Social and personality psychology have been criticized for overreliance on potentially biased self-report variables. In well-being science, researchers have called for more “objective” physiological and cognitive measures to evaluate the efficacy of well-being-increasing interventions. This may now be possible with the recent rise of cost-effective, commercially-available wireless physiological recording devices and smartphone-based cognitive testing. We sought to determine whether cognitive and physiological measures, coupled with machine learning methods, could quantify the effects of positive interventions. The current 2-part (...) study used a college sample (N = 245) to contrast the cognitive (memory, attention, construal) and physiological (autonomic, electroencephalogram) effects of engaging in one of two randomly assigned writing activities (i.e., prosocial or “antisocial”). In the prosocial condition, participants described an interaction when they acted in a kind way, then described an interaction when they received kindness. In the “antisocial” condition, participants wrote instead about an interaction when they acted in an unkind way and received unkindness, respectively. Our study replicated previous research on the beneficial effects of recalling prosocial experiences as assessed by self-report. However, we did not detect an effect of the positive or negative activity intervention on either cognitive or physiological measures. More research is needed to investigate under what conditions cognitive and physiological measures may be applicable, but our findings lead us to conclude that they should not be unilaterally favored over the traditional self-report approach. (shrink)

A physiological model for short-term memory (STM) based on dual theta (5–10 Hz) and gamma (20–60 Hz) oscillation was proposed by Lisman and Idiart (1995). In this model a memory is represented by groups of neurons that fire in the same gamma cycle. According to this model, capacity is determined by the number of gamma cycles that occur within the slower theta cycle. We will discuss here the implications of recent reports on theta oscillations recorded in humans performing the (...) Sternberg task. Assuming that the oscillatory memory models are correct, these findings can help determine STM capacity. (shrink)

rené descartes famously and explicitly rejects appeals to final causes in natural philosophy, suggesting that such appeals depend on knowledge of God’s inscrutable ends.For since I now know that my own nature is very weak and limited, whereas the nature of God is immense, incomprehensible and infinite, I also know without more ado that he is capable of countless things whose causes are beyond my knowledge. And for this reason alone I consider the whole kind of causes, customarily sought from (...) an end, to be totally useless in physics; there is considerable rashness in thinking myself capable of investigating God’s ends.1This rejection did not go unnoticed nor without controversy. In the Fifth.. (shrink)

The phenomenon of ‘plant sleep’ – whereby vegetables rhythmically open and close their leaves or petals in daily cycles – has been a continual source of fascination for those with botanical interests, from the Portuguese physician Cristóbal Acosta and the Italian naturalist Prospero Alpini in the sixteenth century to Percy Bysshe Shelley and Charles Darwin in the nineteenth. But it was in 1757 that the topic received its earliest systemic treatment on English shores with the prodigious author, botanist, actor, and (...) Royal Society critic John Hill’s The Sleep of Plants, and Cause of Motion in the Sensitive Plant. As the present article aims to illustrate, Hill and his respondents used this remarkable behaviour, exhibited by certain plants, as a lens through which to reassess the nature of vegetables, and to address pressing questions of wider natural philosophical import, particularly the degree of continuity between the structures and functions of plants and animals and whether similar mechanisms necessarily account for related movements in different life forms. These disputes, this paper contends, also had profound methodological implications regarding the proper way to conduct experiments, the extent to which it was acceptable to extrapolate from observations, and the status of causal explanations. (shrink)

