Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

Given its non-invasive nature, there is increasing interest in the use of transcutaneous vagus nerve stimulation across basic, translational and clinical research. Contemporaneously, tVNS can be achieved by stimulating either the auricular branch or the cervical bundle of the vagus nerve, referred to as transcutaneous auricular vagus nerve stimulation and transcutaneous cervical VNS, respectively. In order to advance the field in a systematic manner, studies using these technologies need to adequately report sufficient methodological detail to enable comparison of results between (...) studies, replication of studies, as well as enhancing study participant safety. We systematically reviewed the existing tVNS literature to evaluate current reporting practices. Based on this review, and consensus among participating authors, we propose a set of minimal reporting items to guide future tVNS studies. The suggested items address specific technical aspects of the device and stimulation parameters. We also cover general recommendations including inclusion and exclusion criteria for participants, outcome parameters and the detailed reporting of side effects. Furthermore, we review strategies used to identify the optimal stimulation parameters for a given research setting and summarize ongoing developments in animal research with potential implications for the application of tVNS in humans. Finally, we discuss the potential of tVNS in future research as well as the associated challenges across several disciplines in research and clinical practice. (shrink)

ASD VIII, 1 publishes texts by Erasmus related to the Church Fathers: the Vitae of Jerome, John Chrysostom and Origen, the forgery ‘Cyprian’s _De duplici martyrio_, and the prefaces to the Fathers of the Church.

The origin of paraconsistent logic is closely related with the argument, 'from the assertion of two mutually contradictory statements any other statement can be deduced'; this can be referred to as ex contradictione sequitur quodlibet. Despite its medieval origin, only by the 1930s did it become the main reason for the unfeasibility of having contradictions in a deductive system. The purpose of this article is to study what happened earlier: from Principia Mathematica to that time, when it became well established. (...) The two main historical claims that I am going to advance are the following: the first explicit use of ECSQ as the main argument for supporting the necessity of excluding any contradiction from deductive systems is to be found in the first edition of the book Grundzüge der Theoretischen Logik ; Lukasiewicz's position regarding the logical constraints against contradictions varies considerably from his studies on the principle of contradiction in Aristotle, published in 1910 and what is stated in his 'authorized lectured notes' on mathematical logic that appeared in 1929. The two texts are: 1) a paper in German [English translation: Lukasiewicz, J. 1971. 'On the principle of contradiction in Aristotle', Review of Metaphysics, XXIV, 485-509]; and 2) a book in Polish. Lukasiewicz, J. 1910. O zasadzie sprzecznosci u Aristotelesa Studium krytyczne, Warsaw: Panstwowe Wydawnictwo Naukowe [German translation: Lukasiewicz, J. 1993. Über den Satz des Widerspruchs bei Aristotles. Hildesheim: Georg Olms Verlag]. The lecture notes were then published as a book. The second half of this article will concentrate on Lukasiewicz's position on ECSQ. This will lead me to propose that to regard him as a forerunner of paraconsistent logic by virtue of those early writings is accurate only if his book published in Polish is considered but not if the analysis is restricted to the paper originally published in German. Furthermore, I will stress that in the 1929 book he presented one formalization of ECSQ as an axiom for sentential calculus and, also, he used ECSQ to defend the necessity of consistency, apparently independently of Hilbert and Ackermann's book. At the end, I will suggest that the aim of twentieth century usage of ECSQ was to change from the centuries-long philosophical discussion about contradictions to a more 'technical' one. But with paraconsistent logic viewed as a technical solution to this restriction, then, the philosophical problem revives but having now at one's disposal an improved understanding of it. Finally, Lukasiewicz's two different positions about ECSQ open an interesting question about the history of paraconsistent logic: do we have to attempt a consistent reconstruction of it, or are we prepared to admit inconsistencies within it? (shrink)

