Objective: Deep brain stimulation targeted to the ventral intermediate nucleus of the thalamus is effective for motor symptoms in essential tremor, but there is limited data on cognitive outcomes. We examined cognitive outcomes in a large cohort of ET DBS patients.Methods: In a retrospective analysis, we used repeated-measures ANOVA testing to examine whether the age of tremor onset, age at DBS surgery, hemisphere side implanted with lead, unilateral vs. bilateral implantations, and presence of surgical complications influenced the cognitive outcomes. Neuropsychological (...) outcomes of interest were verbal memory, executive functioning, working memory, language functioning, visuospatial functioning, and general cognitive function.Results: We identified 50 ET DBS patients; 29 males; the mean age of tremor onset was 35.84 years with a median age of 38 years. The mean age at DBS was 68.18 years. There were 37 unilateral 30 left, seven right, and 13 bilateral brain implantations. In the subgroup analysis, there was a significant interaction between assessment and age of tremor onset ; F = 4.47; p = 0.043 for working memory. The post hoc testing found improvements for younger onset ET. Similarly, there was a significant interaction between assessment and complications vs. no complications subgroups; F = 4.34; p = 0.043 for verbal memory with worsening scores seen for ET patients with complications. The remaining tests were not significant.Conclusion: In this large cohort of ET patients with, DBS was not accompanied by a significant decline in many cognitive domains. These outcomes were possibly related to the selection of patients with normal cognitive functioning before surgery, unilateral DBS implantations for the majority, and selection of patients with optimal response to DBS. (shrink)

We estimate that 208,000 deep brain stimulation (DBS) devices have been implanted to address neurological and neuropsychiatric disorders worldwide. DBS Think Tank presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The DBS Think Tank was founded in 2012 providing a space where clinicians, engineers, researchers from industry and academia discuss current and emerging DBS technologies and logistical and ethical issues facing the field. (...) The emphasis is on cutting edge research and collaboration aimed to advance the DBS field. The Eighth Annual DBS Think Tank was held virtually on September 1 and 2, 2020 (Zoom Video Communications) due to restrictions related to the COVID-19 pandemic. The meeting focused on advances in: (1) optogenetics as a tool for comprehending neurobiology of diseases and on optogenetically-inspired DBS, (2) cutting edge of emerging DBS technologies, (3) ethical issues affecting DBS research and access to care, (4) neuromodulatory approaches for depression, (5) advancing novel hardware, software and imaging methodologies, (6) use of neurophysiological signals in adaptive neurostimulation, and (7) use of more advanced technologies to improve DBS clinical outcomes. There were 178 attendees who participated in a DBS Think Tank survey, which revealed the expansion of DBS into several indications such as obesity, post-traumatic stress disorder, addiction and Alzheimer’s disease. This proceedings summarizes the advances discussed at the Eighth Annual DBS Think Tank. (shrink)

Patients with advanced Alzheimer's disease experience cognitive impairment and physical disabilities in daily life. Currently, there are no treatments available to slow down the course of the disease, and limited treatments exist only to treat symptoms. However, deep brain stimulation of the nucleus basalis of Meynert has been reported to improve cognitive function in individuals with AD. Here, we report the effects of NBM-DBS on cognitive function in a subject with severe AD. An 80-year-old male with severe AD underwent surgery (...) for bilateral NBM-DBS electrode placement. After 10 weeks of stimulation, Mini-Mental State Examination assessment improved from a score of 5 to 9 points, and assessment using the Alzheimer's Disease Assessment Scale–Cognitive Subscale showed a marked reduction in total score from 43 to 33 points, suggesting cognitive benefits from NBM-DBS. The patient's postoperative course was complicated by a subdural effusion that occurred several days after surgery, with complete recovery. Interestingly, the subject also displayed abnormal thermoregulation with stimulation initiation and stimulation parameter modifications. NBM-DBS may serve as a potential therapy for severe AD patients.Clinical Trial Registration: ChiCTR1900022324. (shrink)

In this essay, I respond to a problem raised by Sarah Broadie in her 1987 article “Nature, Craft and Phronesis in Aristotle.” Broadie analyzes Aristotle’s famous craft analogy for natural causation in order to determine whether or not it requires importing a psychological dimension to natural teleology. She argues that it is possible to make sense of the analogy without psychology, but that the tradeoff is a conception of craft so thoroughly de-psychologized that it is rendered unrecognizable, perhaps even incoherent (...) as a referent. I dispute this suggestion and argue, rather, that Aristotle’s insistence on removing psychology from the craft side of the analogy points to his prioritization of techne itself, rather than any particular craftsman, as primary efficient agent. The lack of psychology that characterizes a techne ensures stability and reliability in the causal process that could not be guaranteed by the idiosyncratic psychologies of various craftspeople. The same kind of stability and reliability belong to nature as an efficient cause, forming the basis of the comparison between craft and natural teleology. It is therefore the craft, not the craftsman, that must stand as analog to nature. I demonstrate the value of this revision by applying the analogy to the case of natural teleology: reproduction as depicted in Aristotle’s Generation of Animals. The result is a reading of Aristotle’s analogies that can assuage Broadie’s concerns and allow for a natural thing’s own nature to more fully inhabit its intended role as an inner source of change. (shrink)

