Background: Research activities in sub-Saharan Africa may be limited to delegated tasks due to the strong control from Western collaborators, which could lead to scientific production of little value in terms of its impact on social and economic innovation in less developed areas. However, the current contexts of international biomedical research including the development of public-private partnerships and research institutions in Africa suggest that scientific activities are growing in sub-Saharan Africa. This study aims to describe the patterns of clinical research (...) activities at a sub-Saharan biomedical research center. Methods: In-depth interviews were conducted with a core group of researchers at the Medical Research Unit of the Albert Schweitzer Hospital from June 2009 to February 2010 in Lambarene, Gabon. Scientific activities running at the MRU as well as the implementation of ethical and regulatory standards were covered by the interview sessions. Results: The framework of clinical research includes transnational studies and research initiated locally. In transnational collaborations, a sub-Saharan research institution may be limited to producing confirmatory and late-stage data with little impact on economic and social innovation. However, ethical and regulatory guidelines are being implemented taking into consideration the local contexts. Similarly, the scientific content of studies designed by researchers at the MRU, if local needs are taken into account, may potentially contribute to a scientific production with long-term value on social and economic innovation in sub-Saharan Africa. Conclusion: Further research questions and methods in social sciences should comprehensively address the construction of scientific content with the social, economic and cultural contexts surrounding research activities. (shrink)

Cornelia Dean draws on her 30 years as a science journalist with the New York Times to expose the flawed reasoning and knowledge gaps that handicap readers when they try to make sense of science. She calls attention to conflicts of interest in research and the price society pays when science journalism declines and funding dries up.--.

This paper explores one organisation’s journey into non-financial reporting, initially motivated by a crisis in public confidence that threatened the organisation’s legitimacy to the present with the organisation embracing integrated reporting. The organisation’s journey is framed through a legitimation lens and is illustrated by aligning internal reflections with external outputs guided by predominant paradigms of good practice, such as the GRI guidelines and more recently integrated reporting 〈IR〉. We find that the organisation’s relationship with external guidelines has evolved from pragmatic (...) adoption as a means of seeking external legitimation to the present position where those that prepare external reports are informed by the organisation’s strategic positioning and not constrained by the promulgation of voluntary guidelines. From the case study, we suggest that the International Integrated Reporting Council may face two hurdles: First, organisations may define social norms based on a broader definition of stakeholders than the definition currently published by the IIRC. The second hurdle is to convince report preparers that adopting integrated reporting 〈IR〉 will positively impact on capital flows. (shrink)

Powerful ultrastructural tools are providing new insights into neuronal circuits, revealing a wealth of anatomically‐defined synaptic connections. These wiring diagrams are incomplete, however, because functional connectivity is actively shaped by neuromodulators that modify neuronal dynamics, excitability, and synaptic function. Studies of defined neural circuits in crustaceans, C. elegans, Drosophila, and the vertebrate retina have revealed the ability of modulators and sensory context to reconfigure information processing by changing the composition and activity of functional circuits. Each ultrastructural connectivity map encodes multiple (...) circuits, some of which are active and some of which are latent at any given time. (shrink)

The goal of the article is to offer a framework against which relations between gesture and sign can be systematically explored beyond the current literature. It does so by a) reconstructing the history of the discussion in the field of gesture studies, focusing on three leading positions (Kendon, McNeill, Goldin-Meadow); and b) by formulating a position to illustrate how this can be achieved. The paper concludes by emphasizing the need for systematic cross-linguistic research on multimodal use of language in its (...) signed and spoken forms. (shrink)

In the age of surveillance capitalism, the prevailing business model underlying the use of social media applications (“apps”) foresees the exchange of personal data for the allowance to use an online service. Such a data business model comes with many potential negative side effects ranging from violation of privacy issues to election manipulation. Therefore, it is of utmost importance to think of alternatives to the current data business model. The present study investigated how strong the support would be for a (...) monetary payment model among a sample of 210 participants. Participants were asked about their willingness to pay for social media, if in turn their data would be private and other problems concerning social media use would be tackled. Only one-fifth of participants (21.43%) supported such a model. From the Big Five Personality traits, Agreeableness was positively associated with support of such a model. Finally, data are also provided on how much participants would be willing to pay for social media on a monthly basis. The present study’s findings are of a preliminary nature and will contribute to the start of an important discussion. (shrink)

