The aim of this work was to compare experimental investigations on effects of lidocaine, calcium and, BRL 34915 on reentries to simulated data obtained by use of a model of propagation based on the Huygens' constriction method already described in previous works. Calcium and lidocaine effects are investigated on anisotropic conduction conditions. In both cases, reduction in conduction velocities are observed. In lidocaine case, a refractory area is located along the longitudinal axis. In agreement with experimental electrical mapping, the simulations (...) show that the stabilization of reentrant excitation is mainly due to the existence of this refractory area around which the reentrant circuit can develop. The experimental study shows that BRL 34915 has both arrhythmogenic and antiarrhythmic effects. A detailed electrophysiological analysis has shown that drug infusion act on normal cardiac cells by decreasing the relative and absolute refractory period. BRL 34915 action is simulated by a decrease in the refractory period showing that the time frequency of the reentrant activity is increased and that the spatial size where the reentry is developing is becoming smaller. These two effects are arrhythmogenic, the simulated data being so in good agreement with the experimental ones. (shrink)

The present work is aimed at investigating the effects of myocardial infarction and ischemia on induction of ventricular fibrillation. Electrophysiologic effects of global and local ischemia (variation of the dispersion of refractory periods as well as conduction velocity) on initiation of reentry mechanisms was studied by means of computer simulations based on a cellular automata model of propagation of activation wave through a ventricular surface element. A local area of ischemia where effects of the dispersion of refractory periods are investigated (...) is then simulated. This is made using a Gaussian distribution characterized by its mean and standard deviation. These simulations show that ischemia is capable of initiating reentry phenomena which propagate through the whole ventricle; they are responsible for ventricular fibrillation which causes sudden cardiac death, even when ischemia only involves limited parts of the myocardium. Statistical study of the probability of reentries as a function of both of the size of ischemic zones and the rate of dispersion of refractory periods shows that the latter parameter is of primary importance in triggering cardiac reentries. (shrink)

Limitations of antiarrhythmic drugs on cardiac sudden death prevention appeared since the early 80's. The "Cardiac Arrhythmia Suppression Trial"(CAST) showed more recently that mortality was significantly higher inpatients treated with some particular antiarrhythmic drugs than in non-treated patients. In this field, our group recently demonstrated that a bolus of a Class 1B antiarrhythmic drug was able to trigger a ventricular fibrillation due to transient blocks induction. The aim of the present work was to systematically study, by use of the van (...) Capelle and Durrer (VCD) model which allows to simulate ventricular activation wave propagation, the link between arrhythmogenic effects and the ability of transient blocks to possibly degenerate in severe arrhythmias. A fragment of the ventricular wall is represented by an array of 16384elements electrically coupled. Effects of induction of one or several transient blocks, as the effects of their size and duration on possible induction of reentries have been studied. Results obtained show that various combinations between these different parameters may trigger reentries, ventricular tachycardia and/or more complex patterns assimilable to ventricular fibrillation. These results clearly evidence the fact that possible induction of transient blocks may directly be related to risk factor associated to arrhythmogenic effects of antiarrhythmic drugs. (shrink)

Probing semantic relations Exploration and identification in specialized texts Alain Auger and Caroline Barrière In recent years, several scientific ...

Anthropocentrism was born with Man, and certain primitive tribes or ethnic groups considered themselves the center of the world. Their members assumed the generic name “the Men,” and all the rest, including other, tribes or ethnic groups, were part of a more or less hostile environment (to use the modern term).

"Depuis une quinzaine d'années, les études sur Montesquieu se sont profondément renouvelées. Le corpus lui-même, grâce aux OEuvres complètes en cours, et notamment avec la première publication intégrale du manuscrit de travail de L'Esprit des lois, offre des perspectives inédites. Mais c'est aussi l'approche même qui a changé : la diversité des questions et des thèmes que son oeuvre permet d'aborder élargit le champ de la recherche, de la philosophie morale et politique à l'histoire ou l'anthropologie, ou encore à la (...) pensée du droit et de la société. Ce volume en tire méthodiquement les conséquences. Dans la perspective de l'édition critique des OEuvres complètes de Montesquieu, c'est à une relecture non pas radicale, mais en finesse et en profondeur qu'invite ce volume, en développant le rapport entre l'homme et la société, en redessinant la relation aux grands massifs de la tradition philosophique d'une pensée dont on suit jusqu'à son terme la logique, en suggérant des relations inédites à travers des rapprochements qui s'imposent, mais n'avaient pourtant guère été faits : ce qui restait informe ou informulé s'est éclairé, ce dont on devinait l'importance s'est approfondi. Ensuite, que restera-t-il à (re)lire? L'Esprit des lois."--Page [4] de la couverture. (shrink)

