Background: Gait analysis after total ankle replacement and ankle arthrodesis is usually measured barefoot. However, this does not reflect reality. The purpose of this study was to compare patients barefoot and with footwear. Methods: We compared 126 patients (total ankle replacement 28, ankle arthrodesis 57, and tibiotalocalcaneal arthrodesis 41) with 35 healthy controls in three conditions (barefoot, standardized running, and rocker bottom shoes). Minimum follow-up was 2 years. We used dynamic pedobarography and a light gate. Main outcome measures: relative midfoot (...) index, forefoot maximal force, walking speed. Findings: The relative midfoot index decreased in all groups from barefoot to running shoes and again to rocker bottom shoes (p < 0.001). The forefoot maximal force increased wearing shoes (p < 0.001), but there was no difference between running and rocker bottom shoes. Walking speed increased by 0.06 m/s with footwear (p < 0.001). Total ankle replacement and ankle arthrodesis were equal in running shoes but both deviated from healthy controls (total ankle replacement/ankle arthrodesis smaller RMI p = 0.07/0.017; increased forefoot maximal force p = 0.757/0.862; slower walking speed p < 0.001). In rocker bottom shoes, this ranking remained the same except the relative midfoot index merged to similar values. Tibiotalocalcaneal arthrodesis were inferior in both shoes. Interpretation: Runners are beneficial and the benefit is greater for fusions and replacements. Rocker bottom shoes have little added benefit. Total ankle replacement and ankle arthrodesis were equal but inferior to healthy controls. Tibiotalocalcaneal arthrodesis has an inferior outcome. (shrink)

Models are of central importance in many scientific contexts. The centrality of models such as inflationary models in cosmology, general-circulation models of the global climate, the double-helix model of DNA, evolutionary models in biology, agent-based models in the social sciences, and general-equilibrium models of markets in their respective domains is a case in point (the Other Internet Resources section at the end of this entry contains links to online resources that discuss these models). Scientists spend significant amounts of time building, (...) testing, comparing, and revising models, and much journal space is dedicated to interpreting and discussing the implications of models. In short, models are one of the principal instruments of modern science. (shrink)

Scientific discourse is rife with passages that appear to be ordinary descriptions of systems of interest in a particular discipline. Equally, the pages of textbooks and journals are filled with discussions of the properties and the behavior of those systems. Students of mechanics investigate at length the dynamical properties of a system consisting of two or three spinning spheres with homogenous mass distributions gravitationally interacting only with each other. Population biologists study the evolution of one species procreating at a constant (...) rate in an isolated ecosystem. And when studying the exchange of goods, economists consider a situation in which there are only two goods, two perfectly rational agents, no restrictions on available information, no transaction costs, no money, and dealings are done immediately. Their surface structure notwithstanding, no competent scientist would mistake descriptions of such systems as descriptions of an actual system: we know very well that there are no such systems. These descriptions are descriptions of a model-system, and scientists use model-systems to represent parts or aspects of the world they are interested in. Following common practice, I refer to those parts or aspects as target-systems. What are we to make of this? Is discourse about such models merely a picturesque and ultimately dispensable façon de parler? This was the view of some early twentieth century philosophers. Duhem (1906) famously guarded against confusing model building with scientific theorizing and argued that model building has no real place in science, beyond a minor heuristic role. The aim of science was, instead, to construct theories, with theories understood as classificatory or representative structures systematically presented and formulated in precise symbolic.. (shrink)

Models and theories are of central importance in science, and scientists spend substantial amounts of time building, testing, comparing and revising models and theories. It is therefore not surprising that the nature of scientific models and theories has been a widely debated topic within the philosophy of science for many years. The product of two decades of research, in this book Roman Frigg provides an accessible yet critical introduction to the debates about models and theories within analytical philosophy of (...) science since the 1920s. Models and Theories is the first book to address the topic from a philosophical perspective, making it essential reading for advanced undergraduates, researchers, and professional philosophers working in philosophy of science, philosophy of mathematics, and philosophy of technology. It will also be of interest to philosophically minded readers working in physics, computer sciences and STEM fields more broadly. (shrink)

