Fatty acids (FAs) are well known to serve as substrates for reactions that provide cells with membranes and energy. In contrast to these metabolic reactions, the physiological importance of FAs themselves known as free FAs (FFAs) in cells remains obscure. Since accumulation of FFAs in cells is toxic, cells must develop mechanisms to detoxify FFAs. One such mechanism is to sequester free polyunsaturated FAs (PUFAs) into a droplet‐like structure assembled by Fas‐Associated Factor 1 (FAF1), a cytosolic protein. This sequestration limits (...) access of PUFAs to Fe2+, thereby preventing Fe2+‐catalyzed PUFA peroxidation. Consequently, assembly of the FAF1‐FFA complex is critical to protect cells from ferroptosis, a cell death pathway triggered by PUFA peroxidation. The observations that free PUFAs in cytosol are not randomly diffused but rather sequestered into a membraneless complex should open new directions to explore signaling pathways by which FFAs regulate cellular physiology. (shrink)

A neural network is a model of the brain’s cognitive process, with a highly interconnected multiprocessor architecture. The neural network has incredible potential, in the view of these artificial neural networks inherently having good learning capabilities and the ability to learn different input features. Based on this, this paper proposes a new chaotic neuron model and a new chaotic neural network model. It includes a linear matrix, a sine function, and a chaotic neural network composed of three chaotic neurons. One (...) of the chaotic neurons is affected by the sine function. The network has rich chaotic dynamics and can produce multiscroll hidden chaotic attractors. This paper studied its dynamic behaviors, including bifurcation behavior, Lyapunov exponent, Poincaré surface of section, and basins of attraction. In the process of analyzing the bifurcation and the basins of attraction, it was found that the network demonstrated hidden bifurcation phenomena, and the relevant properties of the basins of attraction were obtained. Thereafter, a chaotic neural network was implemented by using FPGA, and the experiment proved that the theoretical analysis results and FPGA implementation were consistent with each other. Finally, an energy function was constructed to optimize the calculation based on the CNN in order to provide a new approach to solve the TSP problem. (shrink)

As an advanced network calculation mode, cloud computing is becoming more and more popular. However, with the proliferation of large data centers hosting cloud applications, the growth of energy consumption has been explosive. Surveys show that a remarkable part of the large energy consumed in data center results from over-provisioning of the network resource to meet requests during peak demand times. In this paper, we propose a solution to this problem by constructing a dynamic energy-efficient resource management scheme. As a (...) way of saving energy as well as maintaining cloud user’s quality of experience, the scheme presents a multitier cloud architecture by configuring physical machines into two pools: a hot pool and a warm pool. Each PM is configured with a resource search engine that finds an available virtual machine for the request, and a synchronous sleep mechanism is introduced to the warm pool. To analyze the end-to-end performance of the cloud system’s service with the proposed scheme, we establish a hybrid queueing system composed of three stochastic submodels by using a matrix-geometric solution. Accordingly, the average latency of requests and the energy-saving rate of the system are derived. Through numerical results, we show the influence of the synchronous sleep mechanism on the system performance. Moreover, from the perspective of economics, we build a system cost function to study the trade-off between different performance measures. An improved Salp Swarm Algorithm is presented to minimize the system cost and optimize the sleep parameter. (shrink)

