The human spindle and kinetochore associated complex is required for proper mitotic progression. Extensive studies have demonstrated its important functions in both stable kinetochore-microtubule interactions and spindle checkpoint silencing. We suggest a model to explain how various Ska functions might be fulfilled by distinct pools of Ska at kinetochores. The Ndc80-loop pool of Ska is recruited by the Ndc80 loop, or together with some of its flanking sequences, and the recruitment is also dependent on Cdk1-mediated Ska3 phosphorylation. This pool seems (...) to play a more important role in silencing the spindle checkpoint than stabilizing kinetochore-microtubule interactions. In contrast, the Ndc80-N-terminus pool of Ska is recruited by the N-terminal domains of Ndc80 and appears to be more important for stabilizing kinetochore-microtubule interactions. Here, we review and discuss the evidence that supports this model and suggest further experiments to test the functioning mechanisms of the Ska complex. The human spindle and kinetochore associated complex plays essential functions in proper mitotic progression by promoting stable kinetochore-microtubule interactions and spindle checkpoint silencing. We propose that “distinct pools” of Ska—the Ndc80-loop and Ndc80-N-terminus pools—might fulfill these various functions. (shrink)

There has been a growing interest in research concerning memory modification technologies (MMTs) in recent years. Neuroscientists and psychologists are beginning to explore the prospect of controllable and intentional modification of human memory. One of the technologies with the greatest potential to this end is optogenetics—an invasive neuromodulation technique involving the use of light to control the activity of individual brain cells. It has recently shown the potential to modify specific long-term memories in animal models in ways not yet possible (...) with other MMTs. As the therapeutic potential of optogenetics has already prompted approval of the first human trials, it is especially important and timely to consider the opportunities and dangers this technology may entail. In this article, we focus on possible consequences of optogenetics as an MMT by analyzing fundamental threats potentially associated with memory modifications: the potential disruption of personality and authenticity. (shrink)

Optogenetics is an invasive neuromodulation technology involving the use of light to control the activity of individual neurons. Even though optogenetics is a relatively new neuromodulation tool whose various implications have not yet been scrutinized, it has already been approved for its first clinical trials in humans. As optogenetics is being intensively investigated in animal models with the aim of developing novel brain stimulation treatments for various neurological and psychiatric disorders, it appears crucial to consider both the opportunities and dangers (...) such therapies may offer. In this review, we focus on the memory-modifying potential of optogenetics, investigating what it is capable of and how it differs from other memory modification technologies. We then outline the safety challenges that need to be addressed before optogenetics can be used in humans. Finally, we re-examine crucial neuroethical concerns expressed in regard to other MMTs in the light of optogenetics and address those that appear to be unique to the memory-modifying potential of optogenetic technology. (shrink)

The article is devoted to the Roman Kurkiewicz essays. He is a philosopher, but is also a wellknown newspaper, radio and television journalist. The publication Klapsy polskie contains selected essays printed in ‘Przekrój’. They are alphabetically arranged and concern many issues important for Poles at the time. Political, economic, sporting and cultural events are the starting point for general discussions on the human and the world. Kurkiewicz writes about difficult and controversial topics. The article describes selected examples of different kinds (...) of essay titles. The author refers to the literature, press and TV movies. Selected examples demonstrate the richness of the author’s ideas. (shrink)

I sitt berömda bevis för tidens overklighet påstod McTaggart att det sätt händelser tycks skifta position i tiden från framtid till nutid och till förfluten tid, innebär en motsägelse. Vad McTaggart egentligen menade har varit föremål för en livlig debatt ända sedan beviset först publicerades 1908. Beviset består av två delar. I den första argumenterar McTaggart för att ingenting kan förändras förutom genom att övergå från framtid till förfluten tid. I den andra argumenterar han för att en sådan övergång innebär (...) en motsägelse och att det därför inte kan finnas någon förändring överhuvudtaget, vilket i sin tur innebär att det heller inte finns någon tid. De flesta filosofer är i dag eniga om att McTaggart har fel, men oeniga om på vilket sätt han har fel. Olika filosofer förkastar olika delar av beviset, beroende på om de har vad som kallas en A- eller B-uppfattning av tiden. De som har en A-uppfattning förnekar att tid förstådd som övergång från framtid till förfluten tid är motsägelsefull. De som har en B-uppfattning förnekar att en övergång från framtid till förfluten tid är nödvändig för förändring, men håller med om att sådan övergång är motsägelsefull. Det är min uppfattning att denna oenighet beror på att McTaggarts argument från första början blivit missuppfattat, av både A- och B-teoretiker. Av någon anledning har det alltid betraktats som ett självständigt argument, ett som är oberoende av det ontologiska system McTaggart förespråkade. Jag föreslår ett nytt sätt att förstå hur han menade att tiden är motsägelsefull. Ett sätt som tar hans ontologiska system som utgångspunkt. (shrink)