Determinism and chance seem to be irreconcilable opposites: either something is chancy or it is deterministic but not both. Yet there are processes which appear to square the circle by being chancy and deterministic at once, and the appearance is backed by well-confirmed scientific theories such as statistical mechanics which also seem to provide us with chances for deterministic processes. Is this possible, and if so how? In this essay I discuss this question for probabilities as they occur in the (...) empirical sciences, setting aside metaphysical questions in connection with free will, divine intervention and determinism in history. (shrink)

Max Horkheimer, the founder of the critical theory of the ‘Frankfurt School’, died in July 1973. In his essay dedicated to this great thinker, sociologist and philosopher, the author attempts to uncover the theoretical roots of this critical thinking in the philosopher's early work. He analyses Horkheimer's early commitment to the cause of the victims of social, economic and political oppression as well as all systems that trample on the freedom and dignity of the individual and that discriminate against and (...) persecute minorities. He also pays special attention to Horkheimer's struggle against the authoritarian state, against totalitarianism as well as anti-Semitism. (shrink)

Why do systems prepared in a non-equilibrium state approach, and eventually reach, equilibrium? An important contemporary version of the Boltzmannian approach to statistical mechanics answers this question by an appeal to the notion of typicality. The problem with this approach is that it comes in different versions, which are, however, not recognised as such, much less clearly distinguished, and we often find different arguments pursued side by side. The aim of this paper is to disentangle different versions of typicality-based explanations (...) of thermodynamic behaviour and evaluate their respective success. My conclusion will be that the boldest version fails for technical reasons, while more prudent versions leave unanswered essential questions. (shrink)

Various processes are often classified as both deterministic and random or chaotic. The main difficulty in analysing the randomness of such processes is the apparent tension between the notions of randomness and determinism: what type of randomness could exist in a deterministic process? Ergodic theory seems to offer a particularly promising theoretical tool for tackling this problem by positing a hierarchy, the so-called ‘ergodic hierarchy’, which is commonly assumed to provide a hierarchy of increasing degrees of randomness. However, that notion (...) of randomness requires clarification. The mathematical definition of EH does not make explicit appeal to randomness; nor does the usual way of presenting EH involve a specification of the notion of randomness that is supposed to underlie the hierarchy. In this paper we argue that EH is best understood as a hierarchy of random behaviour if randomness is explicated in terms of unpredictability. We then show that, contrary to common wisdom, EH is useful in characterising the behaviour of Hamiltonian dynamical systems. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

The comic book hero Superman grew from a social crusader and a “champion of the oppressed” in the 1930s, to a patriotic and paternalistic fighter for “Truth, Justice, and the American way” in the 1940s and 1950s, to a compassionate Christ‐like savior in the latter part of the twentieth century – and always defending the Judeo‐Christian values upheld by the American majority. Friedrich Nietzsche’s “superman,” on the other hand, firmly rejects the very same values its superhero namesake upholds. While it (...) has been a common trope in the superhero genre and popular culture in general to characterize figures explicitly based on Nietzsche’s Übermensch as inhuman monsters, this chapter argues that Nietzsche’s concept can be reinstated through the character of Superman himself. Like Übermensch, Superman is strong, creative, noble, independent, and life‐affirming, but unlike him, Superman is compassionate and looks out for the little guy. (shrink)

This is the second of three parts of an introduction to the philosophy of climate science. In this second part about modelling climate change, the topics of climate modelling, confirmation of climate models, the limits of climate projections, uncertainty and finally model ensembles will be discussed.

