: Results of a search for the electroweak associated production of charginos and next-to-lightest neutralinos, pairs of charginos or pairs of tau sleptons are presented. These processes are characterised by final states with at least two hadronically decaying tau leptons, missing transverse momentum and low jet activity. The analysis is based on an integrated luminosity of 20.3 fb−1 of proton-proton collisions at recorded with the ATLAS experiment at the Large Hadron Collider. No significant excess is observed with respect to the (...) predictions from Standard Model processes. Limits are set at 95% confidence level on the masses of the lighter chargino and next-to-lightest neutralino for various hypotheses for the lightest neutralino mass in simplified models. In the scenario of direct production of chargino pairs, with each chargino decaying into the lightest neutralino via an intermediate tau slepton, chargino masses up to 345 GeV are excluded for a massless lightest neutralino. For associated production of mass-degenerate charginos and next-to-lightest neutralinos, both decaying into the lightest neutralino via an intermediate tau slepton, masses up to 410 GeV are excluded for a massless lightest neutralino.[Figure not available: see fulltext.]. (shrink)
What is empiricism and what could it be? Bas C. van Fraassen, one of the world’s foremost contributors to philosophical logic and the philosophy of science, here undertakes a fresh consideration of these questions and offers a program for renewal of the empiricist tradition. The empiricist tradition is not and could not be defined by common doctrines, but embodies a certain stance in philosophy, van Fraassen says. This stance is displayed first of all in a searing, recurrent critique of metaphysics, (...) and second in a focus on experience that requires a voluntarist view of belief and opinion._ _Van Fraassen focuses on the philosophical problems of scientific and conceptual revolutions and on the not unrelated ruptures between religious and secular ways of seeing or conceiving of ourselves. He explores what it is to be or not be secular and points the way toward a new relationship between secularism and science within philosophy. (shrink)
What is empiricism and what could it be? Bas C. van Fraassen, one of the world's foremost contributors to philosophical logic and the philosophy of science, here undertakes a fresh consideration of these questions and offers a program for renewal of the empiricist tradition. The empiricist tradition is not and could not be defined by common doctrines but embodies a certain stance in philosophy, van Fraassen says. This stance is displayed first of all in a searing recurrent critique of metaphysics, (...) and second in a focus on experience that requires a voluntarist view of belief and opinion. (shrink)
Metaphysicians speak of laws of nature in terms of necessity and universality; scientists, in terms of symmetry and invariance. In this book van Fraassen argues that no metaphysical account of laws can succeed. He analyzes and rejects the arguments that there are laws of nature, or that we must believe there are, and argues that we should disregard the idea of law as an adequate clue to science. After exploring what this means for general epistemology, the author develops the empiricist (...) view of science as a construction of models to represent the phenomena. (shrink)
What is empiricism and what could it be? Bas . van Fraassen, one of the world’s foremost contributors to philosophical logic and the philosophy of science, here undertakes a fresh consideration of these questions and offers a program for renewal of the empiricist tradition. The empiricist tradition is not and could not be defined by common doctrines, but embodies a certain stance in philosophy, van Fraassen says. This stance is displayed first of all in a searing, recurrent critique of metaphysics, (...) and secondly in a focus on experience that requires a voluntarist view of belief and opinion. Van Fraassen focuses on the philosophical problems of scientific and conceptual revolutions and on the not unrelated ruptures between religious and secular ways of seeing or conceiving of ourselves. He explores what it is to be or not be secular and points the way toward a new relationship between secularism and science within philosophy. (shrink)
Scientific representation: A long journey from pragmatics to pragmatics Content Type Journal Article DOI 10.1007/s11016-010-9465-5 Authors James Ladyman, Department of Philosophy, University of Bristol, 9 Woodland Rd, Bristol, BS8 1TB UK Otávio Bueno, Department of Philosophy, University of Miami, Coral Gables, FL 33124, USA Mauricio Suárez, Department of Logic and Philosophy of Science, Complutense University of Madrid, 28040 Madrid, Spain Bas C. van Fraassen, Philosophy Department, San Francisco State University, 1600 Holloway Avenue, San Francisco, CA 94132, USA Journal Metascience Online (...) ISSN 1467-9981 Print ISSN 0815-0796. (shrink)