Dem Postmarxismus wird haufig ein mangelndes Verstandnis des Staats vorgeworfen. Dieser Band stellt sich dieser Lesart entgegen und zeichnet ein vielfaltiges Bild der Staatsverstandnisse von Abensour, Agamben, Badiou, Balibar, Bauman, Butler, Castoriadis, Deleuze und Guattari, Derrida, Hardt und Negri, Hall, Holloway, Lefort und Gauchet, Laclau und Mouffe, Nancy, Ranciere und zizek. Die Zugange dieser Autor_innen zum Staat werden anhand zentraler Konzepte in leicht zuganglicher Form dargestellt und von marxistischen und neomarxistischen Staatstheorien abgegrenzt. Im letzten Teil werden die gegenseitigen Beeinflussungen zwischen (...) postmarxistischen Staatsverstandnissen einerseits und feministischen und postkolonialen Zugangen andererseits beschrieben, wie auch die Verschrankung postmarxistischer Theorien mit zeitgenossischen politischen Bewegungen. Insgesamt bietet der Band damit einen erstmaligen Uberblick zu den Konzepten und der Bedeutung postmarxistischer Staatsverstandnisse. (shrink)

Serves as an essential reference for students, researchers, and academics in international relations.

While generally accepted as an interpretive theory, Bull’s emblematic text demonstrates strong structural characteristics. Subsequent attributions move between the interpretive or ‘reflexive’ and t...

Der Band plädiert für eine Resymmetrisierung des Sprachlichen und des Bildlichen für das Verständnis der Gegenwartsgesellschaft. Bildlichkeit wird als eine vom Wahrnehmungsmodus unterschiedene genuin soziale Sinnform aufgefasst. Wir verlassen uns darauf, dass auch Andere ganz selbstverständlich dargestellte Welt von wahrgenommener Welt unterscheiden. Auf die Darstellungen von Darstellungsformen hat sich moderne Kunst spezialisiert. Am Beispiel der Gegenwartskunst wird die Vermehrung, Kombinatorik und wechselseitige Bezugnahme künstlerischer Formen als Katalysator für innerkünstlerische Transformationen identifizierbar.

Dieses Buch schreibt Theorie. Es entwirft am Beispiel von Wilhelm Raabes Erzähltexten zwischen 1856 und 1902 den Grundriss einer ontologischen Narratologie, der über seinen historischen Gegen-stand hinaus systematische Gültigkeit beansprucht. Den Ausgangspunkt bildet die Frage: Was ist Welt?

Perfect Harmony and Melting Strains assembles interdisciplinary essays investigating concepts of harmony during a transitional period, in which the Pythagorean notion of a harmoniously ordered cosmos competed with and was transformed by new theories about sound - and new ways of conceptualizing the world. From the perspectives of philosophy, literary scholarship, and musicology, the contributions consider music's ambivalent position between mathematical abstraction and sensibility, between the metaphysics of harmony and the physics of sound. Essays examine the late medieval and early (...) modern history of ideas concerning the nature of music and cosmic harmony, and trace their transformations in early modern musico-literary discourses. Within this framework, essays further offer original readings of important philosophical, literary, and musicological works. This interdisciplinary volume brings into focus the transformation of a predominant Renaissance worldview and of music's scientific, theological, literary, as well as cultural conceptions and functions in the early modern period, and will be of interest to scholars of the classics, philosophy, musicology, as well as literary and cultural studies. (shrink)

In recent debates about inequality, many have pointed to the predominant position of the finance. This article highlights that structural power, not lobbying resources, are key to explaining variations across countries. It examines finance-government negotiations over national bank rescue schemes during the recent financial crisis. Given the structural power of finance, the variation in bank bailouts across countries cannot be explained by lobbying differences. Instead of observing organized interest intermediation, we can see that disorganization was crucial for the financial industry (...) to get off the hook and let the government carry the burden of stabilizing the economy. Put differently, structural power is strongest when finance remains collectively inactive. In contrast to traditional accounts of the lobbying influence of finance, the comparison highlights that the lack of organization can have crucial redistributive consequences. (shrink)

Inflammatory bowel disease is chronic and incurable. Imperious diarrhea, rectal bleeding, fatigue, and weight loss, the main manifestations, cause a decrease in the quality of the patient’s personal and professional life. The objectives of this study were to identify a possible relationship between early maladaptive schemas and disease activity status using logistic regression, to identify the prevalence of early maladaptive schemes in patients and to propose a psychotherapeutic intervention plan. The following were found in a sample of 46 patients aged (...) 16–76 years. An increase in the domain overvigilance and inhibition score had a significant effect, with an increase of 1.137 CI95% [1.031, 1.254] of the risk of the disease being diagnosed as active. High and very high scores were observed for the emotional deprivation scheme and dependence/incompetence, vulnerability to harm and illness and subjugation schemas. The results show that the proposed model could predict and reconfirm the diagnosis; patients have specific psychotherapeutic needs. The therapeutic goal would be to offer care, empathy and protection, to strengthen self-confidence, to make patients realize that they have the ability to cope, to provide permission, encourage the patient to experiment, and guide the patient to express their anger healthily. The therapy scheme’s intervention could lead to increased long-term disease management capacity and, consequently, reduce costs directly and indirectly caused by this condition. (shrink)