We present a dynamical model of a multi-site fishery. The fish stock is located on a discrete set of fish habitats where it is catched by the fishing fleet. We assume that fishes remain on fishing habitats while the fishing vessels can move at a fast time scale to visit the different fishing sites. We use the existence of two time scales to reduce the dimension of the model : we build an aggregated model considering the habitat fish densities and (...) the total fishing effort. We explore a regulation procedure, which imposes an average residence time in patches. Several equilibria exist, a Fishery Free Equilibria as well as a Sustainable Fishery Equilibria . We show that the dynamics depends on a threshold which is similar to a basic reproduction ratio for the fishery. When the basic reproduction ratio is less or equal to 1, one of the FFEs is globally asymptotically stable , otherwise one of the SFEs is GAS. (shrink)

Alain Badiou is arguably the most significant philosopher in Europe today. Badiou’s seminars, given annually on major conceptual and historical topics, constitute an enormously important part of his work. They served as laboratories for his thought and public illuminations of his complex ideas yet remain little known. This book, the transcript of Badiou’s year-long seminar on the psychoanalytic theory of Jacques Lacan, is the first volume of his seminars to be published in English, opening up a new and vital (...) aspect of his thinking. In a highly original and compelling account of Lacan’s theory and therapeutic practice, Badiou considers the challenge that Lacan poses to fundamental philosophical topics such as being, the subject, and truth. Badiou argues that Lacan is a singular figure of the “anti-philosopher,” a series of thinkers stretching back to Saint Paul and including Kierkegaard and Nietzsche, with Lacan as the last great anti-philosopher of modernity. The book offers a forceful reading of an enigmatic yet foundational thinker and sheds light on the crucial role that Lacan plays in Badiou’s own thought. This seminar, more accessible than some of Badiou’s more difficult works, will be profoundly valuable for the many readers across academic disciplines, art and literature, and political activism who find his thought essential. (shrink)

The subtractive : preface by Francois Wahl -- Philosophy itself -- The (re)turn of philosophy itself -- Definition of philosophy -- What is a philosophical institution? -- Philosophy and poetry -- The philosophical recourse to the poem -- Mallarm's method : subtraction and isolation -- Rimbaud's method : interruption -- Philosophy and mathematics -- Conference on subtraction -- Truth : forcing and unnameable -- Philosophy and politics -- Philosophy and love -- What is love? -- Philosophy and psychoanalysis -- Subject (...) and infinite -- Antiphilosophy : Lacan and Plato -- Writing of the generic -- Writing of the generic : Samuel beckett. (shrink)

Published in 1973, "L'Etourdit" was one of the French philosopher Jacques Lacan's most important works. The book posed questions that traversed the entire body of Lacan's psychoanalytical explorations, including his famous idea that "there is no such thing as a sexual relationship," which seeks to undermine our certainties about intimacy and reality. In There's No Such Thing as a Sexual Relationship, Alain Badiou and Barbara Cassin take possession of Lacan's short text, thinking "with" Lacan about his propositions and what (...) kinds of questions they raise in relation to knowledge. Cassin considers the relationship of the real to language through a Sophist lens, while the Platonist Badiou unpacks philosophical claims about truth. Each of their contributions echoes back to one another, offering new ways of thinking about Lacan, his seminal ideas, and his role in advancing philosophical thought. (shrink)

In this book a noted physiologist and neuroscientist introduces the concept of simplexity, the set of solutions living organisms find that enable them to deal with information and situations, while taking into account past experiences and anticipating future ones. Such solutions are new ways of addressing problems so that actions may be taken more quickly, more elegantly, and more efficiently. In a sense, the history of living organisms may be summed up by their remarkable ability to find solutions that avoid (...) the world's complexity by imposing on it their own rules and functions. Evolution has resolved the problem of complexity not by simplifying but by finding solutions whose processes--though they can sometimes be complex--allow us to act in the midst of complexity and of uncertainty. Nature can inspire us by making us realize that simplification is never simple and requires instead that we choose, refuse, connect, and imagine, in order to act in the best possible manner. Such solutions are already being applied in design and engineering and are significant in biology, medicine, economics, and the behavioral sciences. (shrink)

Uses the thoughts of such great minds as Kierkegaard, Plato, and Beckett to examine the concept of love and redefine it in the face of twenty-first century modernity.

