The construct of moral intensity, proposed by Jones (1991), was used to predict the extent to which individuals were able to recognize moral issues. We tested for the effects of the six dimensions of moral intensity: social consensus, proximity, concentration of effect, probability of effect, temporal immediacy and magnitude of consequences. A scenario-based study, conducted among business individuals in Singapore, revealed that social consensus and magnitude of consequences influenced the recognition of moral issues. The study provided evidence for the effects (...) of temporal immediacy. There was marginal support for the impact of proximity and probability of effect but no evidence that concentration of effect influenced recognition of moral issues. The paper concludes with a discussion of the implications of these results for researchers and organisational practitioners. (shrink)

While regarding twentieth century French philosophy as a protracted conceptual war, Badiou has largely avoided an encounter with Foucault on the philosophical battlefield. According to Badiou, Foucault constructs a history of systems of thought starting from something other than philosophy (linguistic anthropology, postmodern sophism, democratic materialism) and, in so doing, exits the philosophical battleground. The present essay explores the prospect of rapprochement between these two thinkers, drawing attention to their shared concern with the theme of true life. For Foucault and (...) Badiou, the life in truth and for truth compels the subject to invent a new way of being at the site of exception to what there is. Although Badiou remains ambivalent about the Foucauldian notion of the philosophical subject, he ultimately endorses Foucault’s conception of the philosophical life, which calls for courage insofar as it summons the human animal to think differently and become other than what one is. (shrink)

Multidrug resistance (MDR) is developed in a population of somatic mammalian cells in vivo or in vitro when they are selected for resistance to each of a large group of drugs (colchicine, adriamycin, actinomycin D, etc.). It is produced by the amplification of some unknown gene(s) whose product(s) evidently change(s) the plasma membrane permeability of a cell to a selective agent and to other unrelated compounds. A large specific genomic region (150–250 kbp) undergoes amplification in MDR cells selected for the (...) resistance to different drugs. Amplified DNA is located in homogeneously staining regions of chromosomes, double minute chromosomes and small chromatin bodies – episome‐like structures that replicate out of the S‐phase of a cell cycle. The selection of MDR cell variants is accompanied by regular karyotypic evolution specific for this type of drug resistance. (shrink)

The paper presents the reflection on philosophical foundations of contemporary physical concepts of global history and global structure of Universe. It shows that Democritus's dualism of "matter and void" is changed now in dualism of "matter and energy" in the frame of the strings theory, where anything what looks like "a void" is absent. At the same time the Poincare-Perelman's theorem calls to rethink Democritus's philosophy in the light of "space and hole" discourse and call it to come back. On (...) the level of philosophy doctrines for contemporary fundamental physics it in necessary to combine dialectically the concept of "matter and void/hole" and the concept "matter and energy" (or "matter and singular conditions"). It is possible to do on the way of rethinking of H. Bergson's ideas presented in his book "Matter and memory". The conclusion is that fundamental dualism consists the relation "visible matter - invisible historical memory" inside of Universe. (shrink)

A low linear order with no computable copy constructed by C. Jockusch and R. Soare has Hausdorff rank equal to $2$. In this regard, the question arises, how simple can be a low linear order with no computable copy from the point of view of the linear order type? The main result of this work is an example of a low strong $\eta $ -representation with no computable copy that is the simplest possible example.

Terminally differentiating stratified squamous epithelial cells assemble a specialized protective barrier structure on their periphery termed the cornified cell envelope (CE). It is composed of numerous structural proteins that become cross‐linked by several transglutaminase enzymes into an insoluble macromolecular assembly. Several proteins are involved in the initial stages of CE assembly, but only certain proteins from a choice of more than 20 different proteins are used in the final stages of CE reinforcement, apparently to meet tissue‐specific requirements. In addition, a (...) variable selection of proteins may be upregulated in response to genetic defects of one of the CE proteins or tissue injury, in an effort to maintain an effective barrier. Additionally, in the epidermis and hair fiber cuticle, a layer of lipids is covalently attached to the proteins, which provides essential water barrier properties. Here we describe our current understanding of CE structure, a possible mechanism of its assembly, and various disorders that cause a defective barrier. BioEssays 24:789–800, 2002. Published 2002 Wiley Periodicals, Inc. (shrink)

