The human spindle and kinetochore associated complex is required for proper mitotic progression. Extensive studies have demonstrated its important functions in both stable kinetochore-microtubule interactions and spindle checkpoint silencing. We suggest a model to explain how various Ska functions might be fulfilled by distinct pools of Ska at kinetochores. The Ndc80-loop pool of Ska is recruited by the Ndc80 loop, or together with some of its flanking sequences, and the recruitment is also dependent on Cdk1-mediated Ska3 phosphorylation. This pool seems (...) to play a more important role in silencing the spindle checkpoint than stabilizing kinetochore-microtubule interactions. In contrast, the Ndc80-N-terminus pool of Ska is recruited by the N-terminal domains of Ndc80 and appears to be more important for stabilizing kinetochore-microtubule interactions. Here, we review and discuss the evidence that supports this model and suggest further experiments to test the functioning mechanisms of the Ska complex. The human spindle and kinetochore associated complex plays essential functions in proper mitotic progression by promoting stable kinetochore-microtubule interactions and spindle checkpoint silencing. We propose that “distinct pools” of Ska—the Ndc80-loop and Ndc80-N-terminus pools—might fulfill these various functions. (shrink)

Confidentiality represents a core principle of research ethics and forms a standard practice in social research. However, what should a researcher do if they learn about illegal activities or harm during the research process? Few systematic studies consider researchers’ attitudes and reactions in such situations. This paper analyzes this issue on the basis of in-depth interviews with Polish sociologists and anthropologists who conduct qualitative research with vulnerable participants. It discusses the experiences and opinions of researchers concerning the maintenance or breaking (...) of confidentiality in the context of knowledge about illegal activities and harm. It also examines the ways in which the researchers justified their decisions. Most of my interviewees respected confidentiality in spite of knowledge of crime or harm, and referred to their epistemological perspectives regarding the role of the researcher, implicit consequentialist ethical reasoning and personal values. Where researchers did break confidentiality, this owed to their personal values and willingness to protect their informants, especially in cases of minor levels of harm as opposed to serious crime. Therefore, their experiences indicate the failure of both obligatory unconditional assurances of confidentiality and the requirement for researchers to assure confidentiality to the extent permitted by law. I argue that researchers do not need constrictive and potentially punitive rules about confidentiality, but rather sensitizing frameworks about how to contemplate and anticipate the many complexities and moral shadings of situations in the field. (shrink)

This paper deals with Gärdenfors’ theory of conceptual spaces. Let \({\mathcal {S}}\) be a conceptual space consisting of 2-type fuzzy sets equipped with several kinds of metrics. Let a finite set of prototypes \(\tilde{P}_1,\ldots,\tilde{P}_n\in \mathcal {S}\) be given. Our main result is the construction of a classification algorithm. That is, given an element \({\tilde{A}}\in \mathcal {S},\) our algorithm classifies it into the conceptual field determined by one of the given prototypes \(\tilde{P}_i.\) The construction of our algorithm uses some physical analogies (...) and the Newton potential plays a significant role here. Importantly, the resulting conceptual fields are not convex in the Euclidean sense, which we believe is a reasonable departure from the assumptions of Gardenfors’ original definition of the conceptual space. A partitioning algorithm of the space \(\mathcal {S}\) is also considered in the paper. In the application section, we test our classification algorithm on real data and obtain very satisfactory results. Moreover, the example we consider is another argument against requiring convexity of conceptual fields. (shrink)

The program of Evolutionary Ethics (EE) is based on the assumption that our moral features constitute adaptations and as such are to be explained in terms of the evolutionary process of natural selection. However, the fundamental assumption of EE was seriously put into question: the level of analysis relevant for moral features is essentially ontogeny and culture, while the explanation using natural selection applies to the level of phylogeny and genes (Sober, 1995; Ayala, 1995; Okasha, 2009). To the discussion on (...) the validity of the program of EE we propose to bring the recent program of Extended Synthesis (ES, Pigliucci & Muller, 2010), because it attempts to account for the role of the ontogeny in evolution. We conclude, nevertheless, that ES fails to properly account for the importance of ontogeny in evolutionary processes because by extending the notion of inheritance it (con-)fuses the notions of unit of inheritance and of unit of selection (against the well-known distinction made by Hull, 1980). (shrink)

