The ontic conception of explanation is predicated on the proposition that “explanation is a relation between real objects in the world” and hence, according to this approach, scientific explanation cannot take place absent such a premise. Despite the fact that critics have emphasized several drawbacks of the ontic conception, as for example its inability to address the so-called “abstract explanations”, the debate is not settled and the ontic view can claim to capture cases of explanation that are non-abstract, such as (...) causal relations between events. However, by eliminating the distinction between abstract and non-abstract explanations, it follows that ontic and epistemic proposals can no longer contend to capture different cases of explanation and either all are captured by the ontic view or all are captured by the epistemic view. On closer inspection, it turns out that the ontic view deals with events that fall outside the scientists’ scope of observation and that it does not accommodate common instances of explanation such as explanations from false propositions and hence it cannot establish itself as the dominant philosophical stance with respect to explanation. On the contrary, the epistemic conception does account for almost all episodes of explanation and can be described as a relation between representations, whereby the explanans transmit information to the explanandum and that this information can come, dependent on context, in the form of any of the available theories of explanation (law-like, unificatory, causal and non-causal). The range of application of the ontic view thus is severely restricted to trivial cases of explanation that come through direct observation of the events involved in an explanation and explanation is to be mostly conceived epistemically. (shrink)

This monograph evaluates public policy responses to the Covid-19 pandemic through a public choice lens. The book compares two prominent, albeit mutually exclusive, theories in social sciences—public interest theory and public choice theory—and explores how their predictions perform within the framework of the Covid-19 pandemic. The chapters present different pandemic policies alongside empirical data in order to draw conclusions about their efficacy, and, in turn, draw conclusions about the veracity of each theory. By the end of the volume, the reader (...) will be able to draw their own conclusions about whether the pandemic policy responses served the public interest, as public interest theory suggests, or the personal interests of the politicians who implemented them, as public choice theory holds. (shrink)

In the fourteenth chapter of The Philosophy of Information, Luciano Floridi puts forth a criticism of ‘digital ontology’ as a step toward the articulation of an ‘informational structural realism’. Based on the claims made in the chapter, the present paper seeks to evaluate the distinctly Kantian scope of the chapter from a rather unconventional viewpoint: while in sympathy with the author’s doubts ‘against’ digital philosophy, we follow a different route. We turn our attention to the concept of construction as used (...) in the book with the hope of raising some additional questions that might contribute to a better understanding of what is at stake in Floridi’s experimental epistemological response to digital ontology. (shrink)

The ontic conception of explanation is predicated on the proposition that “explanation is a relation between real objects in the world” and hence, according to this approach, scientific explanation cannot take place absent such a premise. Despite the fact that critics have emphasized several drawbacks of the ontic conception, as for example its inability to address the so-called “abstract explanations”, the debate is not settled and the ontic view can claim to capture cases of explanation that are non-abstract, such as (...) causal relations between events. However, by eliminating the distinction between abstract and non-abstract explanations, it follows that ontic and epistemic proposals can no longer contend to capture different cases of explanation and either all are captured by the ontic view or all are captured by the epistemic view. On closer inspection, it turns out that the ontic view deals with events that fall outside the scientists’ scope of observation and that it does not accommodate common instances of explanation such as explanations from false propositions and hence it cannot establish itself as the dominant philosophical stance with respect to explanation. On the contrary, the epistemic conception does account for almost all episodes of explanation and can be described as a relation between representations, whereby the explanans transmit information to the explanandum and that this information can come, dependent on context, in the form of any of the available theories of explanation (law-like, unificatory, causal and non-causal). The range of application of the ontic view thus is severely restricted to trivial cases of explanation that come through direct observation of the events involved in an explanation and explanation is to be mostly conceived epistemically. (shrink)

Different why-questions emerge under different contexts and require different information in order to be addressed. Hence a relevance relation can hardly be invariant across contexts. However, what is indeed common under any possible context is that all explananda require scientific information in order to be explained. So no scientific information is in principle explanatorily irrelevant, it only becomes so under certain contexts. In view of this, scientific thought experiments can offer explanations, should we analyze their representational strategies. Their representations involve (...) empirical as well as hypothetical statements. I call this the “representational mingling” which bears scientific information that can explain events. Buchanan’s thought experiment from constitutional economics is examined to show how mingled representations explain. (shrink)

