Approaches to induce tumor differentiation often result in manageable and therapy‐naïve cellular states in cancer cells. This transformation is achieved by activating pathways that drive tumor cells away from plasticity, a state that commonly correlates with enhanced aggression, metastasis and resistance to therapy. Here, we discuss signaling pathways, epigenetics and non‐coding RNAs as three main regulatory levels with the potential to drive tumor differentiation and hence as potential targets in differentiation therapy approaches. The success of an effective therapeutic regimen in (...) one cancer, however, does not necessarily sustain across cancer types; a phenomenon largely resulting from heterogeneity in the genetic and physiological landscapes of tumor types necessitating an approach designed for each cancer's unique genetic and phenotypic build‐up. (shrink)

Information technology has played a remarkably important role in developing the contemporary educational system. It not only provides easy access to enormous stores of information but also increases students' scientific efficiency. However, the availability of this technology has also led to increased plagiarism. This study attempted to explore how access to Internet technology contributes to plagiarism problems from the perspective of university students in Iran. A qualitative method to semistructured interviews with 20 students suggested important themes: uncertainty avoidance, tendency to (...) use shortcuts to progress, symbolic certification, social learning and modeling of faculty members as mentors, and plagiarism in the name of justice. Survey data from 180 university students suggest that the personality characteristic of conscientiousness had a negative effect on using information technology to commit plagiarism. (shrink)

Tracing the history of the Ottoman and Safavid empires back to the Middle Period of Islamic history, this article focuses on their origins in the chieftaincies and the hybrid cultural formations of the Anatolian regions. While considering the inter/intracivilizational historical context of their respective rise to power, it is argued that the structural makeup of the empires differed primarily in their disparate forms of Sufi-knightly cultures, identified here as knightly-heroic (Ottoman) and millenarian-populist (Safavid), which is essentially tied to two distinctive (...) types of tribal political organizations: frontierchieftaincy (Ottoman) and sectarian-chieftaincy (Safavid). Although the original Ottoman and Safavid chieftaincies, based on the militant Ghazi and Qizilbash orders, dissolved once the roaming bands of warriors were replaced by more settled military formations in the course of long-term state-building processes, the influence of their Sufi-knightly cultural heritages is still manifest in modern Iranian and Turkish societies. (shrink)

The present study aims to assess the restriction of private ownership on the cultural-historical property based on the public interest and evaluate how this restriction is explained and what restrictions the cultural heritage rules and regulations impose on the private ownership. The present descriptive and analytical study seeks to examine the above-mentioned questions using the library method. Based on the results, statute law has defined a large number of restrictions for the owner including the owner restriction in the obligation to (...) declare, implement protection plans, as well as sale and transfer of the cultural-historical property. Theories such as public interest are considered as the basis for the restriction of ownership on historical-cultural property. (shrink)

Sensory processing problems and related dysfunctions are among the most common conditions in children with autism spectrum disorder. This study examined the effect of sensory integration therapy on different aspects of occupational performance in children with ASD. The study was conducted on an intervention group receiving SIT and a control group with 3- to 8-year-old children with ASD. The Short Child Occupational Profile was used to compare the two groups in terms of the changes in their occupational performance and the (...) Sensory Profile was used to assess sensory problems. The intervention group showed significantly greater improvement in all the SCOPE domains, as well as in all the SP domains, except for the “emotional reactions” and “emotional/social responses” domains,. The effectiveness of SIT in improving occupational performance in children with ASD as a health-related factor is supported by our findings. (shrink)

The purpose of this study is to assess the efficacy of transcranial direct current stimulation in patients with treatment-refractory trigeminal neuralgia and examine the utility of neuroimaging methods in identifying markers of such efficacy. Six patients with classical TN refractory to maximal medical treatment, underwent tDCS. All patients underwent pre- and posttreatment functional magnetic resonance imaging during block-design tasks as well as single-shell diffusion MRI acquisition. The precise locations of tDCS electrodes were identified by neuronavigation. Five therapeutic tDCS sessions were (...) carried out for each patient with either anodic or cathodic applications. The Numeric Rating Scale of pain and the Headache Disability Index were used to score the subjective efficacy of treatment. Altered activity of regional sites was identified by fMRI and associated changes in the spinothalamocortical sensory tract were measured by the dMRI indices of fractional anisotropy and mean diffusivity. Fiber counts of the bilateral trigeminal root entry zone were performed as an added measure of fiber loss or recovery. All patients experienced a significant reduction in pain scores with a substantial decline in HDI in the number of contralateral sensory fibers in the STCT with either anodic or cathodic tDCS treatment in four of the six patients. A significant reduction in FA was observed in the ipsilateral REZ in the posttreatment phase in five of the six patients. Preliminary evidence suggests that navigated tDCS presents a promising method for alleviating the pain of TN. Different patterns of activation manifested by anodic and cathodic stimulation require further elaboration to understand their implication. Activation and attenuation of responses at various sites may provide further avenues for condition treatment. (shrink)

