Entry into mitosis is driven by the activity of kinases, which phosphorylate over 7000 proteins on multiple sites. For cells to exit mitosis and segregate their genome correctly, these phosphorylations must be removed in a specific temporal order. This raises a critical and important question: how are specific phosphorylation sites on an individual protein removed? Traditionally, the temporal order of dephosphorylation was attributed to decreasing kinase activity. However, recent evidence in human cells has identified unique patterns of dephosphorylation during mammalian (...) mitotic exit that cannot be fully explained by the loss of kinase activity. This suggests that specificity is determined in part by phosphatases. In this review, we explore how the physicochemical properties of an individual phosphosite and its surrounding amino acids can affect interactions with a phosphatase. These positive and negative interactions in turn help determine the specific pattern of dephosphorylation required for correct mitotic exit. (shrink)

Recent animal research suggests that it may soon be possible to support the human fetus in an artificial uterine environment for part of a pregnancy. A technique of extending gestation in this way (“ectogestation”) could be offered to parents of extremely premature infants (EPIs) to improve outcomes for their child. The use of artificial uteruses for ectogestation could generate ethical questions because of the technology’s potential impact on the point of “viability”—loosely defined as the stage of pregnancy beyond which the (...) fetus may survive external to the womb. Several medical decisions during the perinatal period are based on the gestation at which infants are considered viable, for example decisions about newborn resuscitation and abortion, and ectogestation has the potential to impact on these. Despite these possible implications, there is little existing evidence or analysis of how this technology would affect medical practice. In this paper, we combine empirical data with ethical analysis. We report a survey of 91 practicing Australian obstetricians and neonatologists; we aimed to assess their conceptual understanding of “viability,” and what ethical consequences they envisage arising from improved survival of EPIs. We also assess what the ethical implications of extending gestation should be for newborn and obstetric care. We analyze the concept of viability and argue that while ectogestation might have implications for the permissibility of neonatal life‐prolonging treatment at extremely early gestation, it should not necessarily have implications for abortion policy. We compare our ethical findings with the results of the survey. (shrink)

What does it mean to say that a scientific theory is unified? Prominent attempts by John Watkins, Philip Kitcher, and Margaret Morrison to answer this question face serious difficulties, and many analysts of science remain pessimistic about the possibility of ever rendering precise or explaining what theoretical unity consists in. This paper gives grounds for optimism, offering a novel account of the concept of unification. This account is tested against a detailed study of the standard model in contemporary high-energy (...) physics, a theory for which a high degree of unity has repeatedly been claimed. (shrink)

Eric Watkins and Marcus Willaschek provide a valuable service to people working on Kant’s epistemology and philosophy of mind by laying out a synoptic picture of Kant’s view of theoretical cognition. Their picture incorporates admirably clear accounts of the familiar building blocks of cognition—sensation, intuition, concept, and judgment—as well as some innovative interpretive theses of their own. Watkins and Willaschek’s basic claim is that, for Kant, theoretical cognition is “a mental state [or “representation”] that determines a given object (...) by attributing general features to it”. So Watkins and Willaschek view Kantian cognition fundamentally as a mental state of... (shrink)

This critical notice highlights the important contributions that Eric Watkins's writings have made to our understanding of theories about causation developed in eighteenth-century German philosophy and by Kant in particular. Watkins provides a convincing argument that central to Kant's theory of causation is the notion of a real ground or causal power that is non-Humean (since it doesn't reduce to regularities or counterfactual dependencies among events or states) and non-Leibnizean because it doesn't reduce to logical or conceptual relations. (...) However, we raise questions about Watkins's more specific claims that Kant completely rejects a model on which the first relatum of a phenomenal causal relation is an event and that he maintains that real grounds are metaphysically and not just epistemically indeterminate. -/- . (shrink)

