This study investigated the characteristics of neural oscillation and functional connectivity in college students engaging in binge drinking using resting-state electroencephalography. Also, the associations of visual memory, evaluated by the Rey-Osterrieth Complex Figure Test, and neural oscillation with FC during the resting state were investigated. The BD and non-BD groups were selected based on scores of the Korean version of the Alcohol use disorders Identification Test and the Alcohol Use Questionnaire. EEG was performed for 6 min while the participants rested (...) with eyes closed. The theta, lower-alpha, and upper alpha powers did not differ between the BD and non-BD groups. Concerning FC, the BD group exhibited stronger theta coherence than that of the non-BD group, and in the lower and upper alpha bands, the BD group showed stronger coherence in some areas but weaker coherence in others compared with the non-BD group. However, these significant results were not observed after Bonferroni correction. The BD group showed significantly lower delayed recall scores on the RCFT than did the non-BD group. A positive correlation between the left prefrontal-parietal-occipital midline connection and performance on the delayed recall of the RCFT was observed in the BD group. The present results could suggest that binge drinkers have alterations in brain FC, which may be related to their visual memory deficits. (shrink)

With the growing amount of clinical research, regulations and research ethics are becoming more stringent. This trend introduces a need for quality assurance measures for ensuring adherence to research ethics and human research protection beyond Institutional Review Board approval. Audits, one of the most effective tools for assessing quality assurance, are measures used to evaluate Good Clinical Practice and protocol compliance in clinical research. However, they are laborious, time consuming, and require expertise. Therefore, we developed a simple auditing process and (...) evaluated its feasibility and effectiveness. The screening audit was developed using a routine audit checklist based on the Severance Hospital’s Human Research Protection Program policies and procedures. The measure includes 20 questions, and results are summarized in five categories of audit findings. We analyzed 462 studies that were reviewed by the Severance Hospital Human Research Protection Center between 2013 and 2017. We retrospectively analyzed research characteristics, reply rate, audit findings, associated factors and post-screening audit compliance, etc. Investigator reply rates gradually increased, except for the first year. The studies were graded as “critical,” “major,” “minor,” and “not a finding”, based on findings and number of deficiencies. The auditors’ decisions showed fair agreement with weighted kappa values of 0.316, 0.339, and 0.373. Low-risk level studies, single center studies, and non-phase clinical research showed more prevalent frequencies of being “major” or “critical”. Inappropriateness of documents, failure to obtain informed consent, inappropriateness of informed consent process, and failure to protect participants’ personal information were associated with higher audit grade. We were able to observe critical GCP violations in the routine internal audit results of post-screening audit compliance checks in “non-responding” and “critical” studies upon applying the screening audit. Our screening audit is a simple and effective way to assess overall GCP compliance by institutions and to ensure medical ethics. The tool also provides useful selection criteria for conducting routine audits. (shrink)

미래 한국의 기초는 신뢰, 도덕적 원칙, 개인적 자율, 상호주의, 공평성이라는 도덕적 패러다임을 중심으로 구축되어야 한다고 이야기 한다. 이를 위해서 이 책에 참여한 사회학자들은 일상생활에서 우리가 규범을 따르는 이류하는 아주 간단한 원리에서부터 기업경영의 성패, 패륜적 범죄, 여성문제에서의 도덕, 과학윤리, 시민문화, 시장경제에서의 도덕성까지 사회 전반의 문제를 매우 현실적 사례와 함께 다루고 있다. 그리고 사회를 이해하는 핵심 코드가 바로 도덕이며, 미래 한국사회의 경쟁력도 도덕이 제공할 수 있다고 역설한다.

ArgumentHistorians have accorded a privileged status to the analytic ideal of elements as a distinctive marker of “modern” chemistry. Boyle’s and Lavoisier’s have been used to characterize their modernity, which has in turn justified their status as the founding fathers of modern chemistry. It has been difficult, however, to establish a viable connection between these two fathers or the genealogy of their definitions. I argue in this paper that French didactic tradition gave rise to the definition Boyle stated in the (...) Sceptical Chymist, or the analytic/philosophical ideal of elements. He did not endorse the definition he gave, but criticized its lack of analytic rigor and philosophical sophistication. His critique served as a negative heuristic, leading to Nicolas Lemery’s analytic ideal of “chemical principles” as distinct from “natural principles.” Lemery’s definition survived in French didactic tradition, as is evidenced in Macquer’s and Guyton’s textbooks which provided direct precedents for Lavoisier’s analytic ideal of “elements or principles.”. (shrink)