“Normal science” is a concept introduced by Thomas Kuhn in The Structure of Scientific Revolutions. In Kuhn’s view, normal science means “puzzle solving”, solving problems within the paradigm—framework most successful in solving current major scientific problems—rather than producing major novelties. This paper examines Kuhnian and Popperian accounts of normal science and their criticisms to assess if normal science is good. The advantage of normal science according to Kuhn was “psychological”: subjective satisfaction from successful “puzzle solving”. Popper argues for an “intellectual” (...) science, one that consistently refutes conjectures and offers new ideas rather than focus on personal advantages. His account is criticized as too impersonal and idealistic. Feyerabend’s perspective seems more balanced; he argues for a community that would introduce new ideas, defend old ones, and enable scientists to develop in line with their subjective preferences. The paper concludes that normal science has no one clear-cut set of criteria encompassing its meaning and enabling clear assessment. (shrink)

This full-scaled monograph, rich in factographic material, concerns Nārāyaṇa Guru, a founder of a powerful socio-religious movement in Kerala. He wrote in three languages, drawing on three different literary conventions. The world of this complex philosophic-religious literature is brought closer to the reader with rare deft and dexterity by the Author who not only retrieves for us the original circumstances, language and poetic metre of each work but also supplies histories of their reception. Thanks to numerous glosses, comments and elucidations (...) supplied by the Author, we can much better understand how Nārāyaṇa's mystical universe creatively relates to the Tamil OEaiva Siddhānta and to Kerala's variety of Vedānta tradition. Prof. Cezary Galewicz. (shrink)

I sitt berömda bevis för tidens overklighet påstod McTaggart att det sätt händelser tycks skifta position i tiden från framtid till nutid och till förfluten tid, innebär en motsägelse. Vad McTaggart egentligen menade har varit föremål för en livlig debatt ända sedan beviset först publicerades 1908. Beviset består av två delar. I den första argumenterar McTaggart för att ingenting kan förändras förutom genom att övergå från framtid till förfluten tid. I den andra argumenterar han för att en sådan övergång innebär (...) en motsägelse och att det därför inte kan finnas någon förändring överhuvudtaget, vilket i sin tur innebär att det heller inte finns någon tid. De flesta filosofer är i dag eniga om att McTaggart har fel, men oeniga om på vilket sätt han har fel. Olika filosofer förkastar olika delar av beviset, beroende på om de har vad som kallas en A- eller B-uppfattning av tiden. De som har en A-uppfattning förnekar att tid förstådd som övergång från framtid till förfluten tid är motsägelsefull. De som har en B-uppfattning förnekar att en övergång från framtid till förfluten tid är nödvändig för förändring, men håller med om att sådan övergång är motsägelsefull. Det är min uppfattning att denna oenighet beror på att McTaggarts argument från första början blivit missuppfattat, av både A- och B-teoretiker. Av någon anledning har det alltid betraktats som ett självständigt argument, ett som är oberoende av det ontologiska system McTaggart förespråkade. Jag föreslår ett nytt sätt att förstå hur han menade att tiden är motsägelsefull. Ett sätt som tar hans ontologiska system som utgångspunkt. (shrink)

The text concerns the role of emotions in delusion formation. Provided are definitions from DSM-V and DSM-IV-R and the problems found in those definitions. One of them, the problem of delusion formation, is described when providing cognitive theories of delusions. The core of the paper is a presentation of the emotional and affective disorders in delusions, especially Capgras delusion and Cotard delusion. The author provides a comparison of the kinds of delusions and the conclusions taken from neuroimaging studies. As a (...) result of the fact that an explanation of delusion formation focusing on emotional problems turns out to be insufficient, the author provides examples of the reasoning impairments which coexist with them. At the end of the article, some hypotheses are proposed concerning the role of emotions and reasoning in delusion formation and the relation between belief disorders and emotional disorders. (shrink)