Projet En développant son « empirisme constructif », Bas Van Fraassen est devenu une référence incontournable pour la philosophie des sciences contemporaine. Après la vague de critiques qui, vers les années 1960, avait fait perdre à l'empirisme logique sa prédominance dans le champ des idées, le réalisme scientifique semblait s'être imposé comme le seul compte rendu acceptable du travail et des orientations de la recherche. Quine avait beau énoncer ce que pourrait être un empirisme affranchi de ses deux « dogmes (...) » (l'intangibilité de la distinction vérités analytiques / vérités synthétiques, et la réduction des constructions aux « faits »), le programme d'une philosophie des sciences empiriste renouvelée restait à l'état d'esquisse. Mais par trois ouvrages successifs, Scientific Image (1980), Laws and symmetry (1989), et Quantum mechanics an empiricist view (1991), Van Fraassen a posé les bases d'un empirisme viable, parce que capable de prendre en charge la plupart des spécificités dont se prévaut le réalisme contre l'empirisme classique ou logique, et de rendre raison des développements les plus actuels de la physique. Contre l'empirisme classique ou logique, les réalistes font d'abord valoir que la réduction de toute réalité et de tout acte de référence aux phénomènes, ne rend justice ni à la pratique du langage courant ni à celle des sciences. Lorsque quelqu'un procède à une dénomination, il ne cherche pas à désigner par là une tranche d'apparaître, ou quelque ensemble fini et répertorié d'apparitions; il pointe vers "quelque chose" dont les modalités de manifestation sans fin assignable sont pour partie anticipées et pour partie ouvertes. De même, quand un chercheur scientifique parle de l'objet de ses investigations, il ne limite pas son discours à un ensemble fini de résultats d'expérience obtenus sous des conditions instrumentales actuellement disponibles; il renvoie à une entité dont la variété des manifestations futures est prévue aussi complètement que possible (et avec un succès croissant) par des cadres conceptuels et théoriques révisables. Face à cette objection, Van Fraassen fait jouer un rôle capital aux modèles dans sa version de l'empirisme.. (shrink)
This study analyzes the metaphoric and metonymic nature ofbaş/kafa‘head’ in Turkish idiomatic expressions from a cognitive linguistic perspective. The database for the study is composed of idioms containing the two head-denoting wordsbaşandkafa. Idioms and their definitions are analyzed in terms of their figurative uses of abstract concepts, and the conceptual metaphors and metonymies are identified. Findings are examined under five categories: head as the representative of the person, the seat of mental faculties, the locus of emotions, the sign of superiority/power, (...) and the sign of value. The study proposes a cultural model in which the image schemaswhole-part,containmentandverticalityplay a key role, and reveals cross-cultural similarities and differences in the conceptualization ofhead. The study also provides further support for the embodiment thesis, and underscores the impact of cultural processes in shaping the way the body is conceptualized. (shrink)
The world’s first COVID-19 human challenge trial using the D614G strain of SARS-CoV-2 is underway in the United Kingdom. The Wellcome Trust is funding challenge stock preparation of the Beta variant (B.1.351) for a follow-up human challenge trial, and researchers at Imperial College London are considering conducting that trial. However, little has been written thus far about the ethical justifiability of human challenge trials with SARS-CoV-2 variants of concern. While vaccine resistance as such does not increase risks for volunteers in (...) COVID-19 challenge trials, we explore two specific characteristics of some variants that may initially be thought to make such trials unethical and conclude that SARS-CoV-2 variant challenge trials can remain ethical. (shrink)
Belonging to Hebrew Wisdom literature, the Song of Songs offers a fresh look at love and relationships through its main female character, the Shulamite, which profoundly differs from traditional, religious approaches to love and sexuality. Drawing from exegetical as well as philosophical resources, Abi Doukhan follows the Shulamite's journey away from patriarchy to her own self-individuation as she discovers a wisdom that is deeply personal and feminine.
