Biomarkers are widely used not only as prognostic or diagnostic indicators, or as surrogate markers of disease in clinical trials, but also to formulate theories of pathogenesis. We identify two problems in the use of biomarkers in mechanistic studies. The first problem arises in the case of multifactorial diseases, where different combinations of multiple causes result in patient heterogeneity. The second problem arises when a pathogenic mediator is difficult to measure. This is the case of the oxidative stress (OS) theory (...) of disease, where the causal components are reactive oxygen species (ROS) that have very short half-lives. In this case, it is usual to measure the traces left by the reaction of ROS with biological molecules, rather than the ROS themselves. Borrowing from the philosophical theories of signs, we look at the different facets of biomarkers and discuss their different value and meaning in multifactorial diseases and system medicine to inform their use in patient stratification in personalized medicine. (shrink)

Frege's Puzzle is a founding problem in analytic philosophy. It lies at the intersection of central topics in the philosophy of language and mind: the theory of reference, the nature of propositional attitudes, the nature of semantic theorizing, the relation between semantics and pragmatics, etc. This chapter is an overview of the puzzle and of the space of contemporary approaches to it.

Explores the gamut of social theory Classical and Contemporary Social Theory: Investigation and Application, 1/e, is the most comprehensive, informative social theory book on the market. The title covers multiple schools of thought and applies their ideas to society today. Readers will learn the origins of social theory and understand the role of myriad social revolutions that shaped the course of societies around the world. MySearchLab is a part of the Delaney program. Research and writing tools, including access to (...) academic journals, help students explore social theory in even greater depth. To provide students with flexibility, students can download the eText to a tablet using the free Pearson eText app. This title is available in a variety of formats - digital and print. Pearson offers its titles on the devices students love through Pearson's MyLab products, CourseSmart, Amazon, and more. (shrink)

This chapter contains sections titled: Introduction The Mathematical Theory of Probability The Philosophical Theory of Probability Conclusion References.

.Deep disagreements are those involving a disagreement about (relatively) fundamental epistemic principles. This paper considers the bearing of testimonial injustice, in Miranda Fricker’s sense, on the depth of disagreements, and what this can teach us about the nature and significance of deep disagreements. I start by re-evaluating T. J. Lagewaard’s recent argument that disagreements about the nature, scope, and impact of oppression will often be deepened by testimonial injustice, since the people best placed to offer relevant testimony will be subject (...) to testimonial injustice, pushing the disagreement into one about the bearing of certain epistemic sources on the original debate. I take issue with this last step, but I build on the argument to bring attention to unappreciated and worrying ways in which prejudices can make a disagreement deep in ways that can be hidden from one or more of the participants and from observers. Finally, I revisit some of the ways that deep disagreement has been thought to be problematic for the proper functioning of a democracy, and I examine whether the kinds of hidden deep disagreements I argue for in the paper make these problems any worse, concluding that they likely do. (shrink)

In 1795 Jeremiah Aversham went to execution bearing a flower in his mouth. “He was afterwards hung in chains on Wimbledon common, and for several months,” it was reported, “thousands of the London populace passed their Sundays near the spot as if consecrated by the remains of a hero.” From the perspective of bourgeois morality this was an intolerable scandal. The display of the dead body had become one of those suspicious or ill-defined areas of life that were treated as (...) indecent or marginalised as offensive. The general rearrangement of values in the society transformed the body into an object of aversion as opposed to representation. The change of attitude made it impossible to continue inscribing the bodies of criminals with the degradation of public exposure. (shrink)

The premise of The Diversity of Darkness and Shameful Behaviors is to emphasize the need for enlightened, rational thinking as a paradigm of thought as the culture of shamelessness continues to grow and cast its repulsive dark shadow over those who embrace enlightened reason and basic human rights for all. This unique book utilizes evidence-based approaches in the examination of human behaviors in society that have become increasingly shameful and tolerated among a growing number of enablers. Key features include a (...) combination of academic analysis that draws on numerous and specific examples of the diversity of darkness that encompasses the world along with a balanced practical, everyday-life approach to the study of the socio-political world we live in through the use of contemporary culture references and featured popular culture boxes. Social scientists, social thinkers and the general audience alike will be intrigued and perhaps dismayed by the diversity of shamefully hateful and shamefully deadly topics covered. We should realize that humanity has the intellect to accomplish great feats but heed the growing culture of shamelessness, irrationality and the diversity of darkness. (shrink)