ABSTRACT The phenomenon of ‘plant sleep’ – whereby vegetables rhythmically open and close their leaves or petals in daily cycles – has been a continual source of fascination for those with botanical interests, from the Portuguese physician Cristóbal Acosta and the Italian naturalist Prospero Alpini in the sixteenth century to Percy Bysshe Shelley and Charles Darwin in the nineteenth. But it was in 1757 that the topic received its earliest systemic treatment on English shores with the prodigious author, botanist, actor, (...) and Royal Society critic John Hill’s The Sleep of Plants, and Cause of Motion in the Sensitive Plant. As the present article aims to illustrate, Hill and his respondents used this remarkable behaviour, exhibited by certain plants, as a lens through which to reassess the nature of vegetables, and to address pressing questions of wider natural philosophical import, particularly the degree of continuity between the structures and functions of plants and animals and whether similar mechanisms necessarily account for related movements in different life forms. These disputes, this paper contends, also had profound methodological implications regarding the proper way to conduct experiments, the extent to which it was acceptable to extrapolate from observations, and the status of causal explanations. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Ideas 62.2 (2001) 265-279 [Access article in PDF] The Physiological Sublime: Burke's Critique of Reason Vanessa L. Ryan The eighteenth-century discussion of the sublime is primarily concerned not with works of art but with how a particular experience of being moved impacts the self. The discussion of the sublime most fully explores the question of how we make sense of our experience: "Why (...) and how does this object move me?" Focusing on the perceiving subject, most critics cast the British discussion of the sublime as reflecting a gradual shift towards a Kantian focus not on the object judged, but on the judging mind. Certainly, eighteenth-century thinkers move away from understanding the sublime as a set of qualities that are presumed to be internal to a given object, and shift their attention to the mental effects of those objects. Yet the increasing interest in the perceiving subject in eighteenth-century British thought should not be understood as necessarily anticipating a Kantian perspective. In his classic work on the sublime Samuel H. Monk claims that this aspect of the British debate provides a preliminary discussion of the Kantian "autonomy of the subject" and that it constitutes a movement towards the "subjectivism of Kant." 1 This reading of British aesthetics exclusively in [End Page 265] terms of a preparation for the Kantian description of the subject obscures the differences between the British and the German traditions. It thereby fails to accommodate the reluctance of British thinkers to give up the social and ethical when faced with the sublime: instead of explaining the commonality of the aesthetic experience by positing a "disinterested" and "autonomous" subject, thinkers such as Adam Smith, John Dennis, and Edmund Burke subordinate the freedom of the individual subject in an attempt to reconcile the aesthetic affect with moral conduct.The teleological and Kantian understanding of British eighteenth-century aesthetic theory is largely the result of the central position that has been given to its most famous theorist, Edmund Burke. Although Burke's conception of the sublime differs in some points markedly from that of his British contemporaries, his treatment of the sublime in the Philosophical Enquiry (1757) has come to represent eighteenth-century British thought, and as such it is routinely compared to Kant's analytic of the sublime. Yet at the point where the British tradition seems to come closest to the Kantian, namely, in the writings of Burke, it also most clearly marks its distance from it. Burke is in some ways the least Kantian of eighteenth-century British thinkers. Whereas Kant holds that the sublime allows us to intuit our rational capacity, Burke's physiological version of the sublime involves a critique of reason. The sublime for Burke is a question not of the subject's increasing self-awareness but of the subject's sense of limitation and of the ultimate value of that experience within a social and ethical context.One of the most intransigent problems in distinguishing the strains of thought on the sublime is that the relationship between the object and its sublime effect--between the object taken to arouse heightened response and the affective quality of such a response--is so variously conceived. The sublime experience is seen as leading, on the one hand, to an overpowering of the self and, on the other hand, to an intense self-presence and exaltation, sometimes even to self-transcendence. The central question is thus not to what extent the sublime is located in the subject, but in what way the experience of the sublime affects the perceiving subject: Does the sublime enlarge us, or diminish us? 2 Does the sublime annihilate our sense of self, or does it affirm and heighten our sense of identity? These two opposing views of the effect of the sublime on the self can be seen in the contrast between Kant and Longinus, whose theories exerted an enormous influence in Britain, especially on Burke. Whereas Longinus emphasizes that the sublime overpowers and dominates the self, Kant holds that the feeling of... (shrink)

A key emergent property of group social dynamic is synchrony–the coordination of actions, emotions, or physiological processes between group members. Despite this fact and the inherent nested structure of groups, little research has assessed physiological synchronization between group members from a multi-level perspective, thus limiting a full understanding of the dynamics between members. To address this gap of knowledge we re-analyzed a large dataset comprising physiological and psychological data that were collected in two laboratory studies that involved (...) two different social group tasks. In both studies, following the group task, members reported their experience of group cohesion via questionnaires. We utilized a non-linear analysis method-multidimensional recurrence quantification analysis that allowed us to represent physiological synchronization in cardiological interbeat intervals between group members at the individual-level and at the group-level. We found that across studies and their conditions, the change in physiological synchrony from baseline to group interaction predicted a psychological sense of group cohesion. This result was evident both at the individual and the group levels and was not modified by the context of the interaction. The individual- and group-level effects were highly correlated. These results indicate that the relationship between synchrony and cohesion is a multilayered construct. We re-affirm the role of physiological synchrony for cohesion in groups. Future studies are needed to crystallize our understanding of the differences and similarities between synchrony at the individual-level and synchrony at the group level to illuminate under which conditions one of these levels has primacy, or how they interact. (shrink)

This essay examines Descartes’s impact on medical faculties in the German Reformed context, focusing on the case of the Marburg physician Johann Jakob Waldschmidt (1644–89). It first surveys the wider backdrop of Descartes-reception in German universities, and highlights its generally conciliatory character. Waldschmidt appears as a counterpoint to this tendency. The essay then situates Waldschmidt’s work in the context of confessional politics at the University of Marburg, and specifically of the heightened controversy in Hesse around the teaching of Descartes in (...) the last years of Waldschmidt’s life. The second half of the essay details Waldschmidt’s ambitious program to reform medicine along Cartesian lines, in physiology, pathology, and therapy, and evaluates its merits and limits. (shrink)

Arising restrictions of global economic growth due to limited natural resources and capacity of the biosphere adversely affect on people level of life and future expectation. That leads to mass depression and social instability. To consider this problem, psycho-physiological model of onward hedonist in consumer society is developed and investigated. This model is based on the fact that human nature generates a growing desire, needs to progress. After reaching the limits of growth, member of consumer society feel persistent negative (...) emotions and dissatisfaction. It results to socio-economic stagnation, social and international instability. The first type of possible solutions to this problem is based on the global expansion of the limits of growth (e.g., increasing of macroeconomic demand as a result of new Kondratieff technological cycle). The second type of solutions refers to local limits extension of growth within one or more countries, by means of their economic, political or military expansion in the world. But such solutions lead to international instability. The third type of solutions corresponds to periodical decreasing of the macroeconomic consumption followed by its growth (e.g., global financial crisis, decay of states and their unions, national and military conflicts, wars and so on). Such solution also leads to social and international instability. Humanistic solution consists in creativity development of people (especially middle class of developed countries) to focus on spiritual development. So rising desires of these people in spiritual realm can be satisfied under limits of global economic growth. (shrink)

