Although epistasis is at the center of the Fisher-Wright debate, biologists not involved in the controversy are often unaware that there are actually two different formal definitions of epistasis. We compare concepts of genetic independence in the two theoretical traditions of evolutionary genetics, population genetics and quantitative genetics, and show how independence of gene action (represented by the multiplicative model of population genetics) can be different from the absence of gene interaction (represented by the linear additive model of quantitative genetics). (...) The two formulations converge with weak selection but not with strong selection or, for multiple loci, when the aggregated interaction terms are not negligible. As a result of the different formulations of gene interaction, the presence or absence of linkage disequilibrium,/D/, does not necessarily indicate the presence or absence of fitness epistasis. Indeed, linkage disequilibrium is generated in ‘additive’ models in quantitative genetics whenever two (or more) loci experience simultaneous selection. As a research strategy, it is often practical, for theoretical or experimental reasons, to minimize gene interaction by assuming independence of gene action in regard to fitness, or by assuming linear additive effects of multiple loci on a phenotype. However, minimizing the role of epistasis in theoretical investigations hinders our understanding of the origins of diversity and the evolution of complex phenotypes. (shrink)
A compilation of all previously published writings on philosophy and the foundations of mathematics from the greatest of the generation of Cambridge scholars that included G.E. Moore, Bertrand Russell, Ludwig Wittgenstein and Maynard Keynes.
Trailblazing marine biologist, visionary conservationist, deep ecology philosopher, Edward F. Ricketts has reached legendary status in the California mythos. A true polymath and a thinker ahead of his time, Ricketts was a scientist who worked in passionate collaboration with many of his friends—artists, writers, and influential intellectual figures—including, perhaps most famously, John Steinbeck, who once said that Ricketts's mind “had no horizons.” This unprecedented collection, featuring previously unpublished pieces as well as others available for the first time in their original (...) form, reflects the wide scope of Ricketts’s scientific, philosophical, and literary interests during the years he lived and worked on Cannery Row in Monterey, California. These writings, which together illuminate the evolution of Ricketts’s unique, holistic approach to science, include “Verbatim transcription of notes on the Gulf of California trip,” the basic manuscript for Steinbeck’s and Ricketts’s _Log from the Sea of Cortez;_ the essays “The Philosophy of Breaking Through” and “A Spiritual Morphology of Poetry;” several shorter pieces on topics including collecting invertebrates and the impact of modernization on Mexican village life; and more. An engaging critical biography and a number of rare photographs offer a new and richly detailed view of Ricketts’s life. (shrink)
This collection of essays, addresses, and one interview come from the years 1966-73 and cover a wide spectrum of interest, dealing with such general topics as 'The Absence of God in Modern Culture' and 'The Future of Christianity.'.
This book is a philosophical discussion of moral, legal, and medical issues related to aging, dying, and death. One of its aims is to decide whether and when it might make sense to not resist or bring about the end of one's life. To answer this question it considers views about meaning in life and what makes life worth living. It also evaluates recent attempts to help the general public plan in advance for the end of life. It also considers (...) whether or not physician-assisted suicide is morally permissible and if it should be legalized. (shrink)
"F. A. Hayek and the Epistemology of Politics is an exploration of an important problem that has largely been ignored: the problem of policymaker ignorance, and the limits of political epistemology. Scott Scheall explores Hayek's attitude to the philosophy of science and political philosophy, arguing that Hayek defended a philosophy of science that implied certain potential dangers of politicized science, and that his political philosophy established the potential dangers of misapplying scientific methods and results to matters of public policy. The (...) book offers an explanation for why policymaking often fails and why constituents, whatever their political affiliations, are so often disappointed with political leaders. In this primarily philosophical examination of his work, Hayek's ideas are not merely discussed, analysed, and contextualized, but extended; the book both draws and defends previously unrecognized implications from the Hayekian canon. The book also explores the historical context within which these ideas flourished. The book will be of interest to scholars and researchers of the works of F.A. Hayek, policymakers, and to those of all political, philosophical, and social-scientific persuasions"--. (shrink)