The paper aims to formulate theoretical and methodological foundations as well as basic research questions for studying intervention of artificial intelligence in everyday life of medical and life sciences in the 21 century. It is an invitation for professional philosophical, theoretical and methodological discussion about the necessity and reality of artificial intelligence in contemporary medical/life sciences and medicine. The authors commence with a proposition of their definitions of ‘artificial intelligence’ (AI) and ‘artificial sociality’ (AS). The next section of the paper (...) deals with a review of basic trends in medical/life sciences and medicine. In what follows the authors debate two problems related to incorporation of AI in reality of current medicine. The first is the potential revision of the principles developed in western medicine; the second is the alteration of the contents and forms of medical education. The authors theorize the dynamic interplay between structural expansion and cultural contraction of medicine and life sciences in current practices of higher education and explore how this introduces an essential tension between the necessity and reality for medical professionals to work with AI. The paper shows that attending to institutional dynamics serves as a critical and timely extension of disciplinary/cross/anti-disciplinary critiques of science and medicine, not only since the current inclusion agenda of the AI in medicine may do little to address the real concerns of a medical profession in the XXI century but also because it may inadvertently undermine the institutional recognition and epistemic acceptance of new anti-disciplinary vista for studying AI per se. In conclusion the authors underline basic outcomes of the discussion and propose further routes for inquiry and research. (shrink)

The article realizes the analysis of B. Epstein’s social ontology. Social ontology is teaching on basic principles of constructing of social reality, founded on interdisciplinary and transdisciplinary strategies of investigations of the social world. There are five leading programs in contemporary social ontology: “CIIF-program” of J. Searle, “Cambridge program” of T. Lawson, “Tufts program” of B. Epstein, “critical realism” and “the other institutionalism”. “Tufts program” is one from them. Social ontology tries to make progress on clarifying all of these in (...) the context of specific topics: group intentions, laws, corporations, property, institutions, social groups. To begin an inquiry in social ontology, we need to choose which entities to work out the ontology of, that is, where to focus our attention in analyzing the social world. B. Epstein supposes his own model of re-conceptualization of framework of social ontology: two concepts play here a leading role, - “grounding” and “anchoring”. “Anchoring” and grounding”: these are two fundamental aspects to the building of the social world. Correspondingly, social ontology consists of two distinct projects. The grounding project is the inquiry into the conditions for the social facts to obtain. There are facts in the world are metaphysically sufficient reasons, - that is, grounds, - but it is more exact social facts of some kind. The anchoring project is the inquiry into what puts those conditions in place. Also it should be realized research concerning the grounding conditions for social facts. The last work of B. Epstein “The Ant Trap: Rebuilding the Foundations of Social Sciences” is devoted to criticism of ontological individualism in philosophical analysis of social knowledge. (shrink)

Introduction and the aim of the study. The paper analyzes the place and role of morphogenetic theory within a framework of contemporary socialtheoretical discourse. M. Archer’s morphogenetic theory and P. Donati’s relational conception are considered as two examples of this discourse. Methods. The authors use analytical methods (analysis, synthesis, etc.), applied in contemporary philosophy of social sciences. Scientific novelty. The key idea of the paper is analyzing morphogenetic social theory in terms of analytical scholasticism as a deviant way of contemporary (...) social theory development. Results. Morphogenetic theory is rather a sociological theory than interdisciplinary social theory; the sophisticated language of “morphogenists” mat seem difficult for other scholars to understand; morphogenetic theory demonstrates indefinite perspectives concerning interdisciplinary or transdisciplinary discourse in the context of contemporary stage of social-humanitarian knowledge development. Conclusions. The status of “morphogenetic theory” among other directions of social theory is by far “peripheral”. (shrink)

