to self-produce and self-maintain as integrated entities, to establish their own goals and norms, and to promote the (...) conditions of their existence through their interactions with the environment. Topics covered in this book include organisation and biological emergence, organisms, agency, levels of autonomy, cognition, and a look at the historical dimension of autonomy. The current development of scientific investigations on autonomous organisation calls for a theoretical and philosophical analysis. This can contribute to the elaboration of an original understanding of life - including human life - on Earth, opening new perspectives and enabling fecund interactions with other existing theories and approaches. This book takes up the challenge. (shrink)

The category of ‘organism’ has an ambiguous status: is it scientific or is it philosophical? Or, if one looks at it from within the relatively recent field or sub-field of philosophy of biology, is it a central, or at least legitimate category therein, or should it be dispensed with? In any case, it has long served as a kind of scientific “bolstering” for a philosophical train of argument which seeks to refute the “mechanistic” or “reductionist” trend, which has been perceived (...) as dominant since the 17th century, whether in the case of Stahlian animism, Leibnizian monadology, the neo-vitalism of Hans Driesch, or, lastly, of the “phenomenology of organic life” in the 20th century, with authors such as Kurt Goldstein, Maurice Merleau-Ponty, and Georges Canguilhem. In this paper I try to reconstruct some of the main interpretive ‘stages’ or ‘layers’ of the concept of organism in order to critically evaluate it. How might ‘organism’ be a useful concept if one rules out the excesses of ‘organismic’ biology and metaphysics? Varieties of instrumentalism and what I call the ‘projective’ concept of organism are appealing, but perhaps ultimately unsatisfying. (shrink)

I distinguish between ‘substantival’ and ‘functional’ forms of vitalism in the eighteenth century. Substantival vitalism presupposes the existence of a (substantive) vital force which either plays a causal role in the natural world as studied scientifically, or remains an immaterial, extra-causal entity. Functional vitalism tends to operate ‘post facto’, from the existence of living bodies to the search for explanatory models that will account for their uniquely ‘vital’ properties better than fully mechanistic models can. I discuss representative figures of the (...) Montpellier school (Bordeu, Ménuret, Fouquet) as functional rather than substantival vitalists, and suggest an additional point regarding the reprisal of vitalism(s) in the 20th century, from Driesch to Canguilhem: that in addition to the substantival and functional varieties, we encounter a third species of vitalism, which I term ‘attitudinal’, as it argues for vitalism as a kind of attitude. (shrink)

The INBIOSA project brings together a group of experts across many disciplines who believe that science requires a revolutionary transformative step in order to address many of the vexing challenges presented by the world. It is INBIOSA’s purpose to enable the focused collaboration of an interdisciplinary community of original thinkers. This paper sets out the case for support for this effort. The focus of the transformative research program proposal is biology-centric. We admit that biology to date has been more fact-oriented (...) and less theoretical than physics. However, the key leverageable idea is that careful extension of the science of living systems can be more effectively applied to some of our most vexing modern problems than the prevailing scheme, derived from abstractions in physics. While these have some universal application and demonstrate computational advantages, they are not theoretically mandated for the living. A new set of mathematical abstractions derived from biology can now be similarly extended. This is made possible by leveraging new formal tools to understand abstraction and enable computability. [The latter has a much expanded meaning in our context from the one known and used in computer science and biology today, that is "by rote algorithmic means", since it is not known if a living system is computable in this sense (Mossio et al., 2009).] Two major challenges constitute the effort. The first challenge is to design an original general system of abstractions within the biological domain. The initial issue is descriptive leading to the explanatory. There has not yet been a serious formal examination of the abstractions of the biological domain. What is used today is an amalgam; much is inherited from physics (via the bridging abstractions of chemistry) and there are many new abstractions from advances in mathematics (incentivized by the need for more capable computational analyses). Interspersed are abstractions, concepts and underlying assumptions “native” to biology and distinct from the mechanical language of physics and computation as we know them. A pressing agenda should be to single out the most concrete and at the same time the most fundamental process-units in biology and to recruit them into the descriptive domain. Therefore, the first challenge is to build a coherent formal system of abstractions and operations that is truly native to living systems. Nothing will be thrown away, but many common methods will be philosophically recast, just as in physics relativity subsumed and reinterpreted Newtonian mechanics. -/- This step is required because we need a comprehensible, formal system to apply in many domains. Emphasis should be placed on the distinction between multi-perspective analysis and synthesis and on what could be the basic terms or tools needed. The second challenge is relatively simple: the actual application of this set of biology-centric ways and means to cross-disciplinary problems. In its early stages, this will seem to be a “new science”. This White Paper sets out the case of continuing support of Information and Communication Technology (ICT) for transformative research in biology and information processing centered on paradigm changes in the epistemological, ontological, mathematical and computational bases of the science of living systems. Today, curiously, living systems cannot be said to be anything more than dissipative structures organized internally by genetic information. There is not anything substantially different from abiotic systems other than the empirical nature of their robustness. We believe that there are other new and unique properties and patterns comprehensible at this bio-logical level. The report lays out a fundamental set of approaches to articulate these properties and patterns, and is composed as follows. -/- Sections 1 through 4 (preamble, introduction, motivation and major biomathematical problems) are incipient. Section 5 describes the issues affecting Integral Biomathics and Section 6 -- the aspects of the Grand Challenge we face with this project. Section 7 contemplates the effort to formalize a General Theory of Living Systems (GTLS) from what we have today. The goal is to have a formal system, equivalent to that which exists in the physics community. Here we define how to perceive the role of time in biology. Section 8 describes the initial efforts to apply this general theory of living systems in many domains, with special emphasis on crossdisciplinary problems and multiple domains spanning both “hard” and “soft” sciences. The expected result is a coherent collection of integrated mathematical techniques. Section 9 discusses the first two test cases, project proposals, of our approach. They are designed to demonstrate the ability of our approach to address “wicked problems” which span across physics, chemistry, biology, societies and societal dynamics. The solutions require integrated measurable results at multiple levels known as “grand challenges” to existing methods. Finally, Section 10 adheres to an appeal for action, advocating the necessity for further long-term support of the INBIOSA program. -/- The report is concluded with preliminary non-exclusive list of challenging research themes to address, as well as required administrative actions. The efforts described in the ten sections of this White Paper will proceed concurrently. Collectively, they describe a program that can be managed and measured as it progresses. (shrink)