TB human challenge studies could accelerate TB vaccine development by reducing uncertainty in early-stage vaccine testing, selecting promising vaccine candidates for large-scale field trials, and identifying an immune correlate of protection. However, ethical concerns regarding the exposure of trial participants and bystanders to significant risk have been a limiting factor for TB human challenge models. We analyze the expected social value and risks of different types of TB human challenge models, and conclude that given the massive public health burden of (...) TB, challenge models with even scant probabilities of expediting TB vaccine authorization have enormous expected humanitarian value, saving between 33,000 and 1,375,000 lives over the next ten years. We argue that attenuated M.tb challenge trials can be conducted ethically, and discuss the benefits and drawbacks of conducting virulent M.tb challenge trials. (shrink)
We argue that deliberative decision-making that is inclusive, transparent and accountable can contribute to more trustworthy and legitimate decisions on difficult ethical questions and political trade-offs during the pandemic and beyond.
Analogies, contaminations and assonances between certain aspects of the thought of Aby Warburg and Walter Benjamin are still at the center of the contemporary theoretical debate. In the absence of tangible and documented exchanges, the similarities between the two scholars can be found in the structure of their most original and significant works, the Atlas of Memory and the Passagen-Werk, and in the adoption of the fragment as a conceptual language. Of particular interest is the reflection on baroque which, for (...) both scholars, involves the relation with the ancient tragedy and the modern drama. (shrink)
Archives are being digitised on an enormous scale worldwide, and the connections between Aby Warburg’s Mnemosyne Atlas and the contemporary digital accumulation of data have not been lost on contemporary scholars. By problematising what I suggest is a simplified relation between repetition and replication in the transmission of Warburg’s body of work into a digital era, I believe that an engagement with contemporary digital discourse provides the possibility of seeing his work in a new light while allowing for insights into (...) how Warburg might be instrumental in rendering visible possible discrepancies between individual entities and larger collective patterns, whether within his Mnemosyne Atlas or among datasets more broadly speaking. (shrink)
The aim of this article is (1) to investigate the ‘neurosciences’ as an object of study for historical and genealogical approaches and (2) to characterize what we identify as a particular ‘style of thought’ that consolidated with the birth of this new thought community and that we term the ‘neuromolecular gaze’. This article argues that while there is a long history of research on the brain, the neurosciences formed in the 1960s, in a socio-historical context characterized by political change, faith (...) in scientific and technological progress, and the rise of a molecular gaze in the life sciences. They flourished in part because these epistemological and technological developments were accompanied by multiple projects of institution-building. An array of stakeholders was mobilized around the belief that breakthroughs in understanding the brain were not only crucial, they were possible by means of collaborative efforts, cross-disciplinary approaches and the use of a predominantly reductionist neuromolecular method. The first part of the article considers some of the different approaches that have been adopted to writing the history of the brain sciences. After a brief outline of our own approach, the second part of the article uses this in a preliminary exploration of the birth of the neurosciences in three contexts. We conclude by arguing that the 1960s constitute an important ‘break’ in the long path of the history of the brain sciences that needs further analysis. We believe this epistemological shift we term the ‘neuromolecular gaze’ will shape the future intellectual development and social role of the neurosciences. (shrink)
After Hume, attempts to forge an empiricist epistemology have taken three forms, which I shall call the First, Middle, and Third Way. The First still attempts an a priori demonstration that our cognitive methods satisfy some criterion of adequacy. The Middle Way is pursued under the banners of naturalism and scientific realism, and aims at the same conclusion on non-apriori grounds. After arguing that both fail, I shall describe the general characteristics of the Third Way, an alternative epistemology suitable for (...) empiricism. (shrink)
