The Role of Dorsal Premotor Cortex in Resolving Abstract Motor Rules provides alternative hypotheses about the cognitive functions affected by the application of repetitive transcranial magnetic stimulation. Their model simulated the effect of stimulation of the left dorsal premotor cortex right as participants provide a Models were used to demonstrate that the increased variability in observed response times can result from interference in replanning during the process of responding to the uninstructed stimulus.

Evidence from functional neuroimaging of the human brain indicates that information about salient properties of an object¿such as what it looks like, how it moves, and how it is used¿is stored in sensory and motor systems active when that information was acquired. As a result, object concepts belonging to different categories like animals and tools are represented in partially distinct, sensory- and motor property-based neural networks. This suggests that object concepts are not explicitly represented, but rather emerge from weighted activity (...) within property-based brain regions. However, some property-based regions seem to show a categorical organization, thus providing evidence consistent with category-based, domain-specific formulations as well.Acronyms and DefinitionsBiological motion: motion of animate agents characterized by highly flexible, fully articulated motion vectors, in contrast to the rigid, unarticulated motion vectors associated with most tools.Category-specific disorder: a relatively greater impairment in retrieving information about members of one superordinate object category (e.g., animals) as compared with other categories following brain injury or diseaseIPS: intraparietal sulcusLO: lateral occipital cortexObject concept: memory representations of a class or category of objects. Necessary for numerous cognitive functions including identifying an object as a member of a specific category and drawing inferences about object propertiespMTG: posterior middle temporal gyruspSTS: posterior superior temporal sulcusRepetition suppression: decreased neural response associated with repeated presentation of an identical, or a semantically/conceptually related, stimulusSD: semantic dementiaSemantic memory: a large division of long-term memory containing knowledge about the world including facts, ideas, beliefs, and conceptsSemantic priming: a short-lasting facilitation in processing a stimulus due to the prior presentation of a semantically related stimulusTMS: transcranial magnetic stimulationVPMC: ventral premotor cortex. (shrink)

The tuning-fork model of human social cognition, based on the discovery of mirror neurons (MNs) in the ventral premotor cortex of monkeys, involves the four following assumptions: (1) mirroring processes are processes of resonance or simulation. (2) They can be motor or non-motor. (3) Processes of motor mirroring (or action-mirroring), exemplified by the activity of MNs, constitute instances of third-person mindreading, whereby an observer represents the agent's intention. (4) Non-motor mirroring processes enable humans to represent others' emotions. (...) After questioning all four assumptions, I point out that MNs in an observer's brain could not synchronically resonate with MNs in an agent's brain unless they discharged in a single brain in two distinct tasks at different times. Finally, I sketch a conceptualist alternative to the resonance model according to which a brain mechanism active in both the execution and the perception of e.g., the act of grasping is the neural basis of the concept of e.g., grasping. (shrink)

A premise of Corballis's theory is that speech arose when vocalization co-opted existing gestural functions in the left ventral premotor cortex. Yet, visuomotor functions in this region remain largely unchanged between humans and macaques and have no discernible connection to gestural communication. This functional continuity suggests that language production is not the result of modifying existing motor functions in this region.

Face recognition is impaired in patients with prosopagnosia, which may occur as a side effect of neurosurgical procedures. Face selective regions on the ventral temporal cortex have been localized with electrical cortical stimulation, electrocorticography, and functional magnetic resonance imagining. This is the first group study using within-patient comparisons to validate face selective regions mapping, utilizing the aforementioned modalities. Five patients underwent surgical treatment of intractable epilepsy and joined the study. Subdural grid electrodes were implanted on their ventral (...) temporal cortices to localize seizure foci and face selective regions as part of the functional mapping protocol. Face selective regions were identified in all patients with fMRI, four patients with ECoG, and two patients with ECS. From 177 tested electrode locations in the region of interest, which is defined by the fusiform gyrus and the inferior temporal gyrus, 54 face locations were identified by at least one modality in all patients. fMRI mapping showed the highest detection rate, revealing 70.4% for face selective locations, whereas ECoG and ECS identified 64.8 and 31.5%, respectively. Thus, 28 face locations were co-localized by at least two modalities, with detection rates of 89.3% for fMRI, 85.7% for ECoG and 53.6 % for ECS. All five patients had no face recognition deficits after surgery, even though five of the face selective locations, one obtained by ECoG and the other four by fMRI, were within 10 mm to the resected volumes. Moreover, fMRI included a quite large volume artifact on the ventral temporal cortex in the ROI from the anatomical structures of the temporal base. In conclusion, ECS was not sensitive in several patients, whereas ECoG and fMRI even showed activation within 10 mm to the resected volumes. Considering the potential signal drop-out in fMRI makes ECoG the most reliable tool to identify face selective locations in this study. A multimodal approach can improve the specificity of ECoG and fMRI, while simultaneously minimizing the number of required ECS sessions. Hence, all modalities should be considered in a clinical mapping protocol entailing combined results of co-localized face selective locations. (shrink)