Exploration of the political roles firms play in society is a flourishing stream within corporate social responsibility research. However, few empirical studies have examined multiple levels of political CSR at the same time from a critical perspective. We explore both how the motivations of managers and internal organizational practices affect a company’s choice between competing CSR approaches, and how the different CSR programs of corporate and civil society actors compete with each other. We present a qualitative interpretative case study of (...) how a French children’s clothing retailer develops CSR practices in response to accusations of poor working conditions and child labor in its supply chain. The company’s CSR approach consists of superficial practices, such as supplier audits by a cooperative business-organized nongovernmental organization and philanthropic activities, which enable managers to silence more radical alternative models defended by other NGOs, activists, and trade unions. By this approach, the core business model based on exploitative low-cost country sourcing remains intact through self-regulated CSR. Through the case study, we develop a framework of dynamism in competing CSR programs. We discuss the implications of our study for CSR researchers, company managers, and policy makers. (shrink)

This is the first of three parts of an introduction to the philosophy of climate science. In this first part about observing climate change, the topics of definitions of climate and climate change, data sets and data models, detection of climate change, and attribution of climate change will be discussed.

Continuous reducibilities are a proven tool in Computable Analysis, and have applications in other fields such as Constructive Mathematics or Reverse Mathematics. We study the order-theoretic properties of several variants of the two most important definitions, and especially introduce suprema for them. The suprema are shown to commutate with several characteristic numbers.

Climate change adaptation is largely a local matter, and adaptation planning can benefit from local climate change projections. Such projections are typically generated by accepting climate model outputs in a relatively uncritical way. We argue, based on the IPCC’s treatment of model outputs from the CMIP5 ensemble, that this approach is unwarranted and that subjective expert judgment should play a central role in the provision of local climate change projections intended to support decision-making.

Ernst Cassirer's philosophy of culture has been much discussed in recent years. However, it remains unclear how it evolved from his older theory of knowledge. This study deals with this question on the basis of Cassirer's 'disposition' of a 'philosophy of the symbolic', reconstructed here for the first time. This text shows that the 'symbolic' refers to culture as a whole and to its inherent diversity. Therefore, 'the symbolic' includes the relationship between the general transcendental conditions of culture and its (...) empirical specificities in language and languages, art and the arts, myth and myths, science and disciplines. Cassirer does not comprehend this empirical and specific reality of symbolization depending on pre-existing transcendental conditions. Instead, he proceeds from the empirical diversity of the symbolisations and reflects on their simultaneously general and specific conditions. Thus, Cassirer embarks on a path that he finds paved in Kant's "Critique of Judgement": He consequently defines 'the symbolic' as the horizon for a reflective approach based on empirical findings - and not as the foundation of a systematic derivation of the diversity of culture in the style of the idealistic tradition. (shrink)

Although machine learning has been successful in recent years and is increasingly being deployed in the sciences, enterprises or administrations, it has rarely been discussed in philosophy beyond the philosophy of mathematics and machine learning. The present contribution addresses the resulting lack of conceptual tools for an epistemological discussion of machine learning by conceiving of deep learning networks as ‘judging machines’ and using the Kantian analysis of judgments for specifying the type of judgment they are capable of. At the center (...) of the argument is the fact that the functionality of deep learning networks is established by training and cannot be explained and justified by reference to a predefined rule-based procedure. Instead, the computational process of a deep learning network is barely explainable and needs further justification, as is shown in reference to the current research literature. Thus, it requires a new form of justification, that is to be specified with the help of Kant’s epistemology. (shrink)

We reconsider the Nagelian theory of reduction and argue that, contrary to a widely held view, it is the right analysis of intertheoretic reduction. The alleged difficulties of the theory either vanish upon closer inspection or turn out to be substantive philosophical questions rather than knock-down arguments.

We define and investigate a family of local–global principles for fields involving both orderings and p-valuations. This family contains the PAC, PRC and PpC fields and exhausts the class of pseudo classically closed fields. We show that the fields satisfying such a local–global principle form an elementary class, admit diophantine definitions of holomorphy domains, and their orderings satisfy the strong approximation property.

