According to a widespread view, a complete explanatory reduction of all aspects of the human mind to the electro-chemical functioning of the brain is at hand and will certainly produce vast and positive cultural, political and social consequences. However, notwithstanding the astonishing advances generated by the neurosciences in recent years for our understanding of the mechanisms and functions of the brain, the application of these findings to the specific but crucial issue of human agency can be considered a “pre-paradigmatic science” (...) (in Thomas Kuhn’s sense). This implies that the situation is, at the same time, intellectually stimulating and methodologically confused. More specifically—because of the lack of a solid, unitary and coherent methodological framework as to how to connect neurophysiology and agency—it frequently happens that tentative approaches, bold but very preliminary claims and even clearly flawed interpretations of experimental data are taken for granted. In this article some examples of such conceptual confusions and intellectual hubris will be presented, which derive from the most recent literature at the intersection between neurosciences, on the one hand, and philosophy, politics and social sciences, on the other hand. It will also be argued that, in some of these cases, hasty and over-ambitious conclusions may produce negative social and political consequences. The general upshot will be that very much has still to be clarified as to what and how neurosciences can tell us about human agency and that, in the meantime, intellectual and methodological caution is to be recommended. (shrink)

Organoids are three-dimensional biological structures grown in vitro from different kinds of stem cells that self-organise mimicking real organs with organ-specific cell types. Recently, researchers have managed to produce human organoids which have structural and functional properties very similar to those of different organs, such as the retina, the intestines, the kidneys, the pancreas, the liver and the inner ear. Organoids are considered a great resource for biomedical research, as they allow for a detailed study of the development and pathologies (...) of human cells; they also make it possible to test new molecules on human tissue. Furthermore, organoids have helped research take a step forward in the field of personalised medicine and transplants. However, some ethical issues have arisen concerning the origin of the cells that are used to produce organoids and their properties. In particular, there are new, relevant and so-far overlooked ethical questions concerning cerebral organoids. Scientists have created so-called mini-brains as developed as a few-months-old fetus, albeit smaller and with many structural and functional differences. However, cerebral organoids exhibit neural connections and electrical activity, raising the question whether they are or will one day be somewhat sentient. In principle, this can be measured with some techniques that are already available, which are used for brain-injured non-communicating patients. If brain organoids were to show a glimpse of sensibility, an ethical discussion on their use in clinical research and practice would be necessary. (shrink)

Free will is usually defined by three conditions: the ability to do otherwise; control of one’s own choices; responsiveness to reasons. The compatibility of free will with determinism lies at the heart of the philosophical debate at the metaphysical level. This debate, while being increasingly refined, has not yet reached a conclusion. Recently, neuroscience and empirical psychology have tried to settle the problem of free will with a series of experiments that go in the direction of so-called illusionism: free will (...) as the conscious control of our behavior cannot exist, being a mere illusion. But even in this case, the experimental results are challenged at various levels. Considering that in most moral and legal systems, the subject’s liability derives from their freedom, the usefulness of preserving the concept of freedom – which incidentally responds to a very strong commonsensical intuition – suggests the need for an operational solution. This could be done by resorting to the concepts of capacity and cognitive control, which are measured by a set of well-established neuropsychological tests. Our preliminary proposal is to create an index, the first step towards a specific quantification and measurement of free will, to be used especially in ethical and legal contexts. Theoretical premises, practical difficulties and objections to this approach are also discussed and addressed. (shrink)

Neuroscientific research on the removal of unpleasant and traumatic memories is still at a very early stage, but is making rapid progress and has stirred a significant philosophical and neuroethical debate. Even if memory is considered to be a fundamental element of personal identity, in the context of memory-erasing the autonomy of decision-making seems prevailing. However, there seem to be situations where the overall context in which people might choose to intervene on their memories would lead to view those actions (...) as counterproductive. In this article, I outline situations where the so-called composition effects can produce negative results for everyone involved, even if the individual decisions are not as such negative. In such situations medical treatments that usually everyone should be free to take, following the principle of autonomy, can make it so that the personal autonomy of the individuals in the group considered is damaged or even destroyed. In these specific cases, in which what is called the “conformity to context” prevails, the moral admissibility of procedures of memory-erasing is called into question and the principle of personal autonomy turns out to be subordinate to social interests benefitting every member of the group. (shrink)

Moral bioenhancement is the attempt to improve human behavioral dispositions, especially in relation to the great ethical challenges of our age. To this end, scientists have hypothesised new molecules or even permanent changes in the genetic makeup to achieve such moral bioenhancement. The philosophical debate has focused on the permissibility and desirability of that enhancement and the possibility of making it mandatory, given the positive result that would follow. However, there might be another way to enhance the overall moral behavior (...) of us humans, namely that of targeting people with lower propensity to trust and altruism. Based on the theory of attachment, people who have a pattern of insecure attachment are less inclined to prosocial behavior. We know that these people are influenced by negative childhood memories: this negative emotional component may be erased or reduced by the administration of propranolol when the bad memory is reactivated, thereby improving prosocial skills. It could be objected that memory-editing might be a threat for the person’s identity and authenticity. However, if the notion of rigid identity is replaced by that of extended identity, this objection loses validity. If identity is understood as something that changes over time, moral bioenhancement through memory-editing seems indeed legitimate and even desirable. (shrink)

BackgroundAlthough some of the most radical hypothesis related to the practical implementations of human enhancement have yet to become even close to reality, the use of cognitive enhancers is a very tangible phenomenon occurring with increasing popularity in university campuses as well as in other contexts. It is now well documented that the use of cognitive enhancers is not only increasingly common in Western countries, but also gradually accepted as a normal procedure by the media as well. In fact, its (...) implementation is not unusual in various professional contexts and it has its peak in colleges. Even when certain restrictions in the legislation of a country are indeed in place, they are without doubts easy to overcome. The legitimacy and appropriateness of such restrictions will not be the focus of our investigation.DiscussionOur concern is instead related to the moral and social reasons to publicly acknowledge the use of cognitive enhancers in competitive-selective contexts. These reasons are linked to a more neutral analysis of contemporary Western society: it is a fact that an increasing number of competitive-selective contexts have a substantial number of contenders using cognitive enhancers.SummaryThrough the use of five explicative examples, in this paper we want to analyse the problems related to its use. In particular, it will be our aim to show the tension between one of the main argument used by bio-liberals and the actual implementation of the drugs in competitive, or semi-competitive contexts. (shrink)

Ontological materialism, in its various forms, has become the orthodox view in contemporary philosophy of mind. This book provides a variety of defenses of mind-body dualism, and shows that a thoroughgoing ontological materialism cannot be sustained. The contributions are intended to show that, at the very least, ontological dualism constitutes a philosophically respectable alternative to the monistic views that currently dominate thought about the mind-body relation.

This paper focuses on the emergent neo-Jamesian perspective concerning the phenomenology of art and aesthetic experience. Starting from the distinction between nucleus and fringe in the stream of thought described by William James, it can be argued that our appreciation of a work of art is guided by a vague and blurred perception of a much more powerful content, of which we are not fully aware. Accordingly, a work of art is seen as a kind of metaphor of our mental (...) life, objectified to be able to reach out to a much larger audience. However, it is a “realistic” theory rooted in evolutionary psychology, which claims that our mind developed within a framework shaped by environmental pressures. The aesthetics illustrated by several novelists develops a paradigm for this theory. The search for the neuronal correlates of stream of consciousness allows to make a comparison with the recent findings of neuroaesthetics and to reject its claim that it is unnecessary to take phenomenology and psychology into account. (shrink)

