With no precise boundaries, always on the move and too complex to be defined by space and time, is it possible to map the human subject? This book attempts to do just this, exploring the places of the subject in contemporary culture. The editors approach this subject from four main aspects--its construction, sexuality, limits and politics--using a wide ranging review of literature on subjectivity across the social and human sciences. The first part of the book establishes the idea that the (...) subject is constructed through detailed histories of the subject. The second part shows that sexuality cannot be assumed to be natural through the contributors' research on the place of sexuality in subjectivity and subjectivity in sexuality. The essays in the third part take issue with the idea of a singular, self-contained identity. Power relations and the effects of power are consistent themes throughout the book and the final section deals explicitly with relations of power, whether organized around gender, race, class or other kinds of difference. Contributors: Steve Pile, Nigel Thrift, Miles Ogborn, Carolyn Steedman, David Matless, David Sibley, David Bell, Julia Cream, Vic Seidler, Hester Parr, Chris Philo, Marcus Doel, Paul Rodaway, Nigel Rapport, Stephen Frosh, Valerie Walkerdine, Gillian Rose and Michael Keith. (shrink)

Over the last century, psychoanalysis has transformed the ways in which we think about our relationships with others. Psychoanalytic concepts and methods, such as the unconscious and dream analysis, have greatly impacted on social, cultural and political theory. Reinterpreting the ways in which geography has explored people's mental maps and their deepest feelings about places, The Body and the City outlines a new cartography of the subject. Mapping key coordinates of meaning, identity and power across the sites of body and (...) city, author Steve Pile explores a wide range of critical thinking, particularly the work of Lefebvre, Freud and Lacan to present a pathbreaking psychoanalysis of space. (shrink)

This book uncovers and explores the constant tension between the historical and the transcendental that lies at the heart of Michel Foucault's work. In the process, it also assesses the philosophical foundations of his thought by examining his theoretical borrowings from Kant, Nietzsche, and Heidegger, who each provided him with tools to critically rethink the status of the transcendental. Given Foucault's constant focus on the question of the possibility for knowledge, the author argues that his philosophical itinerary can be understood (...) as a series of attempts to historicize the transcendental. In so doing, he seeks to uncover a specific level that would identify these conditions without falling either into an excess of idealism or of materialism. The author concludes that, although this problem does unify Foucault's work and gives it its specifically philosophical dimension, none of the concepts successively provided manages to name these conditions without falling into the pitfalls that Foucault originally denounced as characteristic of the "anthropological sleep"—various forms of confusion between the historical and the transcendental. Although Foucault's work provides us with a highly illuminating analysis of the major problems of post-Kantian philosophies, ultimately it remains aporetic in that it also fails to overcome them. (shrink)

Hope is hard to characterise because of the exceptional diversity of its applications, to the point that one may wonder whether there is continuity between ordinary cases of hope and what is often called 'hope against hope'. In this paper, I shall follow the relatively small but growing literature on hope and examine propositional hopes, i.e. hopes of the form 'hoping that p', with a particular focus on recent work by Philip Pettit and Adrienne Martin. I shall do this first (...) by identifying a significant difficulty encountered by what has become known as the 'orthodox definition'. The OD defines hope by means of two necessary and sufficient conditions: A hopes that p if and only if A desires that p and A assigns to p a degree of probability between 0 and 1. On this definition, to hope is to desire an outcome we deem neither certain nor impossible. Note that the relevant probability assignment is subjective: the OD allows, for example, that children can hope for Father Christmas to visit them on Christmas Eve. (shrink)