This paper explores the impact of ethical philosophies on developing an authentic leader’s internalized moral perspective. It builds on prior research on moral identity, proposing that ethical philosophies such as deontology, rule utilitarianism, and virtue can be internalized over time to form an authentic leader’s internalized moral identity. The paper argues that while virtues and altruism are discussed in the authentic leadership literature, the relevance of other ethical philosophies to authentic leadership has been largely overlooked. These ethical philosophies embedded in (...) business settings can be internalized and become integral to the content of a leader’s moral identity rather than merely being lenses for moral reasoning. Authentic leaders’ moral identities regulate their moral motivation and actions. In addition, the paper posits that internalized ethical philosophies can be activated by triggering events or changing the domain of moral issues. Authentic leaders with highly internalized moral identities are also encouraged to be morally modest, reflecting on different ethical philosophies when facing new challenges and internalizing them as needed while staying committed to their virtue-centric moral identity. This interdisciplinary paper proposes a framework and presents theoretical propositions to further understand the role of ethical philosophies in shaping an authentic leader’s internalized moral perspective. (shrink)

Biological evolution provides a creative fount of complex and subtle adaptations, often surprising the scientists who discover them. However, because evolution is an algorithmic process that transcends the substrate in which it occurs, evolution’s creativity is not limited to nature. Indeed, many researchers in the field of digital evolution have observed their evolving algorithms and organisms subverting their intentions, exposing unrecognized bugs in their code, producing unexpected adaptations, or exhibiting outcomes uncannily convergent with ones in nature. Such stories routinely reveal (...) creativity by evolution in these digital worlds, but they rarely fit into the standard scientific narrative. Instead they are often treated as mere obstacles to be overcome, rather than results that warrant study in their own right. The stories themselves are traded among researchers through oral tradition, but that mode of information transmission is inefficient and prone to error and outright loss. Moreover, the fact that these stories tend to be shared only among practitioners means that many natural scientists do not realize how interesting and lifelike digital organisms are and how natural their evolution can be. To our knowledge, no collection of such anecdotes has been published before. This paper is the crowd-sourced product of researchers in the fields of artificial life and evolutionary computation who have provided first-hand accounts of such cases. It thus serves as a written, fact-checked collection of scientifically important and even entertaining stories. In doing so we also present here substantial evidence that the existence and importance of evolutionary surprises extends beyond the natural world, and may indeed be a universal property of all complex evolving systems. (shrink)

Metaphors are cognitive and linguistic tools that allow reasoning. They enable the understanding of abstract domains via elements borrowed from concrete ones. The underlying mechanism in metaphorical mapping is the manipulation of concepts. This article proposes another view on what concepts are and their role in metaphor and reasoning. That is, based on current neuroscientific and behavioural evidence, it is argued that concepts are grounded in perceptual and motor experience with physical and social environments. This definition of concepts is then (...) embedded in the Structure-Mapping Theory, a model for metaphorical processing and reasoning. The blended view of structure-mapping and embodied cognition offers an insight into the processes through which the target domain of a metaphor is embodied or realised in terms of its base domain. The implications of the proposed embodied SMT model are then discussed and future topics of investigation are outlined. (shrink)

Marxism is not as alive today as it was during the two preceding centuries; even now, however, Marx’s ideasideas of Karl Marx continue to engage the intellect, imagination, and conscience of humanity across the world. This edited collection brings together some of the most important contributions to one of the largest international Marxist conferences hosted in 2018 on the 200th anniversary of the birth of Karl Marx. Divided into two broad categories, the writers in this volume not only engage critically (...) with the ideas of Marx, but also present novel approaches to the re-appropriation of Marx’s ideasthese ideas for the unique challenges of the 21st century. Taken together, this book depicts the state of research on Marx and Marxism around the world and offers new paths for researchers and activists in the coming years. (shrink)

The evolution of a variety of important chromophore‐dependent biological processes, including microbial light sensing and mammalian color vision, relies on protein modifications that alter the spectral characteristics of a bound chromophore. Three different color opsins share the same chromophore, but have three distinct absorptions that together cover the entire visible spectrum, giving rise to trichromatic vision. The influence of opsins on the absorbance of the chromophore has been studied through methods such as model compounds, opsin mutagenesis, and computational modeling. The (...) recent development of rhodopsin mimic that uses small soluble proteins to recapitulate the binding and wavelength tuning of the native opsins provides a new platform for studying protein‐regulated spectral tuning. The ability to achieve far‐red shifted absorption in the rhodopsin mimic system was attributed to a combination of the lack of a counteranion proximal to the iminium, and a uniformly neutral electrostatic environment surrounding the chromophore. (shrink)

