Results for 'ELEMENT-BINDING PROTEIN'

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  1.  9
    A Ca2+‐Binding Protein with Numerous Roles and Uses: Parvalbumin in Molecular Biology and Physiology.Syed Hasan Arif - 2009 - Bioessays 31 (4):410-421.
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  2. Reducing Mind to Molecular Pathways: Explicating the Reductionism Implicit in Current Cellular and Molecular Neuroscience. [REVIEW]John Bickle - 2006 - Synthese 151 (3):411-434.
    As opposed to the dismissive attitude toward reductionism that is popular in current philosophy of mind, a “ruthless reductionism” is alive and thriving in “molecular and cellular cognition”—a field of research within cellular and molecular neuroscience, the current mainstream of the discipline. Basic experimental practices and emerging results from this field imply that two common assertions by philosophers and cognitive scientists are false: (1) that we do not know much about how the brain works, and (2) that lower-level neuroscience cannot (...)
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  3.  4
    Recoverin, a Calcium-Binding Protein in Photoreceptors.James B. Hurley - 1995 - Behavioral and Brain Sciences 18 (3):497-498.
    Recoverin is a Ca2+-binding protein found primarily in vertebrate photoreceptors. The proposed physiological function of recoverin is based on the finding that recoverin inhibits light-stimulated phosphorylation of rhodopsin. Recoverin interacts with rod outer segment membranes in a Ca2+-dependent manner. This interaction requires N-terminal acylation of recoverin. Four types of fatty acids have been detected on the N-terminus of recoverin, but the functional significance of this heterogeneous acylation is not yet clear.
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  4. PuF, an Antimetastatic and Developmental Signaling Protein, Interacts with the Alzheimer's Amyloid-Beta Precursor Protein Via a Tissue-Specific Proximal Regulatory Element.D. K. Lahiri, B. Maloney, J. T. Rogers & Y. W. Ge - 2013 - Bmc Genomics 14:68.
    BACKGROUND: Alzheimer's disease is intimately tied to amyloid-beta peptide. Extraneuronal brain plaques consisting primarily of Abeta aggregates are a hallmark of AD. Intraneuronal Abeta subunits are strongly implicated in disease progression. Protein sequence mutations of the Abeta precursor protein account for a small proportion of AD cases, suggesting that regulation of the associated gene may play a more important role in AD etiology. The APP promoter possesses a novel 30 nucleotide sequence, or "proximal regulatory element" , at -76/-47, (...)
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  5.  48
    To B or Not to B: A Pheromone‐Binding Protein Regulates Colony Social Organization in Fire Ants.Michael J. B. Krieger - 2005 - Bioessays 27 (1):91-99.
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  6. The Pleiotropic Functions of the Y‐Box‐Binding Protein, YB‐1.Kimitoshi Kohno, Hiroto Izumi, Takeshi Uchiumi, Megumi Ashizuka & Michihiko Kuwano - 2003 - Bioessays 25 (7):691-698.
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  7.  4
    The Role of Thymidylate Synthase as an RNA Binding Protein.Edward Chu & Carmen J. Allegra - 1996 - Bioessays 18 (3):191-198.
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  8.  6
    Role of the Telomeric DNA‐Binding Protein TRF2 in the Stability of Human Chromosome Ends.Katia Ancelin, Christine Brun & Eric Gilson - 1998 - Bioessays 20 (11):879-883.
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  9.  2
    From the Structure to the Function of Villin, an Actin‐Binding Protein of the Brush Border.Evelync Friederich, Eric Pringault, Monique Arpin & Daniel Louvard - 1990 - Bioessays 12 (9):403-408.
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  10.  1
    Applications of Cas9 as an RNA-Programmed RNA-Binding Protein.David A. Nelles, Mark Y. Fang, Stefan Aigner & Gene W. Yeo - 2015 - Bioessays 37 (7):732-739.
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  11.  1
    Regulation of Meiosis: From DNA Binding Protein to Protein Kinase.Maureen McLeod - 1989 - Bioessays 11 (1):9-14.