In the middle of the nineteenth century, advances in experimental psychology and the physiology of the sense organs inspired so-called "Back to Kant" Neo-Kantians to articulate robustly psychologistic visions of Kantian epistemology. But their accounts of the thing in itself were fraught with deep tension: they wanted to conceive of things in themselves as the causes of our sensations, while their own accounts of causal inference ruled that claim out. This paper diagnoses the source of that problem in views of (...) one Neo-Kantian, F. A. Lange, and argues that it is solved only by Ernst Mach. No less than Lange and other Neo-Kantians, Mach was inspired to develop a psychologistic account of the foundations of knowledge, but his account also includes a coherent denial of things in themselves' existence. Finally, this paper uses this account of Lange and Mach on things in themselves to illuminate Mach's relation to a certain strain of the Neo-Kantian philosophy of his own time: his views constitute a more fully coherent version of the psychologistic theory of knowledge Back to Kant figures tried to articulate. (shrink)

The purpose of this paper is to describe some limitations on scientific behaviorist and computational models of the mind. These limitations stem from the inability of either model to account for the integration of experience and behavior. Behaviorism fails to give an adequate account of felt experience, whereas the computational model cannot account for the integration of our behavior with the world. Both approaches attempt to deal with their limitations by denying that the domain outside their limits is a part (...) of psychology. These attempts to turn the shortcomings of the two models into virtues would be more convincing if their limitations were not diametrically opposed. I will argue that in each case the limitations are too restrictive unless the theories are augmented by physiology. (shrink)

Emotions are multimodal processes that play a crucial role in our everyday lives. Recognizing emotions is becoming more critical in a wide range of application domains such as healthcare, education, human-computer interaction, Virtual Reality, intelligent agents, entertainment, and more. Facial macro-expressions or intense facial expressions are the most common modalities in recognizing emotional states. However, since facial expressions can be voluntarily controlled, they may not accurately represent emotional states. Earlier studies have shown that facial micro-expressions are more reliable than facial (...) macro-expressions for revealing emotions. They are subtle, involuntary movements responding to external stimuli that cannot be controlled. This paper proposes using facial micro-expressions combined with brain and physiological signals to more reliably detect underlying emotions. We describe our models for measuring arousal and valence levels from a combination of facial micro-expressions, Electroencephalography (EEG) signals, galvanic skin responses (GSR), and Photoplethysmography (PPG) signals. We then evaluate our model using the DEAP dataset and our own dataset based on a subject-independent approach. Lastly, we discuss our results, the limitations of our work, and how these limitations could be overcome. We also discuss future directions for using facial micro-expressions and physiological signals in emotion recognition. (shrink)

This paper highlights the significance of sensory studies and psychophysical investigations of the relations between psychic and physical phenomena for our understanding of the development of the physics discipline, by examining aspects of research on sense perception, physiology, esthetics, and psychology in the work of Gustav Theodor Fechner, Hermann von Helmholtz, Wilhelm Wundt, and Ernst Mach between 1860 and 1871. It complements previous approaches oriented around research on vision, Fechner’s psychophysics, or the founding of experimental psychology, by charting Mach’s engagement (...) with psychophysical experiments in particular. Examining Mach’s study of the senses and esthetics, his changing attitudes toward the mechanical worldview and atomism, and his articulation of comparative understandings of sensual, geometrical, and physical spaces helps set Mach’s emerging epistemological views in the context of his teaching and research. Mach complemented an analytic strategy focused on parallel psychic and physical dimensions of sensation, with a synthetic comparative approach – building analogies between the retina, the individual, and social life, and moving between abstract and sensual spaces. An examination of the broadly based critique that Mach articulated in his 1871 lecture on the conservation of work shows how his historical approach helped Mach cast what he now saw as a narrowly limiting emphasis on mechanics as a phase yet to be overcome. (shrink)

This paper aims to assess the epistemological value of the notion of sympathy in Galen’s thought. It first shows that Galen makes use of two different concepts of sympathy: the ambient concept, according to which the human body manifests a harmonious part-whole relationship, and the technical concept, with which one connects two pathologies on the basis of the fact that the cause of the ailment is elsewhere than where it surfaces. Neither of these sympathies constitutes in itself a causal explanation (...) of reality. The first merely acknowledges an obvious interrelationship, the second acts as an epistemic tool to shift the focus of diagnosis away from the place where the condition manifests itself. However, the two concepts are not absolutely unrelated; and they come together when the sympathetic paradigm is used to understand the unifying action of the psychic and natural faculties. Very significantly, Galen then provisionally defines the cause as a power or faculty (δύναμις) not out of theoretical necessity but for practical reasons. (shrink)

Microbial systems biology has made enormous advances in relating microbial physiology to the underlying biochemistry and molecular biology. By meticulously studying model microorganisms, in particular Escherichia coli and Saccharomyces cerevisiae, increasingly comprehensive computational models predict metabolic fluxes, protein expression, and growth. The modeling rationale is that cells are constrained by a limited pool of resources that they allocate optimally to maximize fitness. As a consequence, the expression of particular proteins is at the expense of others, causing trade‐offs between cellular objectives (...) such as instantaneous growth, stress tolerance, and capacity to adapt to new environments. While current computational models are remarkably predictive for E. coli and S. cerevisiae when grown in laboratory environments, this may not hold for other growth conditions and other microorganisms. In this contribution, we therefore discuss the relationship between the instantaneous growth rate, limited resources, and long‐term fitness. We discuss uses and limitations of current computational models, in particular for rapidly changing and adverse environments, and propose to classify microbial growth strategies based on Grimes's CSR framework. (shrink)