Philosophers of science have long been concerned with these questions. In the 1980s, influential work by Clark Glymour, Michael Friedman, John Watkins, and Philip Kitcher articulated general accounts of theory unification that attempted to underwrite a connection between unification, truth, and understanding. According to the ‘unifiers,’ as we may call them, a theory is unified to the extent that it has a small theoretical structure relative to the domain of phenomena it covers, and there are general syntactic criteria that (...) allow one to determine how unified a theory is. The explanatory power of a theory, and the understanding of nature it gives us, is a direct consequence of this unity. As well, the more unified a theory is, the better confirmed it will be, and under some conditions a theory’s unity can justify realism about unobservable entities posited by it. In the 1990s disunity became the dominant theme, with books such as John Dupré’s The Disorder of Things and the Galison and Stump anthology arguing that it is a mistake to view science as a unified practice and that rather than an epistemic virtue, unification in science is a metaphysical vice. (shrink)

In the 3rd Analogy, Kant claims that I can perceive that things coexist by synthesizing my perceptions in an order-indifferent way. Reigning orthodoxy holds that I first successively perceive different things, and then (through some further act) determine that the things I perceive coexist. Focusing on prominent examples of this approach, I argue that these accounts fail to do justice to the order-indifferent synthesis that Kant describes: Strawson explains the synthesis in a way which renders Kant’s argument in the 3rd (...) Analogy obviously unconvincing, Watkins makes the synthesis irrelevant to Kant’s argument, while Longuenesse and Allison make the unity of the synthesis obscure. The problems with these views, I contend, show that Kant thinks the rule for synthesizing my perceptions is already operative in the successive perceptions, such that the fundamental act of perception already involves ‘objective time-determinations.’ This connects with the recent dispute about whether Kant is a conceptualist: my argument provides additional evidence that Kant is a conceptualist, while also extending the conceptualist reading to the 3rd Analogy in a novel way. For those who think conceptualism is wrong, my argument serves as a critical notice that non-conceptualists have yet to offer a satisfying interpretation of the 3rd Analogy. (shrink)

This book contains important technical innovations, including comparative measures for the testable content, depth, and unity of scientific theories. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich (...) scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

Difficult Atheism shows how contemporary French philosophy is rethinking the legacy of the death of God in ways that take the debate beyond the narrow confines of atheism into the much broader domain of post-theological thinking. Christopher Watkin argues that Alain Badiou, Jean-Luc Nancy and Quentin Meillassoux each elaborate a distinctive approach to the post-theological, but that each approach still struggles to do justice to the death of God.

Arguments from perceptual variation challenge the view that colors are objective properties of objects, properties that objects have independent of how they are perceived. This paper attempts, first, to diagnose one central reason why arguments from perceptual variation seem especially challenging for objectivists about color. Second, we offer a response to this challenge, claiming that once we focus on determinate colors rather than the determinables they determine, a response to arguments from perceptual variation becomes apparent. Third, our nominal opponents are (...) relationalist (like Cohen in The red and the real: an essay on color ontology, Oxford University Press, Oxford, 2009) and we will argue that the main argument for rejecting objectivism commits the relationalist to a position that is more radical than the one he would wish to endorse. Fourth, we suggest that insight into which properties could be relational may be found by looking to our best scientific theories. (shrink)

