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  1.  36
    SMT and TOFT: Why and How They are Opposite and Incompatible Paradigms.Mariano Bizzarri & Alessandra Cucina - 2016 - Acta Biotheoretica 64 (3):221-239.
    The Somatic Mutation Theory has been challenged on its fundamentals by the Tissue Organization Field Theory of Carcinogenesis. However, a recent publication has questioned whether TOFT could be a valid alternative theory of carcinogenesis to that presented by SMT. Herein we critically review arguments supporting the irreducible opposition between the two theoretical approaches by highlighting differences regarding the philosophical, methodological and experimental approaches on which they respectively rely. We conclude that SMT has not explained carcinogenesis due to severe epistemological and (...)
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  2.  24
    Gravity Constraints Drive Biological Systems Toward Specific Organization Patterns.Mariano Bizzarri, Maria Grazia Masiello, Alessandro Giuliani & Alessandra Cucina - 2018 - Bioessays 40 (1):1700138.
    Different cell lineages growing in microgravity undergo a spontaneous transition leading to the emergence of two distinct phenotypes. By returning these populations in a normal gravitational field, the two phenotypes collapse, recovering their original configuration. In this review, we hypothesize that, once the gravitational constraint is removed, the system freely explores its phenotypic space, while, when in a gravitational field, cells are “constrained” to adopt only one favored configuration. We suggest that the genome allows for a wide range of “possibilities” (...)
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  3.  3
    Constraints Shape Cell Function and Morphology by Canalizing the Developmental Path Along the Waddington's Landscape.Mariano Bizzarri, Alessandro Giuliani, Mirko Minini, Noemi Monti & Alessandra Cucina - 2020 - Bioessays 42 (4):1900108.
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