This article shows that William E. Connolly’s work holds resources for projects of racial justice but must be revised to fully meet the challenge of racial inequality. There are two interrelated problems in Connolly’s theory: first, the drive to destabilize identity, for which he argues, rejects the need for collective identity, which is necessary in democratic politics. Furthermore, because domination renders identity unstable, the call to destabilize identity places too great a burden on already marginalized groups. The problem of destabilizing (...) identity is underwritten by a second problem: the white working class and its grievances occupy too important a position in Connolly’s analysis. This article uses insights provided by James Baldwin to amend Connolly’s contributions. The article argues that there is a need to destabilize the ‘we’ of American politics that allows white, male identity to occupy the ‘heart’ of liberal democracy. Baldwin’s insights help solve the problem of the ‘black hole’ at the center of liberal democracy which, Connolly argues, sustains fundamentalism and racial injustice. This article’s contribution is to amend Connolly’s work to meet the challenge of racial injustice, offer a novel reading of the place of political imagination in Baldwin’s work, and show how political imagination adds depth to conversations about democracy, racial justice, and pluralism. (shrink)

Despite the moral gravity and far-reaching consequences of ethical judgment, evidence shows that such judgment is surprisingly malleable, prone to bias, informed by intuition and implicit associations, and swayed by mere circumstance. In this vein, this research examines how mere colors featured in logos can bias consumers’ ethical judgments about a retailer. Exposure to a logo featuring an eco-friendly color makes an ethically ambiguous practice seem more ethical; however, exposure to a logo featuring a non-eco-friendly color makes the same practice (...) seem less ethical. This effect is due to the embodied meaning of color, not referential meanings associated with the names of colors, and it is mediated by perceptions of a retailer’s eco-friendliness. Furthermore, although the word “green” appears to influence ethical ratings of retail practices more than the word “blue,” visual exposure to either color evokes similar perceptions of eco-friendliness and influences ethical judgments. Study 2c assesses and rules out alternative explanations for this effect. Critically, an eco-friendly color can skew judgments even when the practices judged are not ethically ambiguous. Individual differences in ethical sensitivity moderate the observed effect, such that individuals who are less ethically sensitive are less influenced by color. The article concludes with a discussion on how logo colors shape consumers’ perceptions of retailer ethicality. (shrink)

Anthology of articles on the integral philosophy of Sri Aurobindo Ghose, 1872-1950, modern Indian philosopher.

On Viśiṣṭādvaita philosophy of Rāmānuja, 1017-1137.

Several facets of learning, include imaginative writing transformed from digital technologies. Writing creatively fosters students' creativity and critical thinking abilities, an essential part of literacy education. The long-term effects of digital technologies on imaginative writing skills (IWS), despite the increasing usage. The potential of digital tools diversions might constitute the intended benefits and the application of these technologies utilized in educational institutions. The study aims to investigate how digital tool improve writing skills and develop innovative writing abilities by fostering creativity. (...) The research intends to identify which digital tools offer the most significant benefits and how integrated into educational practices to support imaginative writing development. This study included a total of 60 participants, including males (28) and females (32) for imaginative writing skills. Utilizing SPSS software, a statistical analysis of the data was carried out. The data was analyzed using a t-test, ANOVA, and regression analyses. These analyses demonstrated imaginative writing skills. The research findings demonstrated that digital tools greatly enhanced participant’s creative writing skills, vocabulary growth and story structure. The use of digital tools could significantly improve participant’s capacity for imaginative writing skill development. (shrink)

Morality is an abstract consideration, and language is an important regulator of abstract thought. In instances of moral ambiguity, individuals may pay particular attention to matters of interactional justice. Politeness in language has been linked to greater perceptions of social distance, which we contend is instrumental in regulating attitudes toward a brand. We posit that politeness in a brand’s advertising will impact consumers who are attuned to violations of interactional justice [i.e., those with low belief in a just world ]. (...) In three studies, we demonstrate that the politeness used in advertising as well as consumers’ individual differences in BJW affect judgments and attitudes toward brands. Specifically, individuals with a low just world belief are more likely to harbor negative attitudes towards a brand with ethically ambiguous business practices if the language used in advertising is impersonal than when the language used in advertising is personal. Importantly, for individuals with a low BJW, lowered trust due to the advertisement’s language mediated the relationship between politeness and attitudes toward the brand. Theoretical and managerial implications of this research are discussed. (shrink)