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  12.  1
    Banding Patterns in Drosophila Melanogaster Polytene Chromosomes Correlate with DNA‐Binding Protein Occupancy.Igor F. Zhimulev, Elena S. Belyaeva, Tatiana Yu Vatolina & Sergey A. Demakov - 2012 - Bioessays 34 (6):498-508.
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  13. The Role of E. Coli Single‐Stranded DNA Binding Protein in DNA Metabolism.John W. Chase - 1984 - Bioessays 1 (5):218-222.
  14. Computational Analysis of Maltose Binding Protein Translocation.Mauro Chinappi, Fabio Cecconi & Carlo Massimo Casciola - 2011 - Philosophical Magazine 91 (13-15):2034-2048.
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  15. The RNA‐Binding Protein HuD: A Regulator of Neuronal Differentiation, Maintenance and Plasticity.Julie Deschênes‐Furry, Nora Perrone‐Bizzozero & Bernard J. Jasmin - 2006 - Bioessays 28 (8):822-833.
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  16. To H or Not to B: A Pheromone—Binding Protein Re-at Os Colony Social Organization I Nf Ire a Nts.M. J. Krleger - 2004 - Bioessays 27:9.
     
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  17. FK506 Binding Protein 51 Integrates Pathways of Adaptation.Rein Theo - 2016 - Bioessays 38 (9):894-902.
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  18. Multidrug Resistance Mediated by the ATP‐Binding Cassette Transporter Protein MRP.Susan P. C. Cole & Roger G. Deeley - 1998 - Bioessays 20 (11):931-940.
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  19. Protein Kinase C Binding Partners.Susan Jaken & Peter J. Parker - 2000 - Bioessays 22 (3):245-254.
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  20.  10
    Glycosaminoglycan‐Protein Interactions: Definition of Consensus Sites in Glycosaminoglycan Binding Proteins.Ronald E. Hileman, Jonathan R. Fromm, John M. Weiler & Robert J. Linhardt - 1998 - Bioessays 20 (2):156-167.
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  21.  1
    Glycosaminoglycan-Protein Interactions: Definition of Consensus Sites in Glycosaminoglycan Binding Proteins.Ronald E. Hileman, Jonathan R. Fromm, John M. Weiler & Robert J. Linhardt - 1998 - Bioessays 20 (2):156-167.
  22. Multidrug Resistance Mediated by the ATP-Binding Cassette Transporter Protein MRP.Susan P. C. Cole & Roger G. Deeley - 1998 - Bioessays 20 (11):931-940.
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  23. Binding Consent or Element of Presumed Consent? Conceptualization and Legal Relevance of Advance Health Care Directives in the Context of Multicultural Bioethics.Martino Mona - 2008 - Ethik in der Medizin 20 (3):248-257.
     
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  24.  14
    Basic Function in the Nervous System - a Unified Theory.John Dempsher - 1982 - Acta Biotheoretica 31 (3):185-202.
    A new theory for basic function in the nervous system has recently been proposed (Dempsher, J., 1979a, 1979b; 1980, 1981). The major basic themes of the new theory are as follows: (1) There are two fundamental units of structure and function, the fibre or conducting mechanism, and the neurocentre, where nervous system function as we know it takes place. (2) The nerve impulse is regarded as a mathematical event. The mathematics is the result of a prescribed fusion of energy and (...)
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  25. A Reply to Bechtel and Mundale.Ken Aizawa - manuscript
    One theme in recent philosophical attention to neuroscience has been that closer, more serious attention to actual neuroscientific research, and its results, challenges the familiar view that psychological properties are multiply realized by neuroscientific properties. Shagrir, (1998), presents a number of diverse reasons to think that diversity in neuroscientifically identified structures and properties does not inevitably lead to multiple realization. Bechtel and Mundale, (1999), argue that neuroscientific practice extending over a century contradicts the consequences of the hypothesis that psychological functions (...)