Zusammenfassung Eine Karriere im Hochleistungssport ist mit hohen zeitlichen Belastungen verbunden. Da die Spitzensport- Karriere lebenszeitlich beschränkt ist und in der Regel in der vierten Lebensdekade beendet wird, stellt sich die Frage nach den Auswirkungen eines Engagements im Hochleistungssport auf die Berufskarriere. Hierzu wurden im Rahmen einer quantitativ orientierten Kohortenanalyse ehemalige Spitzensportler zu ihrem beruflichen Werdegang und möglichen Einflussfaktoren des Hochleistungssports retrospektiv befragt. Die Befunde der beiden Teiluntersuchungen zeigen, dass die hohen zeitlichen Anforderungen des Spitzensports den beruflichen Werdegang nur zum (...) Teil beeinträchtigen. Dies gilt nicht nur für sehr erfolgreiche Sportler, sondern auch für Hochleistungssportler, die weniger erfolgreich sind, sowie für Profisportler, die besonders intensiv in das System Hochleistungssport eingebunden sind. Dabei wirken sich Faktoren, wie institutionelle Unterstützungsmaßnahmen, Bekanntheit und soziale Kontakte sowie die Chance im Berufsfeld Spitzensport zu arbeiten, positiv auf die Berufskarriere aus. Allerdings haben sich aufgrund der Professionalisierung des Hochleistungssports die Risiken im kohortenspezifischen Vergleich vergrößert. (shrink)

Learning in intelligent systems is a result of direct or indirect interaction with the environment. Humans can learn by way of different states of (inter-)action such as the execution or the imagery of an action, but their unique potential to induce brain-related as well as mind-related changes in the motor action system is still being debated. The systematic repetition of different states of action (e.g., execution and imagery in terms of physical and mental practice) and their contribution to the learning (...) of complex motor actions has traditionally been approached by way of performance improvements. More recently, approaches highlighting the role of action representation in the learning of complex motor actions have evolved. In the present perspective paper, we build on brain-related findings and sketch recent research on learning by way of imagery and execution from a hierarchical, perceptual-cognitive approach to the motor action system. These findings provide valuable insights into the learning of intelligent systems from a perceptual-cognitive, representation-based perspective and as such add to our current understanding of action representation in memory and its changes with practice. Future research should build bridges between approaches in order to more thoroughly understand functional changes throughout the learning process, and to jointly contribute to developing intelligent cognitive systems and their application in robotics, rehabilitation, or sports. (shrink)

The reign of paper files would seem to be over once files are reduced to the status of icons on computer screens, but Vismann's book, which examines the impact of the file on Western institutions throughout history, shows how the creation of order in medieval and early modern administrations makes its returns in computer architecture.

From the discovery of distant galaxies and black holes to the tiny interstices of the atom, here is the very best on physics and astronomy from the New York Times! The newspaper of record has always prided itself on its award-winning science coverage, and these 125 articles from its archives are the very best, covering more than a century of breakthroughs, setbacks, and mysteries. Selected by former science editor Cornelia Dean, they feature such esteemed and Pulitzer Prize-winning writers as (...) Malcolm W. Browne on teleporting, antimatter atoms, and the physics of traffic jams; James Glanz on string theory; George Johnson on quantum physics; William L. Laurence on Bohr and Einstein; Dennis Overbye on the recent discovery of the Higgs Boson; Walter Sullivan on the colliding beam machine; and more. (shrink)