How does mathematics apply to something non-mathematical? We distinguish between a general application problem and a special application problem. A critical examination of the answer that structural mapping accounts offer to the former problem leads us to identify a lacuna in these accounts: they have to presuppose that target systems are structured and yet leave this presupposition unexplained. We propose to fill this gap with an account that attributes structures to targets through structure generating descriptions. These descriptions are physical descriptions (...) and so there is no such thing as a solely mathematical account of a target system. (shrink)

This paper reviews the debate on the notion of biological function and on functional explanation as this takes place in philosophy. It describes the different perspectives, issues, intuitions, theories and arguments that have emerged. The author shows that the debate has been too heavily influenced by the concerns of a naturalistic philosophy of mind and argues that in order to improve our understanding of biology the attention should be shifted from the study of intuitions to the study of the actual (...) practice of biological inquiry. (shrink)

The work [11] deals with questions of first-order definability in algebraic function fields. In particular, it exhibits new cases in which the field of constant functions is definable, and it investigates the phenomenon of definable transcendental elements. We fix some of its proofs and make additional observations concerning definable closure in these fields.

The term “translation” has three meanings: the practice of the translator, the textual outcome of this practice, and the relationship it creates between texts and languages. In this article, I would like to draw attention to this third aspect, translation as a relation. To do so, I will first propose a historical overview of the first two meanings, as well as of the normative or descriptive aims associated to them. Secondly, I identify three motives for thinking about translation that are (...) primarily concerned with its relational dimension: the lack of a language to speak about the relationship between languages, i.e. about what’s incomparable and what gets subtracted. I conclude this article with the hypothesis that translation as a relation constitutes a refuge event for the plurality of languages. (shrink)

Promoting translational research as a means to overcoming chasms in the translation of knowledge through successive fields of research from basic science to public health impacts and back is a central challenge for research managers and policymakers. Organizational leaders need to assess baseline conditions, identify areas needing improvement, and to judge the impact of specific initiatives to sustain or improve translational research practices at their institutions. Currently, there is a lack of such an assessment tool addressing the specific context of (...) translational biomedical research. To close this gap, we have developed a new survey for assessing the organizational climate for translational research. This self-assessment tool measures employees’ perceptions of translational research climate and underlying research practices in organizational environments and builds on the established Survey of Organizational Research Climate, assessing research integrity. Using this tool, we show that scientists at a large university hospital perceive translation as a central and important component of their work. Importantly, local resources and direct support are main contributing factors for the practical implementation of translation into their own research practice. We identify and discuss potential leverage points for an improvement of research climate to foster successful translational research. (shrink)

Most scientific models are not physical objects, and this raises important questions. What sort of entity are models, what is truth in a model, and how do we learn about models? In this paper I argue that models share important aspects in common with literary fiction, and that therefore theories of fiction can be brought to bear on these questions. In particular, I argue that the pretence theory as developed by Walton (1990, Mimesis as make-believe: on the foundations of the (...) representational arts. Harvard University Press, Cambridge/MA) has the resources to answer these questions. I introduce this account, outline the answers that it offers, and develop a general picture of scientific modelling based on it. (shrink)

I argue that there are at least four different ways in which the term ‘function’ is used in connection with the study of living organisms, namely: function as activity, function as biological role, function as biological advantage, and function as selected effect. Notion refers to what an item does by itself; refers to the contribution of an item or activity to a complex activity or capacity of an organism; refers to the value for the organism of an item having a (...) certain character rather than another; refers to the way in which a trait acquired and has maintained its current share in the population. The recognition of a separate notion of function as biological advantage solves the problem of the indeterminate reference situation that has been raised against a counterfactual analysis of function, and emphasizes the importance of counterfactual comparison in the explanatory practice of organismal biology. This reveals a neglected problem in the philosophy of biology, namely that of accounting for the insights provided by counterfactual comparison. (shrink)

