Reproductive genetic carrier screening provides information about people's chance of having children with certain genetic conditions. Severity of genetic conditions is an important criterion for their inclusion in carrier screening programmes. However, the concept of severity is conceptually complex and underspecified. We analyse why severity is an important concept in carrier screening and for reproductive decision-making and show that assessments of severity can also have normative societal implications. While some genetic conditions are unambiguously associated with a high degree of suffering, (...) there are many factors that contribute to how severe a condition is perceived to be, and perspectives will vary. Attempts to classify genetic conditions according to their severity tend to prioritise biomedical information at the expense of incorporating qualitative aspects of the impact of genetic conditions on people's lives. Further complexity arises because some genotypes can present with variable phenotypes and because some conditions are not always experienced in the same way by all people who have them. To acknowledge this complexity, we argue that an understanding of severity needs to distinguish between the severity of a genetic condition—requiring a generalised approach for purposes of policy development and programme design—and the severity of an instance of a genetic condition in a particular person. Families making reproductive decisions also require access to diverse experiences of the qualitative aspects of living with genetic conditions. As a result, reproductive carrier screening programmes must recognise and respond to the complexity inherent in determining the severity of genetic conditions. (shrink)

This essay concerns the theories of the sublime proposed by Alexander Gerard, Henry Home (Lord Kames), Archibald Alison, and Dugald Stewart. All four thinkers, I argue, aim to provide a philosophical account of the unity of the concept of the sublime, i.e., to respond to the question: what might all objects, art works, etc. that have been identified as sublime (or “grand”) in the philosophical, literary, art-theoretical, and rhetorical tradition have in common? Yet because they find the objects (...) called “sublime” to be so disparate, and because – contra Burke and Kant, the classical philosophical theorists of the sublime, they cannot identify one single feeling that could define the experience of the sublime, they ultimately endorse (what we would call) a “family-resemblance” view of the sublime: certain objects cause in us certain feelings (and so are classed together); other objects are then (for other reasons, i.e., not because they give us similar feelings) associated with some of the previous objects – and therefore we take these objects, and the feelings they may arouse, as sublime as well. Some – notably Gerard and Allison – take our act of appreciation of the sublime to be itself an act of free imaginative association, connecting the perceived object to other objects, memories, feelings, etc. The importance of association in aesthetic appreciation itself might also suggest that the category of the sublime must be a pluralistic and open one: because we may always find new objects sublime, via new associations. As a result, I suggest, these thinkers – by contrast to many other writers on the sublime – allow that art can be as sublime, or even more sublime, than natural objects and indeed can render natural objects sublime. (shrink)

The authors of this volume — all of them recognized representatives of a wide range of academic disciplines — agree that Locke’s work must have had a considerable influence both on English and German literature and the visual arts of Great Britain, especially in the eighteenth and nineteenth centuries. From the perspective of interdisciplinarity and intertextuality, the essays presented here deal with Locke as a source of ideas for Archibald Alison, John Constable, Daniel Defoe, Henry Fielding, Oliver Goldsmith, (...) Johann Timotheus Hermes, William Hogarth, Immanuel Kant, Martin Knutzen, Gottfried Wilhelm von Leibniz, Gotthold Ephraim Lessing, George Lillo, Edward Moore, Johann Gottwerth Müller, Joshua Reynolds, Samuel Richardson, John Ruskin, Joseph Spence, Laurence Sterne, J. M. W. Turner and Thomas Whately, among others. (shrink)

Values of Beauty discusses major ideas and figures in the history of aesthetics from the beginning of the eighteenth century to the end of the twentieth century. The core of the book features Paul Guyer's essays on the epochal contribution of Immauel Kant, and sets Kant's work in the context of predecessors, contemporaries, and successors including David Hume, Alexander Gerard, Archibald Alison, Arthur Schopenhauer, and John Stuart Mill All of the essays emphasize the complexity rather than isolation of (...) our aesthetic experience of both nature and art; and the interconnection of aesthetic values such as beauty and sublimity on the one hand, and prudential and moral values on the other. Guyer emphasizes that the idea of the freedom of the imagination as the key to both artistic creation and aesthetic experience has been a common thread throughout the modern history of aesthetics, although the freedom of the imagination has been understood and connected to other forms of freedom in a variety of ways. (shrink)

