The Ontology for Biomedical Investigations (OBI) is an ontology that provides terms with precisely defined meanings to describe all aspects of how investigations in the biological and medical domains are conducted. OBI re-uses ontologies that provide a representation of biomedical knowledge from the Open Biological and Biomedical Ontologies (OBO) project and adds the ability to describe how this knowledge was derived. We here describe the state of OBI and several applications that are using it, such as adding semantic expressivity to (...) existing databases, building data entry forms, and enabling interoperability between knowledge resources. OBI covers all phases of the investigation process, such as planning, execution and reporting. It represents information and material entities that participate in these processes, as well as roles and functions. Prior to OBI, it was not possible to use a single internally consistent resource that could be applied to multiple types of experiments for these applications. OBI has made this possible by creating terms for entities involved in biological and medical investigations and by importing parts of other biomedical ontologies such as GO, Chemical Entities of Biological Interest (ChEBI) and Phenotype Attribute and Trait Ontology (PATO) without altering their meaning. OBI is being used in a wide range of projects covering genomics, multi-omics, immunology, and catalogs of services. OBI has also spawned other ontologies (Information Artifact Ontology) and methods for importing parts of ontologies (Minimum information to reference an external ontology term (MIREOT)). The OBI project is an open cross-disciplinary collaborative effort, encompassing multiple research communities from around the globe. To date, OBI has created 2366 classes and 40 relations along with textual and formal definitions. The OBI Consortium maintains a web resource providing details on the people, policies, and issues being addressed in association with OBI. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

Die Reaktion der Weltwirtschaft auf Epidemien globalen Ausmasses zeigt, wie anfällig ein global-vernetztes Wirtschaftssystem für Störungen ist. Zentrale volkswirtschaftliche Themen wie Armut, Existenzsicherung, ungleich verteilter Reichtum, Arbeit und Arbeitslosigkeit, Verschuldung, Migration und Schwächen des weltweiten Handels- und Finanzsystems sind zudem nach wie vor ungelöst.Christian J. Jäggi zeigt, dass die grossen Weltreligionen - darunter das Judentum, das Christentum und der Islam - wichtige Beiträge zur Lösung dieser Fragen leisten könnten. In diesem Buch analysiert und diskutiert er Standpunkte des biblischen Christentums (...) zu zentralen volkswirtschaftlichen Fragen. Er skizziert mögliche Elemente einer christlichen Wirtschaftsordnungsethik, erarbeitet Lösungsansätze aus christlicher Perspektive und hinterfragt neuere und neueste Texte der christlichen Kirchen sowie christlicher Theologinnen und Theologen zu Vorstellungen von einer gerechten Wirtschaft"-- Back cover. (shrink)

Die Paragonefrage, erstmals ausgiebig von Leonardo diskutiert, besitzt im gesamten Quattrocento eine rege Vorgeschichte, die bei allen frühen Impulsen durch Petrarca als die entscheidende Phase der Formierung der Debatte betrachtet werden muss. Spektakuläre Textfunde der Humanisten, Kunsttraktate, auch eigenhändig von Malern oder Bildhauern verfasst, die Blüte an Vielfachbegabungen, öffentlichen Künstlerwettbewerben und gattungsmäßigen Grenzüberschreitungen verliehen dem wertenden Vergleich der Künste im Italien des 15. Jahrhunderts sein ganz eigenes Gepräge. Erstmals steht dieses - mitsamt dem Fundus an eruierten Quellen - im Zentrum (...) einer grundlegenden Monographie. Leonardos argumentativer Eigenanteil gewinnt ebenso Konturen wie die Genese der Diskussion. Vorweg zweiseitig bemalte Bildnistafeln wie Leonardos Porträt der Ginevra de ́ Benci bieten mit Steinimitationen und Versen spannungsreiche "Übergriffe" in die Nachbargattungen. Für Piero della Francesca waren sie Programm, als er das vierteilige Landschaftspanorama im buchartigen Montefeltro-Diptychon zum Ariadnefaden einer poetischen Erzählung machte. (shrink)