Plagiarism is a serious, yet widespread type of research misconduct, and is often neglected in developing countries. Despite its far-reaching implications, plagiarism is poorly acknowledged and discussed in the academic setting, and insufficient evidence exists in Latin America and developing countries to inform the development of preventive strategies. In this context, we present a longitudinal case study of seven instances of plagiarism and cheating arising in four consecutive classes of an Epidemiology Masters program in Lima, Peru, and describes the implementation (...) and outcomes of a multifaceted, “zero-tolerance” policy aimed at introducing research integrity. Two cases involved cheating in graded assignments, and five cases correspond to plagiarism in the thesis protocol. Cases revealed poor awareness of high tolerance to plagiarism, poor academic performance, and widespread writing deficiencies, compensated with patchwriting and copy-pasting. Depending on the events’ severity, penalties included course failure and separation from the program. Students at fault did not engage in further plagiarism. Between 2011 and 2013, the Masters program sequentially introduced a preventive policy consisting of: intensified research integrity and scientific writing education, a stepwise, cumulative writing process; honor codes; active search for plagiarism in all academic products; and a “zero-tolerance” policy in response to documented cases. No cases were detected in 2014. In conclusion, plagiarism seems to be widespread in resource-limited settings and a greater response with educational and zero-tolerance components is needed to prevent it. (shrink)

Deep brain stimulation is a well-established therapy for the motor symptoms of Parkinson’s disease, but there remains an opportunity to improve symptom relief. The temporal pattern of stimulation is a new parameter to consider in DBS therapy, and we compared the effectiveness of Temporally Optimized Patterned Stimulation to standard DBS at reducing the motor symptoms of PD. Twenty-six subjects with DBS for PD received three different patterns of stimulation while on medication and using stimulation parameters optimized for standard DBS. Side (...) effects and motor symptoms were assessed after 30 min of stimulation with each pattern. Subjects experienced similar types of side effects with TOPS and standard DBS, and TOPS were well-tolerated by a majority of the subjects. On average, the most effective TOPS was as effective as standard DBS at reducing the motor symptoms of PD. In some subjects a TOPS pattern was the most effective pattern. Finally, the TOPS pattern with low average frequency was found to be as effective or more effective in about half the subjects while substantially reducing estimated stimulation energy use. TOPS DBS may provide a new programing option to improve DBS therapy for PD by improving symptom reduction and/or increasing energy efficiency. Optimizing stimulation parameters specifically for TOPS DBS may demonstrate further clinical benefit of TOPS DBS in treating the motor symptoms of Parkinson’s disease. (shrink)

A Dutch medical student has the potentially more virulent Panton-Valentine leukocidin form of MRSA colonization yet shows no signs or symptoms of infection. More than a year ago, a routine MRSA screening of health care personnel providing care for MRSA-positive patients detected the colonization. Since then, the student has been treated intensively but unsuccessfully in an attempt to decolonize her. During this decolonization period, the medical student was barred from performing patient-related interventions, temporarily interrupting her medical residency. After initial treatment (...) with mupirocin nasal ointment and antibiotics proved ineffective, a more stringent hygiene regime was added that included hand, nose, hair, and body scrubbing with disinfecting soap. Additional precautions included simultaneous treatment of household members and disinfection of the family home. Despite these efforts, her MRSA status has remained positive. WIP guideline s bar any health care worker diagnosed with MRSA from performing patient-related interventions. Unable to complete the residency requirement of at least 1 year of patient care, the medical student was advised to pursue a career in another profession. (shrink)

The aim of this paper is to propose a hermeneutics of the judicial text based on Paul Ricoeur’s philosophy. For this purpose, the paper will propose, firstly, how to approach the judicial decision as text; secondly, the paper will argue from Paul Ricoeur’s notion of “Hermeneutic Arc,” how explanation and understanding as a hermeneutic method are given in the judicial decision. The final purpose is to show how in some cases the comprehension of ourselves could go through the hermeneutics made (...) to the judicial text. (shrink)

I argue that Plato’s use of thought experiments anticipate many of the themes discussed by Thomas S. Kuhn’s classic essay, “A Function for Thought Experiments.” Kuhn’s concern is that thought experiments satisfy the condition of verisimilitude. That is, thought experiments must not be conducted merely to alter the conceptual apparatus of the scientist regarding the phenomenon explored, but rather to alter the scientist’s conceptual apparatus for the sake of altering his actions (i.e., practical rationality). Plato, too, is quite concerned with (...) getting interlocutors to appreciate that theory not be separated from practice, and that theory is necessary for the process of effective decision making. Each of the interlocutors presented in the Republic, Apology and Alcibiades Minor are confrontedwith a thought experiment that is designed to effect how they choose to live. Although the three dialogues I discuss illustrate the Kuhnian admonishment against separating theory form practice, many other dialogues in the Platonic corpus echo Kuhn’s concerns. (shrink)

