23 found
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  1.  23
    Organoids as Hybrids: Ethical Implications for the Exchange of Human Tissues.Sarah N. Boers, Johannes J. M. van Delden & Annelien L. Bredenoord - 2019 - Journal of Medical Ethics 45 (2):131-139.
    Recent developments in biotechnology allow for the generation of increasingly complex products out of human tissues, for example, human stem cell lines, synthetic embryo-like structures and organoids. These developments are coupled with growing commercial interests. Although commercialisation can spark the scientific and clinical promises, profit-making out of human tissues is ethically contentious and known to raise public concern. The traditional bioethical frames of gift versus market are inapt to capture the resulting practical and ethical complexities. Therefore, we propose an alternative (...)
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  2.  13
    Ethics Parallel Research: An Approach for (Early) Ethical Guidance of Biomedical Innovation.Karin R. Jongsma & Annelien L. Bredenoord - 2020 - BMC Medical Ethics 21 (1):1-9.
    BackgroundOur human societies and certainly also medicine are more and more permeated with technology. There seems to be an increasing awareness among bioethicists that an effective and comprehensive approach to ethically guide these emerging biomedical innovations into society is needed. Such an approach has not been spelled out yet for bioethics, while there are frequent calls for ethical guidance of biomedical innovation, also by biomedical researchers themselves. New and emerging biotechnologies require anticipation of possible effects and implications, meaning the scope (...)
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  3.  11
    The Social Value of Clinical Research.Michelle Gjl Habets, Johannes Jm van Delden & AnneLien L. Bredenoord - 2014 - BMC Medical Ethics 15 (1):66.
    International documents on ethical conduct in clinical research have in common the principle that potential harms to research participants must be proportional to anticipated benefits. The anticipated benefits that can justify human research consist of direct benefits to the research participant, and societal benefits, also called social value. In first-in-human research, no direct benefits are expected and the benefit component of the risks-benefit assessment thus merely exists in social value. The concept social value is ambiguous by nature and is used (...)
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  4.  11
    Digital Medicine: An Opportunity to Revisit the Role of Bioethicists.Karin R. Jongsma, Annelien L. Bredenoord & Federica Lucivero - 2018 - American Journal of Bioethics 18 (9):69-70.
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  5.  12
    Experts’ Moral Views on Gene Drive Technologies: A Qualitative Interview Study.Annelien L. Bredenoord, Karin R. Jongsma & N. de Graeff - 2021 - BMC Medical Ethics 22 (1):1-15.
    BackgroundGene drive technologies promote the rapid spread of a particular genetic element within a population of non-human organisms. Potential applications of GDTs include the control of insect vectors, invasive species and agricultural pests. Whether, and if so, under what conditions, GDTs should be deployed is hotly debated. Although broad stances in this debate have been described, the convictions that inform the moral views of the experts shaping these technologies and related policies have not been examined in depth in the academic (...)
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  6.  6
    Broad Consent Is Consent for Governance.Sarah N. Boers, Johannes J. M. van Delden & Annelien L. Bredenoord - 2015 - American Journal of Bioethics 15 (9):53-55.
  7.  8
    Responsible Research with Human Tissues: The Need for Reciprocity Toward Both Collectives and Individuals.Annelien L. Bredenoord, Johannes J. M. van Delden, Sarah N. Boers, Karin R. Jongsma & Michael A. Lensink - 2021 - American Journal of Bioethics 21 (4):75-78.
    Precision medicine research involving human biological material is becoming an increasingly central component of healthcare, and its potential is quickly growing due to rapid technological progress...
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  8.  1
    Educating for Responsible Research Practice in Biomedical Sciences.Elianne M. Gerrits, Annelien L. Bredenoord & Marc H. W. van Mil - 2022 - Science & Education 31 (4):977-996.
    New developments in the field of biomedicine can have extensive implications for society. To steer research efforts in a responsible direction, biomedical scientists should contribute to a forward-looking ethical, and societal evaluation of new developments. However, the question remains how to equip students sufficiently with the skills they need to contribute to this evaluation. In this paper, we examine how the four dimensions of Responsible Research and Innovation inform the identification of learning goals and teaching approaches that contribute to developing (...)
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  9.  24
    Disclosing Individual Genetic Research Results to Deceased Participants' Relatives by Means of a Qualified Disclosure Policy.Annelien L. Bredenoord & Johannes Jm van Delden - 2012 - American Journal of Bioethics 12 (10):10-12.
    The American Journal of Bioethics, Volume 12, Issue 10, Page 10-12, October 2012.
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  10.  12
    Fair Governance of Biotechnology: Patents, Private Governance, and Procedural Justice.Nienke de Graeff, Léon E. Dijkman, Karin R. Jongsma & Annelien L. Bredenoord - 2018 - American Journal of Bioethics 18 (12):57-59.