In der heutigen Zeit haben aktuelle politische Fragen - wie etwa die Konflikte im Nahen Osten - häufig eine religiöse Dimension oder werden auch über die Religion ausgetragen. Eine globale Friedensordnung ist nur denkbar, wenn die großen weltanschaulichen Systeme, also auch die großen Religionen, einbezogen werden. Die großen Religionen haben auch einen wichtigen Beitrag an die Friedensthematik zu leisten. Der vorliegende Band analysiert, diskutiert und entfaltet schwergewichtig die Beiträge der jüdischen Tradition und besonders des jüdischen Schrifttums, also Tanach und Talmud, (...) zu Fragen der Friedensordnung, zu einer übergreifenden politischen Ethik und zu Themen wie Krieg, Gewalt, Frieden und Versöhnung. Zur Sprache kommen neben den Schriften des antik-klassischen Judentums punktuell auch rabbinische Stellungnahmen, jüdische Autoren des Mittelalters und moderne jüdische Autoren. Das Buch ist Bestandteil einer fünfbändigen Reihe. Bereits erschienen ist Frieden, politische Ordnung und Ethik. Fragestellungen - Erklärungsmodelle - Lösungsstrategien (2018). (shrink)

Is the overall value of a world just the sum of values contributed by each value-bearing entity in that world? Additively separable axiologies (like total utilitarianism, prioritarianism, and critical level views) say 'yes', but non-additive axiologies (like average utilitarianism, rank-discounted utilitarianism, and variable value views) say 'no'. This distinction is practically important: additive axiologies support 'arguments from astronomical scale' which suggest (among other things) that it is overwhelmingly important for humanity to avoid premature extinction and ensure the existence of a (...) large future population, while non-additive axiologies need not. We show, however, that when there is a large enough 'background population' unaffected by our choices, a wide range of non-additive axiologies converge in their implications with some additive axiology -- for instance, average utilitarianism converges to critical-level utilitarianism and various egalitarian theories converge to prioritiarianism. We further argue that real-world background populations may be large enough to make these limit results practically significant. This means that arguments from astronomical scale, and other arguments in practical ethics that seem to presuppose additive separability, may be truth-preserving in practice whether or not we accept additive separability as a basic axiological principle. (shrink)

尼采的自然主義或者尼采作為自然主義者可以說是過去二十年英美尼 采學界最為熱門的研究論題之一，而在所有相關作品中，Christian Emden 的《尼采的自然主義》則憑藉其出色的歷史脈絡化工作以及對哲學問題的敏 銳關注而成為尼采研究領域不可忽略的著作。在書中，Emden 在十九世紀早 期新康德主義以及生命科學的脈絡下重構了尼采的自然主義，並認為尼采的 系譜學提供了對規範性的一個自然歷史的詮釋。本文將首先簡介在英美以及 德國學界所展開的對尼采自然主義詮釋的爭論，接著概覽Emden 一書的章 節內容，隨後介紹以及評論此書的核心觀點，最後則以對當代尼采研究的簡 短反思作為結論.

The western-based leadership and ethics literatures were reviewed to identify the key characteristics that conceptually define what it means to be an ethical leader. Data from the Global Leadership and Organizational Effectiveness (GLOBE) project were then used to analyze the degree to which four aspects of ethical leadership – Character/Integrity, Altruism, Collective Motivation, and Encouragement – were endorsed as important for effective leadership across cultures. First, using multi-group confirmatory factor analyses measurement equivalence of the ethical leadership scales was found, which (...) provides indication that the four dimensions have similar meaning across cultures. Then, using analysis of variance (ANOVA) tests each of the four dimensions were found to be universally endorsed as important for effective leadership. However, cultures also varied significantly in the degree of endorsement for each dimension. In the increasingly global business environment, these findings have implications for organizations implementing ethics programs across cultures and preparing leaders for expatriate assignments. (shrink)

