The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or ‘ontologies’. Unfortunately, the very success of this approach has led to a proliferation of ontologies which itself creates obstacles to integration. The Open Biomedical Ontologies (OBO) consortium has set in train a strategy to overcome this problem. Existing (...) OBO ontologies, including the Gene Ontology, are undergoing a process of coordinated reform and new ontologies being created on the basis of an evolving set of shared principles governing ontology development. The result is an expanding family of ontologies designed to be interoperable, logically well-formed, and to incorporate accurate representations of biological reality. We describe the OBO Foundry initiative, and provide guidelines for those who might wish to become involved. (shrink)

Throughout the biological and biomedical sciences there is a growing need for, prescriptive ‘minimum information’ (MI) checklists specifying the key information to include when reporting experimental results are beginning to find favor with experimentalists, analysts, publishers and funders alike. Such checklists aim to ensure that methods, data, analyses and results are described to a level sufficient to support the unambiguous interpretation, sophisticated search, reanalysis and experimental corroboration and reuse of data sets, facilitating the extraction of maximum value from data sets (...) them. However, such ‘minimum information’ MI checklists are usually developed independently by groups working within representatives of particular biologically- or technologically-delineated domains. Consequently, an overview of the full range of checklists can be difficult to establish without intensive searching, and even tracking thetheir individual evolution of single checklists may be a non-trivial exercise. Checklists are also inevitably partially redundant when measured one against another, and where they overlap is far from straightforward. Furthermore, conflicts in scope and arbitrary decisions on wording and sub-structuring make integration difficult. This presents inhibit their use in combination. Overall, these issues present significant difficulties for the users of checklists, especially those in areas such as systems biology, who routinely combine information from multiple biological domains and technology platforms. To address all of the above, we present MIBBI (Minimum Information for Biological and Biomedical Investigations); a web-based communal resource for such checklists, designed to act as a ‘one-stop shop’ for those exploring the range of extant checklist projects, and to foster collaborative, integrative development and ultimately promote gradual integration of checklists. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow scientists to record, manage, and disseminate biomedical information and knowledge in machine-processable form. The goals of the Center are (1) to help unify the divergent and isolated efforts in ontology development by promoting high quality open-source, standards-based tools to create, manage, and use ontologies, (2) to create (...) new software tools so that scientists can use ontologies to annotate and analyze biomedical data, (3) to provide a national resource for the ongoing evaluation, integration, and evolution of biomedical ontologies and associated tools and theories in the context of driving biomedical projects (DBPs), and (4) to disseminate the tools and resources of the Center and to identify, evaluate, and communicate best practices of ontology development to the biomedical community. Through the research activities within the Center, collaborations with the DBPs, and interactions with the biomedical community, our goal is to help scientists to work more effectively in the e-science paradigm, enhancing experiment design, experiment execution, data analysis, information synthesis, hypothesis generation and testing, and understand human disease. (shrink)

Sixteen years ago, Michael Ashburner and his colleagues proposed a hierarchical model for the genetic control of polytene chromosome puffing by the steroid hormone ecdysone. The recent molecular isolation and characterization of three early ecdysone‐inducible genes has confirmed many aspects of this model — these genes are directly induced by ecdysone, repressed by ecdysone‐induced proteins, and appear to encode DNA binding regulatory proteins. The three early genes are also remarkably similar in structure. They are all unusually long and (...) complex, with multiple transcripts that direct the synthesis of several related proteins from each locus. Proteins encoded by two of the early genes bind to both early and late ecdysone‐induced puffs, implying that they are key regulators in the hierarchy. (shrink)

Philosophy of biology has a long and honourable history. Indeed, like most of the great intellectual achievements of the Western World, it goes back to the Greeks. However, until recently in this century, it was sadly neglected. With a few noteworthy exceptions, someone wishing to delve into the subject had to choose between extremes of insipid vitalism on the one hand, and sterile formalizations of the most elementary biological principles on the other. Whilst philosophy of physics pushed confidently ahead, the (...) philosophy of biology languished. In the past decade, however, things have changed dramatically. A number of energetic and thoughtful young philosophers have made real efforts to master the outlines and details of contemporary biology. They have shown that many stimulating problems emerge when analytic skills are turned towards the life-sciences, particularly if one does not feeI con strained to stay only with theoretical parts of biology, but can range over to more medical parts of the spectrum. At the same time, biology itself has had one of the most fruitful yet turbulent periods in its whole history, and more and more biologists have grown to see that many of the problems they face take them beyond the narrow confines of empiric al science: a broader perspective is needed. (shrink)