     
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  26. Taking Down the Unindicted Co-Conspirators of Amyloid Beta-Peptide-Mediated Neuronal Death: Shared Gene Regulation of BACE1 and APP Genes Interacting with CREB, Fe65 and YY1 Transcription Factors. [REVIEW]D. K. Lahiri, Y. W. Ge, J. T. Rogers, K. Sambamurti, N. H. Greig & B. Maloney - 2006 - Curr Alzheimer Res 3:475-83.
    Major hallmarks of Alzheimer's disease include brain deposition of the amyloid-beta peptide , which is proteolytically cleaved from a large Abeta precursor protein by beta and gamma- secretases. A transmembrane aspartyl protease, beta-APP cleaving enzyme , has been recognized as the beta-secretase. We review the structure and function of the BACE1 protein, and of 4129 bp of the 5'-flanking region sequence of the BACE1 gene and its interaction with various transcription factors involved in cell signaling. The promoter region (...)
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  27.  1
    WT1: What has the Last Decade Told Us?Melissa Little, Greg Holmes & Patrick Walsh - 1999 - Bioessays 21 (3):191-202.
    When positionally cloned in late 1989, it was anticipated that mutations within the Wilms' tumour suppressor gene (WT1) would prove responsible for this common solid kidney cancer of childhood. Characterisation of the WT1 expression pattern and of the structure of the encoded protein isoforms and their mode of action has now spanned almost a decade. WT1 proteins act as nucleic acid-binding zinc finger-containing transcription factors involved in both transactivation and repression. These activities are facilitated and constrained by interactions with (...)
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  28.  17
    Evolution of the Gelsolin Family of Actin-Binding Proteins as Novel Transcriptional Coactivators.Stuart K. Archer, Charles Claudianos & Hugh D. Campbell - 2005 - Bioessays 27 (4):388-396.
    The gelsolin gene family encodes a number of higher eukaryotic actin-binding proteins that are thought to function in the cytoplasm by severing, capping, nucleating or bundling actin filaments. Recent evidence, however, suggests that several members of the gelsolin family may have adopted unexpected nuclear functions including a role in regulating transcription. In particular, flightless I, supervillin and gelsolin itself have roles as coactivators for nuclear receptors, despite the fact that their divergence appears to predate the evolutionary appearance of nuclear receptors. (...)
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  29.  13
    The Role of ATF‐2 in Oncogenesis.Spiros A. Vlahopoulos, Stella Logotheti, Dimitris Mikas, Athina Giarika, Vassilis Gorgoulis & Vassilis Zoumpourlis - 2008 - Bioessays 30 (4):314-327.
    Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a cancer cell phenotype. However, other studies demonstrate an antiproliferative or apoptotic role for ATF-2. In this review, we summarize (...)
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  30. Function and Organization: Comparing the Mechanisms of Protein Synthesis and Natural Selection.Phyllis McKay Illari & Jon Williamson - 2010 - Studies in History and Philosophy of Science Part C 41 (3):279-291.
    In this paper, we compare the mechanisms of protein synthesis and natural selection. We identify three core elements of mechanistic explanation: functional individuation, hierarchical nestedness or decomposition, and organization. These are now well understood elements of mechanistic explanation in fields such as protein synthesis, and widely accepted in the mechanisms literature. But Skipper and Millstein have argued that natural selection is neither decomposable nor organized. This would mean that much of the current mechanisms literature does not apply to (...)
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  31.  15
    Computational Modelling of Protein Interactions: Energy Minimization for the Refinement and Scoring of Association Decoys.Alexander Dibrov, Yvonne Myal & Etienne Leygue - 2009 - Acta Biotheoretica 57 (4):419-428.
    The prediction of proteinprotein interactions based on independently obtained structural information for each interacting partner remains an important challenge in computational chemistry. Procedures where hypothetical interaction models (or decoys) are generated, then ranked using a biochemically relevant scoring function have been garnering interest as an avenue for addressing such challenges. The program PatchDock has been shown to produce reasonable decoys for modeling the association between pig alpha-amylase and the VH-domains of camelide antibody raised against it. We designed a (...)