Events regarding individuals’ preferences that do not always follow from standard measures such as “value of statistical life” or “quality-adjusted life years” as well as events that occur in some market-related settings which distort the information conveyed by price mechanisms, suggest that a notable chunk of what Hayek called “local knowledge” remains inaccessible by scientific tools and that only the individuals who interact in these local frameworks can have access to it. This casts serious doubt on the epistemic possibility of (...) economic calculation for if events in the local world do not observe the economic models, it is hard to see how central planners can have knowledge on them. Refined modeling strategies and cutting-edge Artificial Intelligence systems do not manage to overcome this hurdle. They may provide huge datasets in a data model, but since not all events represented in the data model are embeddable in known economic models, the knowledge problem is not evaded. Even if a theory ever manages to capture all possible events as they appear in the data model then we are left with a relationship between models (the theoretical model and the data model) with no direct access to the local world and thus the problem of accessibility of local knowledge remains unresolved. (shrink)

Mihalis Matsas situates the specific questions raised by the translation of Deleuze in Greece within the more general context of philosophical translation and the difficulties raised by the translation of Deleuze’s two books on the cinema.

During the Covid-19 pandemic, public policy was not driven by findings from public health research, but by politicians’ desire to pursue their own interests. The media and politicians inflamed mass hysteria and then imposed ill-considered lockdowns to “solve” the problem. Lockdowns not only failed to protect those at risk from the virus, but also caused enormous collateral damage. Public choice theory helps explaining this decision-making. -/- .

The emphasis in human pluripotent stem cell (hPSC) technologies has shifted from cell therapy to in vitro disease modelling and drug screening. This review examines why this shift has occurred, and how current technological limitations might be overcome to fully realise the potential of hPSCs. Details are provided for all disease‐specific human induced pluripotent stem cell lines spanning a dozen dysfunctional organ systems. Phenotype and pharmacology have been examined in only 17 of 63 lines, primarily those that model neurological and (...) cardiac conditions. Drug screening is most advanced in hPSC‐cardiomyocytes. Responses for almost 60 agents include examples of how careful tests in hPSC‐cardiomyocytes have improved on existing in vitro assays, and how these cells have been integrated into high throughput imaging and electrophysiology industrial platforms. Such successes will provide an incentive to overcome bottlenecks in hPSC technology such as improving cell maturity and industrial scalability whilst reducing cost. (shrink)

Die gebirgige Halbinsel Athos an der nordwestlichen Küste des Ägäischen Meeres mit ihren zwanzig vom 10. bis zum 20. Jahrhundert datierenden Klosteranlagen ist, obwohl sie mit ihrer langen Geschichte einen bedeutenden Faktor des geistigen und kulturellen Lebens von Byzanz darstellt, bisher wenig durch systematische und umfassende Studien erkundet. Ein Grund dafür ist in dem Umstand zu suchen, dass wissenschaftliches Tun im Zentrum des früheren byzantinischen Mönchtums nur unter vollem Einsatz und nach mehrjährigem fachlichen Austausch zustande kommen kann.

Considers Deleuze's ideas on philosophical practice in relation to his work. This book presents analyses of, and aims to provide some context for, this relation in Deleuze's work, by focusing on Deleuze's conception of the relation between thought and practice, the brain and the hand (or mouth).

Los abusos sexuales a menores por parte de sacerdotes de la Iglesia Católica desataron gran preocupación en muchos países del mundo en los últimos años. En Chile, específicamente, el tema develó los vínculos existentes entre distintos ámbitos de poder de las élites a través del denominado caso Karadima. Este artículo se enmarca en el ámbito del Análisis Crítico del Discurso y en él se examinan -desde la perspectiva de las estrategias o funciones del discurso político- proposiciones tomadas de doce (...) episodios de una entrevista y en ellas se explora el comportamiento discursivo de la principal autoridad de la Iglesia Católica en el contexto de dicho caso y a quien además le correspondió recibir e investigar las primeras denuncias, el Cardenal Errázuriz. El estudio busca develar qué estrategias discursivas emplea el hablante y cómo éstas son funcionales a los propósitos de protección de la institución que representa. Del análisis se advierte un intento por desacreditar las acusaciones de las víctimas y validar las acciones emprendidas por su institución y algunos de sus representantes. (shrink)