IntroductionSimilarities in morphology, physiological function, and neurophysiological findings between median and ulnar nerves are not unequivocal. Our previous study confirmed differences in motor fiber parameters between these nerves in healthy persons. We made an attempt to assess and compare the physiological parameters of different sensation modalities in median and ulnar nerves.MethodsThe study was performed in 31 healthy, right-handed volunteers: 17 women, 14 men, mean age 44.8 ± 15.5 years. Standard sensory conduction tests in the median and ulnar nerves (...) were performed together with the estimation of vibratory, temperature, and warm- and cold-induced pain thresholds in the C7 and C8 dermatomes on the palm, using quantitative sensory testing.ResultsThere were no statistically significant differences in the standard sensory conduction test in the median and ulnar nerves across the whole group: between right and left hands, and between women and men. We revealed differences in the temperature and pain thresholds between these nerves, mainly in low temperature perception. There were no differences in estimated thresholds between sides or in female and male groups. The vibratory limits did not differ significantly between nerves, and subgroups.ConclusionThe study confirmed the differences in the physiological sensory perception between the median and ulnar nerves. The median nerve is more sensitive to temperature stimulation than the ulnar nerve, but simultaneously less sensitive to pain-inducing temperature stimuli. These findings should be considered during the examination of hand nerve pathology. (shrink)

The current paper investigates the value and application of a range of physiological and neuroscientific techniques in applied marketing research and consumer science, highlighting new insights from research in social psychology and neuroscience. We review measures of sweat secretion, heart rate, facial muscle activity, eye movements, and electrical brain activity, using techniques including skin conductance, pupillometry, eyetracking and magnetic brain imaging. For each measure, after a brief explanation of the underlying technique, we illustrate concepts and mechanisms that the measure (...) allows researchers in marketing and consumer science to investigate, with a focus on consumer attitudes and behavior. By providing reviews on recent research that applied these methods in consumer science and relevant related fields, we also highlight methodological and theoretical strengths and limitations, with an emphasis on ecological validity. We argue that the inclusion of physiological and neuroscientific techniques can advance consumer research by providing insights into the often unconscious mechanisms underlying consumer behavior. Therefore, such technologies can help researchers and marketing practitioners understand the mechanisms of consumer behavior and improve predictions of consumer behavior. (shrink)

Some natural philosophers in the 17th century believed that they could control their own innards, specifically the animal spirits coursing incessantly through brain and nerves, in order to discipline or harness passion, cognition and action under rational guidance. This chapter addresses the mechanisms thought necessary after Eden for controlling the physiology of passion. The tragedy of human embedding in the body, with its cognitive and moral limitations, was paired with a sense of our confinement in sequential time. I use two (...) strands of 17th-century natural philosophy to exemplify forms of the perceived connection between physiology, memory, and the passions. I deal at length with Cartesian mechanism, and more briefly with Restoration natural philosophy in England. These are fruitful historical domains for connecting cognition and culture, since relations of domination, disruption, or accommodation between present and past are in play for both selves and societies. Despite the difficulty of integrating affect with cognition in theories of brain and mind, the capacity to treat passion and memory together is crucial for future cognitive science to address issues which outsiders care about. (shrink)

Stimulating and thought-provoking, this important new text looks at the welfare problems and philosophical and ethical issues that are caused by changes made to an animal's telos, behaviour and physiology, both positive and negative, to make them more productive or adapted for human uses. These changes may involve selective breeding for production, appearance traits, or competitive advantage in sport, transgenic animals or the use of pharmaceuticals or hormones to enhance production or performance. Changes may impose duties to care for these (...) animals further and more intensely, or they may make the animal more robust. The book considers a wide range of animals, including farm animals, companion animals and laboratory animals. It reviews the ethics and welfare issues of animals that have been adapted for sport, as companions, in work, as ornaments, food sources, guarding and a whole host of other human functions. This important new book sparks debate and is essential reading for all those involved in animal welfare and ethics, including veterinarians, animal scientists, animal welfare scientists and ethologists. (shrink)

The essay examines Kant’s Enlightenment conception of metaphysics as a science to be kept free of ideological prejudice and extrarational cognitive resources and to be established under the conditions of public, intersubjectively valid discourse. I analyze Kant’s self-interpretation of his transcendental philosophy as “metaphysics of metaphysics” and argue for the extensional partial identity of the critique of metaphysics and the metaphysics so rendered possible. In particular, I identify the “future metaphysics” envisioned by Kant as the “metaphysics of nature in general” (...) or the “physiology of pure reason,” which was projected by Kant but never carried out by himself and is not to be confused with the “metaphysics of material nature” presented by Kant in his Metaphysical Principles of Natural Science. I further show how in Kant the “restriction” of the understanding and its pure concepts to sensible intuition is counterbalanced by the “bounding” of sensibility and its formal conditions to the appearances, at the exclusion of the “empty space” of the non-sensory. In drawing on Kant’s distinction between “limit” and “boundary”, I establish the precise position of critical metaphysics “on the boundary” of the world of sense and the world of the understanding. In concluding, I argue that for Kant a “future metaphysics that will be possible as science” is restricted to transcendental philosophy, at the exclusion of the theoretical cognition of the supersensible, which is thereby delegated forever to the object domain of practically based rational but non-scientific belief or faith. (shrink)