Abstract: This paper identifies two central paradoxes threatening the notion of amor fati [love of fate]: it requires us to love a potentially repellent object (as fate entails significant negativity for us) and this, in the knowledge that our love will not modify our fate. Thus such love may seem impossible or pointless. I analyse the distinction between two different sorts of love (eros and agape) and the type of valuation they involve (in the first case, the object is loved (...) because we value it; in the second, we value the object because we love it). I use this as a lens to interpret Nietzsche's cryptic pronouncements on amor fati and show that while an erotic reading is, up to a point, plausible, an agapic interpretation is preferable both for its own sake and because it allows for a resolution of the paradoxes initially identified. In doing so, I clarify the relation of amor fati to the eternal return on the one hand, and to Nietzsche's autobiographical remarks about suffering on the other. Finally, I examine a set of objections pertaining both to the sustainability and limits of amor fati, and to its status as an ideal. (shrink)

This article explores the relationship between skin, ego and second skins. It does so conceptually by re-examining Freud’s suggestion, in The Ego and the Id, that the ego is first and foremost a bodily entity, while also being a projection of a surface (i.e. skin). Drawing upon Anzieu, a dynamic model of inter-weaving surfaces can be seen to underpin an understanding of the ego — and skin ego. This model is fundamentally spatialized. Even so, an appreciation of the spatialities of (...) skin and ego can be developed further. To illuminate these spatialities, this article examines two key experiences of T.E. Lawrence during his military service in Arabia (c. 1917), as he describes them in his autobiographical account Seven Pillars of Wisdom. In a meeting with British military police, and in the notorious Deraa rape incident, what is at stake is Lawrence of Arabia’s skins. Reading these experiences using Freud and Anzieu, the article argues that these events re-present an ongoing chafing of Lawrence’s skin, ego and second skins, which can be called his ‘skin of suffering’. (shrink)

In this paper I distinguish between two main critical questions: ‘how possible’ questions, which look for enabling conditions and raise issues of epistemic normativity; and ‘whether permissible’ questions, which relate to conditions of legitimacy and ethical normativity. I examine the interplay of both types of questions in Foucault’s work and argue that this helps us to understand both the function of the historical a priori in the archeological period and the subsequent accusations of crypto-normativity levelled against Foucault by commentators such (...) as Taylor and Habermas. I chart the complex conceptual space available for a defense. After examining several possible replies, I conclude that the most effective option, and the one that fits Foucault’s approach best, is to refuse the demand for normative justification as self-defeating, and to opt for the cultivation of an appropriate ethical sensibility through an emphasis on critique as a performative practice of the self. I offer in conclusion some thoughts on what such practice may look like for Foucault. (shrink)

ABSTRACTNietzsche's famous claim, ‘das Thun ist Alles’, is usually translated as ‘the deed is everything’. I argue that it is better rendered as ‘the doing is everything’. Accordingly, I propose a processual reading of agency in GM 1 13 which draws both on Nietzsche's reflections on grammar, and on the Greek middle voice, to displace the opposition between deeds and events, agents and patients by introducing the notion of middle-voiced ‘doings’. The relevant question then is not ‘is this a doing (...) or a happening?’ but ‘what is the process unfolding in the doer, and what is her engagement with it?’. I argue that this middle voiced reading makes better sense than either naturalist or expressivist interpretations of the key thought in GM 1 13 that ‘there is no doer behind the doing’, and that GM 1 13 does not only provide us with a critique of slave morality, as is often said, but also with an example of a middle-voiced doing: self-deception. I explore the phenomenology of middle-voiced doings in other passages and show that it has at least three features: reflective awareness of being engaged with an internal process, responsiveness, and absence of reflective control. (shrink)

In this article, I examine the relation between phenomenology and anthropology by placing Foucault's first published piece, “Introduction to Binswanger's Dream and Existence“ in dialectical tension with The Order of Things. I argue that the early work, which so far hasn't received much critical attention, is of particular interest because, whereas OT is notoriously critical of anthropological confusions in general, and of “Man” as an empirico‐transcendental double in particular, IB views “existential anthropology” as a unique opportunity to establish a new (...) and fruitful relation between transcendental forms and empirical contents. This is because IB focuses on a specific object, “Menschsein”, which is neither the transcendental subject nor an empirical being. Thus for the young Foucault, existential anthropology occupies a fertile methodological middle ground between transcendental approaches and empirical forms of analysis. I first interpret anthropology in the light of phenomenology and defend the view that Menschsein is neither a transcendental structure nor a concrete particular, but the instantiation of the first in the second. I argue that for anthropology to yield the full theoretical benefits Foucault claims for it, the particular cases of Menschsein examined in existential analysis have to be regarded as exemplary. I then read phenomenology back in the light of anthropology and examine how, for Foucault, the analysis of Menschsein in dreams benefits fundamental ontology by affording us a clearer view of some of the main existentiale than the focus on everyday waking experience in Being and Time. Finally, I turn to the limits and difficulties of this early position and my reading of it, and to their consequences for Foucault's later view. (shrink)