In diesem Buch wird ein zweihundert Jahre altes Problem gelost: Wie beweist Kant in der Kritik der reinen Vernunft die Vollstandigkeit seiner Urteilstafel? Da diese Tafel, zusammen mit der Kategorientafel (die von ihr abhangt) das Herzstuck von Kants Hauptwerk ausmacht, gilt das Problem von jeher als Kernproblem der Kantinterpretation. Uberraschenderweise kann es durch sorgfaltige immanente Textauslegung gelost werden: Nachweisbar ist, dass das Leitfadenkapitel, also der unmittelbare Kontext der Urteilstafel innerhalb der Kritik, eine dicht geschriebene Argumentationsskizze zu einem strengen Vollstandigkeitsbeweis enthalt, (...) dessen Uberzeugungskraft nichts zu wunschen ubriglasst. Fur die Rekonstruktion dieses Beweises kommt es zunachst auf eine genaue Analyse der Behauptungen an, die Kant mit der Urteilstafel aufstellt. Diese Analyse prasentiert das erste Kapitel. Das zweite bietet dann einen ausfuhrlichen Satz-fur-Satz-Kommentar zu der fur den Vollstandigkeitsbeweis einschlagigen Textpassage und rekonstruiert ihn in allen Details. Das dritte Kapitel schliesslich untersucht den Begriff von 'formaler Logik', den Kant voraussetzt und von dem seine Behauptung abhangt, die in der Urteilstafel vorgenommene Aufzahlung logischer Formen sei vollstandig. Der im Anhang abgedruckte Essay behandelt die bis heute kaum beachtete Auseinandersetzung, die Gottlob Frege in seiner Begriffsschrift von 1879 mit der kantischen Urteilstafel Punkt fur Punkt gefuhrt hat. Freges Kritik an ihr wird im ersten Teil des Anhangs dargestellt und erlautert. Im zweiten Teil wird dann gezeigt, dass diese Kritik in allen Punkten auf grundlegenden Irrtumern und Missverstandnissen beruht. Als besonders schwerwiegender und folgenreicher Irrtum stellt sich Freges Ansicht heraus, die Regeln dessen, was Kant als formale Logik ansah, seien aus dem Axiomensystem der Begriffsschrift ableitbar. (shrink)

Arguing that Kierkegaard (1813-55) can and should be taken seriously as a philosopher even in today's postmodern climate, Strawser (philosophy, Folkuniversitetet, Helsingborg, Sweden) offers evidence that in marking the juncture between objective philosophy and philosophy that recognized its subjective and provisional nature, he represents not a break between the aesthetic and the religious but a bridge between them. Paper edition (unseen), $17.00. Annotation copyrighted by Book News, Inc., Portland, OR.

This book is an annotated translation, with introduction and commentary, of the correspondence between Yi Hwang (T'oegye, 1500-1570) and Ki Taesung (Kobong, 1527-1572) and between Yi I (Yulgok, 1536-1584) and Song Hon (Ugye, 1535-1598), known as the Four-Seven Debate, the most famous philosophical controversy in Korean Neo-Confucian thought. The most complex issues and difficult tensions in the great Neo-Confucian synthesis are at the juncture between the metaphysics of the cosmos and the human psyche. The Four-Seven Debate is perhaps the most (...) searching examination of this tension ever carried out. (shrink)

The International research Library of Philosophy collects in book form a wide range of important and influential essays in philosophy, drawn predominantly from English-language journals. Each volume in the library deals with a field of enquiry which has received significant attention in philosophy in the last 25 years and is edited by a philosopher noted in that field.

In their chapter, “In What Sense Does the One Exist? Existence and Hypostasis in Plotinus,” Paul DiRado and Michael Wiitala consider the problem of the One’s existence. Starting with the modern philosophical distinction between the “is” of predication and the “is” of existence, they show that Plotinus does not make such a distinction. The reason for this, they argue, is that Plotinus does not share with modern philosophers a univocal notion of existence. For Plotinus, both the verb “einai” and (...) the word “hypostasis” have variable meanings. Thus Plotinus can, in some contexts, say that “the One is” without being committed to the view that the One is or exists in the same way that other entities lower in the metaphysical hierarchy (Forms, say) exist. To say that “the One is” is to say that the One is the basis for the being of other entities; the Forms, on the other hand, truly “are,” in that they are the subjects of necessary and unchanging real predication. (shrink)

