Does science have limits? Where does order come from? Can we understand consciousness? Written by Nobel Laureate Leon N. Cooper, this book places pressing scientific questions in the broader context of how they relate to human experience. Widely considered to be a highly original thinker, Cooper has written and given talks on a large variety of subjects, ranging from the relationship between art and science, possible limits of science, to the relevance of the Turing Test. These essays and talks (...) have been brought together for the first time in this fascinating book, giving readers an opportunity to experience Cooper's unique perspective on a range of subjects. Tackling a diverse spectrum of topics, from the conflict of faith and science to whether understanding neural networks could lead to machines that think like humans, this book will captivate anyone interested in the interaction of science with society. (shrink)

This book is a sustained examination of issues in the philosophy of ecology that have been a source of controversy since the emergence of ecology as an explicit scientific discipline. The controversies revolve around the idea of a balance of nature, the possibility of general ecological knowledge and the role of model-building in ecology. The Science of the Struggle for Existence is also a detailed treatment of these issues that incorporates both a comprehensive investigation of the relevant ecological literature (...) and the development of an explicit theoretical framework in the philosophy of science. It addresses issues in the philosophy of ecology that are of particular importance for the deployment of ecology in the solution of environmental problems. It will have a cross-disciplinary appeal and will interest students and professionals in science, the philosophy of science, and environmental studies as well as policy-makers. (shrink)

There is a global shortage of organs for transplantation and despite many governments making significant changes to their organ donation systems, there are not enough kidneys available to meet the demand. This has led scientists and clinicians to explore alternative means of meeting this organ shortfall. One of the alternatives to human organ transplantation is xenotransplantation, which is the transplantation of organs, tissues, or cells between different species. The resurgence of interest in xenotransplantation and recent scientific breakthroughs suggest that (...) genetically-engineered pigs may soon present a realistic alternative as sources of kidneys for clinical transplantation. It is therefore important for nurses and allied health professionals to understand what is involved in xenotransplantation and its future implications for their clinical practices. First, we explore the insufficiency of different organ donation systems to meet the kidney shortage. Second, we provide a background and a summary of the progress made so far in xenotransplantation research. Third, we discuss some of the scientific, technological, ethical, and economic issues associated with xenotransplantation. Finally, we summarise the literature on the attitudes of healthcare professionals toward xenotransplantation. (shrink)

We consider approaches to explanation within the cognitive sciences that begin with Marr's computational level or Marr's implementational level and argue that each is subject to fundamental limitations which impair their ability to provide adequate explanations of cognitive phenomena. For this reason, it is argued, explanation cannot proceed at either level without tight coupling to the algorithmic and representation level. Even at this level, however, we argue that additional constraints relating to the decomposition of the cognitive system into a set (...) of interacting subfunctions are required. Integrated cognitive architectures that permit abstract specification of the functions of components and that make contact with the neural level provide a powerful bridge for linking the algorithmic and representational level to both the computational level and the implementational level. (shrink)

Computability theory originated with the seminal work of Gödel, Church, Turing, Kleene and Post in the 1930s. This theory includes a wide spectrum of topics, such as the theory of reducibilities and their degree structures, computably enumerable sets and their automorphisms, and subrecursive hierarchy classifications. Recent work in computability theory has focused on Turing definability and promises to have far-reaching mathematical, scientific, and philosophical consequences. Written by a leading researcher, Computability Theory provides a concise, comprehensive, and authoritative introduction to (...) contemporary computability theory, techniques, and results. The basic concepts and techniques of computability theory are placed in their historical, philosophical and logical context. This presentation is characterized by an unusual breadth of coverage and the inclusion of advanced topics not to be found elsewhere in the literature at this level. The book includes both the standard material for a first course in computability and more advanced looks at degree structures, forcing, priority methods, and determinacy. The final chapter explores a variety of computability applications to mathematics and science. Computability Theory is an invaluable text, reference, and guide to the direction of current research in the field. Nowhere else will you find the techniques and results of this beautiful and basic subject brought alive in such an approachable and lively way. (shrink)