What does 'autonomy' mean today? Is the Enlightenment understanding of autonomy still relevant for contemporary challenges? How have the limits and possibilities of autonomy been transformed by recent developments in artificial intelligence and big data, political pressures, intersecting oppressions and the climate emergency? The challenges to autonomy today reach across society with unprecedented complexity, and in this book leading scholars from philosophy, economics, linguistics, literature and politics examine the role of autonomy in key areas of contemporary life, forcefully defending a (...) range of different views about the nature and extent of resistance to autonomy today. These essays are essential reading for anyone who wants to understand the predicament and prospects of one of modernity's foundational concepts and one of our most widely cherished values. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Testimony of Sense: Empiricism and the Essay from Hume to Hazlitt by Tim MilnesMargaret WatkinsTim Milnes. The Testimony of Sense: Empiricism and the Essay from Hume to Hazlitt. Oxford: Oxford University Press, 2019. Pp. viii + 278. Hardback. ISBN: 9780198812739. $91.00.In his brief autobiography, “My Own Life,” Hume reports that “almost all [his] life has been spent in literary pursuits and occupations” (E-MOL: xxxi). This is one (...) of at least ten places in this brief work in which he associates himself with “letters” or “literature”—as compared to at most four associations with philosophy. The moral to be inferred is not that Hume considered himself not to be a philosopher. Rather, he conceived of philosophy as a kind of literature. The Treatise was itself a “literary attempt.” Indeed, opposition between the “literary” and “philosophical” aspects of a text would have been foreign to Hume and his contemporaries—a notion for a later age, despite his occasional loose distinction between the relevant genres, as in his list of writings “historical, philosophical, or literary” in “My Own Life” (E-MOL: xxxvi).Yet despite Hume’s own understanding of the continuity between philosophy and literature, broadly conceived, it is still common for contemporary philosophers to ignore literary questions in their examination of Hume’s work, or to presume that one can easily distinguish the “philosophical” parts from the “literary” ones. Tim Milnes’s The Testimony of Sense is therefore a welcome addition to the Hume literature (pun intended). With a particular focus on the essay—a genre of great importance to Hume—Milnes contributes to the small set of engagements with Hume from the disciplinary perspective of English literature. With training in both philosophy and literature, as well as established expertise on Romanticism and its own essays, Milnes is well-qualified for the task. The Testimony of Sense includes sustained engagement with Hume’s contemporaries and successors, but for the purposes of this review, I engage the book primarily as a Hume scholar for Hume scholars.Milnes’s story plays out in three acts. The first establishes the need for public trust created by a skeptical crisis, itself a product of Hume’s criticism of the epistemic program of thinkers in the Cartesian and Lockean traditions. The second explains how the essays of the long eighteenth century constitute a response to that need in various ways. The third reveals in detail how the Romantic essayists, particularly William Hazlitt and Charles Lamb, both respond to and deviate from the “neoclassical” essayists, typified by Hume and Samuel Johnson.The first chapter, “Self and Intersubjectivity,” lays the groundwork by articulating how Hume, Adam Smith, Thomas Reid, and Dugald Stewart identify the need for what we now call intersubjectivity. Milnes describes the common thread as a kind of “natural transcendentalism.” In what sense are these thinkers properly understood as [End Page 175] transcendentalists? The central idea seems to be that all posit things other than reason as “conditions of meaningful thought” (72). For Hume, it is the social, linguistic experience of a community of virtuous judges. The intricate relations between self and other essential to such a community get “internalized within the specular drama of the impartial spectator” (72) in Smith’s writing, which itself takes part in the drama through his “halting, qualified syntax” that mimics “everyday speech” (44). Reid posits a “prescience” of trust, which grounds our reliance on both human testimony and the uniformity of nature, itself undergirded by the design of a benevolent God. Stewart, who posits axiomatic truths that help constitute the “stamina of intellect,” goes furthest, actually calling these truths transcendental (55). This chapter also puts these eighteenth-century thinkers in conversation with twentieth-century theorists, including Habermas, Davidson, and Rorty.Chapter 2, “The Subject of Trust,” deepens the analysis by situating these “natural transcendentalisms” in the broader enlightenment context. In contrast to Descartes, Bacon, and Locke, who were suspicious of our reliance on the opinions of others, the eighteenth-century thinkers understand trust as prior to reason in various ways—though not prior to solidarity. The particulars in each case depend on their responses to skepticism and their accounts of the relation between... (shrink)

This paper examines the idea of objective phenomenology, or a way of understanding the phenomenal character of conscious experiences that doesn’t require one to have had the kinds of experiences under consideration. My central thesis is that structural facts about experience—facts that characterize purely how conscious experiences are structured—are objective phenomenal facts. I begin by precisifying the idea of objective phenomenology and diagnosing what makes any given phenomenal fact subjective. Then I defend the view that structural facts about experience are (...) objective. I also argue that structural facts about experience, despite being objective, nevertheless still give rise to an explanatory gap. (shrink)