In the third act of his journey, Michael McLeod, a beloved physician and professor emeritus of medicine at Duke University, has shown why he's an even more beloved professor of life. In a manner that is clear, practical, and inspiring, this book is an invitation to grow and flourish during what can be one of the most challenging periods in our lives. McLeod demonstrates his courage to share his journey and his willingness to learn from his medical students and (...) from the participants in his conscious aging workshops. As you read his words, you can learn alongside this respected elder. He has put together a powerful guide for living your life fully. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 35.1 (2002) 77-89 [Access article in PDF] Time and Judgment in Demosthenes' De Corona 1 - [PDF] Michael S. Kochin Hannah Arendt concludes the first volume of The Life of the Mind thus: If judgment is our faculty for dealing with the past, the historian is the inquiring man who by relating it sits in judgment over it. If that is so, we may reclaim (...) our human dignity, win it back, as it were, from that pseudo-divinity named History of the modern age, without denying history's importance but denying its right to being the ultimate judge. Old Cato... has left us a curious phrase which aptly sums up the political principle implied in the enterprise of reclamation. He said: "Victrix causa deis placit, sed victa Catoni" ("The victorious cause pleased the gods, but the defeated one pleases Cato"). (1978, 1: 216) 2This article is an exercise in reclamation of the kind that Hannah Arendt describes. I wish to reclaim the cause for which Demosthenes struggled, the cause of democratic freedom, from the judgment of history expressed in the defeat of Athens and her allies at the hands of Philip of Macedon. Though politics is attenuated in the contemporary world, we can understand the peculiar characteristics of political action by reconstructing in our imagination those moments in the past when political life was richest. Here I am going to take up an aspect of political action that is particularly well-illuminated in Demosthenes' speech On the Crown: the role of time in the judgment of political action. 3We can approach Demosthenes' political career for a variety of purposes: The easiest to understand, because it is in many ways the most superficial, is with the motives of the humanist. We study the political speeches of Demosthenes in order to be inspired to value political freedom [End Page 77] and to learn how it can be defended. The trouble with this view is that it assumes that the conditions for political action are present for us, as they were for Demosthenes in the Athens of his time, and that political action is itself something serious men (and now women) ought to undertake. That these two assumptions are edifying and patriotic does not make them true.We can also approach Demosthenes as an exercise in historical science (that is, historische Wissenschaft). The scientific historian wants to learn the facts about the rise of Philip's hegemony over Greece. The scientific historian therefore prefers objectivity to edification. As George Cawkwell, a leading participant in the Demosthenesstreit in the '60s and '70s, wrote, "Moral edification and history can be kept separate" (1969, 166).I find this the most difficult purpose to understand, because it is unclear how this scientific-historical perspective can be connected with the human-all-too-human perspectives of the participants. When, for example, Cawkwell writes of the age of Demosthenes that "The central fact of the age is military, not moral—viz. the huge preponderance in military potential of the Macedonian state over the power of any Greek state," he cites a fact whose truth he himself perceives in part from Philip's victory over the Thebans and Athenians at Chaeroneia in 338 B.C.E. and Alexander's campaign against Thebes in 335. 4 Cawkwell does not trouble himself to explain how Demosthenes or anybody else could possibly have learned the fact of Philip's greater military strength and resources prior to these events. Nor does Cawkwell refute the claim that given Philip's failures before Perinthos and Byzantium in 340, at the very time that Demosthenes led the Athenians to war it was reasonable to suppose Philip much weaker than he had seemed, or seems to us (Pickard-Cambridge 1979, 491). 5 He does not even show how Philip could have known his own capabilities prior to his success. It is thus unclear what use historical-scientific judgment could be, since it is not clear how to relate historical-scientific judgment to the judgment of participants in human affairs.I should stop here, not least because I... (shrink)

Sokrates hat als Figur in der kaiserzeitlichen Philosophie nicht zuletzt auch bei der Auseinandersetzung mit dem Christentum eine Rolle gespielt. Dass dies auch für Aspekte der praktischen Ethik gilt, die mit seinem Namen verbunden werden, ist mit Blick auf die wachsende Jenseitsorientierung der kaiserzeitlichen, platonisch dominierten Philosophie bestritten worden. Michael Erler zeigt, dass die von Sokrates im Gorgias als 'wahre Politik' bezeichnete praktische Anwendung philosophischer Methoden gleichwohl auch im späteren Platonismus eine Rolle spielte und als Hilfestellung für das Leben (...) im Diesseits letztlich der Befreiung der Seele für das Jenseits diente."-- Back cover. (shrink)