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  32.  2
    The Double-Stranded RNA Binding Domain of Human Dicer Functions as a Nuclear Localization Signal.Michael Doyle, Lukas Badertscher, Lukasz Jaskiewicz, Stephan Güttinger, Sabine Jurado, Tabea Hugenschmidt, Ulrike Kutay & Witold Filipowicz - unknown
    Dicer is a key player in microRNA (miRNA) and RNA interference (RNAi) pathways, processing miRNA precursors and doublestranded RNA into ~21-nt-long products ultimately triggering sequence-dependent gene silencing. Although processing of substrates in vertebrate cells occurs in the cytoplasm, there is growing evidence suggesting Dicer is also present and functional in the nucleus. To address this possibility, we searched for a nuclear localization signal (NLS) in human Dicer and identified its C-terminal double-stranded RNA binding domain (dsRBD) as harboring NLS activity. We (...)
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  33. Activation Processes in Ligand‐Activated G Protein‐Coupled Receptors: A Case Study of the Adenosine A2A Receptor.Prosser R. Scott, Ye Libin, Pandey Aditya & Orazietti Alexander - forthcoming - Bioessays.
    Here we review concepts related to an ensemble description of G-protein-coupled receptors. The ensemble is characterized by both inactive and active states, whose equilibrium populations and exchange rates depend sensitively on ligand, environment, and allosteric factors. This review focuses on the adenosine A2 receptor, a prototypical class A GPCR. 19F Nuclear Magnetic Resonance studies show that apo A2AR is characterized by a broad ensemble of conformers, spanning inactive to active states, and resembling states defined earlier for rhodopsin. In keeping (...)
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  34.  17
    Condition C and Epistemic Contexts : A Case Study of Epithets and Anti-Logophoricity Pronouns in French.Pierre Pica - 1995 - In Young-Sun Kim, Byung-Choon Lee, Kyoung-Jae Lee, Kyun-Kwon Yang & Jong-Kuri Yoon (eds.), A Festchrift for Dong-Whee Yang. Hankuk Publishing.
    Epithets and pronominals 'en' and 'y' in French have a variety of Binding properties that are unexpected on conventional approach to Binding Theory. We argue that the linguistic variety observed cross-linguistically (and perhaps, more surprinsingly, within a single language) - derives from the morphological properties of the anaphoric element - which we claim lack number features. Epithets and pronominal like 'en' and 'y' are predicates modifying null but semantically active nouns, and must theefore refer to the Speaker. These properties, we (...)
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  35. Balancing Ethical Responsibility Among Multiple Organizational Stakeholders: The Islamic Perspective.Rafik I. Beekun & Jamal A. Badawi - 2005 - Journal of Business Ethics 60 (2):131-145.
    In spite of a renewed interest in the relationship between spirituality and managerial thinking, the literature covering the link between Islam and management has been sparse – especially in the area of ethics. One potential reason may be the cultural diversity of nearly 1.3 billion Muslims globally. Yet, one common element binding Muslim individuals and countries is normative Islam. Using all four sources of this religion’s teachings, we outline the parameters of an Islamic model of normative business ethics. We explain (...)
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  36.  6
    Recoverin and Ca2+ in Vertebrate Phototransduction.James B. Hurley - 1995 - Behavioral and Brain Sciences 18 (3):425-428.
    Recoverin is a 23 kDa Ca2+binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of lightstimulated phosphodiesterase activity, perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its ammo-terminus. The amino-terminal fatty acid appears to be involved in the interaction of (...)
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  37. ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease.Shlomo Sragovich, Avia Merenlender‐Wagner & Illana Gozes - forthcoming - Bioessays.
