Genomic research—including whole genome sequencing and whole exome sequencing—has a growing presence in contemporary biomedical investigation. The capacity of sequencing techniques to generate results that go beyond the primary aims of the research—historically referred to as “incidental findings”—has generated considerable discussion as to how this information should be handled—that is, whether incidental results should be returned, and if so, which ones.Federal regulations governing most human subjects research in the United States require the disclosure of “the procedures to be followed” in (...) the research as part of the informed consent process. It seems reasonable to assume—and indeed, many commentators have concluded—that genomic investigators will be expected to inform participants about, among other procedures, the prospect that incidental findings will become available and the mechanisms for dealing with them. Investigators, most of whom will not have dealt with these issues before, will face considerable challenges in framing meaningful disclosures for research participants.To help in this task, we undertook to identify the elements that should be included in the informed consent process related to incidental findings. We did this by surveying a large number of genomic researchers (n = 241) and by conducting in‐depth interviews with a smaller number of researchers (n = 28) and genomic research participants (n = 20). Based on these findings, it seems clear to us that routine approaches to informed consent are not likely to be effective in genomic research in which the prospect of incidental findings exists. Ensuring that participants’ decisions are informed and meaningful will require innovative approaches to dealing with the consent issue. We have identified four prototypical models of a consent process for return of incidental findings. (shrink)

Reply to a commentary by Felicitas Holzer and Ignacio Mastroleoon “Models of Consent to Return of Incidental Findings in Genomic Research.”.

A commentary on “Models of Consent to Return of Incidental Findings in Genomic Research,” by Paul S. Appelbaum, Erik Parens, Cameron R. Waldman, Robert Klitzman, Abby Fyer, Josue Martinez, W. Nicholson Price II, and Wendy K. Chung, in the July‐August 2014 issue.

This book is about our practice of criticizing one another for epistemic failings. We clearly evaluate and critique one another for forming unjustified beliefs, harboring biases, and pursuing faulty methods of inquiry. But what is the nature of this criticism? Does it ever rise to the level of blame? The question is puzzling because there are competing sources of pressure in our intuitions about “epistemic blame,” ones not easy to reconcile. The more blame-like a response is, the less at home (...) in the epistemic domain it seems—but the more at home in the epistemic domain a response is, the less blame-like it seems. These competing sources of pressure constitute a puzzle about epistemic blame. The most promising solution to this puzzle focuses on the interpersonal side of epistemic normativity. Members of an epistemic community stand in an “epistemic relationship,” and epistemic blame is a way of modifying this relationship. Understanding epistemic blame as a distinctive kind of relationship modification locates a response that is both robustly blame-like, and entirely at home in the epistemic domain. Epistemic relationships can also illuminate a unique set of issues in the “ethics of epistemic blame,” ones that mirror corresponding issues in the ethics of moral blame. The book examines the scope of appropriate epistemic blame, standing to epistemically blame, and the value of epistemic blame in our social and political lives. Throughout the investigation, a better understanding of the parallels and points of interaction between the epistemic and other normative domains emerges. -/- **Front matter, ToC, and Introduction uploaded here**. (shrink)

The Routledge Companion to Metaphysics is an outstanding, comprehensive and accessible guide to the major themes, thinkers, and issues in metaphysics. The Companion features over fifty specially commissioned chapters from international scholars which are organized into three clear parts: History of Metaphysics Ontology Metaphysics and Science. Each section features an introduction which places the range of essays in context, while an extensive glossary allows easy reference to key terms and definitions. The Routledge Companion to Metaphysics is essential reading for students (...) of philosophy and anyone interested in surveying the central topics and problems in metaphysics from causation to vagueness and from Plato and Aristotle to the present-day. (shrink)

