Results for 'PCR'

23 found
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  1.  15
    Making PCR: A Story of Biotechnology.Paul Rabinow - 1998 - Journal of the History of Biology 31 (1):143-145.
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  2. Paul Rabinow, Making PCR: A Story of Biotechnology Reviewed by.Rachel Ankeny - 1997 - Philosophy in Review 17 (1):67-69.
     
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  3. Paul Rabinow, Making PCR: A Story of Biotechnology[REVIEW]Rachel Ankeny - 1997 - Philosophy in Review 17:67-69.
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  4.  5
    Genome Mapping: PCR Based Meiotic and Somatic Cell Hybrid Analysis.Roger D. Cox & Hans Lehrach - 1991 - Bioessays 13 (4):193-198.
  5. Analysis of Relative Gene Expression Data Using Rea LTime Quantitative PCR a Nd the 2 Ct Method.J. Kenneth & Thomas D. Livak - 2001 - Method 25:4O2 - 408.
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  6.  18
    When Good Transcripts Go Bad: Artifactual RTPCR 'Splicing' and Genome Analysis.Scott William Roy & Manuel Irimia - 2008 - Bioessays 30 (6):601-605.
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  7. Comment on" When Good Transcripts Go Bad: Artifactual RT-PCR'Splicing'and Genome Analysis" Response.Scott William Roy & Manuel Irimia - 2008 - Bioessays 30 (11-12):1257-1258.
     
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  8.  10
    Comment onWhen Good Transcripts Go Bad: Artifactual RT-PCRSplicingand Genome Analysis”.Benoit Chabot, Sherif Abou Elela & Degen Zhuo - 2008 - Bioessays 30 (11-12):1256-1256.
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  9.  12
    Rapid Detection of Selected Aneuploidies by Quantitative Fluorescent PCR.Matteo Adinolfi, Jon Sherlock & Barbara Pertl - 1995 - Bioessays 17 (7):661-664.
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  10. Update of Clostridium Difficile Infection Due to PCR Ribotype 027 in Europe, 2008.E. J. Kuijper, F. Barbut, J. S. Brazier, N. Kleinkauf, T. Eckmanns, M. L. Lambert, D. Drudy, F. Fitzpatrick, C. Wiuff & D. J. Brown - forthcoming - Emergence: Complexity and Organization.
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  11. The Possibility of Alternative Microbial Life on Earth.Carol E. Cleland - unknown
    : Despite its amazing morphological diversity, life as we know it on Earth today is remarkably similar in its basic molecular architecture and biochemistry. The assumption that all (...) life on Earth today shares these molecular and biochemical features is part of the paradigm of modern biology. This paper examines the possibility that this assumption is false, more specifically, that the contemporary Earth contains as yet unrecognized alternative forms of microbial life. The possibility that more than one form of life arose on Earth is consistent with our current understanding of conditions on the early Earth and the biochemical and molecular possibilities for life. Arguments that microbial descendents of an alternative origin of life could not co-exist with familiar life are belied by what we know of the complexity and diversity of microbial communities. Furthermore, the tools that are currently used to explore the microbial worldmicroscopy (with the aid of techniques such as DAPI staining and fluorescence in situ hybridization), cultivation and PCR amplification of rRNA genescould not detect such organisms if they existed. Thus, the fact that we have not discovered any alternative life forms cannot be taken as evidence that they do not exist. (shrink)
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  12.  5
    Transfer Learning and Semisupervised Adversarial Detection and Classification of COVID-19 in CT Images.Ariyo Oluwasanmi, Muhammad Umar Aftab, Zhiguang Qin, Son Tung Ngo, Thang Van Doan, Son Ba Nguyen & Son Hoang Nguyen - 2021 - Complexity 2021:1-11.
    The ongoing coronavirus 2019 pandemic caused by the severe acute respiratory syndrome coronavirus 2 has resulted in a severe ramification on the global healthcare system, principally because (...)