Chris Stewart’s account of his experiences after purchasing a farm in Andalusia, in an isolated farmhouse in the mountains adjacent to Granada, are far from the traditionally bucolic depictions of a pastoral landscape, in which the drawbacks of agricultural life become unquestionably compensated by the bliss of life in nature. Even though, as the title indicates, he seems to be a born romantic and optimist, undefeated by the inconveniences of a life without the everyday commodities of a First-World country in (...) the twenty-first century, his memoir narrative is soon balanced by his own testimony, which provides a realistic counterbalance to Stewart’s initial idealistic portrayal of life in rustic Alpujarras. Nonetheless, as this article intends to demonstrate, it is precisely this necessary demystification of the rural setting prevailing in certain areas in Andalusia that becomes crucial for the establishment of an essential complicity with the audience, thereby trained to appreciate—and even become enthralled by—the reality of the rural surroundings which the contemporary reader can no longer envision as merely a place of “vales and hills” softly covered by “a host of golden daffodils”. El relato que lleva a cabo Chris Stewart acerca de sus experiencias tras adquirir una finca en Andalucía, en un lugar apartado de la sierra lindante con Granada, se aleja de las descripciones bucólicas de paisajes pastorales en los que las desventajas de la vida agrícola quedaban incuestionablemente compensadas por el gozo de la vida en mitad de la naturaleza. Incluso pese a que, tal y como el título de su novela indica, Chris Stewart parece ser un romántico y un optimista de nacimiento, que no se deja vencer por los inconvenientes de una vida sin las comodidades cotidianas de un país del primer mundo en el siglo xxi, su memoria-narrativa se ve inmediatamente equilibrada por su propio testimonio, que proporciona un contrapunto realista al idealizado retrato inicial de la vida en las rústicas Alpujarras. No obstante, como el presente artículo pretende demostrar, es precisamente esta necesaria desmitificación del entorno rural de ciertas zonas de Andalucía lo que resulta crucial para poder establecer una esencial complicidad con el lector, que llega, de este modo, a valorar, e incluso, a sentirse fascinado, por la realidad del contexto agrario, el cual deja ya de percibir meramente como un lugar de «valles y colinas» delicadamente cubierto por «una cohorte de dorados narcisos». (shrink)

I argue that Plato’s use of thought experiments anticipate many of the themes discussed by Thomas S. Kuhn’s classic essay, “A Function for Thought Experiments.” Kuhn’s concern is that thought experiments satisfy the condition of verisimilitude. That is, thought experiments must not be conducted merely to alter the conceptual apparatus of the scientist regarding the phenomenon explored, but rather to alter the scientist’s conceptual apparatus for the sake of altering his actions. Plato, too, is quite concerned with getting interlocutors to (...) appreciate that theory not be separated from practice, and that theory is necessary for the process of effective decision making. Each of the interlocutors presented in the Republic, Apology and Alcibiades Minor are confrontedwith a thought experiment that is designed to effect how they choose to live. Although the three dialogues I discuss illustrate the Kuhnian admonishment against separating theory form practice, many other dialogues in the Platonic corpus echo Kuhn’s concerns. (shrink)

IntroductionTranscranial magnetic stimulation is a consolidated procedure for the treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst stimulation is a modification of TMS with similar efficacy and shorter session duration. The geriatric population has many comorbidities and a high prevalence of depression, but few clinical trials are conducted specifically for this age group. TBS could be an option in this population, offering the advantages of few side effects and no pharmacological interactions. Therefore, our aim is to investigate the (...) efficacy of TBS in geriatric depression.Clinical trial registration[https://clinicaltrials.gov/ct2/], identifier [NCT04842929]. (shrink)

Customer orientation (CO) and the development of long-term relationships with customers are known conditions for growth and profit sustainability. Businesses use special treatments, inducements, and personal gestures to show their appreciation to customers. However, there are concerns about whether these inducements really create the right perceptions in customer's mind. This study suggests that when customers believe that the firm is ethical, the inducements and special treatments received are seen in a positive light and can help develop loyalty. The hypotheses were (...) tested with responses from 299 customers of financial institutions in Chile. Results support the hypotheses that firm's ethical reputation helps in retaining customers. Managerial implications are provided. (shrink)