Can shifting to tidal time potentially slow the catastrophic realities of sea-level rise? Sarah Cameron Sunde’s 36.5 / A Durational Performance with the Sea is a site-specific performance during which Sunde stands in a tidal bay for a full cycle as water engulfs her body and then reveals it again. The public participates. What began in 2013 as a poetic impulse has grown into a complex series of nine durational performances involving communities around the world. In this article, durational (...) performance artist and scholar Raegan Truax gleans insight from Indigenous feminist scholars and Indigenous women-led movements to analyse the choreographic and temporal dynamics of 36.5. Co-writing with the artist, and focusing specifically on Sunde’s durational shift to tidal time, Truax proposes a phenomenological undoing: ‘becoming Sea-swallowed’ as essential to the speculative possibility of ‘becoming otherwise’. (shrink)

ABSTRACT:Deliberative democratic theory, commonly used to explore questions of “political” corporate social responsibility, has become prominent in the literature. This theory has been challenged previously for being overly sanguine about firm profit imperatives, but left unexamined is whether corporate contexts are appropriate contexts for deliberative theory in the first place. We explore this question using the case of Starbucks’ “Race Together” campaign to show that significant challenges exist to corporate deliberation, even in cases featuring genuinely committed firms. We return to (...) the underlying social theory to show that this is not an isolated case: for-profit firms are predictably hostile contexts for deliberation, and significant normative and strategic problems can be expected should deliberative theory be imported uncritically to corporate contexts. We close with recent advances in deliberative democratic theory that might help update the PCSR project, and accommodate the application of deliberation to the corporate context, albeit with significant alterations. (shrink)

'Chains of Being' argues that there can be infinite chains of dependence or grounding. Cameron also defends the view that there can be circular relations of ontological dependence or grounding, and uses these claims to explore issues in logic and ontology.

This book provides a framework for thinking about foundational philosophical questions surrounding machine learning as an approach to artificial intelligence. Specifically, it links recent breakthroughs in deep learning to classical empiricist philosophy of mind. In recent assessments of deep learning's current capabilities and future potential, prominent scientists have cited historical figures from the perennial philosophical debate between nativism and empiricism, which primarily concerns the origins of abstract knowledge. These empiricists were generally faculty psychologists; that is, they argued that the active (...) engagement of general psychological faculties-such as perception, memory, imagination, attention, and empathy-enables rational agents to extract abstract knowledge from sensory experience. This book explains a number of recent attempts to model roles attributed to these faculties in deep neural network based artificial agents by appeal to the faculty psychology of philosophers such as Aristotle, Ibn Sina (Avicenna), John Locke David Hume, William James, and Sophie de Grouchy. It illustrates the utility of this interdisciplinary connection by showing how it can provide benefits to both philosophy and computer science: computer scientists can continue to mine the history of philosophy for ideas and aspirational targets to hit on the way to more robustly rational artificial agents, and philosophers can see how some of the historical empiricists' most ambitious speculations can be realized in specific computational systems. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.1 (2003) 136-137 [Access article in PDF] John Watkins. Human Freedom after Darwin: A Critical Rationalist View. Chicago: Open Court Publishing, 1999. Pp. xi + 348. Cloth, $49.95. Paper, $24.95. John Watkins examines man's place in nature since Darwin. As a critical rationalist, using the methods of science, Watkins hopes to construct a world-view which challenges competing hypotheses and supports his own. He (...) recognizes that his view is, also, a candidate for critical rejection. All scientific views are, in principle, fallible. He divides his book into two parts: Naturalism and Freedom. [End Page 137]In evolutionary development, he accepts, as critically established, the sequence: matter before life, life before mind, and, no mind without a brain. Thus, naturalism is preferred beforesupernaturalism or divine intervention. These guides may support a continuous, steady evolutionaryprocess or discontinuity, mutations, and various stages of change. Darwin acceptedthe former and held physical changes were unaffected by consciousness. All change is, in principle,present from the beginning and unfolds over time. Darwin's view, then, is deterministic.Watkins challenges this position and argues for consciousness affecting physical change in new and unpredictable ways. It is herein that the possibility of animal and human freedom lies. Watkins gives examples of the actions of the hunter and hunted among animals, and of strategies developed by humans during crises, to support the view that there are novel and unpredictable actions by conscious beings. These actions can hardly be called predetermined in the nature of things. There is a huge difference between a general genetic structure for kinds of behavior and specific actions during crises (not that these are the only instances of freedom). At any rate, there is a reciprocal action between an individual and its environment and not merely a unilinear one.In Part II, Freedom, Watkins examines some classical, philosophical views of human freedom. He gives brief, but penetrating, analyses of Hobbes, Descartes, Hume, Kant, Schopenhauer, and Spinoza. Either they account for human action in strictly physical terms that are causally deterministic or they turn to non-empirical sources that are not verifiable. Since the latter make no difference in our account of behavior, they are entities multiplied beyond necessity. Those who give a completely deterministic view—Hobbes, Hume, and Schopenhauer—offer no continuum between cause and chance. Chance turns out to depend upon our ignorance of causes; further examination would show it causally determined.Watkins seems most sympathetic to Spinoza's treatment. In his hard-headed naturalism, Spinoza rejects any non-natural or supernatural accounts of human behavior. He is a strict determinist where man's confrontation with nature is concerned. Human emotions are passive and react to our environment; they do not affect it. Human reason makes no difference, but in its capacity to contemplate eternal truths it offers a way out. Instead of reacting to nature, man may transcend it. This transcendence is the key to Spinoza's view of the intellectual love of God, and human freedom. Watkins criticizes this flight from man's place in nature and the limited use of reason. In this vein, Spinoza seems to abandon the confrontation of nature for a flight to eternal truths. For Watkins, however, reasons must be used in confronting nature. As we saw, he claims that reason may have an effect upon the environment that is novel and unpredictable. Human agency is a part of the evolutionary story. Human agency is not an either/or proposition. There are degrees of effectiveness in human response to nature.In his analysis of human freedom, Watkins turns to the works of Newton, Faraday, Einstein, and others. In studying the problems posed by the consideration of natural phenomena during their time, they showed intellectual perspicacity of the highest order. Faraday's unified field theory brought electrical and magnetic phenomena, previously thought to be disparate, together. Newton's laws of motion brought celestial and terrestrial mechanics under one theory. Einstein changed the way in which space, time, mass, energy, and light were conceived. In a real sense, they were... (shrink)