Summary Although Sir William Forbes of Pitsligo's An Account of the Life and Writings of James Beattie has long served as an invaluable resource for those interested in Beattie's life and thought, there has been little scholarship on the genesis of Forbes's book. This article considers the role played by Dugald Stewart—as well as that of his friend, Archibald Alison—in the making of Forbes's Life of Beattie. It also examines the reasons for Forbes's decision not to print Stewart's (...) letter in its entirety in the Life of Beattie and explores the letter's significance for understanding Stewart's philosophical development. (shrink)

Causes always seem to come prior to their effects. What might explain this asymmetry? Causation's temporal asymmetry isn't straightforwardly due to a temporal asymmetry in the laws of nature—the laws are, by and large, temporally symmetric. Nor does the asymmetry appear due to an asymmetry in time itself. This Element examines recent empirical attempts to explain the temporal asymmetry of causation: statistical mechanical accounts, agency accounts and fork asymmetry accounts. None of these accounts are complete yet and a full explanation (...) of the temporal asymmetry of causation will likely require contributions from all three programs. (shrink)

There are temporal asymmetries in our attitudes towards the past and future. For example, we judge that a given amount of work is worth twice as much if it is described as taking place in the future, compared to the past :796–801, 2008). Does this temporal value asymmetry support a tensed metaphysics? By getting clear on the asymmetry’s features, I’ll argue that it doesn’t. To support a tensed metaphysics, the value asymmetry would need to not vary with temporal distance, apply (...) equally to events concerning oneself and others, and be rational and judged to be so. But evidence suggests the value asymmetry lacks these features. There are, moreover, independent arguments against its rationality. The asymmetry’s features suggest instead that it arises as an emotion-driven generalisation from a temporal bias concerning our future actions. This explanation points towards mechanisms that can play a role in explaining other instances where we generalise about the past and future, and why we’re tempted towards metaphysical pictures of time. (shrink)

We standardly evaluate counterfactuals and abilities in temporally asymmetric terms—by keeping the past fixed and holding the future open. Only future events depend counterfactually on what happens now. Past events do not. Conversely, past events are relevant to what abilities one has now in a way that future events are not. Lewis, Sider and others continue to evaluate counterfactuals and abilities in temporally asymmetric terms, even in cases of backwards time travel. I’ll argue that we need more temporally neutral methods. (...) The past shouldn’t always be held fixed, because backwards time travel requires backwards counterfactual dependence. Future events should sometimes be held fixed, because they’re in the causal history of the past, and agents have evidence of them independently of their decisions now. We need temporally neutral methods to maintain connections between causation, counterfactuals and evidence, and if counterfactuals are used to explain the temporal asymmetry of causation. (shrink)

Reichenbach explains temporally asymmetric phenomena by appeal to entropy and ‘branch structure’. He explains why the entropic gradients of isolated subsystems are oriented towards the future and not the past, and why we have records of the past and not the future, by appeal to the fact that the universe is currently on a long entropic upgrade with subsystems that branch off and become quasi-isolated. Reichenbach’s approach has been criticised for relying too closely on entropy. The more popular approach nowadays (...) is to appeal instead to a particular low-entropy initial state—Albert’s ‘Past Hypothesis’. I’ll argue that this neglect of Reichenbach’s approach is unwarranted. A Reichenbachian account has important advantages over Albert’s: it correctly identifies the minimal temporally asymmetric posit needed to derive key temporally asymmetries and it offers a more adequate account of the record asymmetry. While a Reichenbachian account needs to be supplemented, it provides the right foundations for explaining temporally asymmetric phenomena and what we might ultimately mean by ‘the direction of time’. (shrink)