Background and aimThe postpartum depression literacy of perinatal women is closely related to the occurrence, recognition, and treatment of postpartum depression, therefore valid instruments for evaluating the level of PoDLi are of great significance for both research and clinical practice. This study aimed to cross-culturally adapt the postpartum depression literacy scale into Chinese and to test its psychometric properties among Chinese perinatal women.Materials and methodsA cross-sectional study was conducted from April to May 2022 in a tertiary hospital in Hangzhou, Zhejiang (...) Province, China. 619 out of the 650 perinatal women that were approached via a convenience sampling method completed the Chinese version of the PoDLiS. Content validity [the content validity index of items and scale-level content validity index ] was evaluated by an expert panel. Psychometric properties, including item analysis, structure validity, convergent and discriminant validity, reliability, criterion validity, and floor/ceiling effect were examined.ResultsThe final version of C-PoDLiS is a six-factor structure consisting of 27 items, which explained 61.00% of the total variance. Adequate content validity was ensured by the expert panel. The modified confirmatory factor analysis model revealed that the 6-factor model fitted the data well. The total Cronbach’s α was 0.862, the total McDonald’s ω was 0.869, and the test-retest reliability coefficient was 0.856. Results of convergent validity and discriminant validity provided good or acceptable psychometric support. Significant correlations between scores of the C-PoDLiS and Mental health literacy scale and Attitudes toward seeking professional psychological help short form scale supported good concurrent and predictive validity, respectively. No floor/ceiling effect was found.ConclusionThe C-PoDLiS was demonstrated to be a sound instrument with good reliability and validity for evaluating Chinese perinatal women’s PoDLi levels. Its use in the future can facilitate data aggregation and outcome comparisons across different studies on this topic. (shrink)

Memristor is the fourth basic electronic element discovered in addition to resistor, capacitor, and inductor. It is a nonlinear gadget with memory features which can be used for realizing chaotic, memory, neural network, and other similar circuits and systems. In this paper, a novel memristor-based fractional-order chaotic system is presented, and this chaotic system is taken as an example to analyze its dynamic characteristics. First, we used Adomian algorithm to solve the proposed fractional-order chaotic system and yield a chaotic phase (...) diagram. Then, we examined the Lyapunov exponent spectrum, bifurcation, SE complexity, and basin of attraction of this system. We used the resulting Lyapunov exponent to describe the state of the basin of attraction of this fractional-order chaotic system. As the local minimum point of Lyapunov exponential function is the stable point in phase space, when this stable point in phase space comes into the lowest region of the basin of attraction, the solution of the chaotic system is yielded. In the analysis, we yielded the solution of the system equation with the same method used to solve the local minimum of Lyapunov exponential function. Our system analysis also revealed the multistability of this system. (shrink)

Due to the close relationship among intrinsic/extrinsic motivation, regulatory focus, and creativity revealed by previous literature, intrinsic/extrinsic motivation may play a mediating role between regulatory focus and creativity. Therefore, the present study aimed to investigate the relationship between regulatory focus and creativity by combining intrinsic/extrinsic motivation. In this study, senior high school students completed the Regulatory Focus Questionnaire, the Working Preference Inventory, the Williams Creativity Assessment Packet, and the Kirton Adaption–Innovation Inventory. The correlation analysis showed that both promotion and prevention (...) focus positively correlated with intrinsic motivation; intrinsic motivation and promotion focus positively correlated with creativity personality and innovative-adaptive cognitive style; and extrinsic motivation and prevention focus negatively correlated with innovative–adaptive cognitive style. Furthermore, a path model showed that promotion focus positively predicted creativity through the mediation of intrinsic motivation. In general, our study suggests that intrinsic motivation plays a mediating role between promotion focus and creativity. Our results complement those of previous studies and serve as inspiration for the cultivation of creativity in classroom or enterprise settings. (shrink)

Systemic lupus erythematosus is an inflammatory autoimmune disease with depression as one of its most common symptoms. The aim of this study is to establish a nomogram prediction model to assess the occurrence of depression in patients with SLE. Based on the Hospital Anxiety and Depression Scale cutoff of 8, 341 patients with SLE, recruited between June 2017 and December 2019, were divided into depressive and non-depressive groups. Data on socio-demographic characteristics, medical history, sociopsychological factors, and other risk factors were (...) collected. Between-group differences in clinical characteristics were assessed with depression as the dependent variable and the variables selected by logistic multiple regression as predictors. The model was established using R language. Marital status, education, social support, coping, and anxiety predicted depression. The nomogram prediction model showed that the risk rate was from 0.01 to 0.80, and the receiver operating characteristic curve analysis showed that the area under the curve was 0.891. The calibration curve can intuitively show that the probability of depression predicted by the nomogram model is consistent with the actual comparison. The designed nomogram provides a highly predictive assessment of depression in patients with SLE, facilitating more comprehensive depression evaluation in usual clinical care. (shrink)