Mammalian cells frequently depend on homologous recombination (HR) to repair DNA damage accurately and to help rescue stalled or collapsed replication forks. The essence of HR is an exchange of nucleotides between identical or nearly identical sequences. Although HR fulfills important biological roles, recombination between inappropriate sequence partners can lead to translocations or other deleterious rearrangements and such events must be avoided. For example, the recombination machinery must follow stringent rules to preclude recombination between the many repetitive elements in a (...) mammalian genome that share significant but imperfect homology. This paper takes a conceptual approach in addressing the homology requirements for recombination in mammalian genomes as well as the general strategy used by cells to reject recombination between similar but imperfectly matched sequences. A mechanism of heteroduplex rejection that involves the unwinding of recombination intermediates that may form between mismatched sequences is discussed. BioEssays 30:1163–1171, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

It is clear throughout Cognitive Gadgets Heyes believes the development of cognitive capacities results from the interaction of genes and experience. However, she opposes cognitive instincts theorists to her own view that uniquely human capacities are cognitive gadgets. Instinct theorists believe that cognitive capacities are substantially produced by selection, with the environment playing a triggering role. Heyes’s position is that humans have similar general learning capacities to those present across taxa, and that sophisticated human cognition is substantially created by our (...) socioculturally transmitted environment. It is a core strategy of Heyes to provide evidence of learning altering a cognitive capacity to conclude that a capacity is a cognitive gadget and not an instinct. We draw on recent work on the evolution of learning preparedness to examine the adequacy of this strategy. In particular, we analyse experimental evolution work showing how selection affects cognition within the laboratory. First, this work reveals that change due to learning can still be retained under genetic assimilation. This suggests that domain-specific adaptation can coexist with learning, moderate nativism, an option missed by the instinct versus gadget distinction. Second, we describe the conditions that select for increased preparedness in learning: certainty, reliability, and particular costs. We consider how these conditions can be used when conducting evolutionary reasoning about cognition, applying them to the important capacity for imitation. We find that the conditions lend theoretical support to moderate nativism about the capacity to imitate, which is supported by psychological evidence. (shrink)