This paper wishes to offer a historical derivation of the mature Diderot’s fully materialistic, physiological theory of the soul, and to show the conflict between the theological concept of the soul as a principle of freedom, and the materialistic-deterministic concept of the soul, in his philosophical and literary oeuvre. In historical respect, Diderot formulated his mature position on the basis of Locke’s theory of ‘thinking matter’, of Toland’s idea that ‘action is essential to matter’, of Maupertuis’s theory of ‘spontaneous (...) creative degeneration’. We present and analyze these theories one by one, together with Voltaire’s propaganda of the Lockean conception. Next, d’Alembert’s orthodox philosophy of the soul is examined, as this was Diderot’s immediate target in Le Rêve d’Alembert. The last chapters of the paper describe the afore-mentioned conflict within Diderot’s philosophy of the soul. We reach the conclusion that in Diderot’s theory, soul as a not fully determined substance still seems the ‘differentia’ of man from the rest of the living beings, though he would certainly argue that our freedom is very limited. A philosophical comparison with Kant’s account of human freedom closes the article. (shrink)

The use of automation in cars is increasing. In future vehicles, drivers will no longer be in charge of the main driving task and may be allowed to perform a secondary task. However, they might be requested to regain control of the car if a hazardous situation occurs. Performing a secondary task might increase drivers' mental workload and consequently decrease the takeover performance if the workload level exceeds a certain threshold. Knowledge about the driver's mental state might hence be useful (...) for increasing safety in conditionally automated vehicles. Measuring drivers' workload continuously is essential to support the driver and hence limit the number of accidents in takeover situations. This goal can be achieved using machine learning techniques to evaluate and classify the drivers' workload in real-time. To evaluate the usefulness of physiological data as an indicator for workload in conditionally automated driving, three physiological signals from 90 subjects were collected during 25 min of automated driving in a fixed-base simulator. Half of the participants performed a verbal cognitive task to induce mental workload while the other half only had to monitor the environment of the car. Three classifiers, sensor fusion and levels of data segmentation were compared. Results show that the best model was able to successfully classify the condition of the driver with an accuracy of 95%. In some cases, the model benefited from sensors' fusion. Increasing the segmentation level increased the performance of the model for windows smaller than 4 min, but decreased for windows larger than 4 min. In conclusion, the study showed that a high level of drivers' mental workload can be accurately detected while driving in conditional automation based on 4-min recordings of respiration and skin conductance. (shrink)

Michel Foucault and Roberto Esposito have been two of the most influential biopolitical thinkers of the twentieth century, but their respective approaches to the relationship between life and politics do not address the main problem of the Anthropocene: the relationship between life and energy. Thus, this article analyzes the biophysical limits of biopolitics in the works of Foucault and Roberto Esposito and, to overcome these limits, it proposes to analyze the physiological assembly of the devices of power within the (...) energetic flows of social metabolisms. The article concludes that the physio-political approach to human societies allows us to overcome the biophysical limits of both Foucauldian biopolitics and Esposito's immunological paradigm. (shrink)

Since the 1980s, several studies of visual perception have persuasively argued that important aspects of human vision are best accounted for not by recourse to inner mental representations but rather through socially observable actions and behaviors (e.g. Lynch 1985, Latour 1986, Lynch 1990, Goodwin 1994, Goodwin 1997, Sharrock & Coulter 1998). While there are clearly physiological mechanisms required for vision, psychological accounts of perception in terms of inner mental representations have been dislodged from their position as the basic term (...) in the interface between human beings and their environment and replaced with terms such as "social practice," and "vernacular intelligibility." The focus for these .. (shrink)

In 1872, Emil du Bois-Reymond delivered an astonishing lecture entitled “The Limits of Science” at a Congress of German Scientists and Physicians in Leipzig. No stranger to polemic and bellicose oratory, and possessing among his generation of physiologists unmatched rhetorical abilities, du Bois-Reymond had already attracted much public recognition and acclaim for his denigration of French culture at a time when belligerence and competition between Prussia and France had peaked. Yet, the topic of his 1872 lecture had a signal significance (...) which not only would inform du Bois-Reymond’s subsequent public lectures on literature, art, civilization and science, and the place of Darwin in the modern world, but would also elaborate a mechanistic and fatalistic view of consciousness, one that denied scientific understanding of the phenomenon as even obtainable. Controversy exploded—and from all quarters. Renowned scientists accused him of pessimism and of failing to apprehend the progress of in .. (shrink)

Millán Brusslan focuses upon “Life Force or the Rhodian Genius: A Tale,” an essay Humboldt wrote for Schiller’s journal, Die Horen, to demonstrate that both thinkers are propelled by a life force (Lebenskraft) to the aesthetic realm. In Concerning the Sublime (1801), Schiller’s presentation of nature takes place as the limits of our cognitive faculties (the powers of apprehension) are balanced with that which is beyond mastery, taking us to the realm of freedom, where the ideas of the sublime and (...) of beauty find their home. Millán Brusslan argues that Schiller and Humboldt define this home for beauty and the sublime in distinct ways. Humboldt’s realm of freedom is nature itself, whereas Schiller’s idea of freedom is rooted in the human subject, a subject which eclipses nature. (shrink)