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  13.  56
    Epistemological Issues in the Study of Microbial Life: Alternative Terran Biospheres?Carol E. Cleland - 2007 - Stud. Hist. Phil. Biol. And Biomed. Sci 38 (4):847-61.
    The assumption that all life on Earth today shares the same basic molecular architecture and biochemistry is part of the paradigm of modern biology. This paper argues (...)
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  14. David Miller's Defence of Bartley's Pan Critical Rationalism.Armando Cíntora - 2004 - Sorites 15:50-55.
    W. W. Bartley argued that Popper's original theory of rationality opened itself to a tu quoque argument from the irrationalist and to avoid this Bartley proposed (...)an alternative theory of rationality: pancritical rationalism . Bartley's characterization of PCR leads, however, to self-referential paradox. David Miller outlaws self-reference by distinguishing between positions and statements, Miller's distinction looks, however, suspiciously like an ad hoc manoeuvre or as a stipulation that has to be accepted dogmatically. Furthermore, Miller's move is inadequate because it is a second world answer to a third world problem, that is, to logical paradox. It is then argued that given the paradoxical nature of PCR, Popper's old justificationist critical rationalism with its minimum of dogmatism and irrationalism is malgré tout a better option. (shrink)
     
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  15.  24
    Addressing Cancer Chemotherapeutic Toxicity, Resistance, and Heterogeneity: Novel Theranostic Use of DNAEncoded Small Molecule Libraries.Gerald Kolodny, Xiaoyu Li & Steven Balk - 2018 - Bioessays 40 (10):1800057.
    Major problems in cancer chemotherapy are toxicity, resistance, and cancer heterogeneity. A new theranostic paradigm has been proposed by the authors. Many million small molecules (SM) are (...)
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  16.  28
    Propositional Identity and Logical Necessity.David B. Martens - 2004 - Australasian Journal of Logic 2:1-11.
    In two early papers, Max Cresswell constructed two formal logics of propositional identity, pcr and fcr, which he observed to be respectively deductively equivalent to modal logics (...)
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  17.  34
    Minimal Memetics and the Evolution of Patented Technology.Mark A. Bedau - 2013 - Foundations of Science 18 (4):791-807.
    The nature and status of cultural evolution and its connection with biological evolution are controversial in part because of Richard Dawkins suggestion that the scientific study (...)of culture should includememetics,” an analog of genetics in which genes are replaced bymemes”—the hypothetical units of cultural evolution. Memetics takes different forms; I focus on its minimal form, which claims merely that natural selection shapes to some extent the evolution of some aspects of culture. Advocates and critics of memetics disagree about the scientific status of memetics, but they agree that memetics must face the following fundamental problems. Problem 1: Cultural evolution differs too much from biological evolution. Problem 2: Culture is too complex. Problem 3: Memes are too difficult to identify and track. Problem 4: Memetics produces only trivial results. This paper examines these problems in the context of a minimal memetic analysis in one specific context: patented inventions. Technology is a special subset of culture, and patented inventions are a special subset of technologynot least because there is a detailed written record of every patent. I describe four recent empirical results on technological innovation derived from memetic analysis of the patent record. Result 1: Inkjet printing, PCR, and stents are key drivers of technological innovation. Result 2: Patent genealogies are tangled and incestuous. Result 3: Door-opening innovations drive the evolution of technology. Result 4: The evolving content of the drivers of innovation confirms the importance of inkjet printing, PCR, and stents, among other inventions. These results show that minimal memetics can provide a novel and illuminating analysis the evolution of patented technology. Furthermore, this memetic analysis can answer all of the main problems with memetics. Problem 1 can be dismissed because culture and biology can be quite disanalogous, provided that natural selection still operates in both. Problem 2 is a mirage, because memetic analysis of the patented inventions is consistent with the full richness and complexity of the evolution of technology. Problem 3 is easy to solve, because the patent record makes it trivial to identify and track patents and their key traits through lineages. Problem 4 can be fully answered only after memetic analysis becomes widespread, but the results reviewed here shows that minimal memetics does yield scientific results that are nontrivial and interesting. (shrink)
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  18.  12
    Visions of Eye Commensals: The Known and the Unknown About How the Microbiome Affects Eye Disease.Anthony J. St Leger & Rachel R. Caspi - 2018 - Bioessays 40 (11):1800046.