In 1795 Jeremiah Aversham went to execution bearing a flower in his mouth. “He was afterwards hung in chains on Wimbledon common, and for several months,” it was reported, “thousands of the London populace passed their Sundays near the spot as if consecrated by the remains of a hero.” From the perspective of bourgeois morality this was an intolerable scandal. The display of the dead body had become one of those suspicious or ill-defined areas of life that were treated as (...) indecent or marginalised as offensive. The general rearrangement of values in the society transformed the body into an object of aversion as opposed to representation. The change of attitude made it impossible to continue inscribing the bodies of criminals with the degradation of public exposure. (shrink)

David Malament argued that Hartry Field's nominalisation program is unlikely to be able to deal with non-space-time theories such as phase-space theories. We give a specific example of such a phase-space theory and argue that this presentation of the theory delivers explanations that are not available in the classical presentation of the theory. This suggests that even if phase-space theories can be nominalised, the resulting theory will not have the explanatory power of the original. Phase-space theories thus raise problems for (...) nominalists that go beyond Malament's initial concerns. Thanks to Mark Steiner, Jens Christian Bjerring, Ben Fraser, John Mathewson, and two anonymous referees for helpful comments on an earlier draft of this paper. CiteULike Connotea Del.icio.us What's this? (shrink)

According to a tradition reaching back to Plato, questions about the nature of knowledge are to be answered by offering an analysis in terms of truth, belief, justification, and other factors presumed to be in some sense more basic than knowledge itself. In light of the apparent failure of this approach, knowledge first philosophy instead takes knowledge as the starting point in epistemology and related areas of the philosophies of language and mind. Knowledge cannot be analyzed in the traditional sense, (...) but this does not make it mysterious or unimportant. On the contrary, we are freed to use our grasp of what knowledge is to elucidate the nature of belief, justification, evidence, the speech act of assertion, and the demands on action and practical reasoning, and to treat knowledge as a purely mental state in its own right. Knowledge First? offers the first overview and critical evaluation of knowledge first philosophy as a whole. (shrink)

When scientists act unethically, their actions can cause harm to participants, undermine knowledge creation, and discredit the scientific community. Responsible Conduct of Research training i...

Respect for patient autonomy can apply at two levels: ensuring that patient care reflects their considered values and wishes and honoring patient preferences about how to make momentous decisions. Caregivers who seek to respect patient autonomy in the context of some end-of-life decisions face a dilemma. Because these decisions are fraught, patients may prefer to approach them sequentially, only making decisions at the time they arise. However, respecting patients’ preferences for a sequential approach can increase the likelihood that surrogates and (...) care teams wind up in situations in which they lack information needed to ensure patients receive care that conforms to their considered values after they are no longer competent to make decisions for themselves. Sequential decision-making can thus conflict with the goal of ensuring care reflects the wishes of patients. After illustrating how this dilemma can arise in the use of life-sustaining “bridge” technologies, we argue that care teams may be warranted in requiring patients to articulate their wishes in an advance care plan before treatment begins. In some cases, care teams may even be permitted to refuse to undertake certain courses of care, unless patients articulate their wishes in an advance care plan. (shrink)

Proponents of the predicate view of names explain the reference of an occurrence of a name N by invoking the property of bearing N. They avoid the charge that this view involves a vicious circularity by claiming that bearing N is not itself to be understood in terms of the reference of actual or possible occurrences of N. I argue that this approach is fundamentally mistaken. The phenomenon of ‘reference transfer’ shows that an individual can come to bear a name (...) in virtue of the referential practices of a group of speakers. I develop a picture of name-bearing which captures this fact by treating the extension of name as a function of the way that extension is represented in the presuppositions of groups of speakers. I show that though there is a form of circularity inherent in this approach, it is not vicious circularity. (shrink)

This paper criticises Miranda Fricker's account of the primary harm of testimonial injustice as a kind of epistemic objectification, where the latter is understood on the model provided by Martha Nussbaum's influential analysis of sexual objectification and where it is taken to involve the denial of someone's epistemic agency. I examine the existing objections to Fricker's account of the primary harm, criticising some while accepting the force of others, and I argue that one of Fricker's own central examples of testimonial (...) injustice in fact offers the basis of a particularly telling objection. While Fricker's other critics have mostly concluded that we need to look at alternative theoretical resources to offer an account of the primary harm of testimonial injustice, I aim to show that this is premature; both Fricker and her critics have underestimated the resources provided by Nussbaum's analysis of objectification when offering an account of the primary harm, and something very much in the spirit of Fricker's account survives the objections. (shrink)