Expiratory flow limitation (EFL) can occur in mechanically ventilated patients with chronic obstructive pulmonary disease and other disorders. It leads to dynamic hyperinflation with ensuing deleterious consequences. Detecting EFL is thus clinically relevant. Easily applicable methods however lack this detection being routinely made in intensive care. Using a simple mathematical model, we propose a new method to detect EFL that does not require any intervention or modification of the ongoing therapeutic. The model consists in a monoalveolar representation of the respiratory (...) system, including a collapsible airway that is submitted to periodic changes in pressure at the airway opening: EFL provokes a sharp expiratory increase in the resistance Rc of the collapsible airway. The model parameters were identified via the Levenberg-Marquardt method by fitting simulated data on the airway pressure and the flow signals recorded in 10 mechanically ventilated patients. A sensitivity study demonstrated that only 8/11 parameters needed to be identified, the remaining three being given reasonable physiological values. Flow-volume curves built at different levels of positive expiratory pressure, PEEP, during PEEP trials (stepwise increases in positive end-expiratory pressure to optimize ventilator settings) have shown evidence of EFL in three cases. This was concordant with parameter identification (high Rc during expiration for EFL patients). We conclude from these preliminary results that our model is a potential tool for the non-invasive detection of EFL in mechanically ventilated patients. (shrink)

U članku se ispituje Kantova prosvjetiteljska koncepcija metafizike kao znanosti koju valja držati slobodnom od ideoloških predrasuda i izvanracionalnih kognitivnih resursa te je ustanoviti pod uvjetima javnog, intersubjektivno važećeg diskursa. Analiziram Kantovu vlastitu interpretaciju njegove transcendentalne filozofije kao “metafizike metafizike” i zastupam ekstenzionalni djelomični identitet kritike metafizike i metafizike koja je tako učinjena mogućom. Posebice identificiram “buduću metafiziku”, koju je Kant zamislio kao “metafiziku prirode općenito” ili “fiziologiju čistog uma”, koju je Kant bio zacrtao, ali je sam nikada nije proveo (...) i koju ne treba brkati s “metafizikom materijalne prirode” koju je Kant izložio u svojim Metafizičkim načelima prirodne znanosti . Nadalje pokazujem kako je kod Kanta “ograničenje” razuma i njegovih čistih pojmova na osjetilno zrenje kompenzirano “ograničavanjem” osjetilnosti i njenih formalnih uvjeta na pojave, uz isključenje “praznog prostora” onog neosjetilnog. Oslanjajući se na Kantovo razlikovanje “ograničenja” i “granice” , utvrđujem točnu poziciju kritičke metafizike “na granici” osjetilnog svijeta i razumskog svijeta. Zaključno tvrdim da je “buduća metafizika koja će biti moguća kao znanost” za Kanta ograničena na transcendentalnu filozofiju, uz isključenje teoretske spoznaje nadosjetilnoga, koja je time zauvijek predana predmetnom području praktički zasnovanoga racionalnog, ali ne-znanstvenog vjerovanja ili vjere .The essay examines Kant’s Enlightenment conception of metaphysics as a science to be kept free of ideological prejudice and extrarational cognitive resources and to be established under the conditions of public, intersubjectively valid discourse. I analyze Kant’s self-interpretation of his transcendental philosophy as “metaphysics of metaphysics” and argue for the extensional partial identity of the critique of metaphysics and the metaphysics so rendered possible. In particular, I identify the “future metaphysics” envisioned by Kant as the “metaphysics of nature in general” or the “physiology of pure reason,” which was projected by Kant but never carried out by himself and is not to be confused with the “metaphysics of material nature” presented by Kant in his Metaphysical Principles of Natural Science . I further show how in Kant the “restriction” of the understanding and its pure concepts to sensible intuition is counterbalanced by the “bounding” of sensibility and its formal conditions to the appearances, at the exclusion of the “empty space” of the non-sensory. In drawing on Kant’s distinction between “limit” and “boundary” , I establish the precise position of critical metaphysics “on the boundary” of the world of sense and the world of the understanding. In concluding, I argue that for Kant a “future metaphysics that will be possible as science” is restricted to transcendental philosophy, at the exclusion of the theoretical cognition of the supersensible, which is thereby delegated forever to the object domain of practically based rational but non-scientific belief or faith. (shrink)

Husserl characterizes sleep with the idea of “the relaxation of the will.” One finds a similar approach in the work of Maine de Biran, who explains sleep as “the suspension of the will.” More recently, Brian O’Shaughnessy and Matthew Soteriou have argued that mental actions constitute wakeful consciousness. In clinical practice, patients with disorders of consciousness who show “purposeful” behavior are classified as “minimally conscious,” while those in an “unresponsive wakeful state” merely behave reflexively. To what extent and how are (...) these proposals justified? This question pushes both the first- and the third-personal approaches to their limits: in an unconscious state, like a coma, one cannot reflect upon oneself; likewise, one cannot infer from physiological data whether someone is phenomenally conscious. This work offers a critical review of these proposals regarding the constitutive role for agency in phenomenal consciousness. It then presents revised versions of O’Shaughnessy’s and Soteriou’s Arguments from Synthesis and from Self-Consciousness. The argument is that everything of which one is phenomenally conscious is either a potential reason for a possible agentive power exertion, or just that power exertion itself. The “self” referred to in “self”-consciousness is either the agent or a “non-agent,” carrying out functions for the agent. Agency is therefore constitutive of phenomenal consciousness. The resulting view helps to solve the Combination Problem for panpsychism, by suggesting that agency is what raises sub-personal micro-consciousness to the personal level. The view may also justify the notion of a “Minimally Conscious State” in clinical practice. (shrink)