This article looks at the increasing prominence of bioterrorist threat scenarios in recent US foreign policy. Germ warfare, it argues, is being depicted as the paradigmatic threat of the post-Cold War era, not only because of its affinity for cross-border movement but also because it blurs the lines between deliberate attack and spontaneous natural catastrophe. The article looks at the possible implications of this move for understandings of war, strategy and public health. It also seeks to contextualize the US’s growing (...) military interest in biodefence research within the commercial strategies of the biotech and pharmaceutical industries. In its methodology, the article weaves together elements from defence literature, scientific perspectives on infectious disease, catastrophe theory and political economy. The conceptual underpinnings of the strategy of pre-emptive warfare, it argues, lie as much in the theory of biological emergence as in official US defence strategy. (shrink)

Based on data from a survey of biological scientists at 125 American universities, this article explores how the commercialization of the university affects the problems academic scientists pursue and argues that this reorientation of scientific agendas results in a shift from science in the public interest to science for private goods. Drawing on perspectives from Bourdieu on how actors employ strategic practices toward the accumulation of social capital and acquire dispositional and perceptional tendencies that in turn recondition social structures, (...) the commercialization of the university is construed not as something that ‘‘happens to,’’ but rather something that ‘‘happens through’’ academic scientists. The specific shape and direction of the commercialization of the university is therefore influenced by how scientists incorporate the new resources and social relations of commercialization into their scientific practice and how their creative engagement with shifting structural conditions remakes the culture of academic science. (shrink)

Many students who sign up for undergraduate‐level philosophy arrive with the expectation that moral philosophy is concerned with how one should act in the concrete and familiar situations of everyday life. Yet moral philosophers are often motivated by an ideal of neutrality, and adopt a detached perspective to achieve a scientific view of the competing moral theories. To concretise the points of disagreement they present highly specific examples that are abstracted from daily reality. There is something odd about the (...) image of morality that comes into view. What kind of guidance about how to act in concrete and familiar situations can this form of theorising bring about? This paper examines Iris Murdoch’s account of moral perception as an alternative starting point. Murdoch offers a perspective that is conceptually prior to the separation of thought from action, one that addresses the agent on the level of perception. While accounts of moral perception are often criticized for proposing a complacent moral theory that is inherently conservative, I argue that Murdoch’s account offers a radical – or tragic – form of perfectionism. While moral philosophy cannot provide sufficient reasons to act, Murdoch shows that it can, like art, make us practical, capable of acting. (shrink)

It has been suggested that the enterprise of developing mechanistic theories of the human cognitive architecture is flawed because the theories produced are not directly falsifiable. Newell attempted to sidestep this criticism by arguing for a Lakatosian model of scientific progress in which cognitive architectures should be understood as theories that develop over time. However, Newell's own candidate cognitive architecture adhered only loosely to Lakatosian principles. This paper reconsiders the role of falsification and the potential utility of Lakatosian principles (...) in the development of cognitive architectures. It is argued that a lack of direct falsifiability need not undermine the scientific development of a cognitive architecture if broadly Lakatosian principles are adopted. Moreover, it is demonstrated that the Lakatosian concepts of positive and negative heuristics for theory development and of general heuristic power offer methods for guiding the development of an architecture and for evaluating the contribution and potential of an architecture's research program. (shrink)

There is a long history of controversy in ecology over the role of competition in determining patterns of distribution and abundance, and over the significance of the mathematical modeling of competitive interactions. This paper examines the controversy. Three kinds of considerations have been involved at one time or another during the history of this debate. There has been dispute about the kinds of regularities ecologists can expect to find, about the significance of evolutionary considerations for ecological inquiry, and about the (...) empirical credentials of theoretical studies of competition. Each of these elements is examined with an eye toward gaining philosophical clarification of the issues involved. In the process, certain shortcomings of contemporary philosophical theories are revealed. In particular, I argue that plausibility arguments based on background considerations are an important part of the model building tradition, but that current accounts of the structure and evaluation of scientific theories do little to illuminate this side of theoretical ecology. (shrink)

This paper asks what it means to say that a disorder is a “real” disorder and then considers whether culture-bound syndromes are real disorders. Following J.L. Austin I note that when we ask whether some supposed culture-bound syndrome is a real disorder we should start by specifying what possible alternatives we have in mind. We might be asking whether the reported behaviours genuinely occur, that is, whether the culture-bound syndrome is a genuine phenomenon as opposed to a myth. We might (...) be wondering whether the condition should rightly be considered a disorder, as opposed to some sort of non-disorder condition. We might want to know whether the culture-bound syndrome is really a distinct disorder, in the sense that scientific classification systems should include it as a separate category, or whether it is just a variant of a universally occurring disorder. I argue that some specific difficulties can arise with determining whether a culture-bound syndrome is a real disorder in each of these three senses. However, the frequent assumption that real disorders will necessarily occur universally, and that those that occur only in certain environments are suspicious is not generally justified. (shrink)

