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Ariella Binik
McMaster University
  1.  10
    On the Minimal Risk Threshold in Research With Children.Ariella Binik - 2014 - American Journal of Bioethics 14 (9):3-12.
    To protect children in research, procedures that are not administered in the medical interests of a child must be restricted. The risk threshold for these procedures is generally measured according to the concept of minimal risk. Minimal risk is often defined according to the risks of “daily life.” But it is not clear whose daily life should serve as the baseline; that is, it is not clear to whom minimal risk should refer. Commentators in research ethics often argue that “minimal (...)
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  2. Does Clinical Equipoise Apply to Cluster Randomized Trials in Health Research?Ariella Binik, Charles Weijer, Andrew McRae, Jeremy Grimshaw, Monica Taljaard, Robert Boruch, Jamie Brehaut, Allan Donner, Martin Eccles, Antonio Gallo, Raphael Saginur & Merrick Zwarenstein - 2011 - Trials 12.
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  3. Logistic, Ethical, and Political Dimensions of Stepped Wedge Trials: Critical Review and Case Studies.Audrey Prost, Ariella Binik, Abubakar Ibrahim, Anjana Roy, Manuela de Allegri, Christelle Mouchoux, Tobias Dreischulte, Helen Ayles, James J. Lewis & David Osrin - 2015 - Trials 1 (16):351.
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  4. When is Informed Consent Required in Cluster Randomized Trials in Health Research?Andrew D. McRae, Ariella Binik, Charles Weijer, Angela White, Jeremy M. Grimshaw, Robert Boruch, Jamie C. Brehaut, Allan Donner, Martin P. Eccles, Raphael Saginur, Merrick Zwarenstein & Monica Taljaard - 2011 - Trials 1 (12):202.
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  5.  76
    Why the Debate Over Minimal Risk Needs to Be Reconsidered.Ariella Binik & Charles Weijer - 2014 - Journal of Medicine and Philosophy 39 (4):387-405.
    Minimal risk is a central concept in the ethical analysis of research with children. It is defined as the risks “. . . ordinarily encountered in daily life . . . .” But the question arises: who is the referent for minimal risk? Commentators in the research ethics literature often answer this question by endorsing one of two possible interpretations: the uniform interpretation or the relative interpretation of minimal risk. We argue that describing the debate over minimal risk as a (...)
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  6. Ethical Issues Posed by Cluster Randomized Trials in Health Research.Charles Weijer, Jeremy M. Grimshaw, Monica Taljaard, Ariella Binik, Robert Boruch, Jamie C. Brehaut, Allan Donner, Martin P. Eccles, Antonio Gallo, Andrew D. McRae & Ray Saginur - 2011 - Trials 1 (12):100.
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  7.  18
    Minimal Risk Remains an Open Question.Ariella Binik, Charles Weijer & Mark Sheehan - 2011 - American Journal of Bioethics 11 (6):25 - 27.
    The American Journal of Bioethics, Volume 11, Issue 6, Page 25-27, June 2011.
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  8. Who is the Research Subject in Cluster Randomized Trials in Health Research?Andrew D. McRae, Ariella Binik, Charles Weijer, Jeremy M. Grimshaw, Monica Taljaard, Robert Boruch, Jamie C. Brehaut, Allan Donner, Martin P. Eccles, Antonio Gallo, Ray Saginur & Merrick Zwarenstein - 2011 - Trials 1 (12):118.
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  9.  6
    Position Statement on Ethics, Equipoise and Research on Charged Particle Radiation Therapy.Mark Sheehan, Claire Timlin, Ken Peach, Ariella Binik & Wilson Puthenparampil - 2014 - Journal of Medical Ethics 40 (8):572-575.
    The use of charged-particle radiation therapy is an increasingly important development in the treatment of cancer. One of the most pressing controversies about the use of this technology is whether randomised controlled trials are required before this form of treatment can be considered to be the treatment of choice for a wide range of indications. Equipoise is the key ethical concept in determining which research studies are justified. However, there is a good deal of disagreement about how this concept is (...)