    Activity-dependent neuroprotective protein, discovered in our laboratory in 1999, has been characterized as a master gene vital for mammalian brain formation. ADNP de novo mutations in humans result in a syndromic form of autism-like spectrum disorder, including cognitive and motor deficits, the ADNP syndrome. One of the most important cellular processes associated with ADNP is the autophagy pathway, recently discovered by us as a key player in the pathophysiology of schizophrenia. In this regard, given the link between the microtubule (...)
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  38. Choosing Short: An Explanation of the Similarities and Dissimilarities in the Distribution Patterns of Binding and Covaluation.Mihnea Capraru - manuscript
    Covaluation is the generalization of coreference introduced by Tanya Reinhart. Covaluation distributes in patterns that are very similar yet not entirely identical to those of binding. On a widespread view, covaluation and binding distribute similarly because binding is defined in terms of covaluation. Yet on Reinhart's view, binding and covaluation are not related that way: binding pertains to syntax, covaluation does not. Naturally, the widespread view can easily explain the similarities between binding and covaluation, whereas Reinhart can easily explain the (...)
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  39. Moonlighting is Mainstream: Paradigm Adjustment Required.Shelley D. Copley - 2012 - Bioessays 34 (7):578-588.
    Moonlighting – the performance of more than one function by a single protein – is becoming recognized as a common phenomenon with important implications for systems biology and human health. The different functions of a moonlighting protein may use different regions of the protein structure, or alternative structures that occur due to post-translational modifications and/or differences in binding partners. Often the different functions of moonlighting proteins are used at different times or in different places. The existence of (...)
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  40.  68
    Lectures on Government and Binding.Noam Chomsky - 1981 - Foris.
    A more extensive discussion of certain of the more technical notions appears in my paper "On Binding" (Chomsky,; henceforth, OB). ...
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  41.  9
    Experiences of Activity and Causality in Schizophrenia: When Predictive Deficits Lead to a Retrospective Over-Binding.Martin Jean-Rémy - 2013 - Consciousness and Cognition 22 (4):1361-1374.
    In this paper I discuss an intriguing and relatively little studied symptomatic expression of schizophrenia known as experiences of activity in which patients form the delusion that they can control some external events by the sole means of their mind. I argue that experiences of activity result from patients being prone to aberrantly infer causal relations between unrelated events in a retrospective way owing to widespread predictive deficits. Moreover, I suggest that such deficits may, in addition, lead to an aberrant (...)
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  42. Binding and its Consequences.Christopher J. G. Meacham - 2010 - Philosophical Studies 149 (1):49-71.
    In “Bayesianism, Infinite Decisions, and Binding”, Arntzenius et al. (Mind 113:251–283, 2004 ) present cases in which agents who cannot bind themselves are driven by standard decision theory to choose sequences of actions with disastrous consequences. They defend standard decision theory by arguing that if a decision rule leads agents to disaster only when they cannot bind themselves, this should not be taken to be a mark against the decision rule. I show that this claim has surprising implications for a (...)
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  43.  14
    Collecting, Comparing, and Computing Sequences: The Making of Margaret O. Dayhoff's "Atlas of Protein Sequence and Structure", 1954–1965. [REVIEW]Bruno J. Strasser - 2010 - Journal of the History of Biology 43 (4):623 - 660.
    Collecting, comparing, and computing molecular sequences are among the most prevalent practices in contemporary biological research. They represent a specific way of producing knowledge. This paper explores the historical development of these practices, focusing on the work of Margaret O. Dayhoff, Richard V. Eck, and Robert S. Ledley, who produced the first computer-based collection of protein sequences, published in book format in 1965 as the Atlas of Protein Sequence and Structure. While these practices are generally associated with the (...)
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  44.  83
    Notes on a Semantic Analysis of Variable Binding Term Operators.J. Corcoran & John Herring - 1971 - Logique Et Analyse 55:644-657.
