25 found
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  1. Multiplex Parenting: IVG and the Generations to Come.César Palacios-González, John Harris & Giuseppe Testa - 2014 - Journal of Medical Ethics 40 (11):752-758.
    Recent breakthroughs in stem cell differentiation and reprogramming suggest that functional human gametes could soon be created in vitro. While the ethical debate on the uses of in vitro generated gametes (IVG) was originally constrained by the fact that they could be derived only from embryonic stem cell lines, the advent of somatic cell reprogramming, with the possibility to easily derive human induced pluripotent stem cells from any individual, affords now a major leap in the feasibility of IVG derivation and (...)
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  2.  30
    Lesbian Motherhood and Mitochondrial Replacement Techniques: Reproductive Freedom and Genetic Kinship.Giulia Cavaliere & César Palacios-González - 2018 - Journal of Medical Ethics 44 (12):835-842.
    In this paper, we argue that lesbian couples who wish to have children who are genetically related to both of them should be allowed access to mitochondrial replacement techniques. First, we provide a brief explanation of mitochondrial diseases and MRTs. We then present the reasons why MRTs are not, by nature, therapeutic. The upshot of the view that MRTs are non-therapeutic techniques is that their therapeutic potential cannot be invoked for restricting their use only to those cases where a mitochondrial (...)
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  3.  61
    Mitochondrial Replacement Techniques and Mexico’s Rule of Law: On the Legality of the First Maternal Spindle Transfer Case.César Palacios-González - 2017 - Journal of Law and the Biosciences 4 (1):50–69.
    News about the first baby born after a mitochondrial replacement technique (MRT; specifically maternal spindle transfer) broke on September 27, 2016 and, in a matter of hours, went global. Of special interest was the fact that the mitochondrial replacement procedure happened in Mexico. One of the scientists behind this world first was quoted as having said that he and his team went to Mexico to carry out the procedure because, in Mexico, there are no rules. In this paper, we explore (...)
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  4.  33
    Are There Moral Differences Between Maternal Spindle Transfer and Pronuclear Transfer?César Palacios-González - 2017 - Medicine, Health Care and Philosophy 20 (4):503-511.
    This paper examines whether there are moral differences between the mitochondrial replacement techniques that have been recently developed in order to help women afflicted by mitochondrial DNA diseases to have genetically related children absent such conditions: maternal spindle transfer and pronuclear transfer. Firstly, it examines whether there is a moral difference between MST and PNT in terms of the divide between somatic interventions and germline interventions. Secondly, it considers whether PNT and MST are morally distinct under a therapy/creation optic. Finally, (...)
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  5. Resource Allocation, Treatment, Disclosure, and Mitochondrial Replacement Techniques: Some Comments on de Melo-Martin and Harris.César Palacios-gonzález - 2017 - Cambridge Quarterly of Healthcare Ethics 26 (2):278-287.
    Some Comments on de Melo-Martin and Harris.
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  6.  40
    Does Egg Donation for Mitochondrial Replacement Techniques Generate Parental Responsibilities?César Palacios-González - 2018 - Journal of Medical Ethics 44 (12):817-822.
    Children created through mitochondrial replacement techniques are commonly presented as possessing 50% of their mother’s nuclear DNA, 50% of their father’s nuclear DNA and the mitochondrial DNA of an egg donor. This lab-engineered genetic composition has prompted two questions: Do children who are the product of an MRT procedure have three genetic parents? And, do MRT egg donors have parental responsibilities for the children created? In this paper, I address the second question and in doing so I also address the (...)
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  7.  13
    Mitochondrial Replacement Techniques: Egg Donation, Genealogy and Eugenics.César Palacios-González - 2016 - Monash Bioethics Review 34 (1):37-51.
    Several objections against the morality of researching or employing mitochondrial replacement techniques have been advanced recently. In this paper, I examine three of these objections and show that they are found wanting. First I examine whether mitochondrial replacement techniques, research and clinical practice, should not be carried out because of possible harms to egg donors. Next I assess whether mitochondrial replacement techniques should be banned because they could affect the study of genealogical ancestry. Finally, I examine the claim that mitochondrial (...)
