Organoids are three-dimensional biological structures grown in vitro from different kinds of stem cells that self-organise mimicking real organs with organ-specific cell types. Recently, researchers have managed to produce human organoids which have structural and functional properties very similar to those of different organs, such as the retina, the intestines, the kidneys, the pancreas, the liver and the inner ear. Organoids are considered a great resource for biomedical research, as they allow for a detailed study of the development and pathologies (...) of human cells; they also make it possible to test new molecules on human tissue. Furthermore, organoids have helped research take a step forward in the field of personalised medicine and transplants. However, some ethical issues have arisen concerning the origin of the cells that are used to produce organoids and their properties. In particular, there are new, relevant and so-far overlooked ethical questions concerning cerebral organoids. Scientists have created so-called mini-brains as developed as a few-months-old fetus, albeit smaller and with many structural and functional differences. However, cerebral organoids exhibit neural connections and electrical activity, raising the question whether they are or will one day be somewhat sentient. In principle, this can be measured with some techniques that are already available, which are used for brain-injured non-communicating patients. If brain organoids were to show a glimpse of sensibility, an ethical discussion on their use in clinical research and practice would be necessary. (shrink)

Moral bioenhancement is the attempt to improve human behavioral dispositions, especially in relation to the great ethical challenges of our age. To this end, scientists have hypothesised new molecules or even permanent changes in the genetic makeup to achieve such moral bioenhancement. The philosophical debate has focused on the permissibility and desirability of that enhancement and the possibility of making it mandatory, given the positive result that would follow. However, there might be another way to enhance the overall moral behavior (...) of us humans, namely that of targeting people with lower propensity to trust and altruism. Based on the theory of attachment, people who have a pattern of insecure attachment are less inclined to prosocial behavior. We know that these people are influenced by negative childhood memories: this negative emotional component may be erased or reduced by the administration of propranolol when the bad memory is reactivated, thereby improving prosocial skills. It could be objected that memory-editing might be a threat for the person’s identity and authenticity. However, if the notion of rigid identity is replaced by that of extended identity, this objection loses validity. If identity is understood as something that changes over time, moral bioenhancement through memory-editing seems indeed legitimate and even desirable. (shrink)

According to a widespread view, a complete explanatory reduction of all aspects of the human mind to the electro-chemical functioning of the brain is at hand and will certainly produce vast and positive cultural, political and social consequences. However, notwithstanding the astonishing advances generated by the neurosciences in recent years for our understanding of the mechanisms and functions of the brain, the application of these findings to the specific but crucial issue of human agency can be considered a “pre-paradigmatic science” (...) (in Thomas Kuhn’s sense). This implies that the situation is, at the same time, intellectually stimulating and methodologically confused. More specifically—because of the lack of a solid, unitary and coherent methodological framework as to how to connect neurophysiology and agency—it frequently happens that tentative approaches, bold but very preliminary claims and even clearly flawed interpretations of experimental data are taken for granted. In this article some examples of such conceptual confusions and intellectual hubris will be presented, which derive from the most recent literature at the intersection between neurosciences, on the one hand, and philosophy, politics and social sciences, on the other hand. It will also be argued that, in some of these cases, hasty and over-ambitious conclusions may produce negative social and political consequences. The general upshot will be that very much has still to be clarified as to what and how neurosciences can tell us about human agency and that, in the meantime, intellectual and methodological caution is to be recommended. (shrink)

BackgroundAlthough some of the most radical hypothesis related to the practical implementations of human enhancement have yet to become even close to reality, the use of cognitive enhancers is a very tangible phenomenon occurring with increasing popularity in university campuses as well as in other contexts. It is now well documented that the use of cognitive enhancers is not only increasingly common in Western countries, but also gradually accepted as a normal procedure by the media as well. In fact, its (...) implementation is not unusual in various professional contexts and it has its peak in colleges. Even when certain restrictions in the legislation of a country are indeed in place, they are without doubts easy to overcome. The legitimacy and appropriateness of such restrictions will not be the focus of our investigation.DiscussionOur concern is instead related to the moral and social reasons to publicly acknowledge the use of cognitive enhancers in competitive-selective contexts. These reasons are linked to a more neutral analysis of contemporary Western society: it is a fact that an increasing number of competitive-selective contexts have a substantial number of contenders using cognitive enhancers.SummaryThrough the use of five explicative examples, in this paper we want to analyse the problems related to its use. In particular, it will be our aim to show the tension between one of the main argument used by bio-liberals and the actual implementation of the drugs in competitive, or semi-competitive contexts. (shrink)