Cognitive architectures - task-general theories of the structure and function of the complete cognitive system - are sometimes argued to be more akin to frameworks or belief systems than scientific theories. The argument stems from the apparent non-falsifiability of existing cognitive architectures. Newell was aware of this criticism and argued that architectures should be viewed not as theories subject to Popperian falsification, but rather as Lakatosian research programs based on cumulative growth. Newell's argument is undermined because he failed to (...) demonstrate that the development of Soar, his own candidate architecture, adhered to Lakatosian principles. This paper presents detailed case studies of the development of two cognitive architectures, Soar and ACT-R, from a Lakatosian perspective. It is demonstrated that both are broadly Lakatosian, but that in both cases there have been theoretical progressions that, according to Lakatosian criteria, are pseudo-scientific. Thus, Newell's defense of Soar as a scientific rather than pseudo-scientific theory is not supported in practice. The ACT series of architectures has fewer pseudo-scientific progressions than Soar, but it too is vulnerable to accusations of pseudo-science. From this analysis, it is argued that successive versions of theories of the human cognitive architecture must explicitly address five questions to maintain scientific credibility. (shrink)

In an era when public faith in politicians is dwindling, yet trust in scientists remains relatively high, governments are increasingly emphasizing the role of science based policy-making in response to challenges such as climate change and global pandemics. In this paper we question the quality of some scientific advice given to governments and the robustness and transparency of the entire framework which envelopes such advice, all of which raise serious ethical concerns. In particular we focus on the so-called Imperial (...) Model which heavily influenced the government of the United Kingdom in devising its response to the COVID-19 crisis. We focus on and highlight several fundamental methodological flaws of the model, raise concerns as to the robustness of the system which permitted these to remain unchallenged, and discuss the relevant ethical consequences. (shrink)

The primary purpose of the paper is the broadly exegetical one of explaining and connecting Heidegger's many remarks, made in several different contexts of enquiry, on nature. The three main contexts are those of ontology, scientific methodology, and technology. After showing how Heidegger's central theses in these contexts are related to one another, I argue, in the final section, that his observations on scientific method are pivotal. Unless these are secured, his further claims about ontology and technology lose (...) their essential support. (shrink)

The author examines the question of Galen's affinity with astrology, in view of Galen's extended astrological discussion in the De diebus decretoriis . The critical passages from Galen are examined, and shown to be superficial in understanding. The author performs a lexical sounding of Galen's corpus, using key terms with astrological valences drawn from the Critical Days, and assesses their absence in Galen's other works. He compares Galen's astrology with the astrology of Ptolemy's Tetrabiblos, and evaluates their respective strategies of (...) scientific reasoning. Three types of inference are introduced and applied to Galen's astrology. Finally, he concludes that the empirical side of Galen's science does not depend upon astrological methods or concepts, but that these were introduced for their rhetorical effect in presenting his new medical methodology. It is suggested that continued attention to Galen's astrology has obscured the truly important empirical scientific method that Galen developed. (shrink)

My principal aims are to question the conventional wisdom on two points. First, it argues that cognitive understanding is neither identical with nor reducible to knowledge?why, and that it is a multiform capacity which adds value to knowledge, true belief, and human creative activity. Essential to understanding is epistemic ascent, the rising above bare knowledge, to assess, appraise, compare, contrast, emphasize, connect and so on. Different modes of understanding are distinguished and an accompanying vocabulary of mode?indicators (expressing Fregean ?colour'). Second, (...) I argue for the unity and continuity of understanding and reject any Diltheyesque idea of a great divide between so?called ?explanation? and ?understanding?, a divide which has sometimes been used to make a sharp demarcation between the natural sciences and the humane studies and sciences. A connection between humane and natural?scientific understanding is established through the Linkage Principle. The idea that there is in every case a uniquely right understanding is rejected and the role of multiple descriptions in both the natural sciences and humane understanding is emphasized. (shrink)