The ventral lateral parietal cortex shows robust activation during episodic retrieval, and is involved in content representation, as well as in the evaluation of memory traces. This suggests that the VLPC has a crucial contribution to the quality of recollection and the subjective experience of remembering, and situates it at the intersection of the core and attribution systems.

The linguistic complexity of words has largely been studied on the behavioral level and in experimental settings. Only little is known about the neural processes underlying it in uninstructed, spontaneous conversations. We built up a multimodal neurolinguistic corpus composed of synchronized audio, video, and electrocorticographic (ECoG) recordings from the fronto-temporo-parietal cortex to address this phenomenon based on uninstructed, spontaneous speech production. We performed extensive linguistic annotations of the language material and calculated word complexity using several numeric parameters. We orthogonalized (...) the parameters with the help of a linear regression model. Then, we correlated the spectral components of neural activity with the individual linguistic parameters and with the residuals of the linear regression model, and compared the results. The proportional relation between the number of consonants and vowels, which was the most informative parameter with regard to the neural representation of word complexity, showed effects in two areas: the frontal one was at the junction of the premotor cortex, the prefrontal cortex, and Brodmann area 44. The postcentral one lay directly above the lateral sulcus and comprised the ventral central sulcus, the parietal operculum and the adjacent inferior parietal cortex. Beyond the physiological findings summarized here, our methods may be useful for those interested in ways of studying neural effects related to natural language production and in surmounting the intrinsic problem of collinearity between multiple features of spontaneously spoken material. (shrink)

The frame/content theory of speech production is restricted to output mechanisms in the target article; we suggest that these ideas might best be viewed in the context of language production proceeding as a coordinated dynamical whole. The role of the medial premotor system in generating frames matches the important role it may play in the internally dependent timing of motor acts. The proposed coevolution of cortical architectonics and language production mechanisms suggests a significant divergence between primate and cetacean species (...) corresponding to major differences in areal differentiation trends in cerebral cortex. (shrink)

The exact relationship between qualia and the function of the brain remains elusive. The present approach focuses on the linkage between the neural mechanisms of the brain and the phenomenological and epistemological mechanisms of qualia. It is hypothesized that distinct characteristics of the ventral prefrontal cortical function may be crucial for the generation of these phenomenological and epistemological mechanisms this is reflected in the so-called 'neurophenomenological hypothesis'. The 'phenomenological—qualitative' character of qualia may be related with an early activation in (...) the ventromedial prefrontal cortex . The experience of 'presence' in qualia may be accounted for by a co-activation in both VMPFC and hippocampus and a concurrent deactivation in the ventrolateral prefrontal cortex and posterior cingulate. Past and future temporal dimensions may therefore be integrated within the experience of events, which in turn may account for the phenomenal characteristics of 'presence' and thus 'phenomenal time'. 'Non-structural homogeneity' in the experience of qualia may be accounted for by either 'supramodal character' or 'modality unspecifity' of >the VMPFC. The 'heterogenous' stimuli can therefore be included and integrated within one 'homogenous' event as experienced in qualia. Finally, 'transparency' in the experience of qualia may be related with the 'reciprocal suppression' between VMPFC and VLPFC. Simultaneous cognitive processing during the experience of qualia may be suppressed and may consequently account for their transparent character. Due to several methodological limitations, these 'neurophenomenological hypotheses' must be considered as preliminary. However, they may nevertheless serve as a starting point for the development of a more elaborate neuroscientific hypothesis of qualia in the future. (shrink)

Current views of the parietal cortex have difficulty accommodating the human inferior parietal lobe (IPL) within a simple dorsal versus ventral stream dichotomy. In humans, lesions of the right IPL often lead to syndromes such as hemispatial neglect that are seemingly in accord with the proposal that this region has a crucial role in spatial processing. However, recent imaging and lesion studies have revealed that inferior parietal regions have non-spatial functions, such as in sustaining attention, detecting salient events (...) embedded in a sequence of events and controlling attention over time. Here, we review these findings and show that spatial processes and the visual guidance of action are only part of the repertoire of parietal functions. Although sub-regions in the human superior parietal lobe and intraparietal sulcus contribute to vision-for-action and spatial functions, more inferior parietal regions have distinctly non-spatial attributes that are neither conventionally 'dorsal' nor conventionally 'ventral' in nature. (shrink)

The brain networks underlying human multiple-cue judgment, the judgment of a continuous criterion based on multiple cues, have been examined in a few recent studies, and the ventral precuneus has been found to be a key region. Specifically, activation differences in ventral precuneus (as measured with functional magnetic resonance imaging, fMRI) has been linked to an exemplar-based judgment process, where judgments are based on memory for previous similar cases. What aspects of exemplar-based judgment ventral precuneus supports is (...) however poorly understood. Ventral precuneus is a brain region important for various episodic memory processes, where increased engagement of this region together with the ventromedial prefrontal cortex (vmPFC) and the medial temporal lobes (MTL) during learning have been linked to retrieval success. Several alternatives are plausible, for example that reduced brain activity in ventral precuneus during learning to make exemplar-based judgments could reflect reduced needs for visuo-spatial attention as a function of learning to master the task. The present study used fMRI during a multiple-cue judgment task to gain novel neurocognitive evidence informative for the link between learning-related activity changes in ventral precuneus and exemplar-based judgment. Participants (N = 27) spontaneously learned to make judgments during fMRI, in a multiple-cue judgment task specifically designed to induce exemplar-based processing. Contrasting brain activity during late learning to early learning indeed revealed higher activity in ventral precuneus, the bilateral MTL and the vmPFC. Activity in the ventral precuneus and the vmPFC was found to parametrically increase between each judgment event, and activity levels in the ventral precuneus predicted performance after learning. These results are interpreted such that the ventral precuneus supports the aspects of exemplar-based processes that are related to episodic memory, tentatively by building and retrieving memory representations for judgment. (shrink)

ObjectiveTo prospectively study the cingulate cortex for the localization and role of the grasping action in humans during electrical stimulation of depth electrodes.MethodsAll the patients with intractable focal epilepsy and a depth electrode stereotactically placed in the cingulate cortex, as part of their pre-surgical epilepsy evaluation from 2015 to 2017, were included. Cortical stimulation was performed and examined for grasping actions. Post-implantation volumetric T1 MRIs were co-registered to determine the exact electrode position.ResultsFive patients exhibited contralateral grasping actions during (...) electrical stimulation. All patients had electrodes implanted in the ventral bank of the right cingulate sulcus adjacent to the vertical anterior commissure line. Stimulation of other electrodes in adjacent regions did not elicit grasping.ConclusionGrasping action elicited from a localized region in the mid-cingulate cortex directly supports the concept of the cingulate cortex being crucially involved in the grasping network. This opens an opportunity to explore this region with deep brain stimulation as a motor neuromodulation target for treatment in specific movement disorders or neurorehabilitation. (shrink)

Simulation process and mirroring mechanism appear to be necessary to the recognition of emotional facial expressions. Prefrontal areas were found to support this simulation mechanism. The present research analyzed the role of premotor area in processing emotional faces with different valence , considering both conscious and unconscious pathways. High-frequency rTMS stimulation was applied to prefrontal area to induce an activation response when overt and covert processing was implicated. Twenty-two subjects were asked to detect emotion/no emotion . Error rates and (...) response times were considered in response to the experimental conditions. ERs and RTs decreased in case of premotor brain activation, specifically in response to fear, for both conscious and unconscious condition. The present results highlight the role of the premotor system for facial expression processing, supporting the existence of two analogous mechanisms for conscious and unconscious condition. (shrink)