Customer orientation and the development of long-term relationships with customers are known conditions for growth and profit sustainability. Businesses use special treatments, inducements, and personal gestures to show their appreciation to customers. However, there are concerns about whether these inducements really create the right perceptions in customer’s mind. This study suggests that when customers believe that the firm is ethical, the inducements and special treatments received are seen in a positive light and can help develop loyalty. The hypotheses were tested (...) with responses from 299 customers of financial institutions in Chile. Results support the hypotheses that firm’s ethical reputation helps in retaining customers. Managerial implications are provided. (shrink)

ABSTRACT This essay will explore the constitution of a transcendental theory of space through an examination of the notion of spatial synthesis in the works of Husserl, Paliard, and Deleuze. First, we shall explore the constitution of the sensorial fields in Husserl’s phenomenology. In Husserlian terms, space is not originally an empty form that can eventually be filled with a certain empirical content. Accordingly, the philosopher claims that spatiality is a consequence of the immanent synthesis of sensations. Then, we will (...) move on to Jacques Paliard’s psychology of perception, where we will find both aesthetic and noetic synthesis as transcendental conditions for the perception of space. Lastly, we will explore Deleuze’s theory of intensive space, specifically the concept of depth developed in a dialogue with Paliard. This comparative analysis shows that purely intensive fields of individuation are a transcendental a priori for the perception of an extensive space. (shrink)

: New genetic technologies continue to emerge that allow us to control the genetic endowment of future children. Increasingly the claim is made that it is morally "irresponsible" for parents to fail to use such technologies when they know their possible children are at risk for a serious genetic disorder. We believe such charges are often unwarranted. Our goal in this article is to offer a careful conceptual analysis of the language of irresponsibility in an effort to encourage more care (...) in its use. Two of our more important sub-claims are: A fair judgment of genetic irresponsibility necessarily requires a thick background description of the specific reproductive choice; and there is no necessary connection between an act's being morally wrong and its being irresponsible. These are distinct judgments requiring distinct justifications. (shrink)

BackgroundPhysical activity is known to improve mental health, and is regarded as safe and desirable for uncomplicated pregnancy. In this novel study, we aim to evaluate whether there are associations between maternal physical activity during pregnancy and neonatal brain cortical development.MethodsForty-four mother/newborn dyads were included in this longitudinal study. Healthy pregnant women were recruited and their physical activity throughout pregnancy were documented using accelerometers worn for 3–7 days for each of the 6 time points at 4–10, ∼12, ∼18, ∼24, ∼30, (...) and ∼36 weeks of pregnancy. Average daily total steps and daily total activity count as well as daily minutes spent in sedentary/light/moderate/vigorous activity modes were extracted from the accelerometers for each time point. At ∼2 weeks of postnatal age, their newborns underwent an MRI examination of the brain without sedation, and 3D T1-weighted brain structural images were post-processed by the iBEAT2.0 software utilizing advanced deep learning approaches. Cortical surface maps were reconstructed from the segmented brain images and parcellated to 34 regions in each brain hemisphere, and mean cortical thickness for each region was computed for partial correlation analyses with physical activity measures, with appropriate multiple comparison corrections and potential confounders controlled.ResultsAt 4–10 weeks of pregnancy, mother’s daily total activity count positively correlated with newborn’s cortical thickness in the left caudal middle frontal gyrus, right medial orbital frontal gyrus, and right transverse temporal gyrus ; mother’s daily time in moderate activity mode positively correlated with newborn’s cortical thickness in the right transverse temporal gyrus. At ∼24 weeks of pregnancy, mother’s daily total activity count positively correlated with newborn’s cortical thickness in the left and right isthmus cingulate gyrus.ConclusionWe identified significant relationships between physical activity in healthy pregnant women during the 1st and 2nd trimester and brain cortical development in newborns. Higher maternal physical activity level is associated with greater neonatal brain cortical thickness, presumably indicating better cortical development. (shrink)

Kärin Nickelsen’s Explaining Photosynthesis: Models of Biochemical Mechanisms, 1840–1960 gives a much needed historical and philosophical account of one of the major research projects in modern plant sciences. This look at the scientific models of photosynthesis expands upon Nickelsen’s previous work with eighteenth century botanical illustration which she viewed as a type of modeling activity. Weaving between active research and the discourses around it, Nickelsen boldly attempts to find some bridge between the history of science and the philosophy of science (...) by identifying heuristic strategies based on her historical representation of photosynthesis research. While philosophically productive and rich in historical content, Nickelsen's text demonstrates, in opposition to its stated intention, that the historian’s goal of avoiding grand narratives may be incompatible with drawing philosophical conclusions based on historical work. (shrink)