This paper is about how to interpret and evaluate purported evidence for predicativism about proper names. I aim to point out some underappreciated thorny issues and to offer both predicativists and non-predicativists some advice about how best to pursue their respective projects. I hope to establish three related claims: that non-predicativists have to posit relatively exotic, though not entirely implausible, polysemic mechanisms to capture the range of data that predicativists have introduced ; that neither referentialism nor extant versions of predicativism (...) can offer a very plausible account of the interpretive possibilities for singular unmodified definite descriptions containing names ; and that the most plausible version of predicativism would treat bare names as non-anaphoric definite descriptions. (shrink)

This article argues that the quiet politics of informal business-state interaction explains the political determinants of growth regimes. Building on the business power literature within the study of comparative capitalism, it shows that the noisy politics of elections often leads to changes of government but rarely to fundamental changes in the growth regime. Rather, growth models can be traced to the interactions and interests of dominant corporations within a country and its policymaking elites. The argument is developed through a comparative (...) case study research design, using the case of foreign direct investment–led growth in Ireland and Hungary. FDI-led growth regimes are a universe of cases that rely on state-led industrial and enterprise policies targeting the capital investment of foreign-owned multinational firms. Despite periods of noisy electoral politics challenging basic tenets of the FDI-led growth model in both Hungary and Ireland, the continuity of FDI-oriented growth is traced to the corporate politics of business-state elite deals. (shrink)

A main thread of the debate over mathematical realism has come down to whether mathematics does explanatory work of its own in some of our best scientific explanations of empirical facts. Realists argue that it does; anti-realists argue that it doesn't. Part of this debate depends on how mathematics might be able to do explanatory work in an explanation. Everyone agrees that it's not enough that there merely be some mathematics in the explanation. Anti-realists claim there is nothing mathematics can (...) do to make an explanation mathematical ; realists think something can be done, but they are not clear about what that something is. I argue that many of the examples of mathematical explanations of empirical facts in the literature can be accounted for in terms of Jackson and Pettit's [1990] notion of program explanation, and that mathematical realists can use the notion of program explanation to support their realism. This is exactly what has happened in a recent thread of the debate over moral realism. I explain how the two debates are analogous and how moves that have been made in the moral realism debate can be made in the mathematical realism debate. However, I conclude that one can be a mathematical realist without having to be a moral realist. (shrink)

Frege's puzzle is a fundamental challenge for accounts of mental and linguistic representation. This piece surveys a family of recent approaches to the puzzle that posit representational relations. I identify the central commitments of relational approaches and present several arguments for them. I also distinguish two kinds of relationism—semantic relationism and formal relationism—corresponding to two conceptions of representational relations. I briefly discuss the consequences of relational approaches for foundational questions about propositional attitudes, intentional explanation, and compositionality.

In archival footage uploaded online of a concert at the University of the Western Cape in 1988 musician Robbie Jansen declared that the next composition to be performed was named 'Freedom Where Have You Been'.1 Before counting the band in, Jansen offered a short discourse on the meaning of the phrase hoya chibongo. Hearing the Afrikaans hoorie (meaning listen here) in the expression hoya, Jansen proceeded to split up the word chibongo to accentuate chi- as aurally reminiscent of the suffix (...) -tjie that is used in Afrikaans to mark the diminutive. bongo, in this context as Jansen remarked, is the drum, leading Jansen to exclaim that the phrase hoya chibongo means to 'listen to the (small) drum', the drum that is, according to Jansen, 'the truth'. In Jansen's exact words, 'the drum speaks the truth and the drum has always been our language before these funny words that we are speaking now'. Jansen's translation was markedly oral, not only in its expression of speech and languaging but also in its invocation of a historicity through the oral; an oral tradition, for all intents and purposes. In its locatedness in a musically expressive and performative moment, Jansen expressed a duality of sound that exceeds the oral itself: calling attention to how language might be a conduit for the instrument, and how in some sense the drum might speak across time and space. It usefully deepens the often cliché proclamation rehearsed in and out of music studies in particular that music is universal, or that sound might be thought of as a kind of connective tissue that allows a specific sense-making of the social.2 In Jansens invocation of 'before' in his statement about the drum as language, and in debates around the meaning of sound to the social, it is history - or, a representation of pastness - that is called upon to bring about a set of futures where sound mediates the experience of a temporal matrix where truth, or freedom, might be found. What Jansen does/did was not necessarily an act of translation into a local vernacular as it is the blurring of the oral and the aural in a moment that might express the relation between sound, its interpretation, and its social life, obliquely. The truth for Jansen was what the drum expressed; but it was also the drum itself. The oral is aural, as the aural is oral. (shrink)