《一代直聲百年盡瘁：梁簌溟鄉村建設運動研究》系統梳理了20世紀30年代梁漱溟主持的山東鄉村建設實驗的相關內容，以及不同時期相關實踐者和學者對其鄉村建設實驗進行的各種討論和爭議，試圖全方位挖掘梁漱溟鄉建 思想與實踐的深層學術價值和現實借鑒意義，冀望對今天的農村現代化建設和農村改革，尤其是“三農”問題的解決和優化提供有益的借鑒。.

Background and ObjectiveThere is a paucity of research that has explored “False Alarm” mechanisms. In order to remedy this deficiency in knowledge, the present study used event-related potential technology to reveal the mechanisms underlying False Alarm in response to fear stimuli.MethodsThis study selected snakes as experimental materials and the “oddball paradigm” was used to simulate the conditions of False Alarm. The mechanism underlying False Alarm was revealed by comparing cognitive processing similarities and differences between real snakes and toy snakes.ResultsEvent-related potential (...) findings demonstrated that there was no significant difference between N1 and P2 components induced by real and toy snakes in the early processing stage. Compared with toy snakes, real snakes induced smaller N2 amplitude, larger P3 amplitude, and a shorter P3 latency at the late processing stage. The results of brain topographic mapping analysis showed that the brain regions activated by a real or toy snake were basically the same within the time windows of 110–150 and 220–270 ms, respectively. In the time window of 300–360 and 400–500 ms, the degree of brain regions activation with a real snake was significantly greater than that induced by a toy snake.ConclusionFalse Alarm is caused by the brain’s inability to distinguish, in the early stage of cognitive processing, stimulus objects with similar appearances. When the brain is able to distinguish the differences between different stimulus objects in the late stage of cognitive processing, False Alarm disappears. (shrink)

GraphicalPatients with early- to middle-stage PD were enrolled for C-Gait assessment and traditional walking ability assessments. The correlation of C-Gait assessment and traditional walking tests were studied. Two models were established based on C-Gait assessment and traditional walking tests to explore the value of C-Gait assessment in predicting freezing of gait.ObjectiveEfficient methods for assessing walking adaptability in individuals with Parkinson’s disease are urgently needed. Therefore, this study aimed to assess C-Gait for detecting freezing of gait in patients with early- to (...) middle-stage PD.MethodPeople with PD diagnosis were recruited from April 2019 to November 2019 in Beijing Rehabilitation Hospital. The participants performed six items of walking adaptability on an instrumented treadmill augmented with visual targets and obstacles. The patient’s walking adaptability was evaluated by C-Gait assessment and traditional walking tests, and FOG-related indexes were collected as outcome measures. Two discriminant models were established by stepwise discriminant analysis; area under the receiver operating characteristic curve was used to validate the models.ResultIn total, 53 patients were included in this study. Most C-Gait assessment items had no or low correlations with traditional walking tests. The obstacle avoidance and speed of adaptation items could lead to FOG with high sensitivity. In addition, the C-Gait assessment model had slightly better discrimination of freezers from non-freezers compared with traditional walking test models ; specifically, obstacle avoidance and speed of adaptation have uniquely discriminant potential.ConclusionC-gait assessment could provide additional value to the traditional walking tests for PD. Gait adaptability assessment, as measured by C-Gait, may be able to help identify freezers in a PD population. (shrink)