There are two general approaches to characterising biological functions. One originates with Cummins. According to this approach, the function of a part of a system is just its causal contribution to some specified activity of the system. Call this the ‘C-function’ concept. The other approach ties the function of a trait to some aspect of its evolutionary significance. Call this the ‘E-function’ concept. According to the latter view, a trait's function is determined by the forces of natural selection. The C-function (...) and E-function concepts are clearly quite different, but there is an important relation between them which heretofore has gone unnoticed. The purpose of this paper is to outline that relation.This is not the first paper to discuss the relation of C-function and E-function. Previous attempts all follow either one of two strategies. The first proposes that the two concepts are ‘unified.’ The other proposes that they are radically distinct and apply to wholly different fields within biology. (shrink)

Inside the interdisciplinary field of Jurilinguistics, the main research has been carried out on state languages like English, French, German or Spanish. However, there is a new reality in today´s world, namely the existence of minority languages that have arisen to an official status as sub-state languages for the law and a limited range of branches of the law to be the own way to express themselves. The jurilinguistical point of view of this new reality requires a new approach to (...) it, mainly focused on both a general framework and the situation of each language. This is the reason for a first attempt to formulate a jurilinguistical general framework and a methodological approach to this new field in combination with the study of a particular case language, the Basque language, in order to describe its characters as a sub-state tool for expressing the Basque law and bijuralism, in accordance with its status as an official language in the Basque Autonomous Community and Navarrese Community, both in the Kingdom of Spain. (shrink)

We review and discuss A. H. Louie’s book “More than Life Itself: A Reflexion on Formal Systems and Biology” from an interdisciplinary viewpoint, involving both biology and mathematics, taking into account new developments and related theories.

Is the societal-level of analysis sufficient today to understand the values of those in the global workforce? Or are individual-level analyses more appropriate for assessing the influence of values on ethical behaviors across country workforces? Using multi-level analyses for a 48-society sample, we test the utility of both the societal-level and individual-level dimensions of collectivism and individualism values for predicting ethical behaviors of business professionals. Our values-based behavioral analysis indicates that values at the individual-level make a more significant contribution to (...) explaining variance in ethical behaviors than do values at the societal-level. Implicitly, our findings question the soundness of using societal-level values measures. Implications for international business research are discussed. (shrink)

This paper shows Socratic elenchus as an efficient and effective way of modeling rational knowledge seeking. Like ordinary conversations, the elenctic exchanges in the dialogues presuppose a degree of autonomy on the part of its participants. Socrates’ line of questioning often seems pertinent to a particular interlocutor because he is well aware of the fact that the interlocutor has goals and ambitions or is reputed to be an expert at something. In turn, Socrates’ line ofquestioning reflects his own goals and (...) ambitions. In Alcibiades Major Socrates is trying to turn Alcibiades towards a greater awareness of his limitations. Plato’s dialogues also force readers to consider their own solutions to the topics introduced in them. Consequently, the autonomy of a dialogue’s participants requires that interpreters not exaggerate one aspect of a dialogue’s structural features at the expense of other aspects. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

Humans are unconditionally confronted with social expectations and norms, up to a degree that they, or some of them, have a hard time recognizing what they actually want. This renders them susceptible for introjection, that is, to unwittingly or “unconsciously” mistake social expectations for self-chosen goals. Such introjections compromise an individual’s autonomy and mental health and have been shown to be more prevalent in individuals with rumination tendencies and low emotional self-awareness. In this brain imaging study, we draw on a (...) source memory task and found that introjections, as indicated by imposed tasks that are falsely recognized as self-chosen, involved the bilateral medial prefrontal cortex and the dorsal anterior cingulate cortex. Notably, reduced right MPFC activation within this condition correlated with trait scores of ruminations and reduced emotional self-awareness, but also introversion. Moreover, correct recognition of tasks as self-chosen involved the right MPFC. Accordingly, the right MPFC may play a role in supporting the maintenance of psychological autonomy and counteract introjection, which individuals with certain personality traits seem to be prone to. This research has significant implications for the study of mechanisms underlying autonomous motivation, goal and norm internalization, decision-making, persuasion, education, and clinical conditions such as depression and burnout. (shrink)