& Using functional magnetic resonance imaging, we examined whether individual differences in amygdala activation in response to negative relative to neutral information are related to differences in the speed with which such information is evaluated, the extent to which such differences are associated with medial prefrontal cortex function, and their relationship with measures of trait anxiety and psychological well-being (PWB). Results indicated that faster judgments of negative relative to neutral information were associated with increased left and right amygdala activation. (...) In the prefrontal cortex, faster judgment time was associated with relative decreased activation in a cluster in the ventral anterior cingulate cor-. (shrink)

Own-age bias is a well-known bias reflecting the effects of age, and its role has been demonstrated, particularly, in face recognition. However, it remains unclear whether an own-age bias exists in facial impression formation. In the present study, we used three datasets from two published and one unpublished functional magnetic resonance imaging study that employed the same pleasantness rating task with fMRI scanning and preferential choice task after the fMRI to investigate whether healthy young and older participants showed own-age effects (...) in face preference. Specifically, we employed a drift-diffusion model to elaborate the existence of own-age bias in the processes of preferential choice. The behavioral results showed higher rating scores and higher drift rate for young faces than for older faces, regardless of the ages of participants. We identified a young-age effect, but not an own-age effect. Neuroimaging results from aggregation analysis of the three datasets suggest a possibility that the ventromedial prefrontal cortex was associated with evidence accumulation of own-age faces; however, no clear evidence was provided. Importantly, we found no age-related decline in the responsiveness of the vmPFC to subjective pleasantness of faces, and both young and older participants showed a contribution of the vmPFC to the parametric representation of the subjective value of face and functional coupling between the vmPFC and ventral visual area, which reflects face preference. These results suggest that the preferential choice of face is less susceptible to the own-age bias across the lifespan of individuals. (shrink)

A new class of visuomotor neuron has been recently discovered in the monkey’s premotor cortex: mirror neurons. These neurons respond both when a particular action is performed by the recorded monkey and when the same action, performed by another individual, is observed. Mirror neurons appear to form a cortical system matching observation and execution of goal-related motor actions. Experimental evidence suggests that a similar matching system also exists in humans. What might be the functional role of this matching (...) system? One possible function is to enable an organism to detect certain mental states of observed conspecifics. This function might be part of, or a precursor to, a more general mind-reading ability. Two different accounts of mind-reading have been suggested. According to “theory theory‘, mental states are represented as inferred posits of a naive theory. According to “simulation theory‘, other people’s mental states are represented by adopting their perspective: by tracking or matching their states with resonant states of one’s own. The activity of mirror neurons, and the fact that observers undergo motor facilitation in the same muscular groups as those utilized by target agents, are findings that accord well with simulation theory but would not be predicted by theory theory. (shrink)

Optic neuropathies are conditions that cause disease to the optic nerve, and can result in loss of visual acuity and/or visual field defects. An improved understanding of how these conditions affect the entire visual system is warranted, to better predict and/or restore the visual loss. In this article, we review visually-driven functional magnetic resonance imaging (fMRI) studies of optic neuropathies, including glaucoma and optic neuritis (ON); we also discuss traumatic optic neuropathy (TON). Optic neuropathy-related vision loss results in fMRI deficit (...) within the visual cortex, and is often strongly correlated with clinical severity measures. Using predominantly flickering checkerboard stimuli, glaucoma studies indicated retinotopic-specific cortical alteration with more prominent deficits in advanced than in early glaucoma. Some glaucoma studies indicate a reorganized visual cortex. ON studies have indicated that the impacted cortical areas are briefly hyperactive. For ON, brain deficits are greater in the acute stages of the disease, followed by (near) normalization of responses of the LGN, visual cortex, and the dorsal visual stream, but not the ventral extrastriate cortex. Visually-driven fMRI is sensitive, at least in ON, in discriminating patients from controls, as well as the affected eye from the fellow eye within patients. The use of a greater variety of stimuli beyond checkerboards (e.g., visual motion and object recognition) in recent ON studies is encouraging, and needs to continue to disentangle the results in terms of change over time. Finally, visually-driven fMRI has not yet been applied in TON, although preliminary efforts suggest it may be feasible. Future fMRI studies of optic neuropathies should consider using more complex visual stimuli, and inter-regional analysis methods including functional connectivity. We suggest that a more systematic longitudinal comparison of optic neuropathies with advanced fMRI would provide improved diagnostic and prognostic information. (shrink)