Summary The balloon mania between 1783 and 1785 put an extraordinary strain on the Paris Academy of Sciences, threatening its status as the highest tribunal of European science. Faced with repeated royal directives and public frenzy, the Academy manoeuvred carefully to steer the research toward the hydrogen balloon and thereby to maintain its scientific superiority. Antoine-Laurent Lavoisier seized this moment when the promise of ?the empire of airs? brought science to the centre of public attention to push his theoretical reform (...) for chemistry. He utilized the established protocol of the Academy and the resources of the Republic of Letters to broadly publicize his first decomposition of water in April 1784. Once he attained the publicity and the balloon fever began to cool, he staged a much more elaborate experiment for the experts in February 1785. Although this second, large-scale experiment cost much expense and effort, Lavoisier never published a full account. The differential care given to the two experiments can only be understood in their divergent rhetorical contexts. The written accounts in 1784 addressed the court of public opinion, while the exclusive performance in 1785 aimed at the court of experts to inaugurate the collaborative phase of the Chemical Revolution. (shrink)

Ein Leben lang leidet der Mensch an der nie zu überwindenden Endlichkeit seiner Vernunft, die ihn heftig mit Fragen bedrängt, zu deren Beantwortung sie selbst gar nicht in der Lage ist. Im Blick auf den Versuch, dieses Paradoxon aufzulösen, dass nämlich einerseits das metaphysische Bedürfnis der Vernunft zwar von dieser nicht aus eigener Kraft zufriedengestellt werden kann, andererseits aber diese Einsicht keineswegs ihr bohrendes Fragen zum Schweigen bringt, wird die Verführung nachvollziehbar, das Kind mit dem Bade auszuschütten und der Vernunft (...) rundweg und grundsätzlich eine tragfähige lebens- und handlungsleitende Kraft abzusprechen. Grosse Teile der Postmoderne sind von diesem tiefen Misstrauen, das den Abschied von aller Vernunft zu rechtfertigen scheint, geprägt. Die Alternative zu ihrer Verabschiedung im Aufweis der Möglichkeit - ja Notwendigkeit - von Metaphysik auch und gerade angesichts einer stets in ihrer Endlichkeit gefangenen Vernunft wird in diesem Buch gezeichnet."--Page 4 of cover. (shrink)

This descriptive study was undertaken to identify the degree of ethical sensitivity of staff nurses and to analyze the differences in ethical sensitivity in terms of both general and ethics-related characteristics. Participants were 236 staff nurses working in general hospitals in Korea. Ethical sensitivity was measured by means of an instrument developed by the researchers. The results showed that the mean score for the degree of ethical sensitivity was 0.71 out of a possible maximum score of 1 (range 0.30 to (...) 0.97). For general characteristics, there was a significant difference in ethical sensitivity according to age (F (df 2233)-3.99, P-0.02). For characteristics related to ethics, there was a significant difference in ethical sensitivity according to attitude towards the nursing profession (F (df 4231)-2.94, P-0.03). It is therefore recommended that a training program reflecting these variables be developed to enhance staff nurses’ ethical sensitivity. (shrink)

schaften vorkommenden Aussagen deskriptiv und empirisch nachprüfbar sind, besteht zwischen Realisten und Strukturalisten keine Meinungsdifferenz."33 Aber was die Theorie selbst betrifft, vertritt der Strukturalismus die instrumentalistische ...

The expansion of the higher education system and the rationalization of universities in South Korea, while broadly following the global patterns, reflect the characteristics of the national political system. We show the rapid growth of universities and document core organizational changes among universities: the elaboration of faculty performance evaluation rules, the expansion and differentiation of central administrations, and the emergence of engagement in vision statements. These changes, constructing universities as organizational actors, parallel the changes in higher education systems elsewhere. However, (...) the uniqueness of the Korean experience lies with the role of the state as a catalyst guiding the overall direction and the structure and strategy of universities. We discuss the implications of our research for the rationalization of universities in a highly centralized system. (shrink)

Background: Infectious disease outbreaks such as COVID-19 and MERS pose a major threat to healthcare workers' physical and mental health. Studies exploring the positive changes gained from adapting to traumatic events, known as post-traumatic growth, have attracted much attention. However, it is unclear which factors or experiences lead to PTG among HCWs. The purpose of this mixed-method study was to investigate factors associated with PTG among HCWs who experienced the MERS outbreak in South Korea, and fully describe their experience of (...) developing PTG.Methods: Quantitative data from 78 participants were collected using psychometric tools for Psychological distress, Resilience, and Support for coping, and Post-traumatic growth. Qualitative interviews were conducted with seven nurses. Data were analyzed using the qualitative content analysis method according to the sub-themes of resilience, which was the main factor associated with PTG.Results: We found resilience to have a significant impact on PTG. Thus the qualitative interviews were analyzed using the core concepts of resilience. Qualitative interviews with nurses illustrated how participants experienced the development of resilience in terms of its sub-factors: hardiness, persistence, optimism, and support.Conclusion: HCWs who endured the MERS outbreak showed high levels of PTG, and the analysis of the interview data provided a fuller understanding on the experience of remaining resilient and developing PTG. These results provide practical and pragmatic information helpful for developing intervention strategies and protocols that can help HCWs transform adversity into growth and development. (shrink)