Most commentators assume that the affirmation of life can be defined univocally, as an act the success of which can be assessed by means of the test of the eternal return in GS341; and, that the affirmation of life is synonymous with what Nietzsche calls amor fati, and thus singlehandedly encapsulates Nietzsche’s ethical ideal. I take issue with both assumptions and develop an alternative view. I argue that for Nietzsche there are two ways to affirm life ethically. The first is (...) unreflective and piecemeal. I propose a substantive modification to Bernard Reginster’s procedural approach by suggesting that life is affirmed each time an agent seeks to overcome, and succeeds in overcoming, resistance in the pursuit of a first order desire expressive of love for life – the last clause being mine. I further argue that even with this added clause this first form cannot defeat what Reginster calls the ‘normative core of nihilism’, namely the experiencing of suffering as an objection to life. I identify in Nietzsche’s later work a second form of ethical life affirmation: a holistic, ecstatic act, a Dionysian blessing which ‘calls good’ life as a whole and thus redeems it by making it fully desirable on erotic grounds. Yet even in its two ethical forms the affirmation of life does not suffice to define Nietzsche’s ethical ideal. The very perspective of life affirmation is limited because it remains beholden to the very framework Nietzsche sought to escape: the Christian overarching concern for redemption and preoccupation with theodicic narratives. By contrast, I argue that amor fati, as agapic love of life, affords Nietzsche with a distinct resource to go beyond theodicic prospects and examine its relation to the erotic love of life, which is at the core of both forms of ethical life affirmation. I offer a pluralistic reading of GS341, not simply as a test of life affirmation, but as articulating Nietzsche’s two ethical ideals, amor fati on the one hand, and the affirmation of life in both its forms, on the other. (shrink)

I tease out two early Christian puzzles about agency: (a) agential control: how can agents self-constitute if their primary experience of themselves is not one of control, as in Greek antiquity, but of relative powerlessness? And (b) ethical expertise: how can agents constitute themselves as ethical agents if they cannot trust themselves to recognize, and act in the light of, the good? I argue, first, that Foucault saw the importance of these puzzles and focused on extreme obedience as affording a (...) possible resolution; second, that he failed to resolve the puzzles because of his reliance on an overly voluntarist and reflective understanding of obedience as an exercise of will; and finally, that turning to Cassian’s own thoughts on the relation between extreme obedience and humility as kenosis affords us a way out of the puzzles. (shrink)

I tease out two early Christian puzzles about agency: (a) agential control: how can agents self-constitute if their primary experience of themselves is not one of control, as in Greek antiquity, but of relative powerlessness? And (b) ethical expertise: how can agents constitute themselves as ethical agents if they cannot trust themselves to recognize, and act in the light of, the good? I argue, first, that Foucault saw the importance of these puzzles and focused on extreme obedience as affording a (...) possible resolution; second, that he failed to resolve the puzzles because of his reliance on an overly voluntarist and reflective understanding of obedience as an exercise of will; and finally, that turning to Cassian’s own thoughts on the relation between extreme obedience and humility as kenosis affords us a way out of the puzzles. (shrink)