This interview with Professor Dr Jürgen Stolzenberg, board member of the Kant-Gesellschaft and co-editor of the Kant-Lexikon (2015), explores a wide range of topics — from Leibniz and Wolff to Heidegger and Husserl. The leading idea of Stolzenberg’s philosophical research is the justification of the principle of modern subjectivity in Kant’s philosophy and its transformations until our days. He discusses the meaning and development of the concept of self-consciousness and the understanding of subjectivity in Kant’s ethics as well as in (...) Fichte’s philosophy. Stolzenberg shows the significance of Heidegger’s philosophical relations with Kant, Fichte, and the Neo-Kantians. He outlines the reasons which explain the different structures of the philosophical theories after Kant in comparison with the structure of Kant’s philosophy itself. Answering the question of Kant’s role in affirming the value of human dignity, he emphasises the non-empirical essence of this concept as it is presented in Kant’s ethics and as it should be defended against recent critics. According to Stolzenberg, the principle of modern subjectivity proves to be fruitful in understanding the development of the history of modern music, too. (shrink)

In this paper we prove that any Δ30 degree has an increasing η -representation. Therefore, there is an increasing η -representable set without a strong η -representation.

The paper introduces a conceptually important, but previously unknown essay by the Russian poet, theologian and philosopher Aleksey Khomyakov. This essay, “The Slavic and Orthodox Christian Population of Austria,” was discovered in two versions: an original, previously unpublished manuscript and a later anonymous 1845 text. The author reveals an aesthetic function that certain structural elements perform in Khomyakov’s essay, encouraging the interaction between historiosophical ideas and literary creativity. The essay is emphatically philosophical in its style, as its very composition embraces (...) the classic Hegelian triad of “Being—Nothing—Becoming.” This notion overlaps with Khomyakov’s historiosophical idea of the European Slavdom that flourished in the first millennium B.C., and that then lost its sovereignty being under German rule, and finally enjoyed a renaissance in the 19th century. The paper also shows that the distinctive feature of Khomyakov’s poetry is its prophetism. The contrastive analysis was carried out to identify the affinity between the thematic-figurative patterns of Khomyakov’s early poetry and his essay on the Austrian Slavs, which revealed how the poetic thought had been accumulating and what aspect it had taken on within a philosophical and historical discourse. The author of the article puts forward the hypothesis that the difference in depicting Peter the Great in the two versions of Khomyakov’s essay can be attributed to his dispute with Konstantin Aksakov’s poem “To Peter.” This polemic between two fellow-Slavophils was driven by their diverging approaches to the problem of the ethical dilemma of ends and means. (shrink)

The Transamazon (Br-230) Highway in the state of Pará has had its image frozen for decades: themuddy road, the cars stopped or tractors tearing down a forest, empty of people, opening the amazonianspace to a project of an authoritarian modernization. Reproduced by and reproductive of the teachingsof geography – including for children and teenagers who live on the edge of the road, in settlements andcommunities on the sideroads (vicinais) – in textbooks and discourses that frame regional scale (astotalizing and explanatory) (...) instead of scales emplaced in situ. The result of such dinamics is not restricted to a gap between what one experiences as a phenomenon and what one learns as a concept,it goes towards the reproducibility of an “unexistance of the creative potential” of the people living onthe sideroads, places of the construction of a geography, as well as mapping, that, from there, push usto rethink the unwavering foundations of such frosen images , of the generalistic maps and theirstandardizing projections, scales and simbology. To do so, we have, along with students and teachersof 2 schools on the sideroads of the municipality of Pacajá (PA), in the period of the beggining of 2016to 2019, done several geocartographic exercises: mind maps developped with students about the past,present and the future of the vicinal (sideroad). That is, an attempt to provoque the body into the mapand the map into the body in a context of a limit situation of existance, given the precarious schoolconditions as well as the diferent challenges lived by students and teachers. Such corporal engagementas an attempt to think the sideroads as a location in construction and, from there, a situated opening tothe world, is what gives meaning to geocartography. It is possible to conclude that: a) facing thesedimentary representations paralysing and overview of the Transamazon in the state of Pará , thephenomenological exercise of reactivation of geocartogrphying provoques the emergence of asubjective significance that does not separate the emotional and symbolic perspectives on creatingmaps; b) the corporal engagement and the situated perspective of students and teachers, not only hasthe value of a totalyzing exemple, but that of an opening to what is new as they bring up a simbologythat reveals the need to build a dialogical bridge between what is lived on the sideroads and the worldthat classifies it as “unexisting”. (shrink)