David Albert explains why we can typically influence the future but not the past by appealing to an initial low-entropy state of the universe. And he argues that in the rare cases where we can influence the past, we cannot use this influence to knowingly gain future rewards: so it does not constitute control. I introduce an important new case in which Albert's account implies we can not only influence the past but control it: a case where our actions in (...) the present are reliably correlated with several events in the present and past. To deal with such cases, we need to appeal to epistemic conditions on deliberation: being agents requires our decisions being epistemically undetermined at the time we make them. In a world with the past-hypothesis, this implies that deliberation will typically come prior to decision. Once deliberation in this direction is established, correlations towards the past cannot then be exploited for control. To explain why we cannot effectively control the past, we need to appeal to deliberation, whether as part of a defence of Albert's account, or used independently to explain the asymmetry of control. (shrink)

When we deliberate about what to do, we appear to be free to decide on different options. Three accounts use ordinary beliefs to explain this apparent freedom—appealing to different types of ‘epistemic freedom’. When an agent has epistemic freedom, her evidence while deliberating does not determine what decision she makes. This ‘epistemic gap’ between her evidence and decision explains why her decision appears free. The varieties of epistemic freedom appealed to might look similar. But there is an important difference. Two (...) rely on an agent's ability to justifiably form beliefs unconstrained by evidence, and identify decisions as beliefs—either beliefs about acts or about decisions. But, when used to explain apparent freedom, these accounts face serious problems: they imply that agents have epistemic freedom over evidence-based beliefs, and rely on a faulty notion of justification. Underlying these troubles, it turns out that these accounts presuppose an unexplained apparent ability to form different beliefs. A third variety of epistemic freedom uses ignorance conditions instead (Levi and Kapitan). We appear free partly because we’re ignorant of what we’ll decide. Ignorance-based accounts avoid the above problems, and remain a promising alternative. (shrink)

Do time travellers retain their normal freedom and abilities when they travel back in time? Lewis, Horwich and Sider argue that they do. Time-travelling Tim can kill his young grandfather, his younger self, or whomever else he pleases—and so, it seems can reasonably deliberate about whether to do these things. He might not succeed. But he is still just as free as a non-time traveller. I’ll disagree. The freedom of time travellers is limited by a rational constraint. Tim can’t reasonably (...) deliberate on killing his grandfather, certain that he’ll fail. If Tim follows his evidence, and appropriately self-predicts, he will be certain he won’t kill his grandfather. So if Tim is both evidentially and deliberatively rational, he can’t deliberate on killing his grandfather. This result has consequences. Firstly, it shows how evidential limits in the actual world contribute to our conception of the future as open. Secondly, it undercuts arguments against the possibility of time travel. Thirdly, it affects how we evaluate counterfactuals in time travel worlds, as well as our own. I’ll use the constraint to motivate an evidential and temporally neutral method of evaluating counterfactuals that holds fixed what a relevant deliberating agent has evidence of, independently of her decision. Using this method, an agent’s local abilities may be affected by what happens globally at other times, including the future. (shrink)

This paper reflects on the challenges of writing long conceptual histories of sexual medicine, drawing on the approaches of Michel Foucault and of Reinhart Koselleck. Foucault’s statements about nineteenth-century rupture considered alongside his later-life emphasis on long conceptual continuities implied something similar to Koselleck’s own accommodation of different kinds of historical inheritances expressed as multiple ‘temporal layers.’ The layering model in the history of concepts may be useful for complicating the historical periodizations commonly invoked by historians of sexuality, overcoming historiographic (...) temptations to reduce complex cultural and intellectual phenomena to a unified Zeitgeist. The paper also shows that a haunting reference to ‘concepts’ among scholars of the long history of sexual medicine indicates the emergence of a de facto methodology of conceptual history, albeit one in need of further refinement. It is proposed that reading Koselleck alongside Foucault provides a useful starting-point for precisely this kind of theoretical development. (shrink)