Satu lagi, buku teologi (sosial) yang berbobot terbit! Berawal dari penelitian yang dimaksudkan untuk penyusunan disertasi pada The South East Asia Graduate School of Theology (SEAGST), 2004, Pendeta Gereja Masehi Injili di Halmahera, Julianus Mojau menyodorkannya kepada khalayak ramai di Indonesia. Argumen utama buku ini dapat diformulasikan dalam pertanyaan berikut ini: bagaimana model teologi sosial sebagaimana dihasilkan oleh tokoh-tokoh Kristen Protestan dan dokumen-dokumen yang meretas dari Persekutuan Gereja-gereja di Indonesia selama kurun waktu tiga dasawarsa, konkretnya semasa pemerintahan Orde Baru? Selama (...) kurun waktu tersebut, Mojau mengenali tiga model teologi sosial di lingkungan Kristen Protestan, yakni teologi sosial modernisme, liberatif, dan pluralis. Ketiga model itu diuraikan dengan sangat runtut, gamblang, sistematis, kritis, berikut logika analitik yang memperlihatkan keluasan dan kedalaman wawasan penulis. Terminologi “teologi sosial” ramai dimanfaatkan dalam blantika percaturan keilmuan di lingkungan Kristen Protestan Indonesia setelah (alm.) Pendeta Eka Darmaputera, Bernard Adeney-Risakotta, Martin Lukito Sinaga, dan Th. Sumartana menggantangnya pada awal tahun 2000.Ditunjukkannyadengan sangat jelas, bahwa “praksis” yang mengawali suatu proses berteologi sudah muncul jauh sebelum angka tahun tersebut. Pada prinsipnya segala teologi adalah teologi sosial, menurut kesimpulan A.G. Hoekema, (hlm. xv), meskipun J.S. Aritonang memberikan batasan simpel dan meyakinkan, yang intinya: “Berteologi di tengah realitas sosial yang kompleks,” itulah Teologi Sosial, (hlm. xiii). Setelah Pendahuluan yang panjang (26 halaman), yang memaparkan duduk perkara dan hal ikhwal diskursus yang diusung, berturut-turut dari Bab 1 (tentang teologi sosial modernisme, hlm. 27-142), Bab 2 (tentang teologi sosial liberatif, hlm. 143-279) dan Bab 3 (teologi pluralis, hlm. 280-365), Bab 4 (retrospeksi dan prospek teologi sosial pasca Orde Baru, hlm. 366-403) penulis memperlihatkan kajian dan analisis secara kritis ketiga model kategori teologi sosial Kristen Protestan di Indonesia. Ketiga model teologi tersebut ditempatkan oleh penulis dalam babak Orde Baru Indonesia (tahun 1969-1990-an) di bawah rezim Soeharto dan dalam pertautannya dengan Islam Politik............... Sebagai paparan dan kajian ilmiah yang mengedepankan pandangan putera-puteri terbaik Kristen Protestan berikut dokumen-dokumen DGI/PGI, karya Mojau ini tidak mampu menyembunyikan keyakinannya bahwa kebangkitan Islam Politik hanyalah sebuah euforia artikulasi kesadaran politis-humanistis yang sedang mencari format yang cocok dalam perubahan zaman di tengah proses transisional. Justru karena itulah Gereja-gereja perlu merangkul dan membuka komunikasi serta dialog yang tulus dengan saudara-saudara penganut Islam Politik sebagai sesama yang merindukan kedamaian, kebaikan, dan keadilan. Perjuangan bersama itulah yang dimaksudkan agar politik sebagai kearifan menatalayani kehidupan bersama tercapai. Dalam pembacaan saya, buku ini sangat inspiratif, kaya dengan informasi, mengedepankan pandangan secara komprehensif tanpa menghilangkan sikap kritis dan tajam. Ini fenomenal dan monumental! Mungkin inilah satu-satunya karya yang “berani” mengritik karya T.B. Simatupang. Mojau sendiri, menurut saya, memperlihatkan diri sebagai pribadi yang memegang teguh spirit Protestan sejati, yakni selalu bersikap kritis terhadap segala bentuk deifikasi. Karya ini akan lebih baik lagi jika ada indeks nama atau masalah pada halaman-halaman akhir. Selain itu, istilah “modernisme” yang diimbuhkan pada Teologi Sosial di mata saya memiliki konotasi lain, yakni aliran modernisme yang dikecam oleh (alm.) Pius X sebagai “biang dari segala kesesatan.” Tetapi di atas segala-galanya, analisis Mojau yang tajam membuat lorong-lorong kebuntuan koeksistensi damai dan adil dengan Islam Politik dapat diurai. Dengan demikian tanda tanya pada judul buku ini terjawab dengan pasti. (A. Eddy Kristiyanto, Program Studi Ilmu Teologi, Sekolah Tinggi Filsafat Driyarkara, Jakarta). (shrink)