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  8.  58
    Author's Response to Peer Commentaries: Mexico's Rule of Law and MRTs.César Palacios-González & María de Jesús Medina-Arellano - 2017 - Journal of Law and the Biosciences 4 (3):623–629.
  9.  24
    Human Dignity and the Creation of Human–Nonhuman Chimeras.César Palacios-González - 2015 - Medicine, Health Care and Philosophy 18 (4):487-499.
    In this work I present a detailed critique of the dignity-related arguments that have been advanced against the creation of human–nonhuman chimeras that could possess human-like mental capacities. My main claim is that the arguments so far advanced are incapable of grounding a principled objection against the creation of such creatures. I conclude that these arguments have one, or more, of the following problems: they confuse the ethical assessment of the creation of chimeras with the ethical assessment of how such (...)
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  10.  46
    Mitochondrial Replacement Techniques, Scientific Tourism, and the Global Politics of Science.Sarah Chan, César Palacios-González & María De Jesús Medina Arellano - 2017 - Hastings Center Report 47 (5):7-9.
    The United Kingdom is the first and so far only country to pass explicit legislation allowing for the licensed use of the new reproductive technology known as mitochondrial replacement therapy. The techniques used in this technology may prevent the transmission of mitochondrial DNA diseases, but they are controversial because they involve the manipulation of oocytes or embryos and the transfer of genetic material. Some commentators have even suggested that MRT constitutes germline genome modification. All eyes were on the United Kingdom (...)
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  11.  11
    An Argument for the Intersectional Education of Those Working in International Humanitarian Medical Nongovernmental Organizations.Adriana Clavel-Vazquez & César Palacios-González - 2019 - American Journal of Bioethics 19 (2):42-44.
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  12.  13
    The Ethics of Killing Human/Great-Ape Chimeras for Their Organs: A Reply to Shaw Et Al.César Palacios-González - 2016 - Medicine, Health Care and Philosophy 19 (2):215-225.
    The aim of this paper is to critically examine David Shaw, Wybo Dondorp, and Guido de Wert’s arguments in favour of the procurement of human organs from human/nonhuman-primate chimeras, specifically from great-ape/human chimeras. My main claim is that their arguments fail and are in need of substantial revision. To prove this I first introduce the topic, and then reconstruct Shaw et al.’s position and arguments. Next, I show that Shaw et al.: failed to properly apply the subsidiarity and proportionality principles; (...)
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  13.  37
    Artificial Intelligence.David R. Lawrence, César Palacios-gonzález & John Harris - 2016 - Cambridge Quarterly of Healthcare Ethics 25 (2):250-261.
  14.  2
    Ethical Aspects of Creating Human–Nonhuman Chimeras Capable of Human Gamete Production and Human Pregnancy.César Palacios-González - 2015 - Monash Bioethics Review 33 (2-3):181-202.
    In this paper I explore some of the moral issues that could emerge from the creation of human–nonhuman chimeras capable of human gamete production and human pregnancy. First I explore whether there is a cogent argument against the creation of HNH-chimeras that could produce human gametes. I conclude that so far there is none, and that in fact there is at least one good moral reason for producing such types of creatures. Afterwards I explore some of the moral problems that (...)
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  15.  21
    The Ethics of Clinical Photography and Social Media.César Palacios-González - 2015 - Medicine, Health Care and Philosophy 18 (1):63-70.
    Clinical photography is an important tool for medical practice, training and research. While in the past clinical pictures were confined to the stringent controls of surgeries and hospitals technological advances have made possible to take pictures and share them through the internet with only a few clicks. Confronted with this possibility I explore if a case could be made for using clinical photography in tandem with social media. In order to do this I explore: if patient’s informed consent is required (...)
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  16. Chimeras Intended for Human Gamete Production: An Ethical Alternative?César Palacios-González - 2017 - Reproductive Biomedicine Online 35 (4):387-390.
    Human eggs for basic, fertility and stem-cell research are in short supply. Many experiments that require their use cannot be carried out at present, and, therefore, the benefits that could emerge from these are either delayed or never materialise. This state of affairs is problematic for scientists and patients worldwide, and it is a matter that needs our attention. Recent advances in chimera research have opened the possibility of creating human/non-human animal chimeras intended for human gamete production (chimeras-IHGP). In this (...)