Sketching as a scientific practice goes beyond the simple act of inscribing diagrams onto paper. Scientists produce a wide range of representations through sketching, as it is tightly coupled to model-based reasoning. Chemists in particular make extensive use of sketches to reason about chemical phenomena and to communicate their ideas. However, the chemical sciences have a unique problem in that chemists deal with the unseen world of the atomic-molecular level. Using sketches, chemists strive to develop causal mechanisms that emerge (...) from the structure and behavior of molecular-level entities, to explain observations of the macroscopic visible world. Interpreting these representations and constructing sketches of molecular-level processes is a crucial component of student learning in the modern chemistry classroom. Sketches also serve as an important component of assessment in the chemistry classroom as student sketches give insight into developing mental models, which allows instructors to observe how students are thinking about a process. In this paper we discuss how sketching can be used to promote such model-based reasoning in chemistry and discuss two case studies of curricular projects, CLUE and The Connected Chemistry Curriculum, that have demonstrated a benefit of this approach. We show how sketching activities can be centrally integrated into classroom norms to promote model-based reasoning both with and without component visualizations. Importantly, each of these projects deploys sketching in support of other types of inquiry activities, such as making predictions or depicting models to support a claim; sketching is not an isolated activity but is used as a tool to support model-based reasoning in the discipline. (shrink)

While Kant introduces his critical philosophy in continuity with the experimental tradition begun by Francis Bacon, it is widely accepted that his Copernican revolution places experimental physics outside the bounds of science. Yet scholars have recently contested this view. They argue that in Critique of the Power of Judgment Kant’s engagement with the growing influence of vitalism in the 1780s leads to an account of nature’s formative power that returns experimental physics within scientific parameters. Several critics are sceptical of (...) this revised reading. They argue that Kant’s third Critique serves precisely to deflate the epistemological status of experimental physics, thereby protecting science from the threat of vitalism. In this paper I examine Kant’s account of science in the context of the experimental tradition of philosophy, particularly in relation to the generation dilemma of the eighteenth century. I argue that Kant does not deflate the epistemological status of experimental physics but rather introduces systematicity to the experimental tradition. By identifying the reflective use of reason to organize laws of experience into a systematic whole, Kant aims to ground experimental inquiry on the secure course of a science, opening a conception of science as a research programme. (shrink)

Most studies deny that Kritik der Urteilskraft played a significant role in the early reception of Kant’s philosophy in England. In this paper, I examine the notebooks, letters and lectures of several members of British medical and scientific institutions to tell a different story. Drawing from the writings of Thomas Beddoes, Samuel Taylor Coleridge, Joseph Henry Green and William Whewell, I identify a line of reception in which Kant’s critique of judgement’s power of reflection was used to establish the (...) consilience of the mind’s anticipation of systematic order and the organization of natural bodies. Each discovered in Kant’s Kritik der Urteilskraft a shared principle for judgements of taste and scientific inquiry, made available through the mind’s affective response to the appearance of contingent order in nature. Their writings, I contend, evince a more sophisticated reception of Kant’s philosophy in England than has hitherto been recognized. (shrink)

Although consensus appears to be on the horizon, the foundations of the theory of natural selection remain a matter of controversy. This paper looks at two recent challenges to the emerging "received view" of this theory. It argues that different views of the nature of scientific explanation are playing a pivotal role in the debates. Do explanations in biology fit the covering-law paradigm? What are the explanatory laws of biology like? Until agreement is reached on these fundamental questions, there (...) is little prospect for consensus on the foundations of the theory of natural selection. Furthermore, the three alternative positions identified in this paper each face serious challenges. (shrink)

The scientific understanding of common chronic disease began in the mid-19th century, driven in large part by the development of the modern autopsy. For cardiovascular disease, the recognition that rigid plaques were obstructing muscular arteries, especially in the coronary arteries, provided a mechanism to explain what had been a mysterious "chest pain–sudden collapse" syndrome. The origin of these plaques was totally obscure, however, and they were given the descriptive name of "atherosclerosis," or "hardened porridge" in Greek. Not until 50 (...) years later, when animal experimental models serendipitously revealed the hyper-lipidemic consequences of a diet high in animal fat, followed by accretion of lipid... (shrink)