Among the virtues of relationist approaches to Frege’s puzzle is that they put us in a position to outline structural features of the puzzle that were only implicit in earlier work. In particular, they allow us to frame questions about the relation between the explanatory roles of sense and sameness of sense. In this paper, I distinguish a number of positions about that relation which have not been clearly distinguished. This has a few pay-offs. It allows us to shed light (...) on recent controversies about the ‘essential indexical’, and it also allows us to see what’s at stake between relationists and their opponents. When we see what’s at stake, we can see that we have reason to adopt an account of cognitive significance that incorporates elements of both relationist and Fregean approaches. (shrink)

Department of Economics, University of Calgary, 2500 University Dr NW, Calgary AB, T2N 1N4, Canada. Tel.: +1403220 5861; Fax: +1403220 5861; Email: ahollis{at}ucalgary.ca ' + u + '@' + d + ' '//--> . Abstract The Health Impact Fund has been proposed as an optional, comprehensive advance market commitment system offering financial payments or ‘prizes’ to patentees of new drugs, which are sold globally at an administered low price. The Fund is designed to offer payments based on the therapeutic impact (...) of the drugs or vaccines, so that innovators will have efficient incentives to develop drugs that maximize health gains. Consumers would have improved access to such drugs because of low prices. CiteULike Connotea Del.icio.us What's this? (shrink)

Predicativists hold that proper names have predicate-type semantic values. They face an obvious challenge: in many languages names normally occur as, what appear to be, grammatical arguments. The standard version of predicativism answers this challenge by positing an unpronounced determiner in bare occurrences. I argue that this is a mistake. Predicativists should draw a distinction between two kinds of semantic type—underived semantic type and derived semantic type. The predicativist thesis concerns the underived semantic type of proper names and underdetermines a (...) view about the semantic type of bare occurrences. I’ll argue that predicativists should hold that bare names are derived individual-denoting expressions. I end by considering what this result means for the relationship between predicativism and other metalinguistic theories of names. (shrink)

Antibiotic resistance presents a classic example of the “tragedy of the commons.” In this eponymous tragedy, the commons — shared, public access lands — are overgrazed because farmers can send their livestock onto the land at a zero price. The “tragedy” occurs because overgrazing destroys the land and reduces its ability to provide fodder. The application to antibiotics is obvious: the use of antibiotics creates selection pressure leading to increased proportions of resistant bacteria in the patient and the environment. The (...) increase in frequency of resistant organisms diminishes the effectiveness of antibiotics in treating future infections; thus, the long-term value of the antimicrobial resource is reduced. (shrink)

Fregeanism and Relationism are competing families of solutions to Frege’s Puzzle, and by extension, competing theories of propositional representation. My aim is to clarify what is at stake between them by characterizing and evaluating a Relationist argument. Relationists claim that it is cognitively possible for distinct token propositional attitudes to be, in a sense, qualitatively indistinguishable: to differ in no intrinsic representational features. The idea of an ‘intrinsic representational feature’ is not, however, made especially clear in the argument. I clarify (...) it here and, having done so, offer reason to doubt the argument. This will put us in a position to draw some lessons about the relation between object-directed and representation-internal aspects of cognitive significance. (shrink)

Call an account of names satisfactionalist if it holds that object o is the referent of name a in virtue of o’s satisfaction of a descriptive condition associated with a. Call an account of names minimally descriptivistif it holds that if a competent speaker finds ‘a=b’ to be informative, then she must associate some information with ‘a’ which she does not associate with ‘b’. The rejection of both positions is part of the Kripkean orthodoxy, and is also built into extant (...) versions of the file-picture of reference. In this paper, I argue that the rejection of minimal descriptivism only follows from the rejection of satisfactionalism given certain implausible assumptions about the nature of competence with a proper name. I do this by showing that considerations internal to the file-picture - in particular the idea that competence with a proper name constitutes an ‘epistemically rewarding’ relation to its bearer - motivate an acceptance of minimal descriptivism. (shrink)