Despite the increasingly multinational nature of the workplace, there have been few studies of the convergence and divergence in beliefs about ethics-based leadership across cultures. This study examines the meaning of ethical and unethical leadership held by managers in six societies with the goal of identifying areas of convergence and divergence across cultures. More specifically, qualitative research methods were used to identify the attributes and behaviors that managers from the People’s Republic of China (the PRC), Hong Kong, the Republic of (...) China (Taiwan), the United States (the U.S.), Ireland, and Germany attribute to ethical and unethical leaders. Across societies, six ethical leadership themes and six unethical leadership themes emerged from a thematic analysis of the open-ended responses. Dominant themes for ethical and unethical leadership for each society are identified and examined within the context of the core cultural values and practices of that society. Implications for theory, research, and management practice are discussed. (shrink)

There can be little doubt that, over the last decade or so, the work of Carl Schmitt has emerged as a central point of reference, in both positive and negative terms, for many debates within contemporary political theory. Despite Schmitt's notoriously controversial and complex position within the intellectual field of modern political thought, a growing interest, for instance, in his critique of parliamentary democracy and his conceptualization of partisan warfare can be felt not only among political movements with revolutionary agendas, (...) but it can also easily be observed in main-stream political thought on both sides of the Atlantic.1 With the…. (shrink)

There can be little doubt that the “will to power” remains one of Nietzsche’s most controversial philosophical concepts. Leaving aside its colorful and controversial political history in the first half of the twentieth century, the will to power poses considerable problems for any serious reconstruction of Nietzsche’s project. This is particularly the case for analytic reconstructions, which view Nietzsche’s philosophical naturalism largely through the lens of metaethical concerns that are themselves grounded in a psychological reading of will, affect, value, or (...) ressentiment.1 The will to power, though, defies interpretations that are schooled in contemporary philosophy of mind, or cognitive psychology. Even.. (shrink)

Decision-making under normative uncertainty requires an agent to aggregate the assessments of options given by rival normative theories into a single assessment that tells her what to do in light of her uncertainty. But what if the assessments of rival theories differ not just in their content but in their structure -- e.g., some are merely ordinal while others are cardinal? This paper describes and evaluates three general approaches to this "problem of structural diversity": structural enrichment, structural depletion, and multi-stage (...) aggregation. All three approaches have notable drawbacks, but I tentatively defend multi-stage aggregation as least bad of the three. (shrink)

In philosophy of science concept formation and reduction is usually discussed with respect to definability. In the paper at hand this discussion is slightly expanded to an investigation of concept formation and reduction by analogies. It is argued that many kinds of such analogies bear some important features of partial contextual definitions. -/- With the help of a detailed investigation of the so-called gene-meme-analogy it is then demonstrated how the meme-concept is introduced via analogies into an expanded theory of (cultural) (...) evolution. As a consequence it is shown that the diversity of meanings of the meme-concept fits into the current state of establishing this analogy. (shrink)

One challenge of societies in the 21st century is the conflict of norms between different cultures. In Ancient Greece, too, such conflicts arose, and great thinkers offered great solutions. In this contribution we will argue for the following: - Ancient ethical theories were not only individual ethical theories but also social ethical theories (II). - The ancient methods of scientific examinations are useful not only in classical sciences but also in ethics (III). - Accepting the result of (III) yields highly (...) interesting theoretical results about conflicts of norms between different cultures (IV). (shrink)