The base units of the SI include six units of continuous quantities and the mole, which is defined as proportional to the number of specified elementary entities in a sample. The existence of the mole as a unit has prompted comment in Metrologia that units of all enumerable entities should be defined though not listed as base units. In a similar vein, the BIPM defines numbers of entities as quantities of dimension one, although without admitting these entities as base units. (...) However, there is a basic ontological distinction between continuous quantities and enumerable aggregates. The distinction is the basis of the difference between real and natural numbers. This paper clarifies the nature of the distinction: (i) in terms of a set of measurement axioms stated by Hölder; and (ii) using the formalism known in metrology as quantity calculus. We argue that a clear and unambiguous scientific distinction should be made between measurement and enumeration. We examine confusion in metrological definitions and nomenclature concerning this distinction, and discuss the implications of this distinction for ontology and epistemology in all scientific disciplines. (shrink)

: Sociologists of Scientific Knowledge sometimes claim to study scientists belonging to other forms of life. This claim causes difficulties, as traditionally Wittgensteinians have taken it to be the case that other forms of life are incomprehensible to us. This paper examines whether, and how, sociologists might gain understanding of another form of life, and whether, and how, this understanding might be passed on to readers. I argue that most techniques proposed for gaining and passing on understanding are inadequate, (...) but I end by describing a method that might work. (shrink)

Because physicians use scientific inference for the generalizations of individual observations and the application of general knowledge to particular situations, the Bayesian probability solution to the problem of induction has been proposed and frequently utilized. Several problems with the Bayesian approach are introduced and discussed. These include: subjectivity, the favoring of a weak hypothesis, the problem of the false hypothesis, the old evidence/new theory problem and the observation that physicians are not currently Bayesians. To the complaint that the prior (...) probability is subjective, Bayesians reply that there will be ultimate convergence, but the rebuttal to this is that there will not be uniform convergence. Secondly, since the Bayesian scheme favors a weak hypothesis, theories turn out to be a gratuitous risk. The problem with the false hypothesis comes out in the denominator of the theorem, revealing that a factor which is not a theory at all is being considered in the reasoning. On the old evidence/new theory problem old evidence cannot confirm a new theory so that the posterior probability will equal the prior probability. Finally, empiric studies have shown that current physicians are not Bayesians. But on consideration of Bayesian inference as a system of inference, it can be reasoned that physicians should be Bayesians. However, the problem of physicians' and patients' own subjectivity continue to plague this system of medical decision making. (shrink)