The importance of ethical consumerism to many companies worldwide has increased dramatically in recent years. Ethical consumerism encompasses the importance of non-traditional and social components of a company's products and business process to strategic success - such as environmental protectionism, child labor practices and so on. The present paper utilizes a random utility theoretic experimental design to provide estimates of the relative value selected consumers place on the social features of products.

Nearly all studies of consumers’ willingness to engage in ethical or socially responsible purchasing behavior is based on unconstrained survey response methods. In the present article we ask the question of how well does asking consumers the extent to which they care about a specific social or ethical issue relate to how they would behave in a more constrained environment where there is no socially acceptable response. The results of a comparison between traditional survey questions of “intention to purchase” and (...) estimates of individuals willingness-to-pay for social attributes in products reveal that simple survey questions are too “noisy” to provide operationally meaningful information and overstate intentions to a considerable extent. (shrink)

Plato's Republic is one of the best-known and most widely-discussed texts in the history of philosophy. But how might we get to the heart of this work today, 2,500 years after its original composition? Alain Badiou breathes life into Plato's landmark text and revives its universality. Rather than producing yet another critical commentary, he has instead worked closely on the original Greek and, through spectacular changes, adapted it to our times. In this innovative reimagining of Plato's work, Badiou has (...) removed all references specific to ancient Greek society—from lengthy exchanges about moral courage in archaic poetry to political considerations mainly of interest to the aristocratic elite—and has expanded the range of cultural references. Here, philosophy is firing on all cylinders: Socrates and his companions are joined by Beckett, Pessoa, Freud, and Hegel, among others. Together these thinkers demonstrate that true philosophy endures, ready to absorb new horizons without changing its essence. Moreover, Badiou—who is also a dramatist—has transformed the Socratic dialogue into a genuine oratorial contest. In his version of the Republic, the interlocutors do much more than simply agree with Socrates. They argue, stand up to him, put him on the spot, and show thought in motion. In this work of dramatic scholarship and philosophy, we encounter a modern version of Plato's text that is alive, stimulating, and directly relevant to our own world. (shrink)

Martin Heidegger was an ordinary Nazi and a loyal member of the provincial petty bourgeoisie. He was also a seminal thinker of the Continental tradition and one of the twentieth century's most important philosophers. How are we to make sense of this dual life? Should we factor Heidegger's domestic and political associations into our understanding of his thought, or should we treat his intellectual work independently of his abhorrent politics? How does any thinker reconcile the mundane with the ideal or (...) the pursuit of philosophical inquiry with the demands of civic engagement? In Heidegger, Alain Badiou and Barbara Cassin immerse themselves in the philosopher's correspondence with his wife Elfride to answer these questions as they relate to Heidegger and all thinkers vulnerable to the politics of their times. They focus on Heidegger's tormented relationship with his wife, with Hannah Arendt, and with numerous other women, bringing an unusual level of intimacy to his personal and intellectual worlds. (shrink)

... The purpose of this paper is to try to clarify the extent to which consumers “value” ethical product features when making purchases by utilizing a distinctive methodology – structured choice experiments ( Louviere et al., 2000) – that What Will Consumers Pay ... Jordan J. Louviere ... \n.

