IntroductionInternational sharing of health data opens the door to the study of the so-called ‘Big Data’, which holds great promise for improving patient-centred care. Failure of recent data sharing initiatives indicates an urgent need to invest in societal trust in researchers and institutions. Key to an informed understanding of such a ‘social license’ is identifying the views patients and the public may hold with regard to data sharing for health research.MethodsWe performed a narrative review of the empirical evidence addressing patients’ (...) and public views and attitudes towards the use of health data for research purposes. The literature databases PubMed, Embase, Scopus and Google Scholar were searched in April 2019 to identify relevant publications. Patients’ and public attitudes were extracted from selected references and thematically categorised.ResultsTwenty-seven papers were included for review, including both qualitative and quantitative studies and systematic reviews. Results suggest widespread—though conditional—support among patients and the public for data sharing for health research. Despite the fact that participants recognise actual or potential benefits of data research, they expressed concerns about breaches of confidentiality and potential abuses of the data. Studies showed agreement on the following conditions: value, privacy, risk minimisation, data security, transparency, control, information, trust, responsibility and accountability.ConclusionsOur results indicate that a social license for data-intensive health research cannot simply be presumed. To strengthen the social license, identified conditions ought to be operationalised in a governance framework that incorporates the diverse patient and public values, needs and interests. (shrink)

We work with symmetric extensions based on Lévy collapse and extend a few results of Apter, Cody, and Koepke. We prove a conjecture of Dimitriou from her Ph.D. thesis. We also observe that if V is a model of $$\textsf {ZFC}$$ ZFC, then $$\textsf {DC}_{<\kappa }$$ DC < κ can be preserved in the symmetric extension of V in terms of symmetric system $$\langle {\mathbb {P}},{\mathcal {G}},{\mathcal {F}}\rangle $$ ⟨ P, G, F ⟩, if $${\mathbb {P}}$$ P is $$\kappa $$ (...) κ -distributive and $${\mathcal {F}}$$ F is $$\kappa $$ κ -complete. Further we observe that if $$\delta <\kappa $$ δ < κ and V is a model of $$\textsf {ZF}+\textsf {DC}_{\delta }$$ ZF + DC δ, then $$\textsf {DC}_{\delta }$$ DC δ can be preserved in the symmetric extension of V in terms of symmetric system $$\langle {\mathbb {P}},{\mathcal {G}},{\mathcal {F}}\rangle $$ ⟨ P, G, F ⟩, if $${\mathbb {P}}$$ P is ($$\delta +1$$ δ + 1 )-strategically closed and $${\mathcal {F}}$$ F is $$\kappa $$ κ -complete. (shrink)

We improve on results and constructions by Apter, Dimitriou, Gitik, Hayut, Karagila, and Koepke concerning large cardinals, ultrafilters, and cofinalities without the axiom of choice. In particular, we show the consistency of the following statements from certain assumptions: the first supercompact cardinal can be the first uncountable regular cardinal, all successors of regular cardinals are Ramsey, every sequence of stationary sets in is mutually stationary, an infinitary Chang conjecture holds for the cardinals, and all are singular. In each of the (...) cases, our results either weaken the hypotheses or strengthen the conclusions of known proofs. (shrink)