The heart has a high‐metabolic rate, and its “around‐the‐clock” vital role to sustain life sets it apart in a regenerative setting from other organs and appendages. The landscape of vertebrate species known to perform intrinsic heart regeneration is strongly biased toward ectotherms—for example, fish, salamanders, and embryonic/neonatal ectothermic mammals. It is hypothesized that intrinsic heart regeneration is exclusively limited to the low‐metabolic hearts of ectotherms. The biomedical field of regenerative medicine seeks to devise biologically inspired regenerative therapies to diseased human (...) hearts. Falsification of the ectothermy dependency for heart regeneration hypothesis may be a crucial prerequisite to meaningfully seek inspiration in established ectothermic regenerative animal models. Otherwise, engineering approaches to construct artificial heart components may constitute a more viable path toward regenerative therapies. A more strict definition of regenerative phenomena is generated and several testable sub‐hypotheses and experimental avenues are put forward to elucidate the link between heart regeneration and metabolism. Also see the video abstract here https://youtu.be/fZcanaOT5z8. (shrink)

Thomas Pradeu’s The Limits of the Self provides a precise account of biological identity developed from the central concepts of immunology. Yet the central concepts most relevant to this task are themselves deemed inadequate, suffering from ambiguity and imprecision. Pradeu seeks to remedy this by proposing a new guiding theory for immunology, the continuity theory. From this, an account of biological identity is provided in terms of uniqueness and individuality, ultimately leading to a defense of the heterogeneous organism as expressing (...) the highest degree of individuality. (shrink)

In humans, conscious perception and cognition depends upon the thalamocortical complex, which supports perception, explicit cognition, memory, language, planning, and strategic control. When parts of the T-C system are damaged or stimulated, corresponding effects are found on conscious contents and state, as assessed by reliable reports. In contrast, large regions like cerebellum and basal ganglia can be damaged without affecting conscious cognition directly. Functional brain recordings also show robust activity differences in cortex between experimentally matched conscious and unconscious events. This (...) basic anatomy and physiology is highly conserved in mammals and perhaps ancestral reptiles. While language is absent in other species, homologies in perception, memory, and motor cortex suggest that consciousness of one kind or another may be biologically fundamental and phylogenetically ancient. In humans we infer subjective experiences from behavioral and brain evidence. This evidence is quite similar in other mammals and perhaps some non-mammalian species. On the weight of the biological evidence, therefore, subjectivity may be conserved in species with human-like brains and behavior. (shrink)

“Exercise starts and ends in the brain”: this was the title of a review article authored by Dr. Bengt Kayser back in 2003. In this piece of work, the author highlights that pioneer studies have primarily focused on the cardiorespiratory-muscle axis to set the human limits to whole-body exercise tolerance. In some circumstances, however, exercise cessation may not be solely attributable to these players: the central nervous system is thought to hold a relevant role as the ultimate site of exercise (...) termination. In fact, there has been a growing interest relative to the “brain” response to exercise in chronic cardiorespiratory diseases, and its potential implication in limiting the tolerance to physical exertion in patients. To reach these overarching goals, non-invasive techniques, such as near-infrared spectroscopy and transcranial magnetic stimulation, have been successfully applied to get insights into the underlying mechanisms of exercise limitation in clinical populations. This review provides an up-to-date outline of the rationale for the “brain” as the organ limiting the tolerance to physical exertion in patients with cardiorespiratory diseases. We first outline some key methodological aspects of neuromuscular function and cerebral hemodynamics assessment in response to different exercise paradigms. We then review the most prominent studies, which explored the influence of major cardiorespiratory diseases on these outcomes. After a balanced summary of existing evidence, we finalize by detailing the rationale for investigating the “brain” contribution to exercise limitation in hitherto unexplored cardiorespiratory diseases, an endeavor that might lead to innovative lines of applied physiological research. (shrink)

This book is an introduction to how minds work, including how they make judgments and perceptions, and processes sensory information. It looks at the physiological and psychological methods humans use to function and survive as a species, but that put limits on their knowledge and understanding of the universe, their immediate environment and themselves. Topics include information processing, cognitive biases, visual and audio illusions, perception and misperception of moving and still objects, art perception, limits of symbolic language, and social (...) and evolutionary psychology. (shrink)

To which science, if any, does the intellect’s study belong? Though the student of nature studies every other vital capacity, most interpreters maintain that Aristotle excludes the intellect from natural science’s domain. I survey the three main reasons that lead to this interpretation: the intellect (i) is not realized physiologically in a proprietary organ, (ii) its naturalistic study would corrupt natural science’s boundaries and leave no room for other forms of inquiry, and (iii) it is not, as all other vital (...) capacities are, a principle of movement and rest. I show that the third consideration is the most significant and then defend the view that the student of nature can (and ought to) study the intellect despite its not being a principle of movement. I argue that all of an organism’s vital activities have one and only one nature as their principle, namely, the organism’s soul considered as a unitary whole. The student of nature must concern herself with whatever activities are involved in the coming to be, development, and full realization of these natural forms. (shrink)

Exclusively focused on data that are consistent with the proposed ideas, the target article misses an opportunity to review data that are inconsistent with them. Weaknesses of the emulation theory become especially evident when one tries to incorporate physiologically realistic muscle and reflex mechanisms into it. In particular, it fails to resolve the basic posture-movement controversy.