    -/- A variable binding term operator (vbto) is a non-logical constant, say v, which combines with a variable y and a formula F containing y free to form a term (vy:F) whose free variables are exact ly those of F, excluding y. -/- Kalish-Montague proposed using vbtos to formalize definite descriptions, set abstracts {x: F}, minimalization in recursive function theory, etc. However, they gave no sematics for vbtos. Hatcher gave a semantics but one that has flaws. We give a correct (...)
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  45.  40
    Neuroelectrical Approaches to Binding Problems.Mostyn W. Jones - manuscript
    How do separate brain processes bind to form unified, conscious percepts? This is the perceptual binding problem, which straddles neuroscience and psychology. In fact, two problems exist here: (1) the easy problem of how neural processes are unified, and (2) the hard problem of how this yields unified perceptual consciousness. Binding theories face familiar troubles with (1) and they do not come to grips with (2). This paper argues that neuroelectrical (electromagnetic-field) approaches may help with both problems. Concerning the easy (...)
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  46.  23
    Evidential Variety as a Source of Credibility for Causal Inference: Beyond Sharp Designs and Structural Models.François Claveau - 2011 - Journal of Economic Methodology 18 (3):233-253.
    There is an ongoing debate in economics between the design-based approach and the structural approach. The main locus of contention regards how best to pursue the quest for credible causal inference. Each approach emphasizes one element ? sharp study designs versus structural models ? but these elements have well-known limitations. This paper investigates where a researcher might look for credibility when, for the causal question under study, these limitations are binding. It argues that seeking variety of evidence ? understood specifically (...)
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  47.  80
    Binding Arguments and Hidden Variables.Jonathan Cohen & S. C. Rickless - 2007 - Analysis 67 (1):65-71.
    o (2000), 243). In particular, the idea is that binding interactions between the relevant expressions and natural lan- guage quantifiers are best explained by the hypothesis that those expressions harbor hidden but bindable variables. Recently, however, Herman Cappelen and Ernie Lepore have rejected such binding arguments for the presence of hid- den variables on the grounds that they overgeneralize — that, if sound, such arguments would establish the presence of hidden variables in all sorts of ex- pressions where it is (...)
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  48.  55
    Intermodal Binding Awareness.Casey O'Callaghan - 2014 - In David J. Bennett & Christopher S. Hill (eds.), Sensory Integration and the Unity of Consciousness. MIT Press. pp. 73-103.
    It is tempting to hold that perceptual experience amounts to a co-conscious collection of visual, auditory, tactual, gustatory, and olfactory episodes. If so, each aspect of perceptual experience on each occasion is associated with a specific modality. This paper, however, concerns a core variety of multimodal perceptual experience. It argues that there is perceptually apparent intermodal feature binding. I present the case for this claim, explain its consequences for theorizing about perceptual experience, and defend it against objections. I maintain that (...)
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  49.  66
    Function of Aggregated Reticulocyte Ribosomes in Protein Synthesis.Alfred Gierer - 1963 - J. Mol. Biol 6:148-157.
    Applying mild methods of preparation, part of the ribosomes of rabbit reticulocytes are found in aggregates (later called polyribosomes) of up to six ribosomal units. Upon treatment with RNA-ase, they desintegrate into single ribosomes. The fast-sedimenting aggregates are found to be more active in protein synthesis in terms of incorporation of radioactive amino acids, whereas the single ribosomes are more receptive to stimulation by the artificial messenger RNA poly-U. The findings indicate that the linkage of ribosomes into aggregates is (...)
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  50.  23
    William Astbury and the Biological Significance of Nucleic Acids, 1938–1951.Kersten Hall - 2011 - Studies in History and Philosophy of Science Part C 42 (2):119-128.
    Famously, James Watson credited the discovery of the double-helical structure of DNA in 1953 to an X-ray diffraction photograph taken by Rosalind Franklin. Historians of molecular biology have long puzzled over a remarkably similar photograph taken two years earlier by the physicist and pioneer of protein structure William T. Astbury. They have suggested that Astbury’s failure to capitalize on the photograph to solve DNA’s structure was due either to his being too much of a physicist, with too little interest (...)
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