In diesem Beitrag wird das Verhalten des Papstes im europäischen Dialog der Religionen und Weltanschauungen kritisch erörtert. Am Anfang steht eine kurze Analyse der Sprache der Religionen bzw. Weltanschauungen, die in Anlehnung an Joseph Maria Bochenski durchgeführt ist. Es wird dabei die Auffassung vertreten, dass Religionen und manche Weltanschauungen Behauptungen über die Wirklichkeit aufstellen, Sprache in einer deskriptiv-kognitiven Funktion verwenden, dass ein solcher Sprachgebrauch eine epistemische Verpflichtung auf Bescheidenheit mit sich bringt und dass eine solche Verpflichtung wiederum eine Basis für (...) einen ernstgemeinten europäischen Dialog bieten könnte. Danach werden von einem theologischen Standpunkt ausgehend Bedingungen dafür untersucht, dass ein europäischer Dialog stattfinden kann. Anhand konkreter Beispiele, im Speziellen anhand der "Regensburger Rede" und der "Neuformulierung der Karfreitagsfürbitte für die Juden", wird gezeigt, wie sich der Papst im europäischen Dialog tatsächlich verhält und wie von Seiten der jeweiligen Religion auf dieses Verhalten eingegangen wird. Da er vor allem in der menschlichen Vernunft eine Brücke für einen europäischen Dialog sieht, wird anschließend auf seine Argumentation für eine Ausweitung der Vernunft und seinen Gebrauch der Wörter "Vernunft" und "Glauben" eingegangen. Dabei wird hauptsächlich auf Schriften, in denen der Papst seine Überzeugung ausdrückt, dass Religion und Vernunft sich gegenseitig korrigieren, begrenzen und unterstützen müssen, Bezug genommen. Abschließend wird ein bestimmtes Argument des Papstes für diese Überzeugung expliziert und bewertet. (shrink)

In their paper on the influence of meta-induction to the wisdom of the crowd, Paul Thorn and Gerhard Schurz argue that adding meta-inductive methods to a group influences the group positively, whereas replacing independend methods of a group with meta-inductive ones may have a negative impact. The first fact is due to an improvement of average ability of a group, the second fact is due to an impairment of average diversity within a group by meta-induction. In this paper some critical (...) remarks to meta-inductive group expansion and replacement are made. In particular it is stressed that both ability and diversity are of equal importance to a group’s performance. (shrink)

Ethische Vorstellungen beruhen auf religiösen Glaubensüberzeugungen, aber auch auf Konzepten wie Vernunft, Freiheit und Autonomie. Beide, also religiöse Ethiken und aufklärerisches Denken, stossen heute an ihre Grenzen. Fundamentalismus, religiöse Gewalt, aber auch der Verlust allgemeingültiger Wertvorstellungen und fehlende Verbindlichkeit bedrohen Gesellschaft und Politik. Im ersten Teil dieses Bandes werden wichtige religiöse Zugänge zur Ethik beschrieben. Im zweiten Teil kommen zentrale ethische Aspekte des säkularen Denkens zur Sprache. Die so entstandenen Bausteine können Grundlagen für eine neue universelle Ethik sein.

In diesem Beitrag werden einige wissenschaftstheoretische Thesen u.a. von Paul K. Feyerabend hinsichtlich ad-hoc-Hypothesen untersucht. Es wird dabei gezeigt, dass Feyerabends Empfehlungen dafür, ad-hoc-Hypothesen zu akzeptieren oder abzulehnen, vom Einfluss dieser Hypothesen auf die Entwicklung von Technik abhängen. In einem weiteren Schritt wird angedeutet, dass eine derartige Relativierung auch in gängigen Bestätigungstheorien nahegelegt wird, dass man also gängigen Bestätigungstheorien und Feyerabend zufolge ad-hoc-Hypothesen nur hinsichtlich ihres Einflusses auf die Technikentwicklung akzeptieren oder ablehnen sollte.

One problem of intergenerational justice concerns the question whether the present generation bears moral responsibility for future generations and how to justify such a responsibility. A way of justification is to take a person-affecting view of ethics, according to which no action is morally bad per se, but only with respect to someone (e.g. with respect to future generations). Against a person-affecting view sometimes the so-called non-identity-problem is posed. This problem states that there are actions which - from a person-affecting (...) point of view - have to be considered as bad for a person, although without execution of the action the person would not exist. In this paper I will try to show how this conflict can be solved by an exact analysis of its structure. (shrink)

Eleonore Stump claims in her book "Wandering in Darkness" that the problem of evil can be solved best by the help of narratives. This - so Stump - is due to the fact that narratives allow one to get a general view about relevant parts of the discussion of suffering. In this context she distinguishes the more detailed view of the discussion from a more general one by two different modes of cognition: the mode of gathering "knowledge that" and that (...) one of gathering "knowledge how". Knowledge by narratives is a subcategory of the last-mentioned one. In the paper I argue for the thesis that this distinction is not really crucial for Stump's argumentation and that in fact only "knowledge that" is relevant for her proposed solution. (shrink)