Ross P. Cameron argues that the flow of time is a genuine feature of reality. He suggests that the best version of the A-Theory is a version of the Moving Spotlight view, according to which past and future beings are real, but there is nonetheless an objectively privileged present. Cameron argues that the Moving Spotlight theory should be viewed as having more in common with Presentism than with the B-Theory. Furthermore, it provides the best account of truthmakers for (...) claims about what was or will be the case. Cameron goes on to defend an account of the open future, and argues that this is a better account than that available to the Growing Block theory. (shrink)

As Jonathan Dancy points out, if we are tempted to think morality is a rational enterprise, we would expect moral judgments to be constrained by requirements of consistency. If our judgments and choices use general moral principles as guides or standards -- like the laws that feature in the explicit calculations of Immanuel Kant’s moral agent – we can be somewhat confident we respond to moral salience with consistency and, perhaps, rationally. For Kant, explicit reason ensures consistency because the explicit (...) application of maxims is autonomous from volatile external factors. Contemporary empirical studies in moral psychology show that when we respond morally we seemingly do so from emotion or intuition, not reason. For Kant, emotions and intuitions fluctuate with respect to volatile external factors. They are not the sort of things upon which we ought to base judgment and decision. If we hold the Kantian model true, we must assume that we fail to participate rationally in the moral enterprise. I argue against the Kantian model of moral cognition and turn to Aristotle to develop an account of moral cognition that allows us to retain our standing as rational moral agents. First, I argue for a particularist conception of moral reasons: I deny that the consistency required of a picture of morality as a rational enterprise requires our thought utilizes general moral rules. Next, I develop a particularist account of moral knowledge – a demand from their generalist opponents – by providing an account of moral perception. I subsequently argue that the deliverances of moral perception can constitute knowledge by providing a McDowellian account of perceptual justification. Lastly, I return to examine how the empirical work motivating the idea that we don’t participate in morality rationally. I show how none of these studies threatens the Aristotelian model as a viable alternative to the Kantian model. (shrink)

The World is Born From Zero is an investigation into the relationship between video games and science fiction through the philosophy of speculation. Cameron Kunzelman argues that the video game medium is centered on the evaluation and production of possible futures by following video game studies, media philosophy, and science fiction studies to their furthest reaches. Claiming that the best way to understand games is through rigorous formal analysis of their aesthetic strategies and the cultural context those strategies emerge (...) from, Kunzelman investigates a diverse array of games like The Last of Us, VA-11 Hall-A, and Civilization VI in order to explore what science fiction video games can tell us about their genres, their ways of speculating, and how the medium of the video game does (or does not) direct us down experiential pathways that are both oppressive and liberatory. Taking a multidisciplinary look at these games, The World is Born From Zero offers a unique theorization of science fiction games that provides both science fiction studies and video game studies with new tools for thinking how this medium and mode inform each other. (shrink)

We regularly make graded normative judgements in the epistemic domain. Recent work in the literature examines degrees of justification, degrees of rationality, and degrees of assertability. This paper addresses a different dimension of the gradeability of epistemic normativity, one that has been given little attention. How should we understand degrees of epistemic criticizability? In virtue of what sorts of factors can one epistemic failing be worse than another? The paper develops a dual-factor view of degrees of epistemic criticizability. According to (...) the view, degrees of epistemic criticizability are (i) an inverse function of degrees of doxastic justification and (ii) a function of degrees of agent culpability. The paper develops an account of each factor, and explains how they should be weighted. The paper also addresses the importance of modelling degrees of epistemic criticizability in a broader context. I focus on the role that such a model can play in the ethics of epistemic criticism. (shrink)

