BackgroundIn the Canadian Alliance for Healthy Hearts and Minds cohort, participants underwent magnetic resonance imaging of the brain, heart, and abdomen, that generated incidental findings. The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants were recruited with (...) a follow-up questionnaire administered to 909 participants at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% of participants, with the highest proportions found in the brain and abdomen. The majority of participants informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)
CHARLES LESLIE STEVENSON, Associate Professor of Philosophy in the University of Michigan, though an American, has an important place in the evolution of British ethics in this century. It was in Mind that his first papers on ethics were published in 1937-8. They had considerable influence in Britain in promoting the emotive-persuasive theory of moral language. The author of the theory that much of philosophy and ethics is persuasive rhetoric, was himself a plausible illustration of his own theory. His breeziness (...) of style seemed to sweep difficulties out of the way. His papers had an unconventionality which appealed all the more to the younger generation of philosophers because it shocked the older. He seemed to discredit critics by not appearing able to understand the archaic language they were talking. The ideas of these early papers were taken up into a book, Ethics and Language published in 1944. The book is more ponderous and indeed somewhat pedantic. In it, Stevenson’s ideas lose in freshness what they gain in professorial gravity. But the impressive size of the book, the number and variety of the examples of moral argument which it discussed, the apparently wide range of the treatment, made the book for some time a sort of bible of emotivism. The book was also important as the first major study of ethics based on the neo-Wittgensteinian slogan that moral philosophy is the analysis of moral language. (shrink)
This bibliography records the initial publication of each original work by C.G. Jung, each translation, and significant revisions and expansions of both, up to 1975. In nearly every case, the compilers have examined the publications in German, French and English. Translations are recorded in Danish, Dutch, English, Finnish, French, Greek Hebrew, Hungarian, Italian, Japanese, Norwegian, Portuguese, Russian, Serbo-Croatian, Slovenian, Spanish, Swedish and Turkish. It is arranged according to language, with German and English first, publications being listed chronologically in each language. (...) The _General Bibliography_ lists the contents of the respective volumes of the_ Collected Works_ and the _Gesammelte Werke_, published in Switzerland, and shows the interrelation of the two editions. It also lists Jung's seminars and provides, where possible, information about the origin of works that were first conceived as lectures. An index is provided of all the titles in English and German, and all original works in the other languages. Three specialist indexes, of personal names, organizations and societies and periodicals, complete the work. The publication of the _General Bibliography_, together with the _General Index_, complete the publication of the _Collected Works of C.G. Jung _in English. (shrink)
This six volume backlist collection brings together an assortment of seminal works by highly influential British philosopher A. C. Ewing. This comprehensive and diverse collection encompasses a fantastic selection of his work in the field of moral philosophy and the history of philosophy; ranging from the definition of good, through to his views on punishment and a study on the work of Emmanuel Kant. Spanning more than 30 years in Professor Ewing’s distinguished career, the reissued volumes in this collection, originally (...) published between 1924 and 1959, offer a thorough and engaging insight into Professor Ewing’s work. (shrink)