BackgroundThere is concern in the academic publishing community that it is becoming more difficult to secure reviews for peer-reviewed manuscripts, but much of this concern stems from anecdotal and rhetorical evidence.MethodsWe examined the proportion of review requests that led to a completed review over a 6-year period (2009–2015) in a mid-tier biology journal (Molecular Ecology). We also re-analyzed previously published data from four other mid-tier ecology journals (Functional Ecology, Journal of Ecology, Journal of Animal Ecology, and Journal of Applied Ecology), (...) looking at the same proportion over the period 2003 to 2010.ResultsThe data from Molecular Ecology showed no significant decrease through time in the proportion of requests that led to a review (proportion in 2009 = 0.47 (95 % CI = 0.43 to 0.52), proportion in 2015 = 0.44 (95 % CI = 0.40 to 0.48)). This proportion did decrease for three of the other ecology journals (changes in proportions from 2003 to 2010 = −0.10, −0.18, and −0.09), while the proportion for the fourth (Functional Ecology) stayed roughly constant (change in proportion = −0.04).ConclusionsOverall, our data suggest that reviewer agreement rates have probably declined slightly but not to the extent suggested by the anecdotal and rhetorical evidence. (shrink)

This book presents a straightforward account of disease, the problems of practice, and the moral, legal and financial questions in the field.

The US food regime maintained some degree of stability in terms of prices and production levels for commodities in the world economy. This food regime, resting on supply management policy, began to falter in the early 1970s. In the late-1980s and 1990s, notable changes occurred in the world economy regarding agriculture as the food regime became more market-oriented. The end of the twentieth century saw the breakdown of many institutions, organizations, and international agreements that had tried to stabilize prices and (...) production from 1945 to 1975. This paper examines this period of change and explores the effects on five commodities: cocoa, coffee, corn, soybeans, and wheat. These commodities offer important points of comparison. First, while cocoa, coffee, and wheat were regulated by international organizations and agreements, corn and soybeans were not. Second, the US dominated the international corn and soybean markets, but the cocoa, coffee, and wheat markets were much more competitive. And third, corn, soybeans, and wheat were commodities largely produced in the core of the world economy, while cocoa and coffee were produced in the periphery. Thus, comparing the effect of the fall of the US food regime on these commodities reveals the importance of previous regulation, the level of market competition, and geographic origin in the world economy. (shrink)

Ricœur lectured and wrote for over twenty years on negation (‘Do I understand something better if I know what it is not, and what is not-ness?') and never published his extensive writings on this subject. Ricœur concluded that there are multiple forms of negation; it can, for example, be the other person (Plato), the not knowable nature of our world (Kant), the included opposite (Hegel), apophatic spirituality (Plotinus on not being able to know God) and existential nothingness (Sartre). Ricœur, working (...) on Kant, Hegel and Sartre, decided that all these forms of negation are incompatible and also fatally flawed because they fail to resolve false binaries of negative: positive. Alison Scott-Baumann demonstrates how Ricœur subsequently incorporated negation into his linguistic turn, using dialectics, metaphor, narrative, parable and translation in order to show how negation is in us, not outside us: language both creates and clarifies false binaries. He bestows upon negation a strong and central role in the human condition, and its inevitability is reflected in his writings, if we look carefully. Ricœur and the Negation of Happiness draws on Ricœur's published works, previously unavailable archival material and many other sources. Alison Scott-Baumann argues that thinking positively is necessary but not sufficient for aspiring to happiness - what is also required is affirmation of negative impulses: we know we are split by contradictions and still try to overcome them. She also demonstrates the urgency of analysing current socio-cultural debates about wellbeing, education and equality, which rest insecurely upon our loose use of the negative as a category mistake. (shrink)