Firms use algorithms to make important business decisions. To date, the algorithmic accountability literature has elided a fundamentally empirical question important to business ethics and management: Under what circumstances, if any, are algorithmic decision-making systems considered legitimate? The present study begins to answer this question. Using factorial vignette survey methodology, we explore the impact of decision importance, governance, outcomes, and data inputs on perceptions of the legitimacy of algorithmic decisions made by firms. We find that many of the procedural governance (...) mechanisms in practice today, such as notices and impact statements, do not lead to algorithmic decisions being perceived as more legitimate in general, and, consistent with legitimacy theory, that algorithmic decisions with good outcomes are perceived as more legitimate than bad outcomes. Yet, robust governance, such as offering an appeal process, can create a legitimacy dividend for decisions with bad outcomes. However, when arbitrary or morally dubious factors are used to make decisions, most legitimacy dividends are erased. In other words, companies cannot overcome the legitimacy penalty of using arbitrary or morally dubious factors, such as race or the day of the week, with a good outcome or an appeal process for individuals. These findings add new perspectives to both the literature on legitimacy and policy discussions on algorithmic decision-making in firms. (shrink)

Gender dysphoria is a clinically significant incongruence between expressed gender and assigned gender, with rapidly growing prevalence among children. The UK High Court recently conducted a judicial review regarding the service provision at a youth-focussed gender identity clinic in Tavistock. The high court adjudged it ‘highly unlikely’ that under-13s, and ‘doubtful’ that 14–15 years old, can be competent to consent to puberty blocker therapy for GD. They based their reasoning on the limited evidence regarding efficacy, the likelihood of progressing to (...) cross-sex hormone therapy and the ‘life-changing consequences’ of puberty blockers. In this article, I offer two concurrent arguments to dispute their reasoning. First, I argue that minors can be competent to consent to puberty blockers for GD, because the decision to undergo puberty blocker therapy is no more complex or far-reaching than other medical decisions that we accept a child should be able to make. Second, I argue that—irrespective of competence—such legal restriction for all children fundamentally contradicts the central ethical tenet of child healthcare: best interests. For these two reasons, the high court should not restrict access to puberty blockers for competent GD children. (shrink)

This article revolves around the debate surrounding the lack of a coherent definition for corporate social responsibility (CSR). I make use of Jacques Derrida’s theorizing on contested meaning to argue that CSR’s ambiguity is actually necessary in light of its functional role as a “supplement” to corporate profit-seeking. As a discourse that refuses to conclusively resolve the tension between profit-seeking and prosociality, CSR expresses an important critical perspective which demands that firms act responsibly, while retaining the overall corporate frame of (...) shareholder supremacy. CSR does this by ambivalently affirming both profit-seeking and prosociality, a necessary contradiction. Attempts to reduce CSR’s ambiguity can thus only succeed by undermining its viability as a normative discourse that captures how certain elements of society understand how firms should act. The analysis suggests that greater scholarly attention is needed with regard to the material discursive environments within which discourses such as CSR are deployed. A discursive approach to research could thus benefit future practitioners, who have to act according to fluid standards of responsibility that cannot be authoritatively defined, but which can be better understood than they are at present. (shrink)

Name der Zeitschrift: Journal of Ancient History Jahrgang: 5 Heft: 1 Seiten: 66-92.

This review emphasizes the worldwide and U.S. evolving population demographics and the need for the dental profession to exercise its professional and ethical duty to expand its traditional patient base to provide needed services.

Fourteen healthy children (13.8±2.2 years, range 10 to 16; M:F=5:9) received 30 Hz intermittent theta burst transcranial magnetic stimulation (iTBS) with a stimulation intensity of 70% of resting motor threshold (RMT) with a total of 300 (iTBS300) pulses. All volunteers were free of neurologic, psychiatric and serious medical illnesses, not taking any neuropsychiatric medications, and did not have any contraindications to Transcranial Magnetic Stimulation. Changes in the mean amplitudes of motor-evoked potentials from baseline following iTBS were expressed as a ratio (...) and assessed from 1 to 10 minutes (BLOCK1) and 1 to 30 minutes (BLOCK2) using repeated-measures analysis of variance. All 14 subjects completed iTBS300 over the dominant primary motor cortex (M1) without any clinically reported adverse events. ITBS300 produced significant M1 facilitation (F5,65=3.165, p=0.01) at BLOCK1 and trend level M1 facilitation at BLOCK2 (F10,129=1.69, p=0.089). Although iTBS300 (stimulation duration of 92 seconds at 70% RMT) delivered over M1 in typically developed children was well-tolerated and produced on average significant facilitatory changes in cortical excitability, the post-iTBS300 neurophysiologic response was variable in our small sample. ITBS300-induced changes may represent a potential neuroplastic biomarker in healthy children and those with neuro-genetic or neuro-psychiatric disorders. However, a larger sample size is needed to address safety and concerns of response variability. (shrink)