The aim of this article is to analyze those theories that interpret misidentification delusions in terms of mentalization. The hypothesis under examination holds that a mentalization framework is useful for describing misidentification delusions when identification is thought to be partially based on mentalization. The article provides both a characterization and possible interpretations of such delusions, and possible relations between misidentification and mentalization are scrutinized. Whether the mentalization approach may explain or describe such kinds of mental disorders is considered, with the (...) conclusion that while this approach is unsatisfactory, there is some room for future improvement. (shrink)

W ostatniej dekadzie można zaobserwować postępującą w naukach społecznych kodyfikację i instytucjonalizację etyki badań. Powstaje coraz więcej kodeksów etycznych, które standaryzują zasady etycznego prowadzenia badań oraz komisji etycznych kontrolujących projekty badawcze. Za kodyfikacją oraz instytucjonalizacją etyki naukowych badań społecznych stoi między innymi przekonanie, że kodeksy i komisje etyczne znacząco przyczynią się do etycznego postępowania badaczek i ochronią podmioty zaangażowane w badania, szczególnie ich uczestników, przed krzywdą. W artykule argumentuję, że to nie wystarczy, gdyż zarówno osoby prowadzące badania, jak i komisje (...) etyczne powinny kierować się w swoich decyzjach etycznych wyobraźnią moralną. (shrink)

People regularly make decisions about how often and with whom to interact. During an epidemic of communicable disease, these decisions gain new weight, as individual choices exert more direct influence on collective health and wellbeing. While much attention has been paid to how people’s concerns about the health impact of the COVID-19 pandemic affect their engagement in behaviors that could curb the spread of the disease, less is understood about how people’s concerns about the pandemic’s impact on their social lives (...) affect these outcomes. Across three studies, we find that individuals’ estimates of the pandemic’s social impact are associated with an unwillingness to curtail social interaction and follow other Centers for Disease Control guidelines as the pandemic spreads. First, these associations are present in self-report data of participants’ own behaviors and behavior across hypothetical scenarios; second, participants’ estimates of the pandemic’s impact on social life in their location of residence are associated with movement data collected unobtrusively from mobile phones in those locations. We suggest that perceptions of social impact could be a potential mechanism underlying, and therefore potential intervention target for addressing, disease-preventing behavior during a pandemic. (shrink)

This article asks how people come to interpret themselves and others as autonomous given their multiple dependencies. We draw on a cross-case comparison of ethnographic studies with two populations for whom autonomy is both central and problematic: elderly patients in post-acute care, and young adults with disabilities in an independent living program. Analyzing the institutional efforts to make their clients “as independent as possible,” we find that staff members at each organization formulate autonomy as a temporal project through an ongoing (...) calibration of open futures, ideal pasts, and situational competence. Constantly adjusting and fine-tuning where in time autonomy “really” is, workers arrange present dependence so that the contours of the future remain open for their clients. In other words, they make use of temporal markers to produce recognizable autonomous subjects whose dependencies are momentary. Theorizing this temporal project enables us to see more clearly how all of us engage in the constant business of “doing” autonomy, and to better understand the role of institutions in producing autonomous selves. (shrink)

W niniejszym artykule proponujemy przegląd stanowisk wobec „ucieleśnienia” jako kategorii metodologicznej w humanistyce i naukach społecznych, rozważając, jak różnie bywa to pojęcie używane i co stanowi trzon „podejścia ucieleśnionego”. Teksty zebrane w niniejszym zbiorze egzemplifikują te historycznie rozbieżne tradycje, dając obraz badań nad ucieleśnieniem jako samodzielnego pola refleksji.