The question of bias in methodology and terminology is a problem that faces researchers east, west, north and south; however, it faces Third World intellectuals with special keenness. For although they write in a cultural environment that has its own specific conceptual and cultural paradigms, they nevertheless encounter a foreign paradigm which attempts to impose itself upon their society and upon their very imagination and thoughts. When the term “developmental psychology” for instance is used in the West Arab scholars also (...) say “developmental psychology”, when “applied psychology” is mentioned they hurry to use the same term etc. Why not establish a new science with its own mechanisms, methodologies and points of reference to deal with epistemological biases and open up the gate of ijtihad with respect to them? This collection of papers aims to discover some of the biases latent in our terminology, methodologies, research tools, and conceptual principles, and to propose alternative ones marked by a greater degree of independence and neutrality. This is not to belittle the human value of the West’s creative contributions but to emphasize the danger of making it the ultimate point of reference and then trying to continuously play “catch up” with it. (shrink)

Investors with a pro-social or sustainability agenda increasingly attempt to influence firm managers to adopt socially responsible behavior, either through positive/reward tactics or negative/punishment tactics. This paper considers how investors can use each approach to differentially influence managers to make more CSR investments. The paper uses game theory with an all-pay contest structure to model how a large institutional investor could reward firms for CSR activities by creating a socially responsible investment fund (reward contest) or punish firms via shareholder activism (...) (punishment contest). We identify conditions under which the punishment contest induces a higher level of CSR activity among firms compared to the reward contest. Managers bearing substantial private costs stemming from the activism is one such condition. Spillover effects are seen as the other managers in the economy engage in CSR to avoid being punished by the investor’s activism. This level of engagement is not the case when rewards are used—only those managers with an expectation of being rewarded increase their CSR activity in that scenario. This suggests, for example, that incorporating thresholds or tiers (e.g. gold, silver, and bronze-level winners) can increase the effectiveness of reward contests. Implications for designing both positive and negative CSR inducements are explored. We also identify the ethical dilemmas that relate to such influence attempts. (shrink)

Cook et al. overstate the evidence supporting their associative account of mirror neurons in humans: most studies do not address a key property, action-specificity that generalizes across the visual and motor domains. Multivariate pattern analysis of neuroimaging data can address this concern, and we illustrate how MVPA can be used to test key predictions of their account.

Despite the increasing focus on rationing, and rationing decisions in the NHS, little attention has been given to patient's perceptions of rationing and the potential impact this might have on people's use of services. Drawing on the qualitative findings of a study conducted in the North West of England which was concerned with the pattern and processes of primary care help seeking, this paper sets out to examine perceptions and experiences of rationing in primary care and the potential impact this (...) has on people's use of services. In relation to primary care services people had experienced rationing by deterrence, dilution and delay. There was some evidence that perceptions of rationing impacted on help seeking and the use of primary care services. The implications for understanding the way in which perceptions of rationing might influence the formulation of demand and help seeking by people using primary care services are discussed. (shrink)

La pandémie de COVID-19 a eu un effet mondial. L’impact disproportionné sur les peuples autochtones et les groupes racialisés a mis les défis éthiques au premier plan dans la recherche et la pratique clinique. Au Canada, l’Énoncé de politique des trois Conseils (EPTC2), et plus particulièrement le principe de justice, met l’accent sur les soins supplémentaires à apporter aux personnes « dont les circonstances les rendent vulnérables », notamment les communautés autochtones et racialisées. En l’absence de données fondées sur la (...) race pour mesurer et éclairer la recherche en santé et la pratique clinique, nous courons le risque de causer plus de tort et de contribuer à des injustices continues. Toutefois, en l’absence d’un cadre accepté pour la collecte, la tenue à jour et la communication des données fondées sur la race au Canada, il est nécessaire d’obtenir davantage de conseils sur la façon de bien faire les choses. Il est important de noter qu’un cadre pour la collecte de données fondées sur la race devrait s’appuyer sur les directives existantes des communautés autochtones et d’autres communautés structurellement marginalisées, sur l’EPTC2, sur les recommandations de l’Organisation mondiale de la santé et sur la participation des intervenants concernés. Dans le présent document, nous décrivons des exemples historiques d’études non éthiques sur les Autochtones et les groupes racialisés, nous discutons des défis et des avantages potentiels de la collecte de données fondées sur la race, et nous concluons par les objectifs d’un cadre pancanadien visant à informer la façon dont les données fondées sur la race sont recueillies, stockées et accessibles dans la recherche en santé. (shrink)

Advancements in fetal assessment and therapeutic intervention in medical practice and clinical research call for corresponding progress in regulatory and ethical guidance. In “A new ethical framewo...