Hope is hard to characterise because of the exceptional diversity of its applications, to the point that one may wonder whether there is continuity between ordinary cases of hope and what is often called 'hope against hope'. In this paper, I shall follow the relatively small but growing literature on hope and examine propositional hopes, i.e. hopes of the form 'hoping that p', with a particular focus on recent work by Philip Pettit and Adrienne Martin. I shall do this first (...) by identifying a significant difficulty encountered by what has become known as the 'orthodox definition'. The OD defines hope by means of two necessary and sufficient conditions: A hopes that p if and only if A desires that p and A assigns to p a degree of probability between 0 and 1. On this definition, to hope is to desire an outcome we deem neither certain nor impossible. Note that the relevant probability assignment is subjective: the OD allows, for example, that children can hope for Father Christmas to visit them on Christmas Eve. (shrink)

This chapter contains sections titled: References.

What Heidegger means by “freedom” in Being and Time is somewhat mysterious: while the notion crops up repeatedly in the book, there is no dedicated section or study, and the concept is repeatedly connected to a new and opaque idea – that of the “choice to choose oneself.” Yet the specificity of Being and Time’s approach to freedom becomes apparent when the book is compared to other texts of the same period, in particular The Metaphysical Foundations of Logic, The Fundamental (...) Concepts of Metaphysics, The Essence of Grounds, and The Essence of Freedom. Although there are some differences, the definition of freedom that can be found there identifies it with “existence” or “transcendence,” Dasein’s ek-static opening onto the world. Thus “being in the world must also be primordially bound up with or derived from the basic feature of Dasein’s existence, freedom… Dasein’s transcendence and freedom are identical! Freedom provides itself with intrinsic possibility: a being is, as free, necessarily in itself transcending”. Note the apodictic modality of the claim: it is not simply the case that Dasein, as transcending, is free. Anything that has the structure of being in the world must be free: freedom is co-extensive with Dasein. Yet Dasein is often pictured in Being and Time as anything but free: it “ensnares itself”, is “lost”, “alienated”, and needs to be “liberated”. Thus comparison between Being and Time and other texts on freedom yields an important paradox: although by definition it transcends toward the world, the Dasein of Division I is deprived of freedom. It must be free, and yet phenomenological analysis shows that it is not free. To understand the specific meaning of freedom in Being and Time, one has to square this circle. (shrink)

Nietzsche's views on knowledge have been interpreted in at least three incompatible ways - as transcendental, naturalistic or proto-deconstructionist. While the first two share a commitment to the possibility of objective truth, the third reading denies this by highlighting Nietzsche's claims about the necessarily falsifying character of human knowledge (his so-called error theory). This paper examines the ways in which his work can be construed as seeking ways of overcoming the strict opposition between naturalism and transcendental philosophy whilst fully taking (...) into account the error theory (interpreted non-literally, as a hyperbolic warning against uncritical forms of realism). In doing so, it clarifies the nature of Nietzsche's ontological commitments, both in the early and the later work, and shows that his relation to transcendental idealism is more subtle than is allowed by naturalistic interpreters while conversely accounting for the impossibility of conceiving the conditions of the possibility of knowledge as genuinely a priori. (shrink)

Most commentators assume that the affirmation of life can be defined univocally, as an act the success of which can be assessed by means of the test of the eternal return in GS341; and, that the affirmation of life is synonymous with what Nietzsche calls amor fati, and thus singlehandedly encapsulates Nietzsche’s ethical ideal. I take issue with both assumptions and develop an alternative view. I argue that for Nietzsche there are two ways to affirm life ethically. The first is (...) unreflective and piecemeal. I propose a substantive modification to Bernard Reginster’s procedural approach by suggesting that life is affirmed each time an agent seeks to overcome, and succeeds in overcoming, resistance in the pursuit of a first order desire expressive of love for life – the last clause being mine. I further argue that even with this added clause this first form cannot defeat what Reginster calls the ‘normative core of nihilism’, namely the experiencing of suffering as an objection to life. I identify in Nietzsche’s later work a second form of ethical life affirmation: a holistic, ecstatic act, a Dionysian blessing which ‘calls good’ life as a whole and thus redeems it by making it fully desirable on erotic grounds. Yet even in its two ethical forms the affirmation of life does not suffice to define Nietzsche’s ethical ideal. The very perspective of life affirmation is limited because it remains beholden to the very framework Nietzsche sought to escape: the Christian overarching concern for redemption and preoccupation with theodicic narratives. By contrast, I argue that amor fati, as agapic love of life, affords Nietzsche with a distinct resource to go beyond theodicic prospects and examine its relation to the erotic love of life, which is at the core of both forms of ethical life affirmation. I offer a pluralistic reading of GS341, not simply as a test of life affirmation, but as articulating Nietzsche’s two ethical ideals, amor fati on the one hand, and the affirmation of life in both its forms, on the other. (shrink)