Neuroimaging studies on moral decision-making have thus far largely focused on differences between moral judgments with opposing utilitarian (well-being maximizing) and deontological (duty-based) content. However, these studies have investigated moral dilemmas involving extreme situations, and did not control for two distinct dimensions of moral judgment: whether or not it is intuitive (immediately compelling to most people) and whether it is utilitarian or deontological in content. By contrasting dilemmas where utilitarian judgments are counterintuitive with dilemmas in which they are intuitive, we (...) were able to use functional magnetic resonance imaging to identify the neural correlates of intuitive and counterintuitive judgments across a range of moral situations. Irrespective of content (utilitarian/deontological), counterintuitive moral judgments were associated with greater difficulty and with activation in the rostral anterior cingulate cortex, suggesting that such judgments may involve emotional conflict; intuitive judgments were linked to activation in the visual and premotor cortex. In addition, we obtained evidence that neural differences in moral judgment in such dilemmas are largely due to whether they are intuitive and not, as previously assumed, to differences between utilitarian and deontological judgments. Our findings therefore do not support theories that have generally associated utilitarian and deontological judgments with distinct neural systems. (shrink)

The field of neuroaesthetics attempts to identify the brain processes underlying aesthetic experience, including but not limited to beauty. Previous neuroaesthetic studies have focussed largely on paintings and music, while performing arts such as dance have been less studied. Nevertheless, increasing knowledge of the neural mechanisms that represent the bodies and actions of others, and which contribute to empathy, make a neuroaesthetics of dance timely. Here, we present the first neuroscientific study of aesthetic perception in the context of the performing (...) arts. We investigated brain areas whose activity during passive viewing of dance stimuli was related to later, independent aesthetic evaluation of the same stimuli. Brain activity of six naïve male subjects was measured using fMRI, while they watched 24 dance movements, and performed an irrelevant task. In a later session, participants rated each movement along a set of established aesthetic dimensions. The ratings were used to identify brain regions that were more active when viewing moves that received high average ratings than moves that received low average ratings. This contrast revealed bilateral activity in the occipital cortices and in right premotor cortex. Our results suggest a possible role of visual and sensorimotor brain areas in an automatic aesthetic response to dance. This sensorimotor response may explain why dance is widely appreciated in so many human cultures. (shrink)

The neurological discovery of mirror neurons is of eminent importance for the phenomenological theory of intersubjectivity. G. Rizzolatti and V. Gallese found in experiments with primates that a set of neurons in the premotor cortex represents the visually registered movements of another animal. The activity of these mirror neurons presents exactly the same pattern of activity as appears in the movement of one's own body. These findings may be extended to other cognitive and emotive functions in humans. I (...) show how these neurological findings might be “translated” phenomenologically into our own experienced sensations, feelings and volitions. (shrink)

Shared brain regions have been found for processing action and language, including the left inferior frontal gyrus, the premotor cortex, and the inferior parietal lobule. However, in the context of action and language generation that shares the same action semantics, it is unclear whether the activity patterns within the overlapping brain regions would be the same. The changes in effective connectivity affected by these activity patterns are also unclear. In this fMRI study, participants were asked to perform hand (...) action and verb generation tasks toward object pictures. We identified shared and specific brain regions for the two tasks in the left PMC, IFG, and IPL. The mean activation level and multi-voxel pattern analysis revealed that the activity patterns in the shared sub-regions were distinct for the two tasks. The dynamic causal modeling results demonstrated that the information flows for the two tasks were different across the shared sub-regions. These results provided the first neuroimaging evidence that the action and verb generation were task context driven in the shared regions, and the distinct patterns of neural information flow across the PMC-IFG-IPL neural network were affected by the polymodal processing in the shared regions. (shrink)

We question the idea that the mirror neuron system is the substrate of social affordances perception, and we suggest that most of the activity seen in the parietal and premotor cortex of the human brain is independent of mirroring activity as characterized in macaques, but rather reflects a process of one's own action specification in response to social signals.