PurposeThe purpose of this paper is to examine how the design of characteristics and use of practices incorporated in customer relationship management information systems (CRM‐IS) impact on the expression and realisation of moral agency within organisations.Design/methodology/approachThe paper draws on the findings from an in‐depth UK case study of a CRM‐IS implementation.FindingsThe paper finds that some characteristics and practices within CRM‐IS can restrict the expression and realisation of moral agency in organisational life, resulting in a number of problems. For a greater (...) consideration of MacIntyre's virtue ethics approach in order to respond to such challenges is argued.Originality/valueThe paper offers a relatively rare insight into the significance of the ethical issues arising from the organisational use of CRM‐IS and strategies. The paper should be of interest to managers, computer professionals and academics. (shrink)

In this article I argue for a model of Deweyan 'critical pragmatism' as a therapeutic alternative to traditional models of deliberative democracy that have been crippled by their inheritance of the threadbare liberal/communitarian debate. By orienting my discussion here with respect to the most serious radical democratic challenges to deliberative democracy, I hope to show how Deweyan critical pragmatism may help us develop new approaches to the theory and practice of deliberation that are both more attuned to power relations than (...) traditional models and make more inventive use of everyday life to pursue more meaningful deliberative opportunities for citizens. (shrink)

In the UK, regulation of clinical services is being restructured. We consider two clinical procedures, abortion and IVF treatment, which have similar ethical and political sensitivities. We consider factors including the law, licensing, inspection, amount of paperwork and reporting requirements, the reception by practitioners and costs, to establish which field has the greater ‘regulatory burden’. We test them based on scientific, ethical, social, political factors that might explain differences. We find that regulatory burden borne by IVF services is greater than (...) in abortion, but none of the explanatory theses can provide a justification of this phenomenon. We offer an alternative explanation based on regulatory ‘overspill’ from research regulation and policy making, conceptualisation of risk regulation and a high public profile that locks a regulator into self-preservation. (shrink)

This is the third selection of major works on the Scottish Enlightenment and includes the same combination of hard-to-find and popular works as in the two previous collections. Contents: An Essay on the Natural Equality of Men [1793] William Lawrence Brown, New introduction by Dr. William Scott 308 pp An Enquiry into the Origin of Moral Virtue [1733] Archibald Campbell 586 pp The Philosophical Works [1765] William Dudgeon, New introduction by David Berman 300 pp Institutes of Moral Philosophy For (...) the use of Students in the College of Edinburgh [1769] Adam Ferguson 340 pp A Comparative view of the State and Faculties of Man with those of the Animal World [1774] John Gregory 426 pp An Apology for the Life and Writings of David Hume, Esq [1777] Samuel Jackson A Letter to Adam Smith, On the Life, Death and Philosophy of his friend David Hume Esq [1777] George Horne (Bishop of Norwich) 252 pp. (shrink)

Recently, the theory theory has led to much interesting research. However, this is the first book to look at the theory in extensive detail and to systematically contrast it with other theories.

Recent exciting work on Cavendish’s natural philosophy highlights the important role of motion in her system. But what is motion, according to Cavendish? I argue that motion, for Cavendish, is what I call ‘compositional motion’: for a body to be in motion is just for it to divide from some matter and join with other matter. So when Cavendish claims to reduce all natural change to motion, she is really reducing all natural change to mereological change. Cavendish also uses ‘motion’ (...) to name the power that matter has to set itself in compositional motion. That power is not reducible to local motion. If motion is not local motion and if motive power is not a function of actual motion, then despite her polemics, Cavendish does not reduce natural change to local motion. Instead, she offers a unique and exciting account of natural change. (shrink)