BioPortal is a Web portal that provides access to a library of biomedical ontologies and terminologies developed in OWL, RDF(S), OBO format, Protégé frames, and Rich Release Format. BioPortal functionality, driven by a service-oriented architecture, includes the ability to browse, search and visualize ontologies (Figure 1). The Web interface also facilitates community-based participation in the evaluation and evolution of ontology content.
Baron d’Holbach was a critic of established religion, or a philosophe, in late 18 th -century France. His work is often perceived as less inventive than the work of other materialist philosophes, such as Helvétius and Diderot. However, I claim that d’Holbach makes an original, unjustly overlooked move in the criticism of religious moral teaching. According to the materialist philosophes, this teaching claims that true happiness is only possible in the afterlife. As an alternative, Helvétius and Diderot offer theories according (...) to which the experience of pleasure constitutes happiness, the end of all human desire. In contemporary terms, these theories would represent psychological hedonism. But, as Diderot himself admits, they have a problem in accounting for why people seem to naturally regard some pleasures as preferable to others. I argue that in response to this challenge, instead of accepting the psychological hedonism of his fellow materialists, d’Holbach shows how one can abstain from reducing happiness to pleasure and yet remain a materialist. (shrink)
The relevance of analytic metaphysics has come under criticism: Ladyman & Ross, for instance, have suggested do discontinue the field. French & McKenzie have argued in defense of analytic metaphysics that it develops tools that could turn out to be useful for philosophy of physics. In this article, we show first that this heuristic defense of metaphysics can be extended to the scientific field of applied ontology, which uses constructs from analytic metaphysics. Second, we elaborate on a parallel by French (...) & McKenzie between mathematics and metaphysics to show that the whole field of analytic metaphysics, being useful not only for philosophy but also for science, should continue to exist as a largely autonomous field. (shrink)
There are three slogans in the history of Socialism that are very close in wording, viz. the famous Cabet-Blanc-Marx slogan: "From each according to his ability; To each according to his needs"; the earlier Saint-Simon-Pecqueur slogan: "To each according to his ability; To each according to his works"; and the later slogan in Stalin’s Soviet Constitution: "From each according to his ability; To each according to his work." We will consider the following questions regarding these slogans: a) What are the (...) earliest occurrences of each of these slogans? b) Where does the inspiration for each half of each slogan come from? c) What do the Saint-Simonians mean by “To each according to his ability”? d) What do they mean by “To each according to his works”? e) What motivates the shift from “To each according to his ability” to “From each according to his ability”? f) How should we envisage the progression toward “To each according to his needs”? g) What is the distinction between from “To each according to his works” and “To each according to his work”? (shrink)
The paper discusses the circumstances of the fatal illness and the death of René Descartes in 1650 at the French embassy in Stockholm. It considers the hitherto available evidence, in particular the main medical documents: two letters, the first written in Dutch by Descartes’ servant, Henri Schluter, the second written in Latin by the Dutch doctor Johann van Wullen. English translations of these two documents are given respectively in Appendix 1 and Appendix 3 of this paper. Other documents, letters by (...) the French ambassador, Pierre Chanut, or the report in the Descartes biography by Adrien Baillet, are also discussed. An analysis of the documentary evidence indicates a high probability that Descartes was poisoned with arsenic on two occasions, on February 2nd and again on February 8th, the second poisoning proving to be fatal. The paper then discusses the questions of ‘whodunnit’ and why. (shrink)
Building a meaningful model of biological regulatory network is usually done by specifying the components and their interactions, by guessing the values of parameters, by comparing the predicted behaviors to the observed ones, and by modifying in a trial-error process both architecture and parameters in order to reach an optimal fitness. We propose here a different approach to construct and analyze biological models avoiding the trial-error part, where structure and dynamics are represented as formal constraints. We apply the method to (...) Hopfield-like networks, a formalism often used in both neural and regulatory networks modeling. The aim is to characterize automatically the set of all models consistent with all the available knowledge . The available knowledge is formalized into formal constraints. The latter are compiled into Boolean formula in conjunctive normal form and then submitted to a Boolean satisfiability solver. This approach allows to formulate a wide range of queries, expressed in a high level language, and possibly integrating formalized intuitions. In order to explore its potential, we use it to find cycles for 3-nodes networks and to determine the flower morphogenesis regulatory network of Arabidopsis thaliana. Applications of this technique are numerous and concern the building of models from data as well as the design of biological networks possessing specified behaviors. (shrink)
ABSTRACTResearch that dissociates different types of processes within a given task using a processing tree approach suggests that attitudes may be acquired through evaluative conditioning in the absence of explicit encoding of CS-US pairings in memory. This research distinguishes explicit memory for the CS-US pairings from CS-liking acquired without encoding of CS-US pairs in explicit memory. It has been suggested that the latter effect may be due to an implicit misattribution process that is assumed to operate when US evocativeness is (...) low. In the present research, the latter assumption was supported neither by two high-powered experiments nor by complementary meta-analytic evidence, whereas evocativeness exerted an influence on explicit memory. This pattern of findings is inconsistent with the view that CS-liking acquired without encoding of CS-US pairs in explicit memory reflects an implicit misattribution process at learning. Hence, the underlying learning process is awaiting further empirical scrutiny. (shrink)
We give in this paper indications about the dynamical impact coming from the main sources of perturbation in biological regulatory networks. First, we define the boundary of the interaction graph expressing the regulations between the main elements of the network . Then, we search what changes in the state values on the boundary could cause some changes of states in the core of the system . After, we analyse the role of the mode of updating on the asymptotics of the (...) network, essentially on the occurrence of limit cycles . Finally, we show the influence of some topological changes on the dynamical behaviour of the system. (shrink)
Writers on Descartes are apt to mention one dramatic event of his life—a dream he had in November 1619 in which the “Spirit of Truth” opened up for him “the treasures of all the sciences.” We know of the dream not from the published Descartes, though he perhaps alluded to it in the passage of the Discourse where he speaks of having spent a day alone “in a stove”; no, our textual source is his early biographer Adrien Baillet, writing (...) seventy years after the event. Why do commentators fasten on that episode? I take it they find the paradox alluring—a stern rationalist set on his life-course by an oneiric revelation. (shrink)
We classify actions of groups of finite Morley rank on abelian groups of Morley rank 2: there are essentially two, namely the natural actions of SL(V) and GL(V) with V a vector space of dimension 2. We also prove an identification theorem for the natural module of SL₂ in the finite Morley rank category.