The current COVID-19 pandemic and the previous SARS/MERS outbreaks of 2003 and 2012 have resulted in a series of major global public health crises. We argue that in the interest of developing effective and safe vaccines and drugs and to better understand coronaviruses and associated disease mechenisms it is necessary to integrate the large and exponentially growing body of heterogeneous coronavirus data. Ontologies play an important role in standard-based knowledge and data representation, integration, sharing, and analysis. Accordingly, we initiated the (...) development of the community-based Coronavirus Infectious Disease Ontology in early 2020. -/- As an Open Biomedical Ontology (OBO) library ontology, CIDO is open source and interoperable with other existing OBO ontologies. CIDO is aligned with the Basic Formal Ontology and Viral Infectious Disease Ontology. CIDO has imported terms from over 30 OBO ontologies. For example, CIDO imports all SARS-CoV-2 protein terms from the Protein Ontology, COVID-19-related phenotype terms from the Human Phenotype Ontology, and over 100 COVID-19 terms for vaccines (both authorized and in clinical trial) from the Vaccine Ontology. CIDO systematically represents variants of SARS-CoV-2 viruses and over 300 amino acid substitutions therein, along with over 300 diagnostic kits and methods. CIDO also describes hundreds of host-coronavirus protein-protein interactions (PPIs) and the drugs that target proteins in these PPIs. CIDO has been used to model COVID-19 related phenomena in areas such as epidemiology. The scope of CIDO was evaluated by visual analysis supported by a summarization network method. CIDO has been used in various applications such as term standardization, inference, natural language processing (NLP) and clinical data integration. We have applied the amino acid variant knowledge present in CIDO to analyze differences between SARS-CoV-2 Delta and Omicron variants. CIDO's integrative host-coronavirus PPIs and drug-target knowledge has also been used to support drug repurposing for COVID-19 treatment. -/- CIDO represents entities and relations in the domain of coronavirus diseases with a special focus on COVID-19. It supports shared knowledge representation, data and metadata standardization and integration, and has been used in a range of applications. (shrink)

BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Résumé En Afrique du Sud, de nouveaux mouvements communautaires, où dominent les femmes, les jeunes, les pauvres, où tout le monde participe, sont apparus depuis la fin de l’apartheid. Ils luttent contre l’ANC, refusent de payer les services publics pour compenser les diminutions d’allocations, essaient d’inventer de nouveaux services. Les anciens militants de la libération nationale sont forcés de revoir leurs alliances et de se fondre dans ce mouvement horizontal. L’histoire est réécrite, hors des compromis que les luttes pour l’indépendance (...) avaient faits avec le colonisateur. Il s’agit de lutter contre les politiques imposées par la Banque mondiale et le Fonds monétaire international et, concrètement, contre les expulsions de logement et contre la privatisation des services et des espaces urbains. La communauté a cessé de croire en l’État, dans la figure du père. Alors les gens remplissent les logements vides comme ils l’entendent, avec qui ils veulent, brouillent la frontière entre légal et illégal. Ils s’inspirent de la lutte des piqueteros en Argentine et de ce qu’ils ont entendu de Seattle. (shrink)

Over the past decade, Convergence Research has increasingly gained prominence as a research, development, and innovation (RDI) strategy to address grand societal challenges. However, a dearth of research-based evidence is available to aid researchers, research teams, and institutions with navigating the complexities attendant to the specifics of Convergence Research. This paper presents a multilevel research agenda that accounts for an integral understanding of Convergence Research as a complex adaptive system. Furthermore, by developing a framework that accounts for ancillary, yet essential, (...) systems associated with Convergence Research, we enrich the agenda with a literature-steeped discussion that considers how systems-based practices of collaboration, inquiry, and context interact with the processes and products of Convergence Research. Finally, we synthesize and apply insights from the reviewed literature by providing paths for empirical exploration emphasizing systems-based practices. In so doing, we delineate an extended boundary for a research stream that both clarifies and enlarges our understanding of Convergence Research as a ‘system-of-systems’. (shrink)

The work of Michèle Le Dœuff creatively disrupts established notions of what philosophy might be. Far from being a discipline about the leader and the disciple, a hierarchy of knowledge and paternalism, Le Dœuff proposes a philosophy of dialogue and friendship. The conversations in this book explore how this philosophy can be enacted and explored, and show how openness and generosity can be the starting point of truly rigorous thinking. Introduced and curated by the late philosopher, Pamela Sue Anderson, In (...) Dialogue with Michèle Le Dœuff explores themes like contemporary feminism, joy in philosophy, memory, the significance of friendship to thinking and a key Le Dœuffian concept, the imaginary. Le Dœuff's interlocutors, including Penelope Deutscher, Elizabeth Fallaize and Meenda Dhanda, are some of the most significant thinkers in the fields of feminism and continental thought and provide insights and ways into considering philosophy as a profoundly dialogical exercise. (shrink)

Une étude sur la virtualité toujours présente du mal politique. Pour comprendre le présent de ce mal, il faut rouvrir le passé, remonter notamment au mal radical selon Kant, ