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  1.  7
    A Failure in Solidarity: Ethical Challenges in the Development and Implementation of New Tuberculosis Technologies.Ana Komparic, Angus Dawson, Renaud F. Boulanger, Ross E. G. Upshur & Diego S. Silva - 2019 - Bioethics 33 (5):557-567.
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  2.  5
    Developing and Implementing New TB Technologies: Key Informants’ Perspectives on the Ethical Challenges.Renaud F. Boulanger, Ana Komparic, Angus Dawson, Ross E. G. Upshur & Diego S. Silva - 2020 - Journal of Bioethical Inquiry 17 (1):65-73.
    ObjectiveTo identify the ethical challenges associated with the development and implementation of new tuberculosis drugs and diagnostics.MethodsTwenty-three semi-structured qualitative interviews conducted between December 2015 and September 2016 with programme administrators, healthcare workers, advocates, policymakers, and funders based in the Americas, Europe, and Africa. Interviews were analysed using thematic analysis.ResultsDivergent interests and responsibilities, coupled with power imbalances, are a primary source of ethical challenges; the uncertain risk profiles of new drugs present an additional one. Although this challenge can be partially mitigated (...)
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  3.  31
    The Ethics of Introducing GMOs Into Sub‐Saharan Africa: Considerations From the Sub‐Saharan African Theory of Ubuntu.Ana Komparic - 2015 - Bioethics 29 (9):604-612.
    A growing number of countries in sub-Saharan Africa are considering legalizing the growth of genetically modified organisms. Furthermore, several projects are underway to develop transgenic crops tailored to the region. Given the contentious nature of GMOs and prevalent anti-GMO sentiments in Africa, a robust ethical analysis examining the concerns arising from the development, adoption, and regulation of GMOs in sub-Saharan Africa is warranted. To date, ethical analyses of GMOs in the global context have drawn predominantly on Western philosophy, dealing with (...)
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  4.  16
    An Ethical Justification for Expanding the Notion of Effectiveness in Vaccine Post-Market Monitoring: Insights From the HPV Vaccine in Canada.Ana Komparic, Maxwell J. Smith & Alison Thompson - 2016 - Public Health Ethics 9 (1):78-91.
    Health regulators must carefully monitor the real-world safety and effectiveness of marketed vaccines through post-market monitoring in order to protect the public’s health and promote those vaccines that best achieve public health goals. Yet, despite the fact that vaccines used in collective immunization programmes should be assessed in the context of a public health response, post-market effectiveness monitoring is often limited to assessing immunogenicity or limited programmatic features, rather than assessing effectiveness across populations. We argue that post-market monitoring ought to (...)
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  5. Deploying the Precautionary Principle to Protect Vulnerable Populations in Canadian Post-Market Drug Surveillance.Maxwell Smith, Ana Komparic & Alison Thompson - 2020 - Canadian Journal of Bioethics / Revue canadienne de bioéthique 3 (1):110-118.
    Drug regulatory bodies aim to ensure that patients have access to safe and effective drugs; however, no matter the quality of pre-licensure studies, uncertainty will remain regarding the safety and effectiveness of newly approved drugs until a large and diverse population uses those drugs. Recent analyses of Canada’s post-market drug surveillance system have found that Canada is not keeping pace with international requirements for PMDS, and have noted that efforts must be improved to monitor and address the safety and effectiveness (...)
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