We discuss applications of our account of moral status grounded in person-rearing relationships: which individuals have higher moral status or not, and why? We cover three classes of cases: (1) cases involving incomplete realization of the capacity to care, including whether infants or fetuses have this incomplete capacity; (2) cases in which higher moral status rests in part on what is required for the being to flourish; (3) hypothetical cases in which cognitive enhancements could, e.g., help dogs achieve human-like cognitive (...) capacities. We thereby show that our account does not have the counterintuitive implications alleged by DeGrazia and other critics. (shrink)

Since the 1980s, there has been an increasing acknowledgement of the importance of recognising the ethical dimension of clinical decision-making. Medical professional regulatory authorities in some countries now include ethical knowledge and practice in their required competencies for undergraduate and post graduate medical training. Educational interventions and clinical ethics support services have been developed to support and improve ethical decision making in clinical practice, but research evaluating the effectiveness of these interventions has been limited. We undertook a systematic review of (...) the published literature on measures or models of evaluation used to assess the impact of interventions to improve ethical decision making in clinical care. We identified a range of measures to evaluate educational interventions, and one tool used to evaluate a clinical ethics support intervention. Most measures did not evaluate the key impact of interest, that is the quality of ethical decision making in real-world clinical practice. We describe the results of our review and reflect on the challenges of assessing ethical decision making in clinical practice that face both developers of educational and support interventions and the regulatory organisations that set and assess competency standards. (shrink)

This distinctively interdisciplinary approach to the subject encompasses filmmaking, psychoanalysis, philosophy and popular culture and offers a unique insight into documentary film practice from a psychoanalytic perspective. At the heart of the enquiry is belief that ‘transference-love’ is present in the documentary encounter. With a focus on testimony-driven film and a foreword by Michael Renov, who calls this book 'a radical and compelling account', _Psychoanalysis and Ethics in Documentary Film _covers a range of topics including: Four fundamental concepts of psychoanalysis (...) and documentary film A review of documentary film practice A personal account of the author’s relationship with a subject of her own work A thorough interrogation of the ethics of documentary Ideal for film studies scholars, psychoanalysts, psychotherapists and psychotherapeutically engaged professionals, as well as filmmakers, culture studies students and anyone interested in the process of documentary-making and contemporary culture, this work offers a unique approach. (shrink)

[A] man does not consist of memory alone. He has feeling, will, sensibilities, moral being…. And it is here … that you may find ways to touch him.—A. R. Luria1.

Articles chiefly on Vedic themes and Indic philosophy; most previously published.

Axiological Character of Egotic Sphere in Tischner’s ThoughtThe paper presents the conception of egotic consciousness understood from the axiological and phenomenological perspective. In the work Fenomenologia świadomości egotycznej Tischner presents phenomenological considerations about self-consciousness. In the light of the results of analyses conducted by Tischner, egotic consciousness is understood as axiological sphere. In the perspective of the phenomenology of egotic consciousness, being a result of revealing Tischner’s original thought, in its beginning, Husserl’s conception of transcendental consciousness is one of the (...) possibilities. (shrink)

In his work on internality, identification, and caring, Harry Frankfurt attempts to delineate the organization of agency peculiar to human beings, while avoiding the traditional overintellectualized emphasis on the human capacity to reason about action. The focal point of Frankfurt’s alternative picture is our capacity to make our own motivation the object of reflection. Building upon the observation that marginal agents (such as young children and Alzheimer’s patients) are capable of caring, I show that neither caring nor internality need to (...) depend on the phenomena of reflectiveness. I develop alternative interlocking accounts of caring and internality that are independent of both reflectiveness and evaluation, but that can still do justice to the central role of carings in the organization of agency characteristic of human persons. (shrink)

A being has moral standing if it or its interests matter intrinsically, to at least some degree, in the moral assessment of actions and events. For instance, animals can be said to have moral standing if, other things being equal, it is morally bad to intentionally cause their suffering. This essay focuses on a special kind of moral standing, what I will call “full moral standing” (FMS), associated with persons. In contrast to the var- ious accounts of what ultimately grounds (...) FMS in use in the philosophical literature, I will propose that the emotional capacity to care is a sufficient condition of an individual’s FMS as a person. In developing this account, I will appeal to a set of intuitions not previously mined for this purpose: those generated by conflicts of interests between different life phases of a single individual. (shrink)

Why does a baby who is otherwise cognitively similar to an animal such as a dog nevertheless have a higher moral status? We explain the difference in moral status as follows: the baby can, while a dog cannot, participate as a rearee in what we call “person-rearing relationships,” which can transform metaphysically and evaluatively the baby’s activities. The capacity to engage in these transformed activities has the same type of value as the very capacities (i.e., intellectual or emotional sophistication) that (...) explain unimpaired adult humans’ high moral status. We attempt to extend this account to individuals with severe cognitive impairments. (shrink)

This article concerns information and information services in the modern stations of commercial radios. It includes types of messages, information and news used in radio programs.

In conversations with 10 people from completely different backgrounds, the author tries to discover and embrace the importance of growing up and of gaining experience and knowledge of the world that surrounds us.