L'oeuvre d'Alain Boureau, multiple et dense, se deploie sur les quarante dernieres annees en abordant de nombreux domaines de l'histoire du Moyen Age et du christianisme latin. Elle suit les peregrinations personnelles et professionnelles d'un chercheur a travers un monde peuple de silhouettes incertaines : figures de l'hagiographie, faux-semblants de l'Etat moderne, anges, demons, cadavres et somnambules, vagues individus scolastiques qui eux-memes parlent de creatures etranges. Autant de fantomes d'un passe persistant qu'il a suivis avec tenacite tout au long (...) de sa carriere, et qui nous embarquent a leur tour a travers l'histoire. Ce volume entend garder la trace vivante des deux journees qui furent organisees a Paris en mai 2015 autour de l'oeuvre d'Alain Boureau. Ce Liber amicorum d'un genre un peu particulier, production scolastique en quelque sorte, donne a voir les membres d'un studium, ce qu'etait le seminaire d'Alain Boureau : les amis, les collegues, les proches, celles et ceux qui l'ont accompagne au cours de ses annees passees a l'EHESS. Les textes rassembles rendent compte de trajectoires et de realisations, ils en montrent les apports scientifiques et les enjeux intellectuels. Ils racontent, aussi. Ainsi se manifeste la richesse d'une oeuvre singuliere, construite aux croisements de differentes pratiques des sciences sociales dans une demarche souvent collective, toujours originale et novatrice. (shrink)

Overture -- Jacques Lacan -- Georges Canguilhem and Jean Cavaillès -- Jean-Paul Sartre -- Jean Hyppolite -- Louis Althusser -- Jean-François Lyotard -- Gilles Deleuze -- Michel Foucault -- Jacques Derrida -- Jean Borreil -- Philippe Lacoue-Labarthe -- Gilles Châtelet -- Françoise Proust -- A note on the texts.

We consider a two-patch epidemiological system where individuals can move from one patch to another, and local interactions between the individuals within a patch are governed by the classical SIRS model. When the time-scale associated with migration is much smaller than the time-scale associated with infection, aggregation methods can be used to simplify the initial complete model formulated as a system of ordinary differential equations. Analysis of the aggregated model then shows that the two-patch basic reproduction rate is smaller than (...) the 1 patch one. We extend this result to a linear chain of P patches . These results are illustrated by some examples for which numerical integration of the system of ordinary differential equations is performed. Simulations of an individual based model implemented with a multi-agent system are also carried out. (shrink)

We generally agree with Burt's thesis. However, we note that the author did not discuss epigenetics, the study of how the environment can alter gene structure and function. Given epigenetic mechanisms, the utility of polygenic risk scores (PRS) is limited in studies of development and mental illness. Finally, in this commentary we expand upon the risks of reliance upon PRSs.

Two eminent French philosophers discuss German philosophy—including the legacy of Kant, Hegel, Nietzsche, Adorno, Fichte, Marx, and Heidegger—from a French perspective. In this book, Alain Badiou and Jean-Luc Nancy, the two most important living philosophers in France, discuss German philosophy from a French perspective. Written in the form of a dialogue, and revised and expanded from a 2016 conversation between the two philosophers at the Universität der Künste Berlin, the book offers not only Badiou's and Nancy's reinterpretations of German (...) philosophers and philosophical concepts, but also an accessible introduction to the greatest thinkers of German philosophy. Badiou and Nancy discuss and debate such topics as the legacies of Kant, Hegel, and Marx, as well as Nietzsche, Adorno, Fichte, Schelling, and the unavoidable problem of Heidegger and Nazism. The dialogue is contentious, friendly, and often quotable, with strong—at times passionate—positions taken by both Badiou and Nancy, who find themselves disagreeing over Kant, for example, and in unexpected agreement on Marx, for another. What does it mean, then, to conduct a dialogue on German philosophy from a French perspective? As volume editor Jan Völker observes, “German philosophy” and “French philosophy” describe complex constellations that, despite the reference to nation-states and languages, above all encompass shared concepts and problems—although these take a range of forms. Perhaps they can reveal their essential import only in translation. (shrink)

This work presents a mathematical model describing the interactions between the cross-shore structure of small pelagic fish population an their exploitation by coastal and offshore fisheries. The complete model is a system of seven ODE’s governing three stocks of small pelagic fish population moving and growing between three zones. Two types of fishing fleets are inter-acting with the fish population, industrial boats, constrained to offshore area, and artisanal boats, operating from the shore. Two time scales were considered and we use (...) aggregation methods that allow us to reduce the dimension of the model and to obtain an aggregated model, which is a four dimension one. The analysis of the aggregated model is performed. We discuss the possible equilibriums and their meaning in terms of fishery management. An interesting equilibrium state can be obtained for which we can expect coexistence and a stable equilibrium state between fish stocks and fishing efforts. Some identification parameters are also given in the discussion part of the model. (shrink)