In his interesting commentary, Joshua Shepherd raises two points—one related to epistemology, the other to ethics—about our article on human cerebral organoids.1 2 From the epistemological standpoint, he calls into question the need for a theory of consciousness. A theory of consciousness, for him, is not necessary because of the lack of consensus about the very nature of consciousness. Shepherd suggests that ‘given widespread disagreement, applying a theory of consciousness may not be helpful when attempting to diagnose the presence of (...) consciousness in cerebral organoids’. In Shepherd’s view, it would be better to transfer ‘concepts already under development in work on the presence and structure of consciousness in difficult marginal cases involving traumatic brain injury’.2 We could not agree more on this last point; detecting a minimal capacity for consciousness in the brain of comatose patients is a very similar challenge to inferring the presence of consciousness in cerebral organoids. Every day, as a by-product of saving many lives, intensive care medicine artificially produces thousands of brains that may remain isolated, split or fragmented; in the worst case, cortical islands, or an archipelago of islands, may survive while being disconnected from the outside world. Can these islands host some form of consciousness? That is, does it feel like anything to be a large piece of human cortex? Addressing this difficult question requires the development of general, objective brain-based indices of consciousness that are independent of sensory processing, executive functions and motor outputs.3 Consider, for example, a patient showing reflexive spontaneous behaviour, no response to command and no ability to communicate. In her brain, afferent pathways are damaged, thereby impairing the recruitment of cortical areas in response to sensory stimulation; basal ganglia, as well as other frontal structures supporting executive functions, are impaired. However, resting metabolism and significant electroencephalography …. (shrink)

In terms of ethical implications, Boers, van Delden and Bredenoord have made an interesting step forward with their model of organoids as hybrids, which seeks to find a balance between subject-like value and object-like value. Their framework aims to introduce effective procedures not to exploit donors and to increase their engagement, but it does not seem to take sufficient account of how organoids are used and how donors and society as a whole may want to act about such uses. I (...) will concentrate my remarks on three points that I consider relevant. The first comment concerns the so-called mini-brains. The second one is related to the issue of consent and long-term ‘control’ over the organic material granted by donors. The last comment focuses on ‘genetic minorities’. (shrink)

Ontological materialism, in its various forms, has become the orthodox view in contemporary philosophy of mind. This book provides a variety of defenses of mind-body dualism, and shows that a thoroughgoing ontological materialism cannot be sustained. The contributions are intended to show that, at the very least, ontological dualism constitutes a philosophically respectable alternative to the monistic views that currently dominate thought about the mind-body relation.

Neuroscientific research on the removal of unpleasant and traumatic memories is still at a very early stage, but is making rapid progress and has stirred a significant philosophical and neuroethical debate. Even if memory is considered to be a fundamental element of personal identity, in the context of memory-erasing the autonomy of decision-making seems prevailing. However, there seem to be situations where the overall context in which people might choose to intervene on their memories would lead to view those actions (...) as counterproductive. In this article, I outline situations where the so-called composition effects can produce negative results for everyone involved, even if the individual decisions are not as such negative. In such situations medical treatments that usually everyone should be free to take, following the principle of autonomy, can make it so that the personal autonomy of the individuals in the group considered is damaged or even destroyed. In these specific cases, in which what is called the “conformity to context” prevails, the moral admissibility of procedures of memory-erasing is called into question and the principle of personal autonomy turns out to be subordinate to social interests benefitting every member of the group. (shrink)