We live in the era of Facebook, Fitbit, and Skype. As such, it would be unreasonable to expect that the healthcare industry would not see the same kind of globalization as do our social spheres and consumer activities. Indeed, the explosion of information technology, the ease of transcontinental travel, and the emergence of a more globally aware citizenry allows for scientific collaboration that has had many positive effects on global health. However, the economic and structural disparities between systems of (...) healthcare delivery in the industrialized world and parts of the developing world have created a monster in the form of an international medical tourism industry that endangers the health and safety of citizens of the host country as well as visiting patients. Not only does the practice of medical tourism pose a practical danger to those in direct contact with the industry, but it brings up troubling philosophical problems centering on national responsibility and the commodification of healthcare, among other important issues. In the United States, the driving force behind international medical tourism is the exorbitant cost of healthcare, particularly for the uninsured but also for the underinsured and those who experience catastrophic medical expenses from chronic illness or sudden health crises. Not only have individuals begun to look outside the U.S. for surgical procedures and other expensive therapies, but employers have begun to toy with the idea of outsourcing the medical care of the employees they insure in order to cut costs. In other industrialized nations, the issues that underpin international medical tourism are related to healthcare rationing and reflect different shortcomings in the delivery of healthcare in those nations, such as the United Kingdom and Canada, that have single-payer systems. Yet the regulatory and philosophical implications for both patients and hosts of international healthcare are largely the same. The challenge of regulating international trade in medical care is obvious and becomes particularly acute when there are insurers and employers involved. Complicating matters further, medical care that takes place outside the country of origin of the patient is often brokered by “medical concierge services,” which, though quick to claim indemnity from any harm arising from substandard or inappropriate medical care, cannot be divorced from responsibility for the health outcomes of their clients. Agreements hashed out between concierge services and patients specify that any remedy for harm stemming from their medical care must be pursued within the confines of the law of the host country, but the practical implications of this are troublesome. How can a foreign patient—often without either linguistic or cultural competency in the host country—be expected to navigate the complexity of a foreign legal system, particularly one that may be far less developed than his home country? Furthermore, if insurance companies and employers are involved with such care, who pays for an adverse result or determines responsibility for harm that may befall the patient? Under which countries’ laws? If a patient travels to Singapore for sexual reassignment surgery or a cardiac valve repair, returns to the States and suffers complications, who pays for the restoration of her health? Beyond legal standards and judicial remedies for harm to patients seeking care on the international market, there is the question of what ethical standards and norms apply to such patients. What effect does it have on American patients, for example, to receive care within a system that does not emphasize autonomy and informed consent the way they are used to? Why should foreign physicians care about the cultural mores of their patients’ country of origin? Can they be expected to grasp cultural differences between American, Canadian, and British patients? The medical concierge might respond, “Well, buyer beware!” This is unreasonable: It is nearly impossible for any patient to accurately assess the various options, risks and benefits that go with a particular medical treatment, much less the patient who is attempting to do so on the international market. And the crass invocation of the doctrine of caveat emptor betrays a view of healthcare as a commodity that is naive and inappropriate. Paramount in my mind, however, are the practical implications for the care of the citizens of developing nations that host international patients and the broader philosophical issue of what the goals of the medical profession as a whole and each country’s individual healthcare system should be. While I understand the argument that international medical tourism creates great economic gains for developing nations, which can then be channeled toward the care of their citizenry as a whole, there is much reason to doubt that this “trickle-down” model of economics provides real benefits for underserved, whether in healthcare or other arenas. What is more likely is that, while lucrative international “medi-cities” may keep bright doctors in their home countries, it is also likely to lure them away from the institutions that serve the lion’s share of their countrymen. With the concentration of talented native doctors in private hospitals that serve citizens of the developed world, the population at large is left to obtain care at institutions that suffer “brain drain” from the flight of talented local staff to more prestigious, often “brand name,” institutions that give them more Western-like salaries while allowing them to practice in their countries of origin. The very fact that citizens of the wealthiest nations in the world are forced to go abroad for life-saving care speaks to an abdication of national responsibility on the part of their home countries. The provision of health care is one of the principal responsibilities of any nation and it is unacceptable that a nation with the strength and wealth of the United States would take advantage of the weaker political and economic situations of developing nations in order to shirk its responsibility to its fellow citizens. If we take care of our countrymen and take pride in an equitable system of healthcare delivery, there will be no need to shrug our shoulders and say “Buyer beware” to the patient who heads to the Philippines for heart surgery. (shrink)

Sustained controversy over a philosophical issue is often times symptomatic of differing commitments at a more fundamental philosophical level. I will argue that two current debates over the foundations of the theory of natural selection are cases in point. Alexander Rosenberg, at times together with Mary Williams, challenges what is becoming received orthodoxy about the foundations of this theory. He argues that the currently popular propensity interpretation of fitness does not legitimize explanations in terms of natural selection, and that furthermore, (...) the biological fields which typically study the ways in which selection pressures originate in the organism/environment complex are not in fact part of the theory of natural selection at all. His foils in the first case are Robert Brandon, John Beatty and Susan Mills;2 on the second issue he is engaged in debate with Elliott Sober.3 We will see that, although the controversies are ostensibly about the interpretation of fitness, the issues, at bottom, involve the nature of scientific explanation. (shrink)

For decades, courtrooms around the world have admitted evidence from forensic science analysts, such as fingerprint, tool-mark and bite-mark examiners, in order to solve crimes. Scientific progress, however, has led to significant criticism of the ability of such disciplines to engage in individualization i.e., “match” suspects exclusively to evidence. Despite this, American courts largely reject legal challenges based on arguments that identification evidence provided by these forensic science disciplines is unreliable. In so holding, these courts affirm precedent that it (...) is the adversarial system’s function to weed out frailties in forensic evidence, and find that criticism of the forensic sciences lacks sui generis qualities. This article provides an independent critique of relevant American case law, from which three themes emerge. These themes are (1) the law’s misuse of science; (2) law’s scepticism towards change; and (3) law’s narrow construction of rationality, which generates reductionist concepts, and divorces science from its social context. As such, this article shows how the American judiciary’s approach to this global issue provides a contemporary illustration of key institutional tensions between science and law, and offers some recommendations for reforms that aim to facilitate the legal process to utilize the most reliable forensic science evidence possible. (shrink)