This book researches the thought of Jin Yuelin’s epistemology with some notions and methods of contemporary epistemology as the frame of reference. There are two kinds of academical significance in this book, one is that author has accurately comprehended the specific content, inadequacies and contradictions in Jin’ s epistemology, recognized the methods by which Jin Yuelin built his theory of knowledge. The other is that author has known about the differences in research objects and methods between Jin’s theory and contemporary (...) epistemology, and showed the position of Jin’s epistemology in the whole theory of knowledge through the comparative study. On the one hand, the book focuses on the core problem of Jin Yuelin’ epistemology that is how objective knowledge is produced. On the other hand, it is made up of seven chapters in accordance with the structure of Jin’s Theory of Knowledge. The first chapter introduces and comparatively analyzes the comprehensions about the concepts of “knowledge” and “epistemology” between Jin Yuelin and contemporary epistemologists. This chapter supplies the means and methods for following chapters. The second chapter describes Jin’s standpoint and criticism to idealism starting mode, analyzes the objective starting mode that belongs to Jin’s theory and reveals his negative attitude to skepticism. This chapter shows the essential characteristics of the Jin Yuelin’s epistemology. The given is the content of sensation, which is the most basic part of cognitive activity. Moreover Jin Yuelin regards sensation as foundation of knowledge, so the research on theory of the given is separated from the whole study of cognitive activity and treated as the third chapter, which presents Jin’s theory of the given and analyzes the problems of Jin’s theory, then introduces some kinds of theory of the given and theory of perception in the contemporary epistemology, finally comparatively investigates theories of the given between Jin Yuelin and contemporary epistemologists. From the perspective of cognitive activity, the fourth chapter describes the perceptual activity, the activity of knowing, the activity of thinking, means and outlines of reception in Jin’s epistemology, then exposes its contradictions and inadequacies; Induction is the important research object of the Western epistemologists, similarly Jin Yuelin paid more attention to induction and regards the principle of induction as outline of reception. In fact, his standpoint about the principle of induction is vital and creative, so the study of induction separately belongs to the fifth chapter. This chapter presents the Jin’s comprehension about the principle of induction and some answers to the problem of induction in contemporary epistemology, then comparatively analyzes two kinds of the thought about induction. The sixth chapter successively introduces being, nature and fact which all are objects of cognitive activity, then analyzes the problems within them. From the perspective of cognitive results, the last chapter presents the Jin’s standpoint about verification and demonstration of proposition, definition and criteria of truth, then simply describes the point views of contemporary epistemologists about verification and truth of proposition, finally comparatively investigates two kinds of thought. From the vertical, the thesis analyzes the fundamental sections of objective knowledge one by one, such as the given, experience, idea, proposition and truth. From the horizontal, the book focuses on the three main parts of knowledge event, for example, cognitive activity, objects of knowledge and the true proposition treated as knowledge. In a word, the whole book is coherent and organic unity. Through the comparative study, it can be concluded that it is reasonable for Jin Yuelin to enjoy a high academic status, because he is the first philosopher who specializes in the study of epistemology. At the same times, he improves transmission of logic, metaphysics and epistemology from the Western to China. So, his hard work enriches and expands the realm of Chinese philosophy. With the development of the study of epistemology, descriptive content of it, such as, perceptual activity and rational activity, will be regarded as the objects of psychology and cognitive science. Meanwhile, normative content will be retained. For example, analysis of conditions of knowledge, justification for belief claims, comprehension about the proofs of justification, as well as reactions to challenges of skepticism. The latter will continue to be objects of epistemology, of course, they must establish close relationships with psychology and cognitive science. According to this prospect, we should split Jin Yuelin’s theory of knowledge, of which the descriptive content would be allocated to psychology and cognitive science. On the contrary, the normative content would be kept as important resource for deeply studying epistemology. -/- Key words: Knowledge; Contemporary epistemology; Compare; The given; Idea; The principle of induction; Fact. (shrink)

本书内容包括:纠结于现代和复古之间-评蒋庆的"政治儒学"思想,"原道"与"道源"-评陈明的"即用见体"思想,后现代主义儒学:从现象学到孔夫子-评张祥龙的"现象学儒学"思想,论当代儒学的"生活论"转向- 评黄玉顺的"生活儒学"思想,"天下主义"还是"中西比对"-评盛洪的"经济儒学"思想等.