Does it make sense to refer to bird song - a complex vocalization, full of repetitive and transformative patterns that are carefully calculated to woo a mate - as art? What about a pack of wolves howling in unison or the cacophony made by an entire rain forest? Redefining music as "the art of possibly animate things," Musical Vitalities charts a new path for music studies that blends musicological methods with perspectives drawn from the life sciences. In opposition to humanist (...) approaches that insist on a separation between culture and nature--approaches that appear increasingly untenable in an era defined by human-generated climate change--Musical Vitalities treats music as one example of the cultural practices and biotic arts of the animal kingdom rather than as a phenomenon categorically distinct from nonhuman forms of sonic expression. The book challenges the human exceptionalism that has allowed musicologists to overlook music's structural resemblances to the songs of nonhuman species, the intricacies of music's physiological impact on listeners, and the many analogues between music's formal processes and those of the dynamic natural world. Through close readings of Austro-German music and aesthetic writings that suggest wide-ranging analogies between music and nature, Musical Vitalities seeks to both rekindle the critical potential of nineteenth-century music and rejoin the humans at the center of the humanities with the nonhumans whose evolutionary endowments and planetary fates they share. (shrink)

Anaximander, the sixth-century BCE philosopher of Miletus, is often credited as being the instigator of both science and philosophy. The first recorded philosopher to posit the idea of the boundless cosmos, he was also the first to attempt to explain the origins of the world and humankind in rational terms. Anaximander's philosophy encompasses theories of justice, cosmogony, geometry, cosmology, zoology and meteorology. Anaximander: A Re-assessment draws together these wide-ranging threads into a single, coherent picture of the man, his worldview and (...) his legacy to the history of thought. Arguing that Anaximander's statements are both apodeictic and based on observation of the world around him, Andrew Gregory examines how Anaximander's theories can all be construed in such a way that they are consistent with and supportive of each other. This includes the tenet that the philosophical elements of Anaximander's thought (his account of the apeiron, the extant fragment) can be harmonised to support his views on the natural world. The work further explores how these theories relate to early Greek thought and in particular conceptions of theogony and meterology in Hesiod and Homer. (shrink)

Perception is riddled with cases of reliable misperception. These are cases in which a perceptual state is tokened inaccurately any time it is tokened under normal conditions. On the face of it, this fact causes trouble for theories that provide an analysis of perceptual content in non-semantic, non-intentional, and non-phenomenal terms, such as those found in Millikan (1984), Fodor (1990), Neander (2017), and Schellenberg (2018). I show how such theories can be extended so that they cover such cases without giving (...) up their core commitments. (shrink)

Some accounts of moral responsibility hold that an agent's responsibility is completely determined by some aspect of the agent's mental life at the time of action. For example, some hold that an agent is responsible if and only if there is an appropriate mesh among the agent's particular psychological elements. It is often objected that the particular features of the agent's mental life to which these theorists appeal (such as a particular structure or mesh) are not necessary for responsibility. This (...) is because there appear to be cases in which an agent acts at an earlier time which causes her to lack the appropriate psychological features at some later time and yet, intuitively, she is responsible at that later .. (shrink)

We are all familiar with the phenomenon of a proposition seeming true. Many think that these seeming states can yield justified beliefs. Very few have seriously explored what these seeming states are. I argue that seeming states are not plausibly analyzed in terms of beliefs, partial beliefs, attractions to believe, or inclinations to believe. Given that the main candidates for analyzing seeming states are unsatisfactory, I argue for a brute view of seemings that treats seeming states as irreducible propositional attitudes.

This is a discussion of the state of discussion on pragmatic reasons for belief.