Gene transcription in eukaryotes is associated with conformational changes of a large area of chromatin adjacent to a gene. This rearrangement may involve the whole loop (topological domain) to which a given gene belongs.Regulatory events associated with activation or inactivation of transcription are found to act through relatively short nucleotide sequences, often located several thousand base pairs apart from gene. These sequences, termed enhancers may act independently on their distance from or orientation with respect to the gene.Both long‐range conformational rearrangements (...) of chromatin and any long distance effects of enhancers may be associated with elastic torsional strain in DNA, arising in transcriptionally active chromatin loops. Enhancer effects, in particular, may be associated with conformational transitions in DNA competing for the energy deposited in the elastic spring of the DNA. (shrink)

The typology of rationality is one of major issues of modern philosophy. In an attempt to provide a typology to Oriental materials, a researcher faces additional problems. The diversity of the Orient as such poses a major challenge. When we say “Oriental,” we mean several cultures for which we cannot find a common denominator. The concept of “Orient” involves Arabic, Indian, Chinese, Turkish and other cultures, and the only thing they share is that they are “non-Western.” Moreover, even if we (...) focus just on Islamic culture and look into rationality in this context, we have to deal with a conglomerate of various trends, which does not let us define, with full confidence, a common theoretical basis and treat them as a unity. Nevertheless, we have to go on trying to find common directions in thought development, so as to draw conclusions about types of rationality possible in Islamic culture. A basis for such a typology of rationality in the context of the Islamic world was recently suggested in A.V. Smirnov’s logic of sense theory. However, actual empiric material cannot always fit theoretical models, and the cases that do not fit the common scheme are interesting per se. On the one hand, examination of such cases gives an opportunity to specify certain provisions of the theory and, on the other hand, to define the limits of its applicability. (shrink)

Physical systems without time and dynamics have been considered. The principle of how to construct spacetime in a physical system without time and dynamics has been proposed. It has been found what can be objects in such a spacetime, and what can be an interaction between such objects. Within the framework of the considered class of systems, answers to the following problems of philosophy and physics have been found: the nature of consciousness and the connection of body and consciousness (mind-body (...) problem), the nature of time, the anthropic principle and the problem of fine-tuning the universe, the effectiveness of mathematics in describing physical phenomena, the limits of knowledge. There are a number of indications that our Universe is not based on one of the systems of the class considered. The considered class of systems makes it possible to find answers to questions that cannot be answered for our Universe. This shows that it is fundamentally possible to find answers to these questions for our Universe as well. (shrink)

Introduction. The article analyzes one of the qualitative states of culture, called the cultural gap, which is a phenomenon of ambivalent properties, on the one hand, generating most of the destruc- tive conflicts in the history of mankind, and on the other hand, in constructive overcoming of contra- dictions, prompting creative transformations. The purpose of the study is to give a definition of a cultural gap with the allocation of significant distinctive features found when analyzing any empirically fixed manifestations of (...) it, for subse- quent understanding at the ultimate general level of reflection. Methods. Philosophical-anthropological, systemic, axiological, historical-philosophical and dialectical approaches are used as the methodological basis of the research, making it possible to consider the phenomenon of cultural gap in various aspects. Scientific novelty of the research. An analysis of the main directions of scientific discourse in the subject area under consideration makes it possible for us to conclude that the phenomenon of a cul- tural gap is studied within the framework of social and humanitarian knowledge, but mainly in relation to the analysis of conflict situations and turning points in history. The phrase “cultural gap” itself is beginning to be introduced into scientific circula- tion, however, often outside the established con- ceptual apparatus, in a narrow context and without meaningful disclosure, which makes it scientifically necessary to address the emerging subject field of studying the phenomenon and determining the meaning of the corresponding term. Results. As a result of the study, the author identifies significant signs of the phenomenon of a cultural gap, consisting in the loss of the integrity of certain areas of culture due to the heterogene- ous development of its parts, a critically significant interruption at the level of structure and content of the universals of culture in the deep value and semantic relationships provided by it, supporting mutual understanding and conflict-free coexistence of people. As no less significant signs, one can also designate the polarization and absolutization of cultural contradictions that result in antagonistic relations between representatives of sociocultural communities, separated by the interruption of these relationships Conclusions. The definition of a cultural gap, formed on the basis of existing options for inter- preting and comprehending this phenomenon, its essential and contextual features, is due to the ontological and semantic ambiguity of some of its aspects, due to which it goes beyond a strict defini- tion and is partly projective in nature, containing significant research potential. The realization of this potential through the functional capabilities of philosophical anthropology and philosophy of culture will make it possible to determine the main approaches to identifying, preventing and overcom- ing cultural gaps, including the formation of new worldview meanings and values that can ensure harmonious coexistence between people of differ- ent cultures in modern conditions. (shrink)