Dans un dialogue constant avec la phénoménologie intentionnelle de Husserl, Michel Henry a tenté de mettre au point une nouvelle ontologie phénoménologique, pour cerner spécifiquement ce qu'il nommait «l’essence de la manifestation». Il ouvrait ainsi la voie d’une méthode philosophique originale, celle d’une phénoménologie «radicale», dont il ne cessa de l’appliquer à des objets divers, dans le cadre précis des pensées de l’immanence. Ce livre interroge ce moment de l’élaboration phénoménologique de la philosophie de Michel Henry et montre notamment comment (...) la notion de «sens» joue un rôle essentiel. (shrink)

本书在充分把握有关梁漱溟及其相关资料, 以及相关研究成果的基础上, 针对中国现代政治发展过程中所具有的十分复杂的政治、文化与教育的关系, 真切地还原了梁漱溟探索中国政治现代化之路的心路历程, 客观地评价了他的实践努力. 本书稿将时代与个人, 历史与逻辑较好地结合在一起, 既真实地反映了梁漱溟个人的政治变革追求随着时代发展变化的纵向历程, 也深入而较系统地对他每一阶段的思想和活动进行了专业性 (政治、文化和教育) 的评析, 展现了一定的历史发展的动态.

在中國伊斯蘭教研究中，有“回族四大著作家”（王岱輿、馬注、劉智、馬複初）的說法。馬注思想之所以值得重視和研究，完全與他出生於回族世家，自幼受儒學教育從而在融合伊斯蘭與儒家思想方面，做出了重要貢獻。他的 《清真指南》堪稱伊斯蘭教中國化方面的傑出代表作。當前，世界範圍內伊斯蘭教的賽萊菲耶極其活躍。它在國際政治領域，已經產生了可見的危害；它在思想、文化、宗教領域的流傳，人們同樣不應低估它的嚴重影響。.

本书是作者晚年在老朋友的建议下撰写的回忆录，内容涉及与他交往密切的老朋友、个人经历和治学活动，以及生活情趣等等。.

This study investigates the mechanism of how sensory experiences influence visitors’ digital engagement with a destination through establishing a strong bond and identification between a destination and tourist utilizing a two-step process. First, visitors’ sensory experiences in a destination are identified through a content analysis of online review comments posted by visitors. Afterward, the effects of those sensory experiences on visitors’ digital engagement through destination dependence and identification with that destination are examined. Findings suggest that sensory experiences are critical antecedents (...) of visitors’ bond and identification with a destination. Visitors’ positive destination-related sensory experiences increase their dependence on and identification with the destination, and this dependence and identification positively influence their digital engagement behavior on social media. (shrink)

According to Hobbes, individuals care about their relative standing in a way that shapes their social interactions. To model this aspect of Hobbesian psychology, this paper supposes that agents have social preferences, that is, preferences about their comparative resource holdings. Introducing uncertainty regarding the social preferences of others unleashes a process of trust-unravelling, ultimately leading to Hobbes’s ‘state of war’. This Trust-unravelling Model incorporates important features of Hobbes’s argument that past models ignore.

本書是由崔大華生前撰寫的53篇文章、6篇專著序言以及20篇在三聯書店出版的《讀書》雜誌上隨筆文章彙集而成，凝結了他一生的主要研究成果。綜觀這些文章的內容，其對中國歷史哲學問題的研究有許多真知灼見，在中 國傳統文化道德衰退的今天，其對中國傳統哲學的認識有著很好的借鑒意義。比如，儒道對印度佛教和西方基督教滲入中國的影響，傳統倫理道德對當代人類行為的借鑒，莊子思想對中國文學的發展等。.