The intuitive notion of a binary relation on information-bearers, comparingthem with respect to their closeness to the available information, is oftenconstrued in terms of comparing their symmetric difference with, orcompositional similarity to, the available information. This happens forinstance in some treatments of verisimilitude. We expound an abstractmathematical rendering of the relevant data-dependent relation in theframework of Boolean algebras. For every element t of a Boolean algebra B we construct the t-modulated Boolean algebra Btin which the order relation represents `is at (...) most as compatible with t as'' or `is at best as similar to t as''. In the case of Lindenbaum-Tarskialgebras, t expresses the available information, and the compatibilityrelation turns out to be an entwinement of inferential and conjecturalrelations. It is just classical entailment when no information is available(i.e., when t is logically true) and becomes more boldly abductive themore information is available. The rich algebraic structures of a Boolean algebra –- including its Boolean group structures –- play a significant role in this combination of deduction and abduction and also induce cautious anddaring variants of the compatibility relation. Links with the literature onverisimilitude, abduction, and related topics are indicated. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 36.3 (2003) 277-300 [Access article in PDF] Toward a Fragmatics, or Improvisionary Histories of Rhetoric, the Eternally Ad Hoc Cornelia Wells "Even historical truths are on the move, or truth is not the question." —my self "We don't / know much, and are / professors of it." —from Heather McHugh, "Professional Hazard," in McHugh (1987) In writing a history of rhetoric, we might want to (...) know before anything else both what rhetoric is and why we should care to be writing about it. Or we might begin with a notion of or motive for history or, more precisely, for doing or writing (a) history or histories (as opposed of course to History with a capital H, History proper, the "true whole" story and nothing else) of, specifically, rhetoric. 1 Or we might begin with a notion of subjectivity, of who this we is that concerns itself with this writing activity. Or we might focus on the writing itself, asking the question What is writing? or Who can do it? or What can it do? or What is it about? all of which may be much like answering or debating similar questions frequently asked about/of/through rhetoric. Indeed, rhetoric and writing, rhetoric and discourse, tend to be confused, or ecstatically intermingled, terms.Or fixating, as history so frequently does, on the oxymoronic notion of "final" origins, which function backward(ly) as destinations, we might begin with the question/justification of where or when rhetoric itself geographically/historically began and therefore establish the "proper" beginning place for our story of rhetoric to start. But as the contemporary poet Heather McHugh suggests, "where" may be "a narrow inquiry," and also when, for something always came before and generally from somewhere else, so that, ultimately, when and where never can be finally arrived at. 2 So we might, and probably will, follow the indirection or dereliction (as [End Page 277] opposed to direction) of the goddess Dike to Parmenides: "It is all one to me where I begin, for I shall return again." 3 Like Robert Frost, however, I doubt if I shall ever come back. Or not by the same road, believing with Heraclitus, "One cannot step twice into the same river" (or, perhaps less obviously, twice onto the same road) and that anyway it is "weariness to toil at the same tasks and be always beginning," at least beginning in the same place(s) (1979, Fragments LI and LIII). As they commonly say in Australia, a change is as good as a holiday. And anyway change arrives inevitably.So we may as well (as well as not) change our mind and change our route before it changes itself or us. We may as well turn away, before returning, pause from thinking about writing this particular history of rhetoric, about how or where or why to begin such a task in the "first" place (as if we have never previously occupied any other task or place), and consider instead some of the ways that histories of rhetoric have already been written or told or invented. But why should we make this turn? Well, for reconnaissance, I suppose. To get the lay of the land. To see the other side of the mountain. To show we've done our research. Or because a discipline demands continual recounting. To remain intact or stay in touch. Or for auld lang syne. Or so that improvisionarily, at least, "we shall have agreement on [']known['] premises, and the pursuit of further knowledge" (Rorty 1984, 67). Or to take stock. To see what's missing (as if we could say when the universe is full). Or to justify a point of departure. Or a point of entry into a conversation that preceded and therefore necessarily in some residual sense preempted or determined us. Or for just (only?) or unjust (not only?) cause. Or to establish ethos. Or just because. To show we "know." Auguring or augering (not arguing) a procedure Perhaps the best turn is to turn this essay, literally my attempted say, inside out... (shrink)

While it is well-known that the intense albeit short-lived Hegel renaissance of the 1930s’ and 1940s’ France had a huge influence on later intellectual currents of the 20th century, its importance to Simone de Beauvoir is often left unnoticed or reduced to her appropriation of the master/slave dialectic. This paper argues that Beauvoir – who came to know Hegel through the work of Alexandre Kojève as well as her own studies during the war – in fact, makes recourse to Hegelian (...) dialectics in her conceptual composition of the ‘woman problem’ in The Second Sex. The paper identifies four figures of femininity, from the abstract mystique of the ‘Sphinx’ to the internal conflict of ‘The Little Mermaid’, and shows how the negative determinations culminate in a figure of contradiction, which implies that we may interpret The Second Sex as a work of critical thought. This means that the Hegelian legacy of feminist critique has as its objective an emancipatory project rather than equality. (shrink)