This article aims to provide a brief overview of mental causation problem and its current proposed solutions. Indeed, mental causation turns out as one of the most difficult philosophical conundrums in contemporary philosophy of mind. In the first two sections, we offer an outline of the problem and the philosophical debate about it, and show that mental causation problem is pivotal within the contemporary philosophy of mind. In the third section, we focus on the most popular models of mental causation, (...) namely Kim's and Davidson's accounts, also discussing the objections raised against them. In the final section, we take into consideration some recent proposals poised to solve the mental causation problem, including powerism. Given the logical and metaphysical plausibility of almost all these different options, our conclusion is that mental causation is still an open problem and it is far from being resolved. (shrink)

In his interesting commentary, Joshua Shepherd raises two points—one related to epistemology, the other to ethics—about our article on human cerebral organoids.1 2 From the epistemological standpoint, he calls into question the need for a theory of consciousness. A theory of consciousness, for him, is not necessary because of the lack of consensus about the very nature of consciousness. Shepherd suggests that ‘given widespread disagreement, applying a theory of consciousness may not be helpful when attempting to diagnose the presence of (...) consciousness in cerebral organoids’. In Shepherd’s view, it would be better to transfer ‘concepts already under development in work on the presence and structure of consciousness in difficult marginal cases involving traumatic brain injury’.2 We could not agree more on this last point; detecting a minimal capacity for consciousness in the brain of comatose patients is a very similar challenge to inferring the presence of consciousness in cerebral organoids. Every day, as a by-product of saving many lives, intensive care medicine artificially produces thousands of brains that may remain isolated, split or fragmented; in the worst case, cortical islands, or an archipelago of islands, may survive while being disconnected from the outside world. Can these islands host some form of consciousness? That is, does it feel like anything to be a large piece of human cortex? Addressing this difficult question requires the development of general, objective brain-based indices of consciousness that are independent of sensory processing, executive functions and motor outputs.3 Consider, for example, a patient showing reflexive spontaneous behaviour, no response to command and no ability to communicate. In her brain, afferent pathways are damaged, thereby impairing the recruitment of cortical areas in response to sensory stimulation; basal ganglia, as well as other frontal structures supporting executive functions, are impaired. However, resting metabolism and significant electroencephalography …. (shrink)

: The long dispute between incompatibilists and compatibilists is further exemplified in the discussion between Sam Harris and Daniel Dennett. In this article I try to add to the discussion by outlining a concept of free will linked to five operating conditions and proposing its operationalization and quantification. The idea is to empirically and pragmatically define free will as we need it for moral blame and legal liability, while separating it from the debate on global determinism, local determinism, automatisms and (...) priming phenomena on a psychological level. This is made possible by weakening the claims of determinisms and psychological automatisms, based on the latest research, and by giving a well-outlined definition of free will as I want to defend it. Keywords: Compatibilism; Daniel Dennett; Free Will Quantification; Global Determinism; Local Determinism Un approccio pragmatico ed empirico al libero arbitrio Riassunto: La lunga disputa tra incompatibilisti e compatibilisti trova un’esemplificazione nel dibattito tra Sam Harris e Daniel Dennett. In questo articolo cerco di contribuire alla discussione delineando un concetto di libero arbitrio legato a cinque condizioni operative e proponendo la sua operazionalizzazione e quantificazione. L’idea è di definire empiricamente e pragmaticamente il libero arbitrio di cui abbiamo bisogno per trattare di colpa morale e di responsabilità legale, separandolo dal dibattito su determinismo globale, determinismo locale, automatismi e fenomeni di innesco a livello psicologico. Ciò è reso possibile indebolendo le pretese di determinismi e automatismi psicologici, che si basano su recenti ricerche empiriche, e dando una precisa definizione di libero arbitrio per come voglio difenderlo. Parole chiave: Compatibilismo; Daniel Dennett; Quantificazione del libero arbitrio; Determinismo globale; Determinismo locale. (shrink)