Although the language-related fiber pathways in the human brain, such as the superior longitudinal fasciculus and arcuate fasciculus, are already well-known, understanding more sophisticated cortical regions connected by the fiber tracts is essential to scrutinize the structural connectivity of language circuits. With the regions of interest that were selected based on the Brainnetome atlas, the fiber orientation distribution estimation method for tractography was used to produce further elaborate connectivity information. The results indicated that both fiber bundles had two distinct connections (...) with the prefrontal cortex. The SLF-II and dorsal AF are mainly connected to the rostrodorsal part of the inferior parietal cortex and lateral part of the fusiform gyrus with the inferior frontal junction, respectively. In contrast, the SLF-III and ventral AF were primarily linked to the anterior part of the supramarginal gyrus and superior part of the temporal cortex with the inferior frontal cortex, including the Broca's area. Moreover, the IFJ in the PFC, which has rarely been emphasized as a language-related subregion, also had the strongest connectivity with the previously known language-related subregions among the PFC; consequently, we proposed that these specific regions are interconnected via the SLF and AF within the PFC, IPC, and temporal cortex as language-related circuitry. (shrink)

Summary The balloon mania between 1783 and 1785 put an extraordinary strain on the Paris Academy of Sciences, threatening its status as the highest tribunal of European science. Faced with repeated royal directives and public frenzy, the Academy manoeuvred carefully to steer the research toward the hydrogen balloon and thereby to maintain its scientific superiority. Antoine-Laurent Lavoisier seized this moment when the promise of ‘the empire of airs’ brought science to the centre of public attention to push his theoretical reform (...) for chemistry. He utilized the established protocol of the Academy and the resources of the Republic of Letters to broadly publicize his first decomposition of water in April 1784. Once he attained the publicity and the balloon fever began to cool, he staged a much more elaborate experiment for the experts in February 1785. Although this second, large-scale experiment cost much expense and effort, Lavoisier never published a full account. The differential care given to the two experiments can only be understood in their divergent rhetorical contexts. The written accounts in 1784 addressed the court of public opinion, while the exclusive performance in 1785 aimed at the court of experts to inaugurate the collaborative phase of the Chemical Revolution. (shrink)

The mythical scientist in early twentieth-century America cut a lone figure, “impersonal as the chill northeast wind” and “oblivious of everything save his experiment.” He toiled through the night in his laboratory, “a place unimpressive and unmagical save for the constant-temperature bath with its tricky thermometer and electric bulbs,” as if working in the lab were a prayer that promised illumination—“alone, absorbed, [and] contemptuous of academic success and of popular classes,” he knew all about material forces, but he was blind (...) to the vital force that created all others. Accustomed to the “beautiful dullness of long labors,” he remained “illimitably ignorant” of literature, art, and music. He believed that unerring techniques in experimentation, impartial observations, and exquisitely minute calculations would bring progress—a steady march toward the truth. He chose the highest calling in the world because he was “intensely religious—so religious that he will not accept quarter-truths, because they are an insult to his faith.” He was “so devoted to Pure Science . . . that he would rather have people die by the right therapy than be cured by the wrong. Having built a shrine for humanity, he wanted to kick out of it all mere human beings.” This autocratic figure, brilliantly insane and tyrannically honest, embodied the cult of science and objectivity. (shrink)

We examine whether the current regulatory regime instituted in South Korea and the United States would have prevented Hwang’s potential transgressions in oocyte procurement for somatic cell nuclear transfer, we compare the general aspects and oversight framework of the Bioethics and Biosafety Act in South Korea and the US National Academies’ Guidelines for Human Embryonic Stem Cell Research, and apply the relevant provisions and recommendations to each transgression. We conclude that the Act would institute centralized oversight under governmental auspices while (...) the Guidelines recommend politically-independent, decentralized oversight bodies including a special review body for human embryonic stem cell research at an institutional level and that the Guidelines would have provided more vigorous protection for the women who had undergone oocyte procurement for Hwang’s research than the Act. We also suggest additional regulations to protect those who provide oocytes for research in South Korea. (shrink)

Given the instructional challenges posed by the influx of minority-language children in North America, this article attempts to examine early childhood bi- or multilingualism in one of the fastest growing ethnic minority groups in Canada, Korean-Canadians. By drawing on a Vygotskian perspective, the article focuses on the affective and social aspects of learning for culturally and linguistically diverse (CLD) children and their families. With an emphasis on the integration of language and thought, this article first identifies the instructional applications of (...) Vygotskian perspectives and then describes iterative phases of design-based research aimed at developing technology-mediated collaborative learning environments for trilingual Korean-Canadian children. The technology-mediated collaborative learning environment supported young CLD children's affective, social and cognitive needs and created meaning-centered collaborative learning environments. The paper concludes with a consideration of implications of this technology-mediated collaborative learning environment so as to assist teachers who might be confronted with the educational needs of the growing population of CLD children. (shrink)