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  10.  18
    Rethinking Risk in Pediatric Research.Kathleen Cranley Glass & Ariella Binik - 2008 - Journal of Law, Medicine and Ethics 36 (3):567-576.
    This article reviews four areas of pediatric research in which we have identified questionable levels of allowable risk, exceeding those foreseen by the Commission. They are the following: the categorization of increasingly risky interventions as minimal risk in a variety of protocols; the increasing number of applications for federal panel review of research not otherwise approvable because of higher projected risk levels; research on asymptomatic at risk children; and the inclusion of children and adolescents in placebo-controlled trials for participants of (...)
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  11.  4
    An Ethical Justification for Research with Children.Ariella Binik - unknown
    This thesis is a contribution to the ethical justification for clinical research with children. A research subject’s participation in a trial is usually justified, in part, by informed consent. Informed consent helps to uphold the moral principle of respect for persons. But children’s limited ability to make informed choices gives rise to a problem. It is unclear what, if anything, justifies their participation in research. Some research ethicists propose to resolve this problem by appealing to social utility, proxy consent, arguments (...)
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  12.  18
    Minimal Risk Revisited: The Ethics of Clinical Research with Children.Ariella Binik - unknown
    One of the central problems concerning research with children is the delineation of appropriate levels of risk exposure. In the U.S. Code of Federal Regulations, the "minimal risk" concept serves as an anchoring measure for allowable risk. While the regulations sought to promote a balance between scientific advances and the protection of children's vulnerable status, ambiguities in the language of the regulations and the regulatory definition of "minimal risk" have given rise to a great deal of confusion. Research ethics boards (...)
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  13. A Framework for Assessing Scientific Merit in Ethical Review of Clinical Research.Ariella Binik & Spencer Phillips Hey - 2019 - Ethics and Human Research 41 (2):2-13.
    Ethics guidelines and commentary suggest that a central function of research ethics committees is to assess the scientific merit of the protocols they review. However, some commentators object to this role, and evidence suggests that the assessment of scientific merit is a significant source of confusion and animosity between ethics committees and clinical investigators. In this essay, we argue that ethics committees should assess the scientific value and validity of research protocols and that new decision-making tools are needed to help (...)
     
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  14.  16
    Does Benefit Justify Research with Children?Ariella Binik - 2018 - Bioethics 32 (1):27-35.
    The inclusion of children in research gives rise to a difficult ethical question: What justifies children's research participation and exposure to research risks when they cannot provide informed consent? This question arises out of the tension between the moral requirement to obtain a subject's informed consent for research participation, on the one hand, and the limited capacity of most children to provide informed consent, on the other. Most agree that children's participation in clinical research can be justified. But the ethical (...)
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  15.  8
    On Female Body Experience: “Throwing Like a Girl” and Other Essays, by Iris Marion Young.Ariella Binik - 2008 - Ijfab: International Journal of Feminist Approaches to Bioethics 1 (1):178-181.
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  16.  5
    A Defense of The-Risks-of-Daily-Life.Ariella Binik - 2017 - Kennedy Institute of Ethics Journal 27 (3):413-442.
    Most agree that clinical research offers one of the best prospects of improving pediatric medicine. Most also agree that children may be exposed to some degree of risk while participating in clinical trials. But the degree of risk that should be permitted and the reasons for which it should be permitted remain controversial. In this paper, I examine a central risk threshold in research with children—the threshold constraining risks that do not offer research subjects the prospect of direct medical benefit. (...)
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  17.  14
    Iris Marion Young,On Female Body Experience: “Throwing Like a Girl” and Other Essays.Ariella Binik - 2008 - International Journal of Feminist Approaches to Bioethics 1 (1):178-181.
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  18.  11
    On Female Body Experience:" Throwing Like a Girl" and Other Essays (Review).Ariella Binik - 2008 - International Journal of Feminist Approaches to Bioethics 1 (1):178-181.
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  19.  8
    Randomization Should Be Disclosed to Potential Research Subjects.Ariella Binik & Mark Sheehan - 2013 - American Journal of Bioethics 13 (12):35-37.
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