Free will is usually defined by three conditions: the ability to do otherwise; control of one’s own choices; responsiveness to reasons. The compatibility of free will with determinism lies at the heart of the philosophical debate at the metaphysical level. This debate, while being increasingly refined, has not yet reached a conclusion. Recently, neuroscience and empirical psychology have tried to settle the problem of free will with a series of experiments that go in the direction of so-called illusionism: free will (...) as the conscious control of our behavior cannot exist, being a mere illusion. But even in this case, the experimental results are challenged at various levels. Considering that in most moral and legal systems, the subject’s liability derives from their freedom, the usefulness of preserving the concept of freedom – which incidentally responds to a very strong commonsensical intuition – suggests the need for an operational solution. This could be done by resorting to the concepts of capacity and cognitive control, which are measured by a set of well-established neuropsychological tests. Our preliminary proposal is to create an index, the first step towards a specific quantification and measurement of free will, to be used especially in ethical and legal contexts. Theoretical premises, practical difficulties and objections to this approach are also discussed and addressed. (shrink)

This article aims to provide a brief overview of mental causation problem and its current proposed solutions. Indeed, mental causation turns out as one of the most difficult philosophical conundrums in contemporary philosophy of mind. In the first two sections, we offer an outline of the problem and the philosophical debate about it, and show that mental causation problem is pivotal within the contemporary philosophy of mind. In the third section, we focus on the most popular models of mental causation, (...) namely Kim's and Davidson's accounts, also discussing the objections raised against them. In the final section, we take into consideration some recent proposals poised to solve the mental causation problem, including powerism. Given the logical and metaphysical plausibility of almost all these different options, our conclusion is that mental causation is still an open problem and it is far from being resolved. (shrink)

: The long dispute between incompatibilists and compatibilists is further exemplified in the discussion between Sam Harris and Daniel Dennett. In this article I try to add to the discussion by outlining a concept of free will linked to five operating conditions and proposing its operationalization and quantification. The idea is to empirically and pragmatically define free will as we need it for moral blame and legal liability, while separating it from the debate on global determinism, local determinism, automatisms and (...) priming phenomena on a psychological level. This is made possible by weakening the claims of determinisms and psychological automatisms, based on the latest research, and by giving a well-outlined definition of free will as I want to defend it. Keywords: Compatibilism; Daniel Dennett; Free Will Quantification; Global Determinism; Local Determinism Un approccio pragmatico ed empirico al libero arbitrio Riassunto: La lunga disputa tra incompatibilisti e compatibilisti trova un’esemplificazione nel dibattito tra Sam Harris e Daniel Dennett. In questo articolo cerco di contribuire alla discussione delineando un concetto di libero arbitrio legato a cinque condizioni operative e proponendo la sua operazionalizzazione e quantificazione. L’idea è di definire empiricamente e pragmaticamente il libero arbitrio di cui abbiamo bisogno per trattare di colpa morale e di responsabilità legale, separandolo dal dibattito su determinismo globale, determinismo locale, automatismi e fenomeni di innesco a livello psicologico. Ciò è reso possibile indebolendo le pretese di determinismi e automatismi psicologici, che si basano su recenti ricerche empiriche, e dando una precisa definizione di libero arbitrio per come voglio difenderlo. Parole chiave: Compatibilismo; Daniel Dennett; Quantificazione del libero arbitrio; Determinismo globale; Determinismo locale. (shrink)

This paper focuses on the emergent neo-Jamesian perspective concerning the phenomenology of art and aesthetic experience. Starting from the distinction between nucleus and fringe in the stream of thought described by William James, it can be argued that our appreciation of a work of art is guided by a vague and blurred perception of a much more powerful content, of which we are not fully aware. Accordingly, a work of art is seen as a kind of metaphor of our mental (...) life, objectified to be able to reach out to a much larger audience. However, it is a “realistic” theory rooted in evolutionary psychology, which claims that our mind developed within a framework shaped by environmental pressures. The aesthetics illustrated by several novelists develops a paradigm for this theory. The search for the neuronal correlates of stream of consciousness allows to make a comparison with the recent findings of neuroaesthetics and to reject its claim that it is unnecessary to take phenomenology and psychology into account. (shrink)