Critical phenomena in stock exchange are regularly occurring and difficult to predict events, often leading to disastrous consequences. The presented paper is devoted to the search and research of early warning signals of critical transitions in stock exchange based on the results of a multifractal analysis of a series of transactions in shares of public companies. We have proposed and justified the use of certain features of behavior of multifractal spectrum shape parameters such as signals. As model time series, on (...) which methods of multifractal analysis were tested, we used a series of the number of unstable sites of the sandpile automaton on the random Erdős–Rényi graph, self-organizing into critical and bistable states. It was found that the early warning signals for both cellular automata and stock exchanges are an increase in the magnitude of the maximum position, a decrease in the width, and a decrease, followed by a sharp increase, in the value of the spectrum asymmetry parameter. (shrink)

In this article, I present a sociological approach to the problem of meaningful work that dwells on its broad social and cultural sources, as opposed to the focus on subjective and organizational factors currently prevailing in the field. Specifically, I consider two sociological perspectives, those of community and autonomy, as important conceptual tools for understanding the ambivalent character of modern culture in providing individuals with a sense of meaningfulness of their activities. I also review some of the existing research on (...) meaningful work and interpret it through this conceptual distinction, both to show the latter’s relevance for the field and to identify the gaps it might help fill. As a result, based on the sociological perspectives, I propose a general conceptual model and discuss five directions to further advance the theoretical comprehension of meaningful work, and I suggest some implications of these perspectives for normative business ethics. (shrink)

The starting point of my study is Kant’s remark to the effect that Garve in his treatise on the connection between morality and politics presents arguments in defence of unjust principles. Recognition of these principles is, according to Kant, an inadvisable concession to those who are inclined to abuse it. I interpret this judgement by making a detailed comparison of the texts of the two treatises. I demonstrate that Garve’s work is an eclectic attempt to combine in one concept the (...) lessons of historical experience with the ideas drawn from British empiricism and German rationalism. These ideas were criticised by Kant in his “critical” period. There is a consensus among researchers that Garve condoned the expansionist policy of Frederick II of Prussia, totally denied that legality in international relations was possible and in general deserved the reputation of an conservative. From that point of view the key values for Garve were the security and well-being of the state. I offer an alternative interpretation of Garve’s position because I believe that the value of political stability plays an important role in it. Such an interpretation makes it possible to treat Garve’s narrative as it was assessed by Kant, i.e. as a concession to the common principles of political practice as a result of a failure to find the guiding theory. My study has established that the role of Garve’s work in the writing of Kant’s treatise Toward Perpetual Peace was more significant than Kant’s own words suggest. Besides, I show that it was under Garve’s influence that Kant turned to the problem of excessive complexity of the principles involved in the search for concrete political decisions. Garve obviously laments this complexity and yet makes these principles still more complex. Kant offers a simpler solution of the problem on the basis of his theory of morals and right. (shrink)

Structures without time and dynamics are considered. The principle is proposed how to build space-time in a structure without time and dynamics. It is found what can be objects in such a space-time, and what can be an interaction between such objects.Within the framework of the considered class of structures, answers were found to the following problems of philosophy and physics: the nature of consciousness and the connection between the body and consciousness (mind-body problem), nature of time, anthropic principle and (...) the problem of fine-tuning the universe, the effectiveness of mathematics in describing physical phenomena, limits of knowledge.The considered class of structures makes it possible to find answers to questions that cannot be answered for our Universe. This shows the fundamental possibility of finding answers to these questions for our Universe as well. (shrink)