The intent of this article is to outline, integrate, and interpret relevant scientific, economic, and social issues of rbST technology that have contributed to the acceptance dilemma for this product. The public is divided into social groups, each with its own set of criteria on which they base rbSTs acceptability. Criteria for the scientific community may best be described as physiological. However, for consumers, criteria may be more practical, or procedural, including human health, animal welfare, environmental concerns, and overproduction. (...) Because the business of dairy production depends on demand from the consuming public, the criteria for acceptance of rbST by producers largely reflects those of the consumers. Of necessity, producers are also critical of rbST from a business and animal improvement standpoint. Although this article demonstrates that rbST has met most physiological criteria for acceptance, the consuming public has treated the acceptance issue with forceful skepticism. The question this article addresses is, why? The authors comment that with rbST and other biotechnologies applied to agricultural animal production, it will be the responsibility of government health agencies, scientists, and manufacturers of the products to provide early, adequate, and honest public education. Attention to the concerns of the public may be the only means to prevent hysteria over this and future agricultural products of biotechnology and will, therefore, allow the public to form logical and thoughtful criteria assessments with respect to acceptance or rejection of each product. (shrink)

The intent of this article is to outline, integrate, and interpret relevant scientific, economic, and social issues of rbST technology that have contributed to the acceptance dilemma for this product. The public is divided into social groups, each with its own set of criteria on which they base rbSTs acceptability. Criteria for the scientific community may best be described as physiological. However, for consumers, criteria may be more practical, or procedural, including human health, animal welfare, environmental concerns, and overproduction. (...) Because the business of dairy production depends on demand from the consuming public, the criteria for acceptance of rbST by producers largely reflects those of the consumers. Of necessity, producers are also critical of rbST from a business and animal improvement standpoint. Although this article demonstrates that rbST has met most physiological criteria for acceptance, the consuming public has treated the acceptance issue with forceful skepticism. The question this article addresses is, why? The authors comment that with rbST and other biotechnologies applied to agricultural animal production, it will be the responsibility of government health agencies, scientists, and manufacturers of the products to provide early, adequate, and honest public education. Attention to the concerns of the public may be the only means to prevent hysteria over this and future agricultural products of biotechnology and will, therefore, allow the public to form logical and thoughtful criteria assessments with respect to acceptance or rejection of each product. (shrink)

This thesis is a study of the relationship between Schopenhauer and the biology in the early nineteenth century. Schopenhauer improved Kant’s epistemology based on the findings of the brain physiology of the time and extended the area of the apriority and rationality. The brain paradox is based on the interpretation that Schopenhauer insists on both materialism and idealism. But what Schopenhauer received in French physiology is not materialism but vitalism. This view of Schopenhauer is also revealed by his suggesting primordial (...) animal, which is not mechanistically explained, to Lamarck’s physicalism. Schopenhauer’s ethics does not presuppose mechanistic materialism or idealism. Schopenhauer sets the limits of natural science only to criticize the mechanical materialism. One identical being presupposed by his ethics is accepted by natural sciences. (shrink)

People with higher levels of emotional intelligence (EI: adaptive emotional traits, skills and abilities) typically achieve more positive life outcomes, such as psychological wellbeing, educational attainment, and job-related success. Although the underpinning mechanisms linking EI with those outcomes are largely unknown, it has been suggested that EI may work as a ‘stress buffer’. Theoretically, when faced with a stressful situation, emotionally intelligent individuals should show a more adaptive response than those with low EI, such as reduced reactivity (less mood deterioration, (...) less physiological arousal), and faster recovery once the threat has passed. A growing number of studies have begun to investigate that hypothesis in respect to EI measured as both an ability (AEI) and trait (TEI), but results are unclear. To test the ‘stress-buffering’ function of EI, we systematically reviewed experimental studies that explored the relationship between both types of EI and acute stress reactivity or recovery. By searching 4 databases, we identified 45 eligible studies. Results showed that EI was only adaptive in certain contexts, and that findings differed according to stressor type, and how EI was measured. In terms of stress reactivity, TEI related to less mood deterioration during sports-based stressors (e.g. competitions), physical discomfort (e.g. dental procedure), and cognitive stressors (e.g. memory tasks), but did not appear as helpful in other contexts (e.g. speeches). Furthermore, effects of TEI on physiological stress responses, such as heart rate, were inconsistent. Effects of AEI on subjective and objective stress reactivity were often non-significant, with high levels detrimental in some cases. However, data suggest that both higher AEI and TEI relate to faster recovery from acute stress. In conclusion, results provide mixed support for the stress-buffering effect of EI. Limitations and quality of studies are also discussed. Findings could have implications for EI training programmes. (shrink)