Many governments have seen digital health technologies as promising tools to tackle the current COVID-19 pandemic. A much-talked example in this context involves the recent deluge of digital contact tracing apps aimed at detecting Covid-19 exposure. In this short contribution we look at the bio-political justification of this phenomenon and reflect on whether DCT apps constitute, as it is often argued, a serious potential breach of our right to privacy. Despite praising efforts attempting to develop legal and ethical frameworks for (...) DCT apps’ usage; we argue that such endeavours are not sufficient to tackle the more fundamental problem of mass surveillance, which will remain largely unaddressed unless we deal with the biopolitical arguments presented and resort to a technical and structural defence. (shrink)

According to the thesis of powerism, our world is pervaded by causal powers which are metaphysically basic. The aim of this paper is to defend the existence of the self, defined as a substantial entity, and its mental powers. This claim, which may seem a bold one, should not be deemed as inconsistent with scientific evidence. In fact, this approach does not ignore empirical knowledge, but is not bound only to it in order to understand entities, properties, and the relationship (...) between them. Aristotelian powerism may show that the self, as the subject of one’s mental acts, is a substance that has an essential nature. Firstly, we shall analyze the immediate evidence we have in support of the existence of the self as a substantial entity. We will show that the self is a substance because it possesses an essential character, i.e. an individual essence. We will take into account the Aristotelian perspective of substance, trying to show how the presence of a necessary property that makes every subject identical to itself and the phenomenal features of one’s private experience point to the existence of a substantial entity that corresponds to the self. Secondly, we will try to justify the adoption of a metaphysical theory of causation based on powers, analyzing it in comparison with the main competing theories, namely hypotheticalism and nomism. Then, we shall proceed to show the causal properties of the substance in question, namely the mental powers. In fact, thirdly, we will embrace the thesis of powerism by defending the existence of a set of mental powers that should be attributed to the self. We will describe the main features of mental powers and we will show that they are conceivable as the pure intentional acts we perform by directing an intentional state towards an intentional object. In this way we show how a classic problem of philosophy of mind, relevant to science as well, can be addressed in an original way by a metaphysical approach involving powers. (shrink)

What is the goal of creativity? Is it just a symbolic reshuffling or a moment of semantic extension? Similar to the contrast between syntax and semantics, creativity has an internal and an external aspect. Contrary to the widespread view that emphasises the problem-solving role of creativity, here we consider whether creativity represents an authentic moment of ontological discovery and semantic openness like Schopenhauer and Picasso suggested. To address the semantic aspect of creativity, we take advantage of recent externalist models of (...) the mind suggesting that the mind is more than symbol recombination. (shrink)

Many attempts have been made to explain the rise of religious phenomena based on evolutionary models, which attempt to account for the way in which religion can constitute a useful system to increase the fitness of both the individual and the group. These models implicitly mean that beliefs are simply effective adaptations to the environment and in this sense they cannot be truly accepted by those who adhere to the religions in question. In this paper, I use the evolution of (...) culture model elaborated by Cavalli Sforza to propose an approach that can explain the change of institutionalized religions over a more limited time frame than the long times of biological evolution. This model could be heuristically effective in the study of religious phenomena and could also be applicable in terms of theology and philosophy of religion. Given the limits of space, I will only try to take a few steps in this direction, trying to answer some of the major questions that arise about such an approach. In particular, one may ask whether, unlike others, the evolution of culture model applied to religions can make it possible to put into brackets - or to remain agnostic about - the value and the truth of the beliefs and precepts of the religion which is studied. (shrink)