Why do counsellors and psychotherapists practice? What is the purpose? What real benefit does the client gain and what benefit accrues to society as a whole? Do liberal and postmodern values leave counselling and psycho-therapy vulnerable to being devalued by consumerism, individualism and relativism? This unique text subjects counselling and psychotherapy to a proper and thorough moral and ethical analysis. Using radical new theories, the author opens up the field of counselling to rational debate, giving it a thorough analysis that (...) is political, sociological and philosophical in outlook. Drawing on the communicative ethics of Habermas, he provides a new basis for understanding the purpose of counselling and psychotherapy. Using an argument that is both challenging and stimulating, the liberal and postmodern approaches are decisively investigated and rejected. Of interest to specialists and non-specialists alike, this work offers a new vision for counselling, which is both appealing and soundly argued. (shrink)

A study of Picasso's status in the art community and his influence on the avant-garde market follows his early year search for a gallery and his monumental rise to fame, noting his popularity among dealers and his commercial strategies.

A study investigating how the founders of Marxism came to terms with the emergence of liberal democracy as a political system. It examines, in language without jargon, how they defined democracy and how they evaluated the liberal constitutional state, by placing their ideas in historical context.

Reviews democracy's theoretical and historical bases and analzes these aspects of British politics and government which reflect or preclude truly democratic principles and practices.

With a selection of essays chosen from a wide range of possible candidates this collection strikes an optimal balance between direct relevance to controversies and rigorous contributions from Hegelian scholarship with regard to Hegel and the law.

Keine ausführliche Beschreibung für "Gesellschaft und Geschichte" verfügbar.

This chapter contains sections titled: Introduction Unselving Anticipation Departures Conclusion: Schools as Places of Unselving Acknowledgement Notes References.

Brown (advanced graduate student, Irish-Scottish studies) and Harrison (archaeologist, Dublin Excavations Publication project) were also the organizers of the graduate student conference at Trinity College in 1999, from which these papers come. Written by young academics, and somewhat uneven in qual.

Although America’s founders may have been inspired by the political thought of ancient Greece and Rome, the United States is more often characterized by its devotion to the pursuit of commerce. Some have even said that a modern commercial republic such as the United States unavoidably lowers its moral horizon to little more than a concern with securing peace and prosperity so that commerce can flourish. Michael Chan reconsiders this view of America through close readings of Aristotle and Alexander (...) Hamilton, showing that America at its founding was neither as modern nor as low as we have been led to believe. He challenges the virtue/commerce divide that dominates modern thought by demonstrating that the prevailing views of Aristotle and Hamilton on commerce reflect misleading half-truths. Chan first examines Aristotle’s views of economics as presented in the _Politics_, arguing that Aristotle was not as hostile to commerce as is commonly believed. He points out the philosopher’s belief in the value of commercial acquisition in the interest of supplying citizens with the “equipment of virtue,” citing Aristotle’s praise of commercial Carthage over agrarian but much-esteemed Sparta. Chan then turns to a detailed account of the political economy of Hamilton, a proponent of an advanced industrial republic modeled on Great Britain. While many take Hamilton’s advocacy of public credit, a national bank, and manufacturing as evidence of his rejection of classical republican thought in favor of modernity, Chan contends that Hamilton embraced a classically inspired economic statesmanship that transcended a concern with merely securing peace and prosperity. Leading the reader through the complexities of Hamilton’s thought, Chan shows that he intended commerce to pursue the wider classical goals of forming the character of citizens, establishing harmony and justice, and pursuing national greatness. Rather than attempting to brand Hamilton an Aristotelian, Chan seeks to incorporate into the study of Hamilton’s political economy what Aristotle himself regarded as the statesman’s characteristic virtue, prudence. By reflecting on Hamilton in the context of Aristotle’s own reflections on commerce, Chan casts him in a new light that cuts across the ongoing debate about liberal versus classical republican elements of the American founding. His cogent analysis also raises important questions regarding the American system as it is being challenged by conflicting worldviews. _Aristotle and Hamilton on Commerce and Statesmanship _makes a significant contribution to our understanding of both Hamiltonian thought and the moral worthiness of democratic capitalism. (shrink)

Ce texte est l'introduction de Technology's Pulse. Essays on Rhythm in German Modernism, London, Institute of Germanic & Romance Studies, 2012, ouvrage dont on trouvera la présentation ici. Nous remercions Michael Cowan de nous avoir autorisé à le reproduire sur RHUTHMOS. - 1er XXe siècle – Nouvel article.