Results for 'Chimerism'

5 found
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  1. Allorecognition, Germline Chimerism, and Stem Cell Parasitism in the Colonial Ascidian, Botryllus Schlosseri.Anthony W. De Tomaso - 2014 - Biological Theory 9 (4):423-430.
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    The Ontological Status of Embryos: A Reply to Jason Morris.Patrick Lee, Christopher Tollefsen & Robert P. George - 2014 - Journal of Medicine and Philosophy 39 (5):483-504.
    In various places we have defended the position that a new human organism, that is, an individual member of the human species, comes to be at fertilization, the union of the spermatozoon and the oocyte. This individual organism, during the ordinary course of embryological development, remains the same individual and does not undergo any further substantial change, unless monozygotic twinning, or some form of chimerism occurs. Recently, in this Journal Jason Morris has challenged our position, claiming that recent findings (...)
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    Twinning and Fusion as Arguments Against the Moral Standing of the Early Human Embryo.Marc Ramsay - 2011 - Utilitas 23 (2):183-205.
    Some philosophers argue that, because it is subject to twinning and fusion, the early human embryo cannot hold strong moral standing. Supposedly, the fact that an early human embryo can twin or fuse with another embryo entails that it is not a distinct individual, thus precluding it from holding any level of moral standing. I argue that appeals to twinning and fusion fail to show that the early human embryo is not a distinct individual and that these appeals do not (...)
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    On the Moral Status of Humanized Chimeras and the Concept of Human Dignity.An Ravelingien, Johan Braeckman & Mike Legge - 2006 - Between the Species 13 (6):7.
    Recent advances in the technology of creating chimeras have evoked controversy in policy debates. At centre of controversy is the fear that a substantial contribution of human cells or genes in crucial areas of the animal’s body may at some point render the animal more humanlike than any other animals we know today. Authors who have commented on or contributed to policy debates specify that chimeras which would be too humanlike would have an altered moral status and threaten our notion (...)
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    Mesenchymal Stem Cells for Systemic Therapy: Shotgun Approach or Magic Bullets?Susan M. Millard & Nicholas M. Fisk - 2013 - Bioessays 35 (3):173-182.
    Given their heterogeneity and lack of defining markers, it is surprising that multipotent mesenchymal stem/stromal cells (MSCs) have attracted so much translational attention, especially as increasing evidence points to their predominant effect being not by donor differentiation but via paracrine mediators and exosomes. Achieving long-term MSC donor chimerism for treatment of chronic disease remains a challenge, requiring enhanced MSC homing/engraftment properties and manipulation of niches to direct MSC behaviour. Meanwhile advances in nanoparticle technology are furthering the development of MSCs (...)
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