This book brings together an international group of scholars to discuss the ramifications of Heidegger's Black Notebooks for philosophy and the humanities. In contrast to both those who seek to exonerate Heidegger and those who simply condemn him, they urge careful reading and rereading of his work to turn Heideggerian thought against itself.

The first critical work to attempt the mammoth undertaking of reading Badiou's Being and Event as part of a sequence has often surprising, occasionally controversial results. Looking back on its publication Badiou declared: “I had inscribed my name in the history of philosophy”. Later he was brave enough to admit that this inscription needed correction. The central elements of Badiou's philosophy only make sense when Being and Event is read through the corrective prism of its sequel, Logics of Worlds, published (...) nearly twenty years later. At the same time as presenting the only complete overview of Badiou's philosophical project, this book is also the first to draw out the central component of Badiou's ontology: indifference. Concentrating on its use across the core elements Being and Event-the void, the multiple, the set and the event-Watkin demonstrates that no account of Badiou's ontology is complete unless it accepts that Badiou's philosophy is primarily a presentation of indifferent being. Badiou and Indifferent Being provides a detailed and lively section by section reading of Badiou's foundational work. It is a seminal source text for all Badiou readers. (shrink)

For Kant, knowledge involves certainty. If “certainty” requires that the grounds for a given propositional attitude guarantee its truth, then this is an infallibilist view of epistemic justification. Such a view says you can’t have epistemic justification for an attitude unless the attitude is also true. Here I want to defend an alternative fallibilist interpretation. Even if a subject has grounds that would be sufficient for knowledge if the proposition were true, the proposition might not be true. And so there (...) is sometimes still rational room for doubt. The goal of this paper is to present four different models of what “certainty” amounts to, for Kant, each of which is compatible with fallibilism. (shrink)

In his 1978 paper “Mathematical Explanation”, Mark Steiner attempts to modernize the Aristotelian idea that to explain a mathematical statement is to deduce it from the essence of entities figuring in the statement, by replacing talk of essences with talk of “characterizing properties”. The language Steiner uses is reminiscent of language used for proofs deemed “pure”, such as Selberg and Erdős’ elementary proofs of the prime number theorem avoiding the complex analysis of earlier proofs. Hilbert characterized pure proofs as those (...) that use only “means that are suggested by the content of the theorem”, a characterization we have elsewhere called “topical purity”. In this paper we will examine the connection between Steiner’s account of mathematical explanation and topical purity. Are Steiner-explanatory proofs necessarily topically pure? Are topically pure proofs necessarily Steiner-explanatory? Answers to these questions will shed light on the general question of the relation between purity and explanatory power. (shrink)

While many aspects of cognition have been shown to be shared between humans and non-human animals, there remains controversy regarding whether the capacity to mentally time travel is a uniquely human one. In this paper, we argue that there are four ways of representing when some event happened: four kinds of temporal representation. Distinguishing these four kinds of temporal representation has five benefits. First, it puts us in a position to determine the particular benefits these distinct temporal representations afford an (...) organism. Second, it provides the conceptual resources to foster a discussion about which of these representations is necessary for an organism to count as having the capacity to mentally time travel. Third, it enables us to distinguish stricter from more liberal views of mental time travel that differ regarding which kind(s) of temporal representation is taken to be necessary for mental time travel. Fourth, it allows us to determine the benefits of taking a stricter or more liberal view of mental time travel. Finally, it ensures that disagreement about whether some species can mentally time travel is not merely the product of unrecognised disagreement about which temporal representation is necessary for mental time travel. We argue for a more liberal view, on the grounds that it allows us to view mental time travel as an evolutionarily continuous phenomenon, and to recognise that differences in the ways that organisms mentally time travel might reflect different temporal representations, or combinations thereof, that they employ. Our ultimate aim, however, is to create the conceptual framework for further discussion regarding what sorts of temporal representations are required for mental time travel. (shrink)