We study the case of two sibling species ofHippolais(Aves). Very little differences can be observed in the morphology of both species. The breeding area of these species are complementary. Roughly, one species breeds North and East of Europe (Hippolais icterina) while the other breeds South and West of Europe (Hippolais polyglotta). There exitst a narrow zone of sympatry passing through Burgundy. Since several years, it has been observed that this area of sympatry was moving in the North-East direction at a (...) European scale. This means that progressivelyH. icterina is declining and is replaced byH. polyglotta. Some assumptions can be made in order to explain this evolution, for instance competition or predation. Series of observations concerning the diets of nestlings of both species have been realized. These observations show some differences in the diet compositions. The breeding success of the two species has been studied. Numerical simulations of a competition model taking into account the observed differences between the food types eaten by the two species are presented. These simulations do not explain the regression ofH. icterina. Then, we present numerical simulations of a predation model with one predator attacking the nestlings of both species. These simulations show that with time one of the two preys must extinct. Predation rather than competition seems to be the right explanation. (shrink)

We present a mathematical model of two competing marine species that are harvested. We consider three models according to different levels of complexity, without and with species refuge and density-independent and density-dependent species movement between fishing area and refuge. We particularly study the effects of the fishing pressure on the outcome of the competition. We focus on conditions that allow an inferior competitor to invade as a result of fishing pressure. The model is discussed in relationship to the case of (...) the thiof and the octopus along the Atlantic West African coast. At the origin, the thiof was abundant and the octopus scarce in that region. Since, the fishing pressure has strongly increased in some fishing areas leading to the depletion of the thiof and the invasion of its competitor, the octopus. (shrink)

Outcomes of interspecific competition, and especially the possibility of coexistence, have been extensively studied in theoretical ecology because of their implications in community assemblages. During the last decades, the influence of different time scales through the local/regional dynamics of animal communities has received an increasing attention. Nevertheless, different time scales involved in interspecific competition can result form other processes than spatial dynamics. Here, we envision and analyze a new theoretical framework that couples a game theory approach for competition with a (...) demographic model. We take advantage of these two time scales to derive a reduced model governing the total densities of the two populations and we study how these two time scales interfere and influence outcomes of species competition. We find that a competition process occurring on a faster time scale than demography yields a “priority effect” where the first species introduced outcompetes the other one. We then confirm previous findings stipulating that species coexistence is favored by large difference in time scales because the extinction/recolonization process. Our results then highlight that an integration of demographic and competition time scales at both local and regional levels is mandatory to explain communities assemblages and should become a research priority. (shrink)

The sociology of knowledge is faced with a problem of historical temporality that it has carefully avoided up until now. The subject has been avoided or ignored because a discussion of it in depth would run the risk of questioning all modern scientific thought. The problem is that of the concept of absolute time as it is used in evolutionist theory. In this category of theory I include not only social evolutionism, abused for a long time and recently reanimated by (...) the “socio-biologists,” but also biological, paleontological, geological and other types of evolutionism, that is, those qualified as “scientific.”. (shrink)

A leading historian opens up a new terrain for understanding the past: the history of ignorance.

Quels enseignements tirer de la crise pandémique mondiale de 2020? La violence extrême du risque sanitaire nous a évidemment rappelé que nous étions mortels - quels que soient nos systèmes de santé. Mais au-delà, ce sont nos équilibres sociaux, éthiques, économiques ou politiques qui ont été remis en cause. Comment justifier éthiquement le tri des patients? Quelles décisions politiques prendre au moment où la protection de la santé est mise en rivalité avec la nécessité de soutenir une activité économique également (...) vitale? La mondialisation est-elle responsable de nos vulnérabilités? Autant de questions épineuses abordées dans cet essai, qui revendique la pertinence d'une approche philosophique de terrain, loin d'une réflexion abstraite sur la fragilité écologique ou d'une critique convenue de nos systèmes mondialisés. Si le risque incite au repli sur soi, l'enjeu est ici de comprendre que la résilience ne passera que par une plus grande solidarité internationale et une redéfinition de la souveraineté."--Page 4 of cover. (shrink)