Focusing on the close connection between Friedrich Nietzsche's historical thought and the discourse of German historicism in the second half of the nineteenth century, this article argues in a thick contextual reading that Nietzsche's second VomNutzenundNachtheilderHistoriefürdasLeben(1874), needs to be understood as a reflection on the political dimension of historical consciousness, outlining what I shall term a In contrast to the standard emphasis on Nietzsche's presumed aestheticism, he is shown to react to rather specific developments within the contemporary intellectual context, such (...) as the establishment of specific historical foundation myths for a new German nation state, exemplified by the public monuments and commemorations of the 1870s, the effect of such foundation myths on the political imagination of historical scholarship, and the intellectual antagonism between Basel's and the German nation state. (shrink)

In their paper on the influence of meta-induction to the wisdom of the crowd, Paul Thorn and Gerhard Schurz argue that adding meta-inductive methods to a group influences the group positively, whereas replacing independent methods of a group with meta-inductive ones may have a negative impact. The first fact is due to an improvement of average ability of a group, the second fact is due to an impairment of average diversity within a group by meta-induction. In this paper some critical (...) remarks to meta-inductive group expansion and replacement are made. In particular it is stressed that both ability and diversity are of equal importance to a group's performance. (shrink)

Volume 20, Issue 6, June 2020, Page 40-42.

Brian Leiter and Peter Kail have delivered thoughtful critiques of my book, Nietzsche’s Naturalism: Philosophy and the Life Sciences in the Nineteenth Century.1 It is a great pleasure to respond to these critiques, since they raise some crucial issues with regard to Nietzsche’s understanding of naturalism and normativity. On the one hand, there are many areas of agreement: Nietzsche’s philosophical project is best understood along the lines of naturalism; developments in the nineteenth-century life sciences, broadly speaking, play a crucial role (...) in the formation of Nietzsche’s naturalism; and Nietzsche’s relationship to both Darwin and Darwin’s neo-Kantian interpreters is more complex than generally assumed. On the... (shrink)

Volume 20, Issue 3, March 2020, Page 35-37.

Nietzsche’s Catharsis: The Theory of Tragedy and the Anthropology of Power. Nietzsche’s conception of catharsis undercuts the Aristotelian tradition by emphasizing that catharsis does not aim at a purification of the passions but at a cleansing of human judgment from moral sentiment. As such, Nietzsche develops a naturalistic counter-model to eighteenth-century theories of pity. By bringing together ancient Greece and the experience of modernity, this counter-model shifts the concept of catharsis into the realm of the political and enriches the theory (...) of tragedy with an anthropology of power. What is at stake in Nietzsche’s discussion of catharsis is an insight into the instability of normative order, which is triggered by the modern experience of the „phenomenon of Napoleon“ as an overcoming of Enlightenment conceptions of moral conscience. If modernity has to be understood along the lines of tragedy, Napoleon Bonaparte is the cathartic event in the realm of the political. (shrink)

*The views represented in this article are those of the author and do not necessarily represent the views or policies of the American Medical Association.

This paper discusses one of the advantages of applying formal methods in ethics. First, an approach from democratic morality—which is a special case of contractualist ethics that brings together theories of legal and moral philosophy—will be adopted, in order to argue for the non-trivial thesis that moral norms are increasingly democratically motivated. To accept this thesis also as a desired way of justifying ethical principles raises some issues, such as the problem of providing adequate principles for moral opinion pooling. Secondly, (...) it is therefore shown how formal criteria of rationality provide at least a partial solution to such problems. In a broad context this results can be seen as formal preliminaries to contractualist ethics. (shrink)

This paper argues that Georg Simmel's Philosophy of Money is best understood as a political theory that focuses on the normativity of finance capitalism and the latter's effects on modern societies. Simmel shares some common ground with recent critiques of capitalism, such as the work of Thomas Piketty and Joseph Vogl, but he also presents a more comprehensive philosophical framework for understanding the dynamics of capitalism and financialization.