This three-part chapter explores a higher-order logic we call ‘Classicism’, which extends a minimal classical higher-order logic with further axioms which guarantee that provable coextensiveness is sufficient for identity. The first part presents several different ways of axiomatizing this theory and makes the case for its naturalness. The second part discusses two kinds of extensions of Classicism: some which take the view in the direction of coarseness of grain (whose endpoint is the maximally coarse-grained view that coextensiveness is sufficient for (...) identity), and some which take the view in the direction of fineness of grain (whose endpoint is the maximally fine-grained theory containing all distinctness claims compatible with Classicism). The third part introduces some techniques for constructing models of Classicism, and uses them to prove the consistency of many of the extensions of Classicism introduced in the second part. (shrink)

The aim of the Analytic of Concepts is to derive and deduce a set of pure concepts of the understanding, the categories, which play a central role in Kant’s explanation of the possibility of synthetic a priori cognition and judgment. This chapter is structured around two questions. First, what is a pure concept of the understanding? Second, what is involved in a deduction of a pure concept of the understanding? In answering the first, we focus on how the categories differ (...) from the pure forms of sensibility and examine whether they are known only to be the pure forms of human thinking or rather the forms of discursive cognition as such. In answering the second, we draw a distinction between the application and the exemplification of the categories and use it to identify different ways of understanding Kant’s project in the Transcendental Deduction of the Categories. These questions connect because the answer to the first determines how we should understand the kind of entitlement which is to be established in the Deduction. (shrink)

Public reason in practice and theory -- False starts: unsuccessful justifications of public reason -- Respect for persons as a constraint on coercion -- Higher-order unanimity escape clause -- Civic friendship as a constraint on reasons for decision -- Public reason and (same-sex) marriage.

The fallacy fallacy is either the misdiagnosis of fallacy or the supposition that the conclusion of a fallacy must be a falsehood. This paper explores the relevance of these and related errors of reasoning for the appraisal of arguments, especially within virtue theories of argumentation. In particular, the fallacy fallacy exemplifies the Owl of Minerva problem, whereby tools devised to understand a norm make possible new ways of violating the norm. Fallacies are such tools and so are vices. Hence a (...) similar problem arises with argumentative vices. Fortunately, both instances of the problem have a common remedy. (shrink)

Some have it that wholes are, somehow, identical to their parts. This doctrine is as alluring as it is puzzling. But in this paper, I show that the doctrine is inconsistent with two widely accepted theses. Something has to go.

In this highly accessible book eight distinguished experts from a wide range of disciplines consider the nature and use of evidence in the modern world.

This paper argues that pragmatists must be more cognizant of the concept of "power" and its consequences. To demonstrate this, I show how Foucault's analytics of power can be brought into Peirce's theory of signs. Central to both philosophers is the role of action. Using the concept of action, I explain that Foucault's conception of power, action on actions, can be understood as structuring Peircian habits, which are rules for action. From here I build out to Peirce's semiotics, illustrating how (...) power channels the meanings of signs in certain directions. The rest of the paper is dedicated to reconstructing in light of Foucault Peirce's claim that the subject is nothing more than the signs it uses. I argue that any understanding of the subject must account for the subject being distributed through a field of power. The paper concludes by proposing a new "philosophy of the subject" which seeks to reconcile Foucault's concerns with those of pragmatism. (shrink)

It is widely acknowledged that interdisciplinarity (ID) is very diverse. Our contribution is a demonstration that considerable diversity exists also on the level of understandings of ID that researchers working in the same ID field express. Specifically, we analyse qualitatively, building on the method of culture contrast, six interviews with researchers working in computational linguistics and language technology in Estonia. We identify six understandings of ID expressed by the interviewees: centred on an ID method; a disciplinary method in an ID (...) field; an ID way of seeing and thinking; ID education; ID interests; one’s field as naturally ID. We show how understandings of ID are significant for analysing research practice, since they are involved in how researchers form a positive picture of themselves and their colleagues. We also show how an awareness of different understandings of ID is useful for discussing the significance of integration in ID. (shrink)