Embora a extensão da dependência entre teorias da estética e modelos da mente seja urna questão de aceso debate, é justo afirmar que as abordagens actuáis da consciência sugerem novas perspectivas sobre a natureza da experiência estética. As recentes descobertas da neurociência têm afetado a nossa forma de ver a estética e a arte. Todavia, enquanto é frequentemente sugerido que a neurociência vai, em breve, obter urna descrição completa da natureza da mente e, portanto, da experiência estética, aqui consideram-se as (...) consequências da recente bifurcação teórica a respeito da localizacão da mente (ou seja, as posições externalistas versus internalistas). A partir deste ponto de vista, as questões da unidade e do significado são usadas para investigar a natureza da experiência estética e da arte. A discussão baseia-se na distinção de William James entre núcleo e periferia, levando a uma perspectiva de convergência entre a psicologia, a fenomenologia e a neurociência. Por fim, a arte é explorada como urna janela para olhar para dentro de aspectos fundamentais da vida mental, quer por meio dos recentes resultados de imagens do cérebro, quer através dos modelos mais abrangentes da mente. While the extent of the dependence between theories of aesthetics and models of the mind is a matter of lively debate, it is fair to claim that current approaches to consciousness suggest new perspectives about the nature of aesthetic experience. Recent findings of neuroscience have affected how we see aesthetics and art. Nevertheless, while it is often suggested that neuroscience will soon offer a comprehensive account of the nature of mind and thus of aesthetic experience, here we consider the consequences on the recent theoretical bifurcation as to where mind is located (namely the externalist vs. the internalist stance). From such a view, the issues of unity and meaning are used to probe into the nature of aesthetic experience and art. The discussion draws upon William James' distinction between nucleus and fringe and puts forward a converging perspective between psychology, phenomenology and neuroscience. Eventually, art is exploited as a window to peer inside fundamental aspects of mental life by means both of recent brain imaging results and more extended models of the mind. (shrink)

:The microbiome is proving to be increasingly important for human brain functioning. A series of recent studies have shown that the microbiome influences the central nervous system in various ways, and consequently acts on the psychological well-being of the individual by mediating, among others, the reactions of stress and anxiety. From a specifically neuroethical point of view, according to some scholars, the particular composition of the microbiome—qua microbial community—can have consequences on the traditional idea of human individuality. Another neuroethical aspect (...) concerns the reception of this new knowledge in relation to clinical applications. In fact, attention to the balance of the microbiome—which includes eating behavior, the use of psychobiotics and, in the treatment of certain diseases, the use of fecal microbiota transplantation—may be limited or even prevented by a biased negative attitude. This attitude derives from a prejudice related to everything that has to do with the organic processing of food and, in general, with the human stomach and intestine: the latter have traditionally been regarded as low, dirty, contaminated and opposed to what belongs to the mind and the brain. This biased attitude can lead one to fail to adequately consider the new anthropological conceptions related to the microbiome, resulting in a state of health, both physical and psychological, inferior to what one might have by paying the right attention to the knowledge available today. Shifting from the ubiquitous high-low metaphor to an inside-outside metaphor can thus be a neuroethical strategy to achieve a new and unbiased reception of the discoveries related to the microbiome. (shrink)

In this paper, I use the comparison between human beings and intelligent machines to shed light on the concept of teleology. What characterizes human beings and distinguishes them from a robot capable of achieving complex objectives? In the first place, by stipulating that what characterizes human beings are mental states, I consider the mark of the mental. A smart robot probably has no consciousness but we might have reason for doubt while interacting with it. And a smart robot shows intentionality. (...) I focus on the type of naturalized intentionality that is at stake here. Then I go back to the traditional idea of teleology, and to the scientific criticism of it, through the question of the kind of purposes that artificial intelligence may set itself. Husserl's basic idea of teleology therefore serves to have an authoritative term of comparison and to introduce the intuitive difference between human beings and intelligent machines based on the homo pictor thought experiment proposed by Jonas. My conclusion is that a specific finalism, understood in a non-criterial sense, is what qualifies the human being and differentiates the latter from smart robots. (shrink)

Human cerebral organoids are three-dimensional in vitro cell cultures that mimic the developmental process and organization of the developing human brain. In just a few years this technique has produced brain models that are already being used to study diseases of the nervous system and to test treatments and drugs. Currently, HCOs consist of tens of millions of cells and have a size of a few millimeters. The greatest limitation to further development is due to their lack of vascularization. However, (...) recent research has shown that human cerebral organoids can manifest the same electrical activity and connections between brain neurons and EEG patterns as those recorded in preterm babies. All this suggests that, in the future, HCOs may manifest an ability to experience basic sensations such as pain, therefore manifesting sentience, or even rudimentary forms of consciousness. This calls for consideration of whether cerebral organoids should be given a moral status and what limitations should be introduced to regulate research. In this article I focus particularly on the study of the emergence and mechanisms of human consciousness, i.e. one of the most complex scientific problems there are, by means of experiments on HCOs. This type of experiment raises relevant ethical issues and, as I will argue, should probably not be considered morally acceptable. (shrink)