Gitik and Rinot :1771–1795, 2012) proved assuming the existence of a supercompact that it is consistent to have a strong limit cardinal \ of countable cofinality such that \, there is a very good scale at \, and \ fails along some reflecting stationary subset of \\). In this paper, we force over Gitik and Rinot’s model but with a modification of Gitik–Sharon :311, 2008) diagonal Prikry forcing to get this result for \.

Fontanella :193–207, 2014) showed that if \ is an increasing sequence of supercompacts and \, then the strong tree property holds at \. Building on a proof by Neeman, we show that the strong tree property at \ is consistent with \, where \ is singular strong limit of countable cofinality.

In a recent Target Article Naomi Scheinerman (2023a) has offered an important and compelling call to institutionalize popular participation for heritable genome engineering through the inclusion of...

Throughout the COVID-19 pandemic, shortages of scarce healthcare resources consistently presented significant moral and practical challenges. While the importance of vaccines as a key pharmaceutical intervention to stem pandemic scarcity was widely publicized, a sizable proportion of the population chose not to vaccinate. In response, some have defended the use of vaccination status as a criterion for the allocation of scarce medical resources. In this paper, we critically interpret this burgeoning literature, and describe a framework for thinking about vaccine-sensitive resource (...) allocation using the values of responsibility, reciprocity, and justice. Although our aim here is not to defend a single view of vaccine-sensitive resource allocation, we believe that attending critically with the diversity of arguments in favor (and against) vaccine-sensitivity reveals a number of questions that a vaccine-sensitive approach to allocation should answer in future pandemics. (shrink)

Jin Qian Dans son Discours sur la théologie naturelle des Chinois, Leibniz produit une interprétation du premier principe de la philosophie chinoise. Le présent article s’interroge sur les conditions de cette interprétation en la comparant avec la controverse entre Leibniz et Descartes par rapport à la conception de la substance. Il sera montré que, bien que Leibniz utilise un « principe herméneutique » dans son interprétation de la philosophie chinoise, ce principe n’est pas suffisant mais repose sur des conditions plus (...) fondamentales. La comparaison avec la controverse Leibniz-Descartes sur la substance permet d’identifier deux conditions majeures de l’application de ce principe herméneutique, à savoir la théorie dynamique de la substance et la conception de la théologie naturelle comme fondement de la physique, deux points sur lesquels divergent Leibniz et Descartes. (shrink)

Let U be an initial segment of $^*{\mathbb N}$ closed under addition (such U is called a cut) with uncountable cofinality and A be a subset of U, which is the intersection of U and an internal subset of $^*{\mathbb N}$ . Suppose A has lower U-density α strictly between 0 and 3/5. We show that either there exists a standard real $\epsilon$ > 0 and there are sufficiently large x in A such that | (A+A) ∩ [0, 2x]| > (...) (10/3+ $\epsilon$ ) | A ∩ [0, x]| or A is a large subset of an arithmetic progression of difference greater than 1 or A is a large subset of the union of two arithmetic progressions with the same difference greater than 2 or A is a large subset of the union of three arithmetic progressions with the same difference greater than 4. (shrink)

volume 1. Yi tong ; Zhou yi jiang zuo -- volume 2. Zhou yi quan jie -- volume 3. "Zhou yi, Xi ci zhuan" xin bian xiang jie ; "Shang shu, Yu xia shu" xin jie -- volume 4. Zhongguo nu li she hui de ji ge wen ti ; Lun jing tian zhi du ; Zhongguo nu li she hui shi -- volume 5. Kongzi xin zhuan -- volume 6. Jing xue gai lun ; Xian Qin si xiang shi (...) ; Xian Qin si xiang shi zhuan ti jiang shou ti gang -- volume 7. Lun wen Jing xue bian, Shi xue bian -- volume 8. Lun wen Shi xue bian, Zi xue bian -- volume 9. Lun wen Zi xue bian, Xu ba bian, Za zhu bian ; Zi zhuan -- volume 10. Fu lu. (shrink)