The paper examines two forms of naturalistic moral realism, “Micro-structure realism” and “Reason realism” . The latter, as we defend it, locates the objectivity of moral facts in socially constructed reality, but the former, as exemplified by David Brink\'s model of naturalistic moral realism, secures the objectivity of moral facts in their micro- structure and a nomic supervenience relationship. We find MSR\'s parity argument for this account of moral facts implausible; it yields a relation ship between moral facts and their (...) natural- scientific constitution that has a queer, slapped- together quality. We argue that the relationship needs to be spelled out by a process of social construction, involving collective intentionality and constitutive rules. We explain how our constructivist model of RR differs from a form of it defended by Michael Smith , which analyzes moral facts by reference not to construction but rather to a hypothetical situation of full rationality. We agree with Smith, as against Bernard Williams, that a rational agent may have reasons for acting that go beyond the agent\'s “subjective motivational set,” but we locate such reasons by reference to the agent\'s member ship in an actual community, and we explore the prospects for moral objectivity given this constraint on moral reasons. (shrink)

The paper examines two forms of naturalistic moral realism, “Micro-structure realism” and “Reason realism”. The latter, as we defend it, locates the objectivity of moral facts in socially constructed reality, but the former, as exemplified by David Brink\'s model of naturalistic moral realism, secures the objectivity of moral facts in their micro- structure and a nomic supervenience relationship. We find MSR\'s parity argument for this account of moral facts implausible; it yields a relation ship between moral facts and their natural- (...) scientific constitution that has a queer, slapped- together quality. We argue that the relationship needs to be spelled out by a process of social construction, involving collective intentionality and constitutive rules. We explain how our constructivist model of RR differs from a form of it defended by Michael Smith, which analyzes moral facts by reference not to construction but rather to a hypothetical situation of full rationality. We agree with Smith, as against Bernard Williams, that a rational agent may have reasons for acting that go beyond the agent\'s “subjective motivational set,” but we locate such reasons by reference to the agent\'s member ship in an actual community, and we explore the prospects for moral objectivity given this constraint on moral reasons. (shrink)

James’s positivism is different from Comte’s, Clifford’s, and the logical positivists’. Notably, itpresupposes a difference between natural–scientific inquiries and the metaphysical inquiry he callsradical empiricism. Equally importantly, the positivism of James’s great book, The Principles ofPsychology, studies the cerebral conditions of the will. This cerebralism is necessary background forunderstanding James’s voluntarism, the will–to–believe doctrine that came later. James’s positivismgoes hand–in–hand with his value pluralism; they are responsible for different domains of inquiry,natural-scientific and ethical, respectively. It is a mistake (...) to impose a “master moral syllogism” ontothe former, implying that all facts are constituted by the will as guided by a utilitarian moral principle.Cerebral shaping of the will occurs not only through the “front door” of experience, especially in theformation of habit, but also through the “back stairs” of mutation and natural selection, which createsbrains suited to different pursuits. The brain is no tabula rasa. (shrink)

James’s positivism is different from Comte’s, Clifford’s, and the logical positivists’. Notably, it presupposes a difference between natural–scientific inquiries and the metaphysical inquiry he calls radical empiricism. Equally importantly, the positivism of James’s great book, The Principles of Psychology, studies the cerebral conditions of the will. This cerebralism is necessary background for understanding James’s voluntarism, the will–to–believe doctrine that came later. James’s positivism goes hand–in–hand with his value pluralism; they are responsible for different domains of inquiry, natural-scientific and (...) ethical, respectively. It is a mistake to impose a “master moral syllogism” onto the former, implying that all facts are constituted by the will as guided by a utilitarian moral principle. Cerebral shaping of the will occurs not only through the “front door” of experience, especially in the formation of habit, but also through the “back stairs” of mutation and natural selection, which creates brains suited to different pursuits. The brain is no tabula rasa. (shrink)

Mission-oriented climate change research is often unverifiable. Therefore, many stakeholders look to peer-reviewed climate change research for trustworthy information about deeply uncertain and impactful phenomena. This is because peer-review signals that research has been vetted for scientific standards like reproducibility and replicability. Here we evaluate the transparency of research methodologies in mission-oriented computational climate research. We find that only five percent of our sample meets the minimal standard of fully open data and code required for reproducibility and replicability. The (...) widespread lack of minimal openness standards in peer-reviewed climate change research jeopardizes scientific credibility and risks poor societal outcomes as we manage growing climate risks. The scientific community can and must do better. We, the authors, outline necessary openness standards that we commit to as researchers, reviewers, and readers. We invite you to join us. (shrink)