It is often contended that certain enhancement technologies are acceptable, because they simply update traditional ways of pursuing the improvement of human capacities. This is not true with reference to moral bioenhancement, because of the radical difference between traditional and biotechnological ways of producing moral progress. These latter risk having serious negative effects on our moral agency, by causing a substantial loss of freedom and capacity of authentic moral behaviour, by affecting our moral identity and by imposing a standard conception (...) of moral personality. (shrink)

Nel presente testo si propone un approccio alla neuroetica che si prefigge di attribuirle uno specifico ambito d’indagine in quanto esplorazione di ciò che apprendiamo su noi stessi e sul nostro “funzionamento”, grazie principalmente alle neuroscienze. In altre parole, si tratta di un nuovo genere di antropologia che si occupa dell’intersezione di diverse discipline la quale acquista sempre maggiore centralità nel dibattito contemporaneo a motivo della forte naturalizzazione delle indagini sugli esseri umani. L’oggetto di studio – alla luce di questa (...) particolare caratterizzazione della neuroetica – non sarà quindi ciò che possiamo fare, bensì ciò che sappiamo o riteniamo di sapere in modo affidabile. (shrink)

Gracias a los rápidos progresos de las neurociencias cognitivas, algunos investigadores, sobre todo de áreas anglosajonas, comienzan a utilizar criterios basados sobre la neurobiología para redimensionar o disolver el concepto de persona -fundamentalmente en ámbito bioético- en cuanto definido ilusorio.En particular, se sostiene que exista un network cerebral innato, que comprende cuatro áreas especificas del encéfalo, que produciría en modo automático la percepción de una categoría especial de cosas, definidas personas. Tal hipÓtesis se basa sobre una creciente cantidad de datos (...) experimentales, tomados de modo individual y corroborados en las pruebas acumuladas.Frente a la dificultad de definir con precisión a la "persona" en los casos bioéticamente más dificiles y controvertidos, se sugiere por tanto que la idea misma sea abandonada en cuanto fruto de un mecanismo evolutivo-adaptativo actualmente inadecuado fi-ente a los dilemas creados por la medicina contemporánea. Se realiza así una naturalización total del concepto para luego sugerir el regreso a una perspectiva utilitarista respecto a los casos bioéticos en los cuales falle un acuerdo común.Después de haber presentado en detalle la propuesta presentada por MJ Farah y A.S Heberlein, en el presente articulo se ofrecen algunos argumentos para rejÚtar el monismo metodológico en el cual tal propuesta se basa, en particular subrayando la dimensión histórica del concepto de persona, surgido gradualmente y no en modo homogéneo, en contraste con la perspectiva neurobiológica innatista. Se pone en evidencia, por tanto el necesario pluralismo epistemológico que acompaña la definición de persona. No es posible excfuir a priori la dimensión filosófica, que es siempre jitndamental, mientras los descubrimientos de las neurociencias se proponen como elementos empiricos complementarios, actualmente no prescindibles por su crecienle relevancia. (shrink)

Can transfusions of blood plasma slow down ageing or even rejuvenate people? Recent preclinical studies and experimental tests inspired by the technique known as parabiosis have aroused great media attention, although for now there is no clear evidence of their effectiveness. This line of research and the interest it is triggering testify to the prominent role played by the idea of combating the “natural” ageing process in the scientific and social agenda. While seeking to increase the duration of healthy living (...) time may be considered a duty, it also raises ethical questions about how to pursue this goal. Specifically, therapies and techniques accessible only to a fraction of the population seem destined to exponentially increase social inequality and to produce undesirable consequences. In this article we address the issue precisely in the light of the prospected use of plasma for the rejuvenation of a small elite of people. (shrink)