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  17.  2
    Epilepsy, Decisional Vulnerability, and the Nature of Predictive Brain Implants.César Palacios-González - 2015 - American Journal of Bioethics Neuroscience 6 (4):18-19.
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  18.  12
    Enhancing Sisyphus.César Palacios-González & David R. Lawrence - 2015 - American Journal of Bioethics Neuroscience 6 (1):26-27.
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  19. Genetic Parenthood and Causation: An Objection to Douglas and Devolder’s Modified Direct Proportionate Genetic Descent Account.César Palacios-González - 2019 - Bioethics 33 (9):1085-1090.
    In a recent publication Tom Douglas and Katrien Devolder have proposed a new account of genetic parenthood, building on the work of Heidi Mertes. Douglas and Devolder’s account aims to solve, among other things, the question of who are the genetic parents of an individual created through somatic cell nuclear transfer (i.e. cloning): (a) the nuclear DNA provider or (b) the progenitors of the nuclear DNA provider. Such a question cannot be answered by simply appealing to the folk account of (...)
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  20.  84
    Mexico and Mitochondrial Replacement Techniques: What a Mess.César Palacios-González - 2018 - British Medical Bulletin 128.
    Abstract Background The first live birth following the use of a new reproductive technique, maternal spindle transfer (MST), which is a mitochondrial replacement technique (MRT), was accomplished by dividing the execution of the MST procedure between two countries, the USA and Mexico. This was done in order to avoid US legal restrictions on this technique. -/- Sources of data Academic articles, news articles, documents obtained through freedom of information requests, laws, regulations and national reports. -/- Areas of agreement MRTs are (...)
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  21. Mitochondrial Replacement Techniques: Genetic Relatedness, Gender Implications, and Justice.César Palacios-González & Tetsuya Ishii - 2017 - Gender and the Genome 1 (4):1-6.
    In 2015 the United Kingdom (UK) became the first nation to legalize egg and zygotic nuclear transfer procedures using mitochondrial replacement techniques (MRTs) to prevent the maternal transmission of serious mitochondrial DNA diseases to offspring. These techniques are a form of human germline genetic modification and can happen intentionally if female embryos are selected during the MRT clinical process, either through sperm selection or preimplantation genetic diagnosis (PGD). In the same year, an MRT was performed by a United States (U.S.)-based (...)
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  22.  2
    Reproductive Genome Editing Interventions Are Therapeutic, Sometimes.César Palacios-González - forthcoming - Bioethics.
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  23.  22
    Substance Over Style: Is There Something Wrong with Abandoning the White Coat?César Palacios-González & David R. Lawrence - 2015 - Journal of Medical Ethics 41 (6):433-436.
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  24.  25
    ‘Yes’ to Mitochondrial Replacement Techniques and Lesbian Motherhood: A Reply to Françoise Baylis.César Palacios-González & Giulia Cavaliere - 2019 - Journal of Medical Ethics 45 (4):280-281.
    In a recent paper – Lesbian motherhood and mitochondrial replacement techniques: reproductive freedom and genetic kinship – we argued that lesbian couples who wish to have children who are genetically related to both of them should be allowed access to mitochondrial replacement techniques. Françoise Baylis wrote a reply to our paper –‘No’ to lesbian motherhood using human nuclear genome transfer– where she challenges our arguments on the use of MRTs by lesbian couples, and on MRTs more generally. In this reply (...)
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  25.  3
    Beyond Individual Triage: Regional Allocation of Life-Saving Resources such as Ventilators in Public Health Emergencies.Jonathan Pugh, Dominic Wilkinson, Cesar Palacios-Gonzalez & Julian Savulescu - forthcoming - Health Care Analysis:1-20.
    In the first wave of the COVID-19 pandemic, healthcare workers in some countries were forced to make distressing triaging decisions about which individual patients should receive potentially life-saving treatment. Much of the ethical discussion prompted by the pandemic has concerned which moral principles should ground our response to these individual triage questions. In this paper we aim to broaden the scope of this discussion by considering the ethics of broader structural allocation decisions raised by the COVID-19 pandemic. More specifically, we (...)
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