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Adam La Caze
University of Queensland
  1.  10
    The Use of Mechanistic Evidence in Drug Approval.Jeffrey K. Aronson, Adam La Caze, Michael P. Kelly, Veli-Pekka Parkkinen & Jon Williamson - 2018 - Journal of Evaluation in Clinical Practice 24 (5):1166-1176.
    The role of mechanistic evidence tends to be under‐appreciated in current evidence‐based medicine, which focusses on clinical studies, tending to restrict attention to randomized controlled studies when they are available. The EBM+ programme seeks to redress this imbalance, by suggesting methods for evaluating mechanistic studies alongside clinical studies. Drug approval is a problematic case for the view that mechanistic evidence should be taken into account, because RCTs are almost always available. Nevertheless, we argue that mechanistic evidence is central to all (...)
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  2.  61
    The Role of Basic Science in Evidence-Based Medicine.Adam La Caze - 2011 - Biology and Philosophy 26 (1):81-98.
    Proponents of Evidence-based medicine (EBM) do not provide a clear role for basic science in therapeutic decision making. Of what they do say about basic science, most of it is negative. Basic science resides on the lower tiers of EBM's hierarchy of evidence. Therapeutic decisions, according to proponents of EBM, should be informed by evidence from randomised studies (and systematic reviews of randomised studies) rather than basic science. A framework of models explicates the links between the mechanisms of basic science, (...)
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  3. Evidence-Based Policy: Promises and Challenges.Mark Colyvan & Adam La Caze - unknown
    Evidence-based policy is gaining support in many areas of government and in public affairs more generally. In this paper we outline what evidence—based policy is then discuss its strengths and weaknesses. In particular, we argue that it faces a serious challenge to provide a plausible account of evidence. This account needs to be at least in the spirit of the hierarchy of evidence subscribed to by evidence-based medicine (from which evidence—based policy derives its name and inspiration). Yet evidence-based policy’s hierarchy (...)
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  4.  80
    Evidence-Based Medicine Can’T Be….Adam La Caze - 2008 - Social Epistemology 22 (4):353 – 370.
    Evidence-based medicine (EBM) puts forward a hierarchy of evidence for informing therapeutic decisions. An unambiguous interpretation of how to apply EBM's hierarchy has not been provided in the clinical literature. However, as much as an interpretation is provided proponents suggest a categorical interpretation. The categorical interpretation holds that all the results of randomised trials always trump evidence from lower down the hierarchy when it comes to informing therapeutic decisions. Most of the critical replies to EBM react to this interpretation. While (...)
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  5.  14
    Why Randomized Interventional Studies.Adam La Caze - 2013 - Journal of Medicine and Philosophy 38 (4):352-368.
    A number of arguments have shown that randomization is not essential in experimental design. Scientific conclusions can be drawn on data from experimental designs that do not involve randomization. John Worrall has recently taken proponents of randomized studies to task for suggesting otherwise. In doing so, however, Worrall makes an additional claim: randomized interventional studies are epistemologically equivalent to observational studies, providing the experimental groups are comparable according to background knowledge. I argue against this claim. In the context of testing (...)
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  6.  36
    A Challenge for Evidence-Based Policy.Adam La Caze & Mark Colyvan - 2017 - Axiomathes 27 (1):1-13.
    Evidence-based policy has support in many areas of government and in public affairs more generally. In this paper we outline what evidence-based policy is, then we discuss its strengths and weaknesses. In particular, we argue that it faces a serious challenge to provide a plausible, over-arching account of evidence. We contrast evidence-based policy with evidence-based medicine, especially the role of evidence in assessing the effectiveness of medicines. The evidence required for policy decisions does not easily lend itself to randomized controlled (...)
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  7.  17
    The Use of Evidence of Mechanisms in Drug Approval.Jeffrey Aronson, Adam La Caze, Michael Kelly, Veli-Pekka Parkkinen & Jon Williamson - forthcoming - Journal of Evaluation in Clinical Practice.
    The role of mechanistic evidence tends to be under-appreciated in current evidencebased medicine (EBM), which focusses on clinical studies, tending to restrict attention to randomized controlled studies (RCTs) when they are available. The EBM+ programme seeks to redress this imbalance, by suggesting methods for evaluating mechanistic studies alongside clinical studies. Drug approval is a problematic case for the view that mechanistic evidence should be taken into account, because RCTs are almost always available. Nevertheless, we argue that mechanistic evidence is central (...)
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  8.  75
    A Problem for Achieving Informed Choice.Adam La Caze - 2008 - Theoretical Medicine and Bioethics 29 (4):255-265.
    Most agree that, if all else is equal, patients should be provided with enough information about proposed medical therapies to allow them to make an informed decision about what, if anything, they wish to receive. This is the principle of informed choice; it is closely related to the notion of informed consent. Contemporary clinical trials are analysed according to classical statistics. This paper puts forward the argument that classical statistics does not provide the right sort of information for informing choice. (...)
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  9.  18
    Review of Deborah G. Mayo, Aris Spanos (Eds.), Error and Inference: Recent Exchanges on Experimental Reasoning, Reliability, and the Objectivity and Rationality of Science[REVIEW]Adam La Caze - 2010 - Notre Dame Philosophical Reviews 2010 (7).
    Deborah Mayo's view of science is that learning occurs by severely testing specific hypotheses. Mayo expounded this thesis in her (1996) Error and the Growth of Experimental Knowledge (EGEK). This volume consists of a series of exchanges between Mayo and distinguished philosophers representing competing views of the philosophy of science. The tone of the exchanges is lively, edifying and enjoyable. Mayo's error-statistical philosophy of science is critiqued in the light of positions which place more emphasis on large-scale theories. The result (...)
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  10.  8
    Probabilities All the Way Down.Adam La Caze - 2006 - Metascience 15 (3):547-551.