Nietzsche's views on knowledge have been interpreted in at least three incompatible ways-as transcendental, naturalistic, or proto-deconstructionist. While the first two share a commitment to the possibility of objective truth, the third reading denies this by highlighting Nietzsche's claims about the necessarily falsifying character of human knowledge. This chapter examines the ways in which his work can be construed as seeking ways of overcoming the strict opposition between naturalism and transcendental philosophy, whilst fully taking into account the error theory. In (...) doing so, it clarifies the nature of Nietzsche's ontological commitments, both in the early and the later work, and shows that his relation to transcendental idealism is more subtle than is allowed by naturalistic interpreters, while conversely accounting for the impossibility of conceiving the conditions of possibility of knowledge as genuinely a priori. (shrink)

There has been and still is much debate in the literature as to whether Foucault is (or not) a historian (as opposed to being a philosopher). When he became famous through the publication of The Order of Things, in 1966, many historians of ideas immediately attacked him for the alleged inaccuracy or mistaken character of his analyses1. At the same time, the French philosophical establishment rejected him for being too historical in his approach, to the extent that when the first (...) large Foucault Colloquium was held in Paris in 1988, its (pro-Foucaldian) organisers felt that the title best suited to characterise and defend his work was “Michel Foucault Philosophe”2. Perhaps the latest example of this debate is the recent set of exchanges between G. (shrink)

Hope is hard to characterise because of the exceptional diversity of its applications, to the point that one may wonder whether there is continuity between ordinary cases of hope and what is often called 'hope against hope'. In this paper, I shall follow the relatively small but growing literature on hope and examine propositional hopes, i.e. hopes of the form 'hoping that p', with a particular focus on recent work by Philip Pettit and Adrienne Martin. I shall do this first (...) by identifying a significant difficulty encountered by what has become known as the 'orthodox definition'. The OD defines hope by means of two necessary and sufficient conditions: A hopes that p if and only if A desires that p and A assigns to p a degree of probability between 0 and 1. On this definition, to hope is to desire an outcome we deem neither certain nor impossible. Note that the relevant probability assignment is subjective: the OD allows, for example, that children can hope for Father Christmas to visit them on Christmas Eve. (shrink)

Since fully covering such a topic in the short space imparted to this paper is an impossible task, I have chosen to focus on three philosophers: Nietzsche, Heidegger and Sartre. Of the three, only the latter was undoubtedly an existentialist ⎯ Heidegger explicitly rejected the categorisation (in the Letter on Humanism), and there is disagreement among commentators about Nietzsche’s status1. However, they have two major common points which justify my focusing on them: firstly, they uphold the primacy of existence over (...) essence. Against the rationalist trend prevalent until the end of the XVIIIth Century, which saw human nature as determined a priori (as rational), all three authors consider human beings as living, self-interpreting entities, whose understanding of themselves is dependent on specific cultural and historical conditions. Given that this self-understanding is taken as constitutive of what it means to be human, it becomes impossible to define the essence of man independently of (let alone prior to) his existence. Secondly (and consequently), they reject the idea that philosophy can start from the study of man as a detached, disembodied consciousness primarily bent on knowing the world ⎯ or even that such a consciousness exists, except as a fiction propagated by rationalism2. Man is viewed as an embodied being, whose reason and cognitive powers are only the visible part of a much deeper and wider engagement with the world. In turn, this rejection of the primacy of rationality and of consciousness explains the central part played by affectivity in our three authors’ works. In all its forms3, affectivity is strongly tied to the body (although existentialist thinkers hold that it is neither identical to nor determined by physical reactions4): once the importance of embodiment has been recognised, an analysis of affectivity becomes necessary to understand the ways in which human beings relate both to themselves and to the world. Whereas the rationalist tradition mostly rejected affectivity5, either on moral grounds (as emotions interfere with self-mastery) or for epistemological reasons (because they cloud the clarity of mind supposedly required by knowledge), Nietzsche, Heidegger and Sartre insist on rehabilitating it, mostly for two reasons: firstly, as it is constitutive of what it means to be human, affectivity just cannot be set aside ⎯ so the rationalist ideal to do away with emotions is unmasked as an illusion, the roots of which need to be investigated.. (shrink)