There is a number of studies, in which it is established that the observed flows of microposts generated by microblogging social networks are characterized by avalanche-like behavior. Time series of microposts depicting such streams are the time series with a power-law distribution, with 1/f noise and long memory. Despite this, there are no studies devoted to the detection and analysis of self-organized critical state, subcritical phase, and supercritical phase. The presented paper is devoted to the detection and investigation of such (...) critical states and phases. An algorithm is proposed that allowed to detect of critical phases and critical conditions on Twitter, based on the analysis of retweets time series corresponding to the three debates of the 2016 United States Presidential Election, as the most popular debate in the history of America, collecting 84 million live views. (shrink)

We characterize the linear order types $\tau $ with the property that given any countable linear order $\mathcal {L}$, $\tau \cdot \mathcal {L}$ is a computable linear order iff $\mathcal {L}$ is a computable linear order, as exactly the finite nonempty order types.

The article focuses on two lecture courses - The Idea of time and The History of the Idea of Time - delivered by the French philosopher Henri Bergson at Collge de France in 1901-1903. While these courses cannot replace Bergsons published works for understanding his philosophy, they can shed new light on Bergsons popularity. Due to the requirements of the genre, Bergson presents his views in a most succinct and convincing manner and showcases his most original ideas. In these lectures (...) Bergson reinterprets traditional philosophical categories such as the absolute and the relative, the infinite and the finite, and explores two major modes of cognition - conceptual and intuitive knowledge. Major thrust of Bergsons arguments is targeted at conceptual cognition because it is incapable of grasping the duration. Conceptual cognition relies on signs to operate representations of reality. Bergson demonstrates that signs, including concepts, are general, fixating and they appeal to action. Conceptual cognition, therefore, is based on fragmenting continuous processes in reality. However, when discussing intuitive cognition Bergson provides but an outline by referring to intellectual sympathy, plunging into the thing in itself. Despite this apophatic description of the alternative - intuitive - mode of cognition Bergson insists on fundamental transformation of philosophy. We conclude that already in the early 1900s Bergson has in mind an entire project of reconstituting metaphysics and reorienting it towards the problem of time, what might be described as temporal turn in philosophy of the twentieth century. (shrink)

A study of the relationship of trends towards specialization and universalization of scientific knowledge is most fruitful when sociological and epistemological methods are compared. Sociological methods describe the growth of scientific knowledge quantitatively as an increase in volume, whereas epistemological methods do it qualitatively in terms of an increase in the level of generalization. The sociological explanation of the specialization of researchers is based on the limited resources of the study time, the epistemological explanation of the differentiation of disciplines is (...) in the ontological differences of the objects of research. On the contrary, epistemological universalization – the formulation of generalizing theories is conditioned by the social need to ensure the connectivity of the network of technical practices. The history of the development of natural sciences shows a tendency towards absorption of the less developed paradigms by more developed ones. In other words, scientific knowledge increases cumulatively both in quantitative and qualitative terms. (shrink)

The paper is aimed at providing general outlines of the more than two-century history of the theory of moral sanctions. It rests on a thesis about unity of all disciplines studying morality. The aim of the paper has been achieved trough an analysis of how some basic concepts were borrowed and basic ideas were transformed. The first tradition links moral sanctions with public condemnation. Some of its adherents simply identified public condemnation with moral sanction. This opinion prevailed until the middle (...) of the XXth century. Later it was suggested that a sanction becomes genuinely moral only when a transgressor herself is sensitive to condemnation because she recognizes that she deserves it and feels shame, guilt or remorse. It means that an external side of the sanction has to be complemented by an internal one. The first tradition presupposes a deep and thorough analysis of an external side of the moral sanction, i.e. various forms of sanctioning behavior (avoidance, censure, denunciation, reproach, scolding etc.) The second tradition was initiated by J.S. Mill and H. Sidgwick, it includes among moral sanctions the very negative emotions of self-appraisal. For adherents of this tradition, model and most important moral sanctions are internal: guilt and remorse. Characteristics of internal (autonomous) and external (heteronomous) sanctions were established in the XXth century anthropology. Later this distinction became current in the contemporary ethics. (shrink)