Segregation Distorter (SD) is a meiotic drive system in Drosophila that causes preferential transmission of the SD chromosome from SD/SD+ males owing to induced dysfunction of SD+ spermatids. Since its discovery in 1956, SD and its mode of action have baffled biologists. Recently, substantial progress has been made in elucidating this puzzle. Sd, the primary gene responsible for distortion encodes a mutant RanGAP, a key protein in the Ran signaling pathway required for nuclear transport and other nuclear functions. The mutant (...) protein is enzymatically active but mislocalized to nuclei, which apparently disrupts Ran signaling by reducing intranuclear Ran‐GTP levels. Some evidence suggests that a defect in nuclear transport may be the main cause of sperm dysfunction. Although important questions remain, the basic mechanism of distortion is now understood sufficiently well that specific hypotheses can be formulated and tested. This previously mysterious genetic system may now offer unique insights into novel aspects of regulation by Ran. BioEssays 25:108–115, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

日本の戦後思想の核心とは、圧倒的な外来思想への、自己の戦争体験と近代日本の露わになった後進性を手がかりにした、ポストコロニアルな抵抗にある。非西洋世界が近代化にむけた苦闘にあるこのとき、日本の戦後思想 は、どのような可能性をもつのか。「リスク近代」の果てにせり上がってきた、世界が抱え込む「有限性」という概念を手がかりに、21世紀世界の思想的課題と、未来構想の可能性を問う。.

トリアージ、ワクチンの分配、ゲノム編集、さらに倫理、思想、文学、政治社会まで、様々な領域の喫緊の問題として「尊厳」を論じる。.

科学が自然を破壊した今、人間は人工的に反人工的な自然を保持するべく努力しなければなりません。科学技術は、この逆説に耐え抜かねばならないのでしょう。.

-- dai 4-5-kan. Saikontan -- dai 6-kan. Shin Saikontan -- dai 7-8-kan. Seiken igen -- dai 9, <11>-14-kan. Shōyōroku.

Kyosei, a traditional Japanese concept, has been applied to a variety subjects, from biology to business. It has more recently become synonymous with the concepts of corporate responsibility, ethical decision making, stakeholder maximization, and responsible reciprocity. The purpose of this paper is to trace kyosei's modern business application back to ancient Confucian thought. The ideals associated with Confucianism were instrumental in the creation of Japanese business codes of ethics during the early part of the seventeenth century. A short history of (...) this period is presented to provide a contextual framework for understanding these codes. A specific code of ethics, called the shuchu kiyaku, is presented for the first time in English and shown to have direct roots in Confucian writings. Statements from modern company codes and from modern Japanese and American businessmen are presented to reflect the philosophy of business embodied in that ancient code of ethics. (shrink)