Ayurveda is a traditional system of healthcare that is native to India and has a rich documented literature of its own. Most of the historians agree that the documentation of core Ayurveda literature took place approximately in between 400 BCE and 200 CE, while acknowledging that the roots of its theoretical framework can be traced back to a much earlier period. For multiple reasons many significant contributions of Ayurveda literature to various streams of biological and medical sciences have remained under-recognized (...) while recounting the historical milestones of development. This is true in the context of the physiology of digestion and metabolism too. In this communication we try to reconstruct a picture of the processes of digestion and metabolism as had been understood by ancient Ayurveda scholars. Though this understanding was primitive and insufficient in many ways, we argue that this deserves to be documented and acknowledged. To help with grasping the importance of these contributions, we juxtapose them with the corresponding insights pertaining to this subject reported by prominent western scientists. The major contributions of Ayurveda that have been recounted in this paper are those related to the description of three distinct phases of digestion (Avasthapaka), multiple sets of transformative entities acting at different levels of metabolism (Agni), and the roles ascribed to various internal and external factors in executing these physiological functions. (shrink)

This paper explores how educators might intervene in canonized texts of the human subject on which a particular and exclusive kind of humanism rests. In imagining possible interventions educators might make, I turn to and trace Jacques Derrida's on‐going deconstruction of the philosophical texts of subjectivity. In his body of work, Derrida destabilizes fixed notions of the human subject and the institutions it founds . From Derrida's points of destabilization and through a differing but similar deconstructive stance, I also consider (...) Gayatri Spivak's suggestive question ‘Who is not the subject of humanism?’ to provide another possible trajectory for intervention that educators might take. Departing from knowledge‐based conceptions of human subjectivity, Spivak urges educators to respond to their students in meaningful encounter with the ‘Other’ while Derrida suggests human beings might begin the difficult and complex task of re‐envisioning an altered humanism, a humanism founded on the call of the Other in institutional sites like education. By an engaged rereading of the texts of human subjectivity upon which human beings are written and by turning to respond to the face of the human beings in and outside their classrooms as a means of encountering the Other's humanity, I suggest that educators be the catalyst for changing what it means to be human and education the means by which we approach a humanism yet to be. (shrink)

"Darshanika Cintan ke Vividha Āyāma" (Diverse dimensions of philosophical thinking), is a compilation book of various research articles in which the discursive diversity of philosophy is reflected. On the one hand, it pursues the basic problems of philosophy, such as the relevance of philosophy, the nature and justification of metaphysics, the metaphysical analysis of the nature of value, etc., while on the other hand, it Is involved in the analysis and testing of the concept of life-world, globalization and multiculturalism, environmental (...) ethics and applied ethics etc. Proper analysis and evaluation of the most important problems of Indian epistemology, for example, the idea of syntax (Vākyārtha Vicāra), Prāmanyavāda , and the issue of evidential implication (Pramānatarabhāva), has been heuristically presented. Some lively topics of contemporary Indian philosophy like Logical conclusion of Manvendra Nath Roy's materialism, Kant's influence on contemporary Indian philosophy, Post-independence Indian philosophical thinking, and the future form of Indian philosophy are included. There is a unique combination of linguistic beauty and clarity, systematic presentation, critical attitude and philosophical insight in the writings of the author duo. This is undoubtedly a valuable work which deserves to be welcomed by teachers, scholars and students of philosophy. (shrink)

Organizational ambidexterity (OA)—the simultaneous pursuit of explorative and exploitative innovations—engenders nested (paradoxes manifesting across organizational levels) and knotted paradoxes (intertwined co-occurring paradoxes at the same or across organizational levels). Both nested and knotted paradoxes are managed by internal stakeholders using approaches that are socially constructed by influences emanating from within and beyond an organization. External stakeholders also help shape organizational innovations but their influence on the management of paradoxes has largely been overlooked. In this study, we collected and analyzed data (...) from internal ( n = 19) and external stakeholders ( n = 18) in organizations pursuing explorative and exploitative clean energy transitions at nine Canadian energy utilities. We find that the external stakeholders engage with knotted inclusivity–efficiency and existing–emerging needs paradoxes. Our findings add to OA and business and society literature by revealing how the approaches that internal and external stakeholders adopt for paradox management have implications for each other, and thus OA. We also provide practical insight into how external stakeholder paradoxes can be managed through stakeholder inclusivity and enhanced transparency of innovation plans, with positive implications for OA. (shrink)

This book offers the first comparative account of the changes and stabilities of public perceptions of science within the US, France, China, Japan, and across Europe over the past few decades. The contributors address the influence of cultural factors; the question of science and religion and its influence on particular developments (e.g. stem cell research); and the demarcation of science from non-science as well as issues including the incommensurability versus cognitive polyphasia and the cognitive (in)tolerance of different systems of knowledge.