Students using Ritalin in preparation for their exams is a hotly debated issue, while meditating or drinking coffee before those same exams is deemed uncontroversial. However, taking Ritalin, meditating and drinking coffee or even education in general, can all be considered forms of cognitive enhancement. Although social acceptance might change in the future, it is interesting to examine the current reasons that are used to distinguish cases deemed problematic or unproblematic. Why are some forms of cognitive enhancement considered problematic, while (...) others are not? In this paper, we consider cognitive enhancement as the amplification or extension of core capacities of the mind, using augmentation or improvements of our information-processing systems. We will analyse cognitive enhancement in an educational setting in order to clarify the fuzzy distinction between problematic and unproblematic forms of cognitive enhancement. We will show that the apparent distinction made by many people between problematic and unproblematic enhancement is not based on any fundamental difference between these two categories. (shrink)
Detecting a specific horizon in seismic images is a valuable tool for geologic interpretation. Because hand picking the locations of the horizon is a time-consuming process, automated computational methods were developed starting three decades ago. Until now, most networks have been trained on data that were created by cutting larger seismic images into many small patches. This limits the networks ability to learn from large-scale geologic structures. Moreover, currently available networks and training strategies require label patches that have full and (...) continuous horizon picks, which are also time-consuming to generate. We have developed a projected loss function that enables training on labels with just a few annotated pixels and has no issue with the other unknown label pixels. We use this loss function for training convolutional networks with a multiresolution structure, including variants of the U-net. Our networks learn from a small number of large seismic images without creating patches. Training uses all seismic data without reserving some for validation. Only the labels are split into training/testing. We validate the accuracy of the trained network using the horizon picks that were never shown to the network. Contrary to other work on horizon tracking, we train the network to perform nonlinear regression, not classification. As such, we generate labels as the convolution of a Gaussian kernel and the known horizon locations that communicate uncertainty in the labels. The network output is the probability of the horizon location. We examine the new method on two different data sets, one for horizon extrapolation and another data set for interpolation. We found that the predictions of our methodology are accurate even in areas far from known horizon locations because our learning strategy exploits all data in large seismic images. (shrink)
Bas van Fraassen's anti-realist account of science has played a major role in shaping recent philosophy of science. His constructive empiricism, in particular, has been widely discussed and criticized in the journal literature and is a standard topic in philosophy of science course curricula. Other aspects of his empiricism are less well known, including his empiricist account of scientific laws, his relatively recent re-evaluation of what it is to be an empiricist, and his empiricist structuralism. This essay attempts to provide (...) an overview of these diverse aspects of van Fraassen's empiricism and to show how they relate to one another. It also focuses on the nature of van Fraassens's epistemic voluntarism and its relationship to his empiricist philosophy of science. (shrink)
This article explores Levinas' critique of Western epistemology as centered on justification (i.e. a strictly rational, argumentative approach), thereby ignoring the permeable, open and inter-subjective element of the quest for knowledge. In a masterful play on words, Levinas proposes rather a shift from justification to justice, from argumentation to permeability to exteriority, and sets this shift at the foundation of any genuine journey to knowledge.
In response to parts I-III of G Rosen's "What is Constructive Empiricism?", "Philosophical Studies", 74, 1994, 143-178, this paper examines several construals of the position of constructive empiricism. At issue, in part, is the equation of intentional aspects of science with the intentions and opinions of scientists. In addition it is necessary to distinguish the constructive empiricist -- a philosopher holding that acceptance of theories in science need not involve belief that they are true -- from the scientific agnostic' who (...) accepts but does not believe current science. What is at stake for empiricism is a view of science that will admit it as a paradigm for rational inquiry. (shrink)
A general form is proposed for epistemological theories, the relevant factors being: the family of epistemic judgments, the epistemic state, the epistemic commitment , and the family of possible epistemic inputs . First a simple theory is examined in which the states are probability functions, and the subject of probability kinematics introduced by Richard Jeffrey is explored. Then a second theory is examined in which the state has as constituents a body of information and a recipe that determines the accepted (...) epistemic judgments on the basis of this corpus. Through an examination of several approaches to the statistical syllogism, a relation is again established with Jeffrey's generalized conditionalization. (shrink)