Sale of Sperm, Health Records, Minimally Conscious States, and Duties of Candour Content Type Journal Article Category Recent Developments Pages 7-14 DOI 10.1007/s11673-011-9347-6 Authors Cameron Stewart, Centre for Health Governance, Law and Ethics, Sydney Law School, University of Sydney, Sydney, NSW, Australia 2006 Bernadette Richards, Law School, University of Adelaide, Adelaide, SA, Australia 5005 Richard Huxtable, Centre for Ethics in Medicine, University of Bristol, Bristol, BS8 1TH UK Bill Madden, School of Law, University of Western Sydney, Sydney, NSW, Australia (...) Tina Cockburn, School of Law, Queensland University of Technology, Brisbane, QLD, Australia Journal Journal of Bioethical Inquiry Online ISSN 1872-4353 Print ISSN 1176-7529 Journal Volume Volume 9 Journal Issue Volume 9, Number 1. (shrink)

I respond to Tim Smartt’s (2023) skepticism about epistemic blame. Smartt’s skepticism is based on the claims that (i) mere negative epistemic evaluation can better explain everything proponents of epistemic blame say we need epistemic blame to explain; and (ii) no existing account of epistemic blame provides a plausible account of the putative force that any response deserving the label “blame” ought to have. He focuses primarily on the prominent “relationship-based” account of epistemic blame to defend these claims, arguing that (...) the account is explanatorily idle, and cannot distinguish between epistemically excused and epistemically blameworthy agents. I argue that Smartt mischaracterizes the account’s role for judgments of epistemic relationship impairment, leading to mistaken claims about the account’s predictions. I also argue that the very feature of the account that Smartt mischaracterizes is key to understanding what epistemic blame does for our epistemic responsibility practices that mere negative epistemic evaluation cannot. (shrink)

Paul Sheehy has argued that the modal realist cannot satisfactorily allow for the necessity of God's existence. In this short paper I show that she can, and that Sheehy only sees a problem because he has failed to appreciate all the resources available to the modal realist. God may be an abstract existent outside spacetime or He may not be: but either way, there is no problem for the modal realist to admit that He exists at every concrete possible world.

We report on the small-scale (0.5 13 h - 1M, a large-scale bias of ~2.0 and a satellite fraction of 12 ± 2 per cent. Thus, these galaxies occupy haloes with average masses in between those of the higher redshift BOSS CMASS sample and the original SDSS I/II luminous red galaxy sample © 2012 The Authors Published by Oxford University Press on behalf of the Royal Astronomical Society © doi:10.1093/mnras/sts314.

Why comply with epistemic norms? In this paper, I argue that complying with epistemic norms, engaging in epistemically responsible conduct, and being epistemically trustworthy are constitutive elements of maintaining good epistemic relations with oneself and others. Good epistemic relations are in turn both instrumentally and finally valuable: they enable the kind of coordination and knowledge acquisition underpinning much of what we tend to associate with a flourishing human life; and just as good interpersonal relations with others can be good for (...) their own sake, standing in good epistemic relations is good for its own sake. On my account, we have reason to comply with epistemic norms because it is a way of respecting the final value of something that also tends to be an instrumentally valuable thing: good epistemic relations. Situating the account within the recent social turn in debates about epistemic instrumentalism, I argue that the dual‐value aspect of good epistemic relations can explain important anti‐instrumentalist intuitions, in a well‐motivated way, within a broadly instrumentalist framework. (shrink)