    Until recently, the ocular surface is thought by many to be sterile and devoid of living microbes. It is now becoming clear that this may not be (...)
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  19.  32
    Modeling of Pathophysiological Coupling Between Brain Electrical Activation, Energy Metabolism and Hemodynamics: Insights for the Interpretation of Intracerebral Tumor Imaging.Agnès Aubert, Robert Costalat, Hugues Duffau & Habib Benali - 2002 - Acta Biotheoretica 50 (4):281-295.
    Gliomas can display marked changes in the concentrations of energy metabolism molecules such as creatine (Cr), phosphocreatine (PCr) and lactate, as measured using magnetic resonance spectroscopy (MRS). (...)
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  20.  5
    Aminas biógenas en alimentos: métodos moleculares para la detección e identificación de bacterias productoras.Beatriz Del Río, Begoña Redruello, María Fernández, Victor Ladero & Miguel A. Álvarez - 2020 - Arbor 196 (795):545.
    Las aminas biógenas son compuestos nitrogenados de pequeño tamaño con actividad biológica que se forman por la descarboxilación enzimática de ciertos aminoácidos. Las aminas biógenas se encuentran (...)
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  21.  6
    Bioethics and Contaminated Vaccines.Mauro Tognon & Paolo Carinci - 2001 - Global Bioethics 14 (1):61-65.
    We described herein the potential health risks and some bioethics considerations derived from the antipolio vaccines contaminated with the oncogenic monkey DNA virus, named simian virus 40. (...)
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  22.  2
    Differential Effects of Physical and Social Enriched Environment on Angiogenesis in Male Rats After Cerebral Ischemia/Reperfusion Injury.Xin Zhang, Jing-Ying Liu, Wei-Jing Liao & Xiu-Ping Chen - 2021 - Frontiers in Human Neuroscience 15.
    Different housing conditions, including housing space and the physiological and social environment, may affect rodent behavior. Here, we examined the effects of different housing conditions on post- (...)stroke angiogenesis and functional recovery to clarify the ambiguity about environmental enrichment and its components. Male rats in the model groups underwent right middle cerebral artery occlusion followed by reperfusion. The MCAO rats were divided into four groups: the physical enrichment group, the social enrichment group, the combined physical and social enrichment group and the ischemia/reperfusion + standard conditioning group. The rats in the sham surgery group were housed under standard conditions. In a set of behavioral tests, including the modified Neurological Severity Score, rotarod test, and adhesive removal test, we demonstrated that the animals in the enriched condition groups exhibited significantly improved neurological functions compared to those in the standard housing group. Smaller infarction volumes were observed in the animals of the PSE group by MRI detection. The enriched conditions increased the microvessel density in the ischemic boundary zone, as revealed by CD31 immunofluorescent staining. The immunochemical and q-PCR results further showed that environmental enrichment increased the expression levels of angiogenic factors after ischemia/reperfusion injury. Our data suggest that all three enrichment conditions promoted enhanced angiogenesis and functional recovery after ischemia/reperfusion injury compared to the standard housing, while only exposure to the combination of both physical and social enrichment yielded optimal benefits. (shrink)
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  23.  2
    Bioethics and Contaminated Vaccines.Mauro Tognon & Paolo Carinen - 2001 - Global Bioethics 14 (2-3):89-94.
    We described herein the potential health risks and some bioethics considerations derived from vaccines accidentally contaminated with the oncogenic monkey DNA virus, named simian virus 40. SV40- (...)contaminated vaccines, mainly antipolio vaccines, were administered to human populations world-wide during the years 195563. Recently, by PCR techniques, many groups reported the presence of SV40 footprints in human tumour specimens as well as in normal tissues. Although no firm conclusions have yet been established for human diseases and SV40 infection, the administration of a monkey virus with oncogenic potential in the human population provoked great concern and criticisms. (shrink)
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