The current informal practice of pharmacometrics as a combination art and science makes it hard to appreciate the role that informatics can and should play in the future of the discipline and to comprehend the gaps that exist because of its absence. The development of pharmacometric informatics has important implications for expediting decision making and for improving the reliability of decisions made in model-based development. We argue that well-defined informatics for pharmacometrics can lead to much needed improvements in the efficiency, (...) effectiveness, and reliability of the pharmacometrics process. The purpose of this paper is to provide a description of the pervasive yet often poorly appreciated role of informatics in improving the process of data assembly, a critical task in the delivery of pharmacometric analysis results. First, we provide a brief description of the pharmacometric analysis process. Second, we describe the business processes required to create analysis-ready data sets for the pharmacometrician. Third, we describe selected informatic elements required to support the pharmacometrics and data assembly processes. Finally, we offer specific suggestions for performing a systematic analysis of existing challenges as an approach to defi ning the next generation of pharmacometric informatics. (shrink)
Restorative justice should have greater weight as a criterion in criminal justice sentencing practice. It permits a realistic recognition of the kinds of harm and damage caused by offences, and encourages individualized non-custodial sentencing options as ways of addressing these harms. Non-custodial sentences have proven more effective than incarceration in securing social reconciliation and preventing recidivism, and they avoid the serious social and personal costs of imprisonment. This paper argues in support of restorative justice as a guiding idea in sentencing. (...) As part of this defence, it considers whether the use of the idea of restorative justice will conflate criminal law with civil law or displace the authority of the criminal courts, and whether the sentences it recommends are best thought of as punishments or alternatives to punishment. (shrink)
In the Journal of Moral Education, 39(2), Brenda Almond and Lawrence Blum debate the importance of tolerance versus acceptance in sex education. Blum defines acceptance as ?positive regard?, in contradistinction to mere tolerance, ?a live and let live attitude toward others, an acceptance of coexistence, but with a disapproval of that ?other??. Employing consequentialist and definitional arguments, he defends an acceptant educational policy. I shore up this defence by addressing the issue of autonomy: specifically, I refute the claim that (...) acceptance undermines parental autonomy in a morally unacceptable fashion. Drawing on Philip Pettit and Michael Smith?s defence of the idea of ?orthonomy? or right-rule, I argue that orthonomy, rather than autonomy, should guide educational policy-making. I then show that the principle of orthonomy, together with teachers? professional responsibilities to ensure a safe and prejudice-free learning environment, entails that teachers have an inalienable responsibility to promote homophilic (gay-positive) values, regardless of whether they or their students? parents agree. (shrink)
In Issue 7 of Think, Brendan Larvor criticised the Archbishop of Canterbury, Rowan Williams, for suggesting that atheism and humanism ought not to be taught in schools alongside the religious faiths. In Issue 9, Brenda Watson defended the Archbishop's view. Here, Larvor replies to Watson. The numbers below refer to numbered points in Watson's piece.
Although T.L.S. Sprigge described idealist philosophy as the stage beyond religion, his pantheistic idealism, while not itself a religion, offers a conception of God that seeks to meet the aspiration of human beings to understand their own place in the universe. While he shared with most mid twentieth century British philosophers a basic assumption of the primacy of experience, Sprigge took this strong empiricist assumption in a Berkeleyian rather than a Humean direction. This enabled him to find a place for (...) the phenomenon of religious consciousness, which he saw as the source of a yearning that can be met by absolute idealism's conception of a ‘Whole’ that encompasses ourselves and all aspects of our world. He describes this recognition as the faltering adumbration of a truth – one that is sometimes encountered in aesthetic experience, and sometimes more directly in the lives of mystics. The metaphysical basis for this form of absolute idealism is provided by a concept of time in which each fleeting ‘now’ has a fixed and permanent place, and by a theory of identity according to which personal individuality is dissolved in a unitary ‘Whole’. (shrink)
Although Almond argues that the contemporary West has lost touch with the value of tolerance, I argue that that value applied to those of different religions and sexual orientations is too minimal a standard for a pluralistic society. I suggest, in the spirit of the work of Charles Taylor and Tariq Modood, the more robust standard of respect and acceptance. In addition, I have criticised Almond?s privileging of parental values over school values, seeing in that privileging a failure to recognise (...) both the civic function of schooling in a pluralistic society and the professional responsibilities of teachers to provide a safe and stigma?free environment of learning (a goal both educational and civic in character). I argue that Almond?s briefly presented rejection of same?sex marriage and privileging of ?biological? families is insufficiently defended. Moreover within the philosophical framework of her own concerns about the weakening of a commitment to marriage in Western society in the past several decades, I argue that she should be more supportive of same?sex marriage. Finally, I argue that her account of the problems occasioned by new immigrant groups, especially Muslims, in the West is very sketchy and fails to connect with her critique of secularism. (shrink)
Brenda Almond throws down a timely challenge to liberal consensus about personal relationships. She maintains that the traditional family is fragmenting in Western societies, causing serious social problems. She urges that we reconsider our attitudes to sex and reproduction in order to strengthen our most important social institution, the family.
Sometimes referred to as "the last taboo," money has remained something of a secret within psychoanalysis. Ironically, while it is an ingredient in almost every encounter between analyst and patient, the analyst's personal feelings about money are rarely discussed openly or in any great depth. So what is it about money that relegates it to the background, both on the couch and off? In _Money Talks_, Brenda Berger, Stephanie Newman, and their excellent cast of contributors address this and other (...) questions surrounding the tender topic of money, how we talk about it, and how it talks to us. Its multiple meanings are explored in the contexts of patients and analysts and the ways in which they relate, in the training and practice of the analysts themselves, as well as the psychological and cultural consequences of having too much or too little in both flush and tight economic times. Throughout, a clinical sensibility is brought to bear on money's softly spoken place in therapy and life. _Money Talks_ paves the way for an open discourse into the psychology of money and its pervasive influence on the psyche of both patient and analyst. (shrink)
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