I argue that there are at least four different ways in which the term ‘function’ is used in connection with the study of living organisms, namely: function as activity, function as biological role, function as biological advantage, and function as selected effect. Notion refers to what an item does by itself; refers to the contribution of an item or activity to a complex activity or capacity of an organism; refers to the value for the organism of an item having a (...) certain character rather than another; refers to the way in which a trait acquired and has maintained its current share in the population. The recognition of a separate notion of function as biological advantage solves the problem of the indeterminate reference situation that has been raised against a counterfactual analysis of function, and emphasizes the importance of counterfactual comparison in the explanatory practice of organismal biology. This reveals a neglected problem in the philosophy of biology, namely that of accounting for the insights provided by counterfactual comparison. (shrink)

Dieses Buch schlägt - unter dem Titel "synthetischer Materialismus" - einen neuen Weg zur Klärung des Geist-Materie-Problems vor. Ausgangspunkt ist die These, dass wir als Betrachter der Welt frei sind, dieselben Gegenstände in unterschiedlich komplexe raum-zeitliche Zusammenhänge einzuordnen, und dass sich daraus unterschiedliche Möglichkeiten der Klassifikation von Gegenständen ergeben können: Wenn wir von "Lebewesen", "Handlungssubjekten" und "Personen" sprechen, und ihnen psychische Phänomene zuschreiben, nutzen wir den Umstand, dass die Konstellationen von Kohlehydraten, Eiweißen, Wasser und Nukleinsäuren, die jene Entitäten auch sind, (...) in einer besonderen Weise mit Teilen ihrer Vergangenheit, Gegenwart und Zukunft in Verbindung gebracht werden können. Der synthetische Materialismus vermag so zu zeigen, dass es zwischen einem ausschließlich "materialistischen" Verständnis der Welt und jenen Sichtweisen, innerhalb derer wir manche Komplexe von materiellen Phänomenen als Individuen mit ihnen selbst bewussten Empfindungen, Absichten und Überzeugungen verstehen, Übergänge gibt, die methodisch-wissenschaftlich nachvollzogen werden können und die nicht zu nutzen töricht wäre. (shrink)

Models are of central importance in many scientific contexts. The roles the MIT bag model of the nucleon, the billiard ball model of a gas, the Bohr model of the atom, the Gaussian-chain model of a polymer, the Lorenz model of the atmosphere, the Lotka- Volterra model of predator-prey interaction, agent-based and evolutionary models of social interaction, or general equilibrium models of markets play in their respective domains are cases in point.

This paper is concerned with reasonings that purport to explain why certain organisms have certain traits by showing that their actual design is better than contrasting designs. Biologists call such reasonings 'functional explanations'. To avoid confusion with other uses of that phrase, I call them 'design explanations'. This paper discusses the structure of design explanations and how they contribute to scientific understanding. Design explanations are contrastive and often compare real organisms to hypothetical organisms that cannot possibly exist. They are not (...) causal but appeal to functional dependencies between an organism's different traits. These explanations point out that because an organism has certain traits, it cannot be alive if the trait to be explained were replaced by a specified alternative. They can be understood from a mechanistic point of view as revealing the constraints on what mechanisms can be alive. (shrink)

This monograph offers a critical introduction to current theories of how scientific models represent their target systems. Representation is important because it allows scientists to study a model to discover features of reality. The authors provide a map of the conceptual landscape surrounding the issue of scientific representation, arguing that it consists of multiple intertwined problems. They provide an encyclopaedic overview of existing attempts to answer these questions, and they assess their strengths and weaknesses. The book also presents a comprehensive (...) statement of their alternative proposal, the DEKI account of representation, which they have developed over the last few years. They show how the account works in the case of material as well as non-material models; how it accommodates the use of mathematics in scientific modelling; and how it sheds light on the relation between representation in science and art. The issue of representation has generated a sizeable literature, which has been growing fast in particular over the last decade. This makes it hard for novices to get a handle on the topic because so far there is no book-length introduction that would guide them through the discussion. Likewise, researchers may require a comprehensive review that they can refer to for critical evaluations. This book meets the needs of both groups. (shrink)