Background: Freezing of gait is a common symptom in Parkinson’s disease and can be difficult to treat with dopaminergic medications or with deep brain stimulation. Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation delivers current in various frequencies of bursts, while maintaining an intra-burst frequency identical to conventional DBS.Objective: To evaluate the safety and tolerability of BCDBS in PD patients with FOG.Methods: Ten PD subjects with STN or GPi DBS (...) and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state.Results: There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS.Conclusions: BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy. (shrink)
Science once had an unshakable faith in its ability to bring the forces of nature—even human nature—under control. In this wide-ranging book Anson Rabinbach examines how developments in physics, biology, medicine, psychology, politics, and art employed the metaphor of the working body as a human motor. From nineteenth-century theories of thermodynamics and political economy to the twentieth-century ideals of Taylorism and Fordism, Rabinbach demonstrates how the utopian obsession with energy and fatigue shaped social thought across the ideological spectrum.
A fundamental way in which human thought has developed has been constantly to explain the earliest "classics" that are the source of that thought. All in all, the number of such classics is not very high, their explanations are past counting. Moreover, they are constantly increasing, giving rise to an explanatory chain deriving from the classics. In the development of Chinese philosophy, this aspect is particularly noticeable, so that one can describe Chinese philosophy as a continual explanation of the classics. (...) This holds for both Confucianism and Daoism. The main classics of Daoism are the Laozi and the Zhuangzi. These two works have been constantly reread and reinterpreted throughout history. From the late nineteenth century onward, Chinese philosophy came into closer contact with Western philosophy. Foreign concepts were brought in to provide philosophers with new "insight." Some thinkers applied this new insight or these foreign concepts to the Daoist classics. In this way, they brought a new explanation of the Daoist classics and enriched the ways of interpreting the texts.1 Paving the way in this direction were Yan Fu. Zhang Taiyan, Liang Qichao, Wang Guowei, and Hu Shi. (shrink)
A fundamental way in which human thought has developed has been constantly to explain the earliest "classics" that are the source of that thought. All in all, the number of such classics is not very high, their explanations are past counting. Moreover, they are constantly increasing, giving rise to an explanatory chain deriving from the classics. In the development of Chinese philosophy, this aspect is particularly noticeable, so that one can describe Chinese philosophy as a continual explanation of the classics. (...) This holds for both Confucianism and Daoism. The main classics of Daoism are the Laozi and the Zhuangzi. These two works have been constantly reread and reinterpreted throughout history. From the late nineteenth century onward, Chinese philosophy came into closer contact with Western philosophy. Foreign concepts were brought in to provide philosophers with new "insight." Some thinkers applied this new insight or these foreign concepts to the Daoist classics. In this way, they brought a new explanation of the Daoist classics and enriched the ways of interpreting the texts.1 Paving the way in this direction were Yan Fu . Zhang Taiyan , Liang Qichao , Wang Guowei , and Hu Shi. (shrink)
These essays by eminent European intellectual and cultural historian Anson Rabinbach address the writings of key figures in twentieth-century German philosophy. Rabinbach explores their ideas in relation to the two world wars and the horrors facing Europe at that time. Analyzing the work of Benjamin and Bloch, he suggests their indebtedness to the traditions of Jewish messianism. In a discussion of Hugo Ball's little-known _Critique of the German Intelligentsia_, Rabinbach reveals the curious intellectual career of the Dadaist and antiwar (...) activist turned-nationalist and anti-Semite. His examination of Heidegger's "Letter on Humanism" and Jaspers's _The Question of German Guilt_ illuminates the complex and often obscure political referents of these texts. Turning to Horkheimer and Adorno's _Dialectic of Enlightenment_, Rabinbach offers an arresting new interpretation of this central text of the critical theory of the Frankfurt School. Subtly and persuasively argued, his book will become an indispensable reference point for all concerned with twentieth-century German history and thought. (shrink)
These essays by eminent European intellectual and cultural historian Anson Rabinbach address the writings of key figures in twentieth-century German philosophy. Rabinbach explores their ideas in relation to the two world wars and the horrors facing Europe at that time. Analyzing the work of Benjamin and Bloch, he suggests their indebtedness to the traditions of Jewish messianism. In a discussion of Hugo Ball's little-known _Critique of the German Intelligentsia_, Rabinbach reveals the curious intellectual career of the Dadaist and antiwar (...) activist turned-nationalist and anti-Semite. His examination of Heidegger's "Letter on Humanism" and Jaspers's _The Question of German Guilt_ illuminates the complex and often obscure political referents of these texts. Turning to Horkheimer and Adorno's _Dialectic of Enlightenment_, Rabinbach offers an arresting new interpretation of this central text of the critical theory of the Frankfurt School. Subtly and persuasively argued, his book will become an indispensable reference point for all concerned with twentieth-century German history and thought. (shrink)
In (2011) McLeod suggested that the first century Chinese philosopher Wang Chong 王充 may have been a pluralist about truth. In this reply I contest McLeod's interpretation of Wang Chong, and suggest "quasi-pluralism" (albeit more as an alternative to pluralism than as an interpretation of Wang Chong), which combines primitivism about the concept of truth with pluralism about justification.
Within various contexts, such as politics and parenting, Confucianism has been criticized on the basis that it endorses ‘unquestioning obedience’ to authorities. In recent years, several philosophers have argued against this view by appealing to textual evidence from Classical Confucian philosophers. In this essay, I examine Wang Yangming’s views on this subject, arguing that Wang teaches that criticism of those who stand in a socially superior role relation is not only permitted, but encouraged. From this, I consider the (...) implications that Wang’s analysis has for contemporary discussions of disagreement between epistemic superiors and inferiors and epistemic peerhood. I will argue that Wang’s position is much closer to the total evidence view than the preemptive view. Relatedly, I will suggest that Wang provides a novel proposal about how to recognise or disregard epistemic ‘superiors’, especially in the context of moral knowledge. (shrink)