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  11.  10
    Next Generation DNA Sequencing: Always Allow an Opt Out.Annelien L. Bredenoord, Rhodé M. Bijlsma & Hans van Delden - 2015 - American Journal of Bioethics 15 (7):28-30.
  12.  25
    A Thick Opt-Out Is Often Sufficient.Noor A. A. Giesbertz, Annelien L. Bredenoord & Johannes J. M. van Delden - 2013 - American Journal of Bioethics 13 (4):44 - 46.
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  13.  16
    Toward a “Post-Posthuman Dignity Area” in Evaluating Emerging Enhancement Technologies.Annelien L. Bredenoord, Rieke van der Graaf & Johannes Jm van Delden - 2010 - American Journal of Bioethics 10 (7):55-57.
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  14.  17
    Ancillary Care Obligations for Social Media Platforms.Annelien L. Bredenoord & Martin Boeckhout - 2017 - American Journal of Bioethics 17 (3):29-31.
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  15.  41
    Toward a “Post-Posthuman Dignity Area” in Evaluating Emerging Enhancement Technologies.J. M. van Delden Johannes, Graavanf Rieke der & L. Bredenoord Annelien - 2010 - American Journal of Bioethics 10 (7):55-57.
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  16.  14
    The Right to an Open Future Concerning Genetic Information.Annelien L. Bredenoord, Martine C. de Vries & Hans van Delden - 2014 - American Journal of Bioethics 14 (3):21-23.
  17.  3
    Governing Gene Drive Technologies: A Qualitative Interview Study.N. de Graeff, Karin R. Jongsma, Jeantine E. Lunshof & Annelien L. Bredenoord - 2022 - AJOB Empirical Bioethics 13 (2):107-124.
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  18. Better Governance Starts with Better Words: Why Responsible Human Tissue Research Demands a Change of Language.Annelien L. Bredenoord, Sarah N. Boers, Karin R. Jongsma & Michael A. Lensink - 2022 - BMC Medical Ethics 23 (1).
    The rise of precision medicine has led to an unprecedented focus on human biological material in biomedical research. In addition, rapid advances in stem cell technology, regenerative medicine and synthetic biology are leading to more complex human tissue structures and new applications with tremendous potential for medicine. While promising, these developments also raise several ethical and practical challenges which have been the subject of extensive academic debate. These debates have led to increasing calls for longitudinal governance arrangements between tissue providers (...)
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  19.  15
    Understanding (in) Consent for Governance.Michael A. Lensink, Sarah N. Boers, Karin R. Jongsma & Annelien L. Bredenoord - 2019 - American Journal of Bioethics 19 (5):43-45.
    Volume 19, Issue 5, May 2019, Page 43-45.
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  20.  19
    Scanning the Body, Sequencing the Genome: Dealing with Unsolicited Findings.Roel H. P. Wouters, Candice Cornelis, Ainsley J. Newson, Eline M. Bunnik & Annelien L. Bredenoord - 2017 - Bioethics 31 (9):648-656.
    The introduction of novel diagnostic techniques in clinical domains such as genomics and radiology has led to a rich ethical debate on how to handle unsolicited findings that result from these innovations. Yet while unsolicited findings arise in both genomics and radiology, most of the relevant literature to date has tended to focus on only one of these domains. In this article, we synthesize and critically assess similarities and differences between “scanning the body” and “sequencing the genome” from an ethical (...)
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  21.  16
    Personalized assent for pediatric biobanks.Noor A. A. Giesbertz, Karen Melham, Jane Kaye, Johannes J. M. van Delden & Annelien L. Bredenoord - 2016 - BMC Medical Ethics 17 (1):59.
    Pediatric biobanking is considered important for generating biomedical knowledge and improving health care. However, the inclusion of children’s samples in biobanks involves specific ethical issues. One of the main concerns is how to appropriately engage children in the consent procedure. We suggest that children should be involved through a personalized assent procedure, which means that both the content and the process of assent are adjusted to the individual child. In this paper we provide guidance on how to put personalized assent (...)
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  22.  9
    Geometry of Trust: Why We Need to Distinguish Between Horizontal and Vertical Trust.Karin R. Jongsma & Annelien L. Bredenoord - 2018 - American Journal of Bioethics 18 (4):48-50.
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  23.  10
    Participant Selection for Preventive Regenerative Medicine Trials: Ethical Challenges of Selecting Individuals at Risk: Figure 1.Sophie L. Niemansburg, Michelle G. J. L. Habets, Wouter J. A. Dhert, Johannes J. M. van Delden & Annelien L. Bredenoord - 2015 - Journal of Medical Ethics 41 (11):914-916.
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