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Alessandro Blasimme
University of Zürich
  1.  22
    Becoming Partners, Retaining Autonomy: Ethical Considerations on the Development of Precision Medicine.Alessandro Blasimme & Effy Vayena - 2016 - BMC Medical Ethics 17 (1):67.
    Precision medicine promises to develop diagnoses and treatments that take individual variability into account. According to most specialists, turning this promise into reality will require adapting the established framework of clinical research ethics, and paying more attention to participants’ attitudes towards sharing genotypic, phenotypic, lifestyle data and health records, and ultimately to their desire to be engaged as active partners in medical research.Notions such as participation, engagement and partnership have been introduced in bioethics debates concerning genetics and large-scale biobanking to (...)
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  2.  7
    Health Research with Big Data: Time for Systemic Oversight.Effy Vayena & Alessandro Blasimme - 2018 - Journal of Law, Medicine and Ethics 46 (1):119-129.
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  3.  23
    Biomedical Big Data: New Models of Control Over Access, Use and Governance.Alessandro Blasimme & Effy Vayena - 2017 - Journal of Bioethical Inquiry 14 (4):501-513.
    Empirical evidence suggests that while people hold the capacity to control their data in high regard, they increasingly experience a loss of control over their data in the online world. The capacity to exert control over the generation and flow of personal information is a fundamental premise to important values such as autonomy, privacy, and trust. In healthcare and clinical research this capacity is generally achieved indirectly, by agreeing to specific conditions of informational exposure. Such conditions can be openly stated (...)
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  4.  12
    Genomic Incidental Findings: Reducing the Burden to Be Fair.Velizara Anastasova, Alessandro Blasimme, Sophie Julia & Anne Cambon-Thomsen - 2013 - American Journal of Bioethics 13 (2):52-54.
  5.  13
    "Tailored-to-You": Public Engagement and the Political Legitimation of Precision Medicine.Alessandro Blasimme & Effy Vayena - 2016 - Perspectives in Biology and Medicine 59 (2):172-188.
    Some patients tolerate a given drug well, without adverse reactions. For others, though, an identical dose of the same medication can have toxic effects. Moreover, while a drug can be effective at relieving symptoms for some patients, it may fail to do the same for others suffering with the same disease. With such variability in treatment responses, tailoring medical interventions to individual patients has long been an aspiration of medicine. Until recently, however, medicine lacked a clear understanding of the biological (...)
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  6.  21
    Informed Consent and the Disclosure of Clinical Results to Research Participants.Effy Vayena, Samia A. Hurst, Celine Moret & Alessandro Blasimme - 2017 - American Journal of Bioethics 17 (7):58-60.
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  7.  13
    Humanised Models of Cancer in Molecular Medicine: The Experimental Control of Disanalogy.Paolo Maugeri & Alessandro Blasimme - 2011 - History and Philosophy of the Life Sciences 33 (4).
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  8.  22
    What Mechanisms Can’T Do: Explanatory Frameworks and the Function of the P53 Gene in Molecular Oncology.Alessandro Blasimme, Paolo Maugeri & Pierre-Luc Germain - 2013 - Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences 44 (3):374-384.
    What has been called the new mechanistic philosophy conceives of mechanisms as the main providers of biological explanation. We draw on the characterization of the p53 gene in molecular oncology, to show that explaining a biological phenomenon implies instead a dynamic interaction between the mechanistic level—rendered at the appropriate degree of ontological resolution—and far more general explanatory tools that perform a fundamental epistemic role in the provision of biological explanations. We call such tools “explanatory frameworks”. They are called frameworks to (...)
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  9.  18
    Disclosing Results to Genomic Research Participants: Differences That Matter.Alessandro Blasimme, Alexandra Soulier, Sophie Julia, Samantha Leonard & Anne Cambon-Thomsen - 2012 - American Journal of Bioethics 12 (10):20-22.
    The American Journal of Bioethics, Volume 12, Issue 10, Page 20-22, October 2012.
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  10.  15
    Reprogramming Potentiality: The Co-Production of Stem Cell Policy and Democracy.Alessandro Blasimme, Bettina Schmietow & Giuseppe Testa - 2013 - American Journal of Bioethics 13 (1):30-32.
  11.  5
    Genes Wide Open: Data Sharing and the Social Gradient of Genomic Privacy.Tobias Haeusermann, Marta Fadda, Alessandro Blasimme, Bastian Greshake Tzovaras & Effy Vayena - forthcoming - Ajob Empirical Bioethics:1-15.
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  12.  7
    Democratizing Health Research Through Data Cooperatives.Alessandro Blasimme, Effy Vayena & Ernst Hafen - 2018 - Philosophy and Technology 31 (3):473-479.
    Massive amounts of data are collected and stored on a routine basis in virtually all domains of human activities. Such data are potentially useful to biomedicine. Yet, access to data for research purposes is hindered by the fact that different kinds of individual-patient data reside in disparate, unlinked silos. We propose that data cooperatives can promote much needed data aggregation and consequently accelerate research and its clinical translation. Data cooperatives enable direct control over personal data, as well as more democratic (...)
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  13.  14
    Genome Editing and Dialogic Responsibility: “What's in a Name?”.Alessandro Blasimme, Ignacio Anegon, Jean-Paul Concordet, John De Vos, Anne Dubart-Kupperschmitt, Marc Fellous, Pierre Fouchet, Nelly Frydman, Carine Giovannangeli, Pierre Jouannet, Jean-Loius Serre, Julie Steffann, Emmanuelle Rial-Sebbag, Mogens Thomsen & Anne Cambon-Thomsen - 2015 - American Journal of Bioethics 15 (12):54-57.
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  14.  9
    Intentionality and the Welfare of Minded Non-Humans.Alessandro Blasimme & Lisa Bortolotti - 2010 - Teorema: International Journal of Philosophy 29 (2):83-96.
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