Hand function improvement in stroke survivors in the chronic stage usually plateaus by 6 months. Brain-computer interface (BCI)-guided robot-assisted training has been shown to be effective for facilitating upper-limb motor function recovery in chronic stroke. However, the underlying neuroplasticity change is not well understood. This study aimed to investigate the whole-brain neuroplasticity changes after 20-session BCI-guided robot hand training, and whether the changes could be maintained at the 6-month follow-up. Therefore, the clinical improvement and the neurological changes before, immediately after, (...) and 6 months after training were explored in 14 chronic stroke subjects. The upper-limb motor function was assessed by Action Research Arm Test (ARAT) and Fugl-Meyer Assessment for Upper-Limb (FMA), and the neurological changes were assessed using resting-state functional magnetic resonance imaging. Repeated-measure ANOVAs indicated that long-term motor improvement was found by both FMA (F[2,26]= 6.367,p= 0.006) and ARAT (F[2,26]= 7.230,p= 0.003). Seed-based functional connectivity analysis exhibited that significantly modulated FC was observed between ipsilesional motor regions (primary motor cortex and supplementary motor area) and contralesional areas (supplementary motor area, premotor cortex, and superior parietal lobule), and the effects were sustained after 6 months. The fALFF analysis showed that local neuronal activities significantly increased in central, frontal and parietal regions, and the effects were also sustained after 6 months. Consistent results in FC and fALFF analyses demonstrated the increase of neural activities in sensorimotor and fronto-parietal regions, which were highly involved in the BCI-guided training.Clinical Trial Registration:This study has been registered atClinicalTrials.govwith clinical trial registration number NCT02323061. (shrink)

Though dividing one’s attention between two input streams typically impairs performance, detecting a behaviorally relevant stimulus can sometimes enhance the encoding of unrelated information presented at the same time. Previous research has shown that selection of this kind boosts visual cortical activity and memory for concurrent items. An important unanswered question is whether such effects are reflected in processing quality and functional connectivity in visual regions and in the hippocampus. In this fMRI study, participants were asked to memorize a stream (...) of naturalistic images and press a button only when they heard a predefined target tone. Images could be presented with a target tone, with a distractor tone, or without a tone. Auditory target detection increased activity throughout the ventral visual cortex but lowered it in the hippocampus. Enhancements in functional connectivity between the ventral visual cortex and the hippocampus were also observed following auditory targets. Multi-voxel pattern classification of image category was more accurate on target tone trials than on distractor and no tone trials in the fusiform gyrus and parahippocampal gyrus. This effect was stronger in visual cortical clusters whose activity was more correlated with the hippocampus on target tone than on distractor tone trials. In agreement with accounts suggesting that subcortical noradrenergic influences play a role in the attentional boost effect, auditory target detection also caused an increase in locus coeruleus activity and phasic pupil responses. These findings outline a network of cortical and subcortical regions that are involved in the selection and processing of information presented at behaviorally relevant moments. (shrink)

Illusory kinesthetic sensation was influenced by motor imagery of the wrist following tendon vibration. The imagery and the illusion conditions commonly activated the contralateral cingulate motor area, supplementary motor area, dorsal premotor cortex, and ipsilateral cerebellum. This supports the notion that motor imagery is a mental rehearsal of movement, during which expected kinesthetic sensation is emulated by recruiting multiple motor areas, commonly activated by pure kinesthesia.

Prism adaptation is a form of visuomotor training that produces both sensorimotor and cognitive aftereffects depending on the direction of the visual displacement. Recently, a neural framework explaining both types of PA-induced aftereffects has been proposed, but direct evidence for it is lacking. We employed Structural Equation Modeling, a form of effective connectivity analysis, to establish directionality among connected nodes of the brain network thought to subserve PA. The findings reveal two distinct network branches: a loop involving connections from the (...) parietal cortices to the right parahippocampal gyrus, and a branch linking the lateral premotor cortex to the parahippocampal gyrus via the cerebellum. Like the sensorimotor aftereffects, the first branch exhibited qualitatively different modulations for left versus right PA, and critically, changes in these connections were correlated with the magnitude of the sensorimotor aftereffects. Like the cognitive aftereffects, changes in the second branch were qualitatively similar for left and right PA, with greater change for left PA and a trend correlation with cognitive aftereffects. These results provide direct evidence that PA is supported by two functionally distinct subnetworks, a parietal–temporal network responsible for sensorimotor aftereffects and a fronto-cerebellar network responsible for cognitive aftereffects. (shrink)