There has been a significant amount of uncertainty and controversy over the prospects for general knowledge in ecology. Environmental decision makers have begun to despair of ecology's capacity to provide anything more than case by case guidance for the shaping of environmental policy. Ecologists themselves have become suspicious of the pursuit of the kind of genuine nomothetic knowledge that appears to be the hallmark of other scientific domains. Finally, philosophers of biology have contributed to this retreat from generality by (...) suggesting that there really are no laws in biology. This paper addresses these issues by providing a framework for thinking about general knowledge claims in ecology. It introduces a philosophical taxonomy that classifies generalizations into three broad categories – phenomenological, causal and theoretical. It then turns to the difficult problem of laws, arguing that, while there are probably no laws as that term has been understood in philosophy of science, it doesn't follow that everything in ecology is equally contingent. A mechanism for recognizing degrees of contingency in ecological generalizations is developed. The paper concludes by examining the implications of the analysis for the controversies noted at the outset. (shrink)

Formal clinical trials of pig-to-human organ transplant—known as xenotransplantation—may begin this decade, with the first trials likely to consist of either adult renal transplants or pediatric cardiac transplant patients. Xenotransplantation as a systematic scientific study only reaches back to the latter half of the 20th century, with episodic xenotransplantation events occurring prior to that. As the science of xenotransplantation has progressed in the 20th and 21st centuries, the public's knowledge of the potential therapy has also increased. With this, there (...) have been shifting ethical stances toward xenotransplantation in key areas, such as religious and public viewpoints towards xenotransplantation, animal rights, and public health concerns. This review provides a historical–ethical account of xenotransplantation and details if or how viewpoints have shifted over time. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress (...) that has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

SummaryDuring the 1920s and 1930s, Italian physicists established strong relationships with scientists from other European countries and the United States. The career of Bruno Rossi, a leading personality in the study of cosmic rays and an Italian pioneer of this field of research, provides a prominent example of this kind of international cooperation. Physics underwent major changes during these turbulent years, and the traditional internationalism of physics assumed a more institutionalized character. Against this backdrop, Rossi's early work was crucial (...) in transforming the study of cosmic rays into a branch of modern physics. His friendly relationships with eminent scientists — notably Enrico Fermi, Walther Bothe, Werner Heisenberg, Hans Bethe, and Homi Bhabha — were instrumental both for the exchange of knowledge about experimental practices and theoretical discussions, and for attracting the attention of physicists such as Arthur Compton, Louis Leprince-Ringuet, Pierre Auger and Patrick Blackett to the problem of cosmic rays. Relying on material from different archives in Europe and the United States, this case study aims to provide a glimpse of the intersection between national and international dimensions during the 1930s, at a time when the study of cosmic rays was still very much in its infancy, strongly interlaced with nuclear physics, and full of uncertain, contradictory, and puzzling results. Nevertheless, as a source of high-energy particles it became a proving ground for testing the validity of the laws of quantum electrodynamics, and made a fundamental contribution to the origins of particle physics. (shrink)

This work explores the attitudes of American scientists towardsinternational scientific activity, with particular respect to theoceanic sciences, during the three decades after the First WorldWar. In the mid-1950s, the Eisenhower Administration favouredthe thesis that increased international collaboration wouldstrengthen the Free World, ease Cold War tensions, and promotethe growth of science. This essay analyses elements in thatthesis, namely, scientific chauvinism, humanitarianism, andscientific interdependence. The narrative traces these themesthrough key episodes in the history of international cooperationin oceanic science, revealing how (...) this experience shapedstrategies and expectations for cooperative scientific research. (shrink)

This contribution describes—with some documentary support from Peirce’s correspondence of his first and second European trips—Peirce’s conception of science as a collective and co-operative activity of all those whose lives are animated by the desire to find out the truth, whose lives are animated by “an impulse to penetrate into the reason of things.” The paper has two sections: first, Peirce as an inventor and builder of research instruments around which scientific communities are formed, and, second, Peirce’s own experience (...) of cooperation within science. (shrink)

Using the approach known as ‘Economics of Scientific Knowledge’, this paper defends the view of scientific norms as the result of a ‘social contract’, i.e., as an equilibrium in the game of selecting the norms under which to proceed to play the game of scientific research and publication. A categorisation of the relevant types of scientific norms is offered, as well as a discussion about the incentives of the researchers in choosing some or other alternative rules.