Some have argued that chance and determinism are compatible in order to account for the objectivity of probabilities in theories that are compatible with determinism, like Classical Statistical Mechanics (CSM) and Evolutionary Theory (ET). Contrarily, some have argued that chance and determinism are incompatible, and so such probabilities are subjective. In this paper, I argue that both of these positions are unsatisfactory. I argue that the probabilities of theories like CSM and ET are not chances, but also that they are (...) not subjective probabilities either. Rather, they are a third type of probability, which I call counterfactual probability. The main distinguishing feature of counterfactual-probability is the role it plays in conveying important counterfactual information in explanations. This distinguishes counterfactual probability from chance as a second concept of objective probability. (shrink)

This philosophical and sociological look at friendship and happiness begins with a review of Aristotle's three categories of friendship--friends of utility, friends of pleasure and friends of the good. Modern variations--casual friends, close friends, best friends--are described, along with the growing phenomena of virtual friendships and cyber socialization in the Internet age. Inspired in part by Bertrand Russell's The Conquest of Happiness, the authors propose that conquering unhappiness is key to achieving the self-satisfaction Russell called zest and Aristotle called eudaimonia (...) or thriving by our own efforts. -Publisher description. (shrink)

This paper re-examines the debate between those who, with Miranda Fricker, diagnose the primary, non-contingent harm of testimonial injustice as a kind of epistemic objectification and those who contend it is better thought of as a kind of epistemic othering. Defenders of the othering account of the primary harm have often argued for it by presenting cases of testimonial injustice in which the testifier’s epistemic agency is affirmed rather than denied, even while their credibility is unjustly impugned. In previous work, (...) I have instead argued that such cases suggest that we need to enrich our conception of epistemic objectification in ways encouraged by Martha Nussbaum’s cluster analysis of objectification. Here I continue to make the case for this approach, and I consider the othering account in more detail. I focus in particular on Gaile Pohlhaus Jr.’s arguments for a version of the othering account in terms of the notion of derivatization, which turns on the idea that only such an account can enable us to properly understand the harms of testimonial injustice, in particular the ways in which it interferes with a subject’s epistemic agency and autonomy, and I’ll argue that such arguments should not sway us. Finally, I’ll further support my contention that it is illuminating and helpful to think of the primary harm of testimonial injustice in terms of epistemic objectification, though I will concede that the notion of epistemic othering may offer further helpful resources for understanding how subjects can be harmed by testimonial injustice. (shrink)

Four experiments investigated how people judge the plausibility of category-based arguments, focusing on the diversity effect, in which arguments with diverse premise categories are considered particularly strong. In Experiment 1 we show that priming people as to the nature of the blank property determines whether sensitivity to diversity is observed. In Experiment 2 we find that people's hypotheses about the nature of the blank property predict judgements of argument strength. In Experiment 3 we examine the effect of our priming methodology (...) on people's tendency to bring knowledge about causality or similarity to bear when evaluating arguments, and in Experiment 4 we show that whether people's hypotheses about the nature of the blank property were causal predicted ratings of argument strength. Together these results suggest that diversity effects occur because diverse premises lead people to bring general features of the premise categories to mind. Although our findings are broadly consistent with Bayesian and Relevance-based approaches to category-based inductive reasoning, neither approach captures all of our findings. (shrink)

Predicativism about names—the view that names are metalinguistic predicates—has yet to confront a foundational issue: how are names represented in the lexicon? I provide a positive characterization of the structure of the lexicon from the point of view Predicativism. I proceed to raise a problem for Predicativism on the basis of that characterization, focusing on cases in which individuals have names which are spelled the same way but pronounced differently. Finally, I introduce two potential strategies for solving the problem, and (...) offer reasons not to be optimistic about either. (shrink)

It is natural to think of precise probabilities as being special cases of imprecise probabilities, the special case being when one’s lower and upper probabilities are equal. I argue, however, that it is better to think of the two models as representing two different aspects of our credences, which are often vague to some degree. I show that by combining the two models into one model, and understanding that model as a model of vague credence, a natural interpretation arises that (...) suggests a hypothesis concerning how we can improve the accuracy of aggregate credences. I present empirical results in support of this hypothesis. I also discuss how this modeling interpretation of imprecise probabilities bears upon a philosophical objection that has been raised against them, the so-called inductive learning problem. (shrink)