Embora a extensão da dependência entre teorias da estética e modelos da mente seja urna questão de aceso debate, é justo afirmar que as abordagens actuáis da consciência sugerem novas perspectivas sobre a natureza da experiência estética. As recentes descobertas da neurociência têm afetado a nossa forma de ver a estética e a arte. Todavia, enquanto é frequentemente sugerido que a neurociência vai, em breve, obter urna descrição completa da natureza da mente e, portanto, da experiência estética, aqui consideram-se as (...) consequências da recente bifurcação teórica a respeito da localizacão da mente (ou seja, as posições externalistas versus internalistas). A partir deste ponto de vista, as questões da unidade e do significado são usadas para investigar a natureza da experiência estética e da arte. A discussão baseia-se na distinção de William James entre núcleo e periferia, levando a uma perspectiva de convergência entre a psicologia, a fenomenologia e a neurociência. Por fim, a arte é explorada como urna janela para olhar para dentro de aspectos fundamentais da vida mental, quer por meio dos recentes resultados de imagens do cérebro, quer através dos modelos mais abrangentes da mente. While the extent of the dependence between theories of aesthetics and models of the mind is a matter of lively debate, it is fair to claim that current approaches to consciousness suggest new perspectives about the nature of aesthetic experience. Recent findings of neuroscience have affected how we see aesthetics and art. Nevertheless, while it is often suggested that neuroscience will soon offer a comprehensive account of the nature of mind and thus of aesthetic experience, here we consider the consequences on the recent theoretical bifurcation as to where mind is located (namely the externalist vs. the internalist stance). From such a view, the issues of unity and meaning are used to probe into the nature of aesthetic experience and art. The discussion draws upon William James' distinction between nucleus and fringe and puts forward a converging perspective between psychology, phenomenology and neuroscience. Eventually, art is exploited as a window to peer inside fundamental aspects of mental life by means both of recent brain imaging results and more extended models of the mind. (shrink)

What is the goal of creativity? Is it just a symbolic reshuffling or a moment of semantic extension? Similar to the contrast between syntax and semantics, creativity has an internal and an external aspect. Contrary to the widespread view that emphasises the problem-solving role of creativity, here we consider whether creativity represents an authentic moment of ontological discovery and semantic openness like Schopenhauer and Picasso suggested. To address the semantic aspect of creativity, we take advantage of recent externalist models of (...) the mind suggesting that the mind is more than symbol recombination. (shrink)

Gracias a los rápidos progresos de las neurociencias cognitivas, algunos investigadores, sobre todo de áreas anglosajonas, comienzan a utilizar criterios basados sobre la neurobiología para redimensionar o disolver el concepto de persona -fundamentalmente en ámbito bioético- en cuanto definido ilusorio.En particular, se sostiene que exista un network cerebral innato, que comprende cuatro áreas especificas del encéfalo, que produciría en modo automático la percepción de una categoría especial de cosas, definidas personas. Tal hipÓtesis se basa sobre una creciente cantidad de datos (...) experimentales, tomados de modo individual y corroborados en las pruebas acumuladas.Frente a la dificultad de definir con precisión a la "persona" en los casos bioéticamente más dificiles y controvertidos, se sugiere por tanto que la idea misma sea abandonada en cuanto fruto de un mecanismo evolutivo-adaptativo actualmente inadecuado fi-ente a los dilemas creados por la medicina contemporánea. Se realiza así una naturalización total del concepto para luego sugerir el regreso a una perspectiva utilitarista respecto a los casos bioéticos en los cuales falle un acuerdo común.Después de haber presentado en detalle la propuesta presentada por MJ Farah y A.S Heberlein, en el presente articulo se ofrecen algunos argumentos para rejÚtar el monismo metodológico en el cual tal propuesta se basa, en particular subrayando la dimensión histórica del concepto de persona, surgido gradualmente y no en modo homogéneo, en contraste con la perspectiva neurobiológica innatista. Se pone en evidencia, por tanto el necesario pluralismo epistemológico que acompaña la definición de persona. No es posible excfuir a priori la dimensión filosófica, que es siempre jitndamental, mientras los descubrimientos de las neurociencias se proponen como elementos empiricos complementarios, actualmente no prescindibles por su crecienle relevancia. (shrink)