We advance a theory of inductive reasoning based on similarity, and test it on arguments involving mammal categories. To measure similarity, we quantified the overlap of neural activation in left Brodmann area 19 and the left ventral temporal cortex in response to pictures of different categories; the choice of of these regions is motivated by previous literature. The theory was tested against probability judgments for 40 arguments generated from 9 mammal categories and a common predicate. The results are (...) interpreted in the context of Hume’s thesis relating similarity to inductive inference. (shrink)

Objective: Atypical patterns of language lateralization due to early reorganizational processes constitute a challenge in the pre-surgical evaluation of patients with pharmaco-resistant epilepsy. There is no consensus on an optimal analysis method used for the identification of language dominance in MEG. This study examines the concordance between MEG source localization of beta power desynchronization and fMRI with regard to lateralization and localization of expressive and receptive language areas using a visual verb generation task.Methods: Twenty-five patients with pharmaco-resistant epilepsy, including six (...) patients with atypical language lateralization, and ten right-handed controls obtained MEG and fMRI language assessment. Fourteen patients additionally underwent the Wada test. We analyzed MEG beta power desynchronization in sensor (controls) and source space (patients and controls). Beta power decrease between 13 and 35 Hz was localized applying Dynamic Imaging of Coherent Sources Beamformer technique. Statistical inferences were grounded on cluster-based permutation testing for single subjects.Results: Event-related desynchronization of beta power in MEG was seen within the language-dominant frontal and temporal lobe and within the premotor cortex. Our analysis pipeline consistently yielded left language dominance with high laterality indices in controls. Language lateralization in MEG and Wada test agreed in all 14 patients for inferior frontal, temporal and pari... (shrink)

The typical approach to decoding speech from the brain (using brain-machine interfaces) is to decode low-level linguistic units (e.g. phonemes, syllables) from motor articulation areas (e.g. Premotor cortex) with the aim of assembling these low-level units into higher-level discourse. We propose that brain-to-speech decoding may benefit from adopting a functional view of language, which conceives of language as an instrumental tool for interacting with others' intentions in order to fulfil one's own intentions. This functional view of language motivates (...) adopting usability (i.e. the decoder's usefulness as a tool for achieving goals), in addition to decoding accuracy, as a criterion for assessing decoder performance. Decoders may achieve gains in usability by incorporating data about communicative situations and speaker intentions in order to generate and fill in speech act templates. We suggest that this intention-oriented, template-based, and functionally inspired view of brain-to-speech decoding may facilitate efforts to achieve naturalistic speech decoding. (shrink)

Mirror neurons are a particular class of visumotorical neurons, originally discovered in area F5 of the monkey premotorical cortex. They discharge both (1) when the animal performs a specific action and (2) when it observes a similar action. Actually, it is often assumed that this unique functioning could explain different abilities ranging from imitation behaviour to faculty of speech. In this article, we discuss the question what is meant by the expression: The neuron x mirrors the action y by (...) perception z . The problem resulted from the fact, that neurons cannot mirror anything—except in the light of a metaphorical description. How can this metaphorical description be dissolved for a distinct and explicit scientific terminology? The basic steps of our argumentation are as follows. (1) The expression to mirror can be defined in mutual relation between different types of actions in respect of at least two participants: the proponent A, who conducts a special action x (e.g. grapping a peanut (A(x)) and the opponent B who observes these actions y (B(y)) and vice versa. (2) In order to detect different tokens as a type of action and to guarantee the changes of the participants there must be constituted a speech act in a dialogue, in which types of actions are defined by the invariance of special equivalence. (3) The change of the participants represents and defines the metaphorical expression to mirror in the light of a non-metaphorical and reproducible schema. (4) Then, the invariance of the type of action can be identified in different speech acts. Three of them (called narratives) were defined paradigmatically: (4.1) the ethological-narrative; (4.2) the neurophysiological-narrative; (4.3) the language-narrative. (5) These narratives are the modelling and explicit formulations of the primarily metaphorical expression: The neuron x mirrors the action y by perception z. (shrink)

The evolutionary continuity between the prespeech functions of premotor cortex and its new linguistic functions, the main thesis of MacNeilage's target article, is confirmed by the recent discovery of “mirror” neurons in monkeys and a corresponding action-observation/action-execution matching system in humans. Physiological data (and other considerations) appear to indicate, however, that brachiomanual gestures played a greater role in language evolution than MacNeilage would like to admit.