This article explores the links between habit, fashion and subjectification to extend analysis of the clothed body beyond the semiotic frames that have tended to dominate discussions of fashion across the social sciences and humanities. Our goal is to explain how fashion’s diverse materialities participate in the modulations of subjectivity, affecting bodies in diverse encounters between matter, signs and practices. We develop our analysis by way of Gilles Deleuze’s discussion of encounters, habit and memory. Our principal contention is that fashion (...) may usefully be theorised in terms of specific habits of coordination by which affects, memories, sensations and desires are transmitted between bodies in varied spatial, temporal, material and affective encounters. Following the work of John Protevi, we argue that such coordination expresses a distinctive mode of subjectification according to the specific encounters immanent to it. We ground this discussion in detailed analysis of the work of Melbourne artist Fiona Abicare. Abicare’s installation and performance-based practice invokes the affective and habitual aspects of fashion as each is instantiated in encounters between bodies. Abicare’s attention to the habits and memories of the clothed body alludes to the varied practices of subjectification by which diverse subjects of fashion emerge. (shrink)

Is there a distinctively epistemic kind of blame? It has become commonplace for epistemologists to talk about epistemic blame, and to rely on this notion for theoretical purposes. But not everyone is convinced. Some of the most compelling reasons for skepticism about epistemic blame focus on disanologies, or asymmetries, between the moral and epistemic domains. In this paper, I defend the idea that there is a distinctively epistemic kind of blame. I do so primarily by developing an account of the (...) nature of epistemic blame. My account draws on a prominent line of theorizing in moral philosophy that ties blame to our relationships with one another. I argue that with my account of epistemic blame on hand, the most compelling worries about epistemic blame can be deflated. There is a distinctively epistemic kind of blame. (shrink)

It is generally assumed that existing artificial systems are not phenomenally conscious, and that the construction of phenomenally conscious artificial systems would require significant technological progress if it is possible at all. We challenge this assumption by arguing that if Global Workspace Theory (GWT) — a leading scientific theory of phenomenal consciousness — is correct, then instances of one widely implemented AI architecture, the artificial language agent, might easily be made phenomenally conscious if they are not already. Along the way, (...) we articulate an explicit methodology for thinking about how to apply scientific theories of consciousness to artificial systems and employ this methodology to arrive at a set of necessary and sufficient conditions for phenomenal consciousness according to GWT. (shrink)

In this book encounter with Kostas Axelos' Introduction to Future Ways of Thought: On Marx and Heidegger, I introduce Axelos as an imaginative reader of Marx and Heidegger. His approach draws on their parallels to imagine what is possible. I argue that Axelos makes three unique contributions to the Heideggerian-Marxist project. First, Axelos’ understanding of the planetary epoch relies on a reading of Marx that is heavily influenced by Heidegger’s concept of “world”. Second, he builds on the idea of an (...) “open world” meant to combat the technological over-determination characteristic of the planetary era. Third, Axelos preserves the significance of Heidegger and Marx to outline the possibilities of a thinking that, as of yet, remain a future undertaking. I conclude with some ideas about how Axelos' thinking may be further developed. (shrink)

I address an intuition commonly endorsed by metaphysicians, that there must be a fundamental layer of reality, i.e., that chains of ontological dependence must terminate: there cannot be turtles all the way down. I discuss applications of this intuition with reference to Bradley’s regress, composition, realism about the mental and the cosmological argument. I discuss some arguments for the intui- tion, but argue that they are unconvincing. I conclude by making some suggestions for how the intuition should be argued for, (...) and discussing the ramifications of giving the justification I think best. (shrink)

What are the ontological commitments of a sentence? In this paper I offer an answer from the perspective of the truthmaker theorist that contrasts with the familiar Quinean criterion. I detail some of the benefits of thinking of things this way: they include making the composition debate tractable without appealing to a neo-Carnapian metaontology, making sense of neo-Fregeanism, and dispensing with some otherwise recalcitrant necessary connections.

Improving structural theories of international politics -- Socializing states in the international system -- Socializing the United States: emergence to major member -- Socializing the United States: structural imperatives and great power status -- Socializing Israel: emergence to major member.

Atrial natriuretic peptides appear to elicit their actions in some target tissues by binding to a novel cell‐surface transmembrane protein which possesses both peptide binding and guanylate cyclase activities. Ligand binding stimulates enzyme activity to produce increased intracellular concentrations of cyclic GMP which, in turn, mediates the cell's physiological response.