Being and Time, Heidegger praises Kant as “the first and only person who has gone any stretch of the way towards investigating the dimension of temporality or has even let himself be drawn hither by the coercion of the phenomena themselves” (SZ: 23).1 Kant was, before Husserl (and perhaps, in Heidegger's mind, more than him), a true phenomenologist in the sense that the need to curtail the pretension of dogmatic metaphysics to overstep the boundaries of sensible experience led him to (...) focus on phenomena and the conditions of their disclosure: thus, the “question of the inner possibility of such knowledge of the super-sensible , however, is presented as thrown back upon the more general question of the inner possibility of a general making-manifest(Offenbarmachen) of beings (Seiende) as such” (GA 3: 10, emphasis supplied). So Kant shouldn’t be read as an epistemologist (contrary to Descartes, for example), but as an ontologist2: “Kant's inquiry is concerned with what determines nature as such -- occurrent beings as such -- and with how this ontological determinability is possible” (GA 25: 75). Heidegger sees this investigation into the “ontological determinability” of entities as an a priori form of inquiry: “what is already opened up and projected in advance ie the horizon of ontological determinability . . . is what in a certain sense is “earlier” than a being and is called a priori” (GA 25: 37). This a priori character of ontological determinability forms the main link between Kant's critical project and fundamental ontology, itself characterised as a form of transcendental philosophy: “transcendental knowledge is a knowledge which investigates the possibility of an understanding of being, a pre-ontological understanding of being. And such an investigation is the task of ontology. Transcendental knowledge is ontological knowledge, i.e. a priori knowledge of the ontological constitution of beings” (GA 25: 186). Thus Heidegger presents his own inquiry into the nature of Being as a way to address the same issue as Kant: “what is asked about is Being -- that which determines entities as entities, that on the basis of which entities are already understood, however we may discuss them in detail.. (shrink)

In this paper, I examine the relation between phenomenology and anthropology by placing Foucault?s first published piece, Introduction to Binswanger?s?Dream and Existence? in dialectical tension with The Order of Things. I argue that the early work, which so far hasn?t received much critical attention, is of particular interest because while OT is notoriously critical of anthropological confusions in general, and of?Man? as an empirico-transcendental double in particular, IB views?existential anthropology? as a unique opportunity to establish a new and fruitful relation (...) between transcendental forms and empirical contents. This is because IB focuses on a specific object,?Menschsein?, which is neither the transcendental subject nor an empirical being. Thus for the young Foucault existential anthropology occupies a fertile methodological middle ground between transcendental approaches and empirical forms of analysis. I first interpret anthropology in the light of phenomenology and defend the view that Menschsein is neither a transcendental structure nor a concrete particular, but as the instantiation of the first in the second. I argue that for anthropology to yield the full theoretical benefits Foucault claims for it, the particular cases of Menschsein examined in existential analysis have to be regarded as exemplary. I then read phenomenology back in the light of anthropology and examine how, for Foucault, the analysis of Menschsein in dreams benefits fundamental ontology by affording us a clearer view of some of the main existentiale than the focus on everyday waking experience in Being and Time. Finally, I turn to the limits and difficulties of this early position and my reading of it, and to their consequences for Foucault?s later view. (shrink)

In one of his last texts, Foucault defined his philosophical enterprise as an “analysis of the conditions in which certain relations between subject and object are formed or modified, insofar as they are constitutive of a possible knowledge”1, or again as “the manner in which the emergence of games of truth constituted, for a particular time and place and certain individuals, the historical a priori of a possible experience”2. Despite its eclipse during the genealogical period, the notion of the historical (...) a priori is thus reaffirmed as central by later Foucault. There is, however, an essential modification with respect to its archaeological problematisation: in The Order of Things, the various historical a priori were characterized by a specific relation between being and language, a relation in which the subject of knowledge did not always nor necessarily have a place. The Renaissance episteme was defined by the homogeneity of words and things, and its Classical counterpart, by the transparent distance between being and representation, which excluded any positioning for the subject (the “place of the king”). Thus within the archaeological configuration, only the contemporary historical a priori was characterized by the invention of a new position for the subject of knowledge, that of Man, which generated the Analytic of Finitude and ultimately resulted in the “anthropological sleep” criticised at the end of The Order of Things. So although later Foucault re-focuses his work around the notion of the historical a priori, he gives the notion a considerable twist whereby the conditions of truth saying are no longer referred back to an implicit connection between being and language, but to the various relations historically established between “modes of subjectivation”3 and “modes of objectification”4. Correspondingly, these relations are not to be analysed from discourse, as in archaeology, nor from the constituting structures of subjectivity, as in phenomenology, but genealogically, i.e.. (shrink)

Review Symposium on John Forrester and Laura Cameron’s Freud In Cambridge.

Pleiotropically acting eukaryotic corepressors such as retinoblastoma and SIN3 have been found to physically interact with many widely expressed “housekeeping” genes. Evidence suggests that their roles at these loci are not to provide binary on/off switches, as is observed at many highly cell‐type specific genes, but rather to serve as governors, directly modulating expression within certain bounds, while not shutting down gene expression. This sort of regulation is challenging to study, as the differential expression levels can be small. We hypothesize (...) that depending on context, corepressors mediate “soft repression,” attenuating expression in a less dramatic but physiologically appropriate manner. Emerging data indicate that such regulation is a pervasive characteristic of most eukaryotic systems, and may reflect the mechanistic differences between repressor action at promoter and enhancer locations. Soft repression may represent an essential component of the cybernetic systems underlying metabolic adaptations, enabling modest but critical adjustments on a continual basis. (shrink)

[A revised and updated version of an earlier article 'Understanding Creativity: Affect Decision and Inference' (unpublished), posted at PhilArchive in 2021.] -/- This book looks at the creative process in the human mind. -/- Creativity involves a major restructuring of the conceptual space where a sustained inferential process eventually links remote conceptual domains, thereby opening up the possibility of a large number of new correlations between remote concepts by a cascading process. Since the process of inductive inference depends crucially on (...) decisions at critical junctures of the inferential chain, it becomes necessary to examine the basic mechanism underlying the making of decisions. In the framework that we attempt to build up for the understanding of scientific creativity, this role of decision making in the inferential process assumes central relevance. -/- Referring to the process of inferential exploration of the conceptual space that generates the possibility of correlations being established between remote conceptual domains, such exploration is guided and steered at every stage by the affect system, -/- While the affect system plays a guiding role in the exploration of the conceptual space, the process of exploration itself consists of the establishment of correlations between concepts by means of beliefs and heuristics, the self-linked ones among the latter having a special role in making possible the inferential journey along alternative routes whenever the shared rules of inference become inadequate. -/- Representing the conceptual space in the form of a complex network, the overall process can be likened to one of self-organised criticality commonly observed in the dynamical evolution of complex systems. An instance of self-organised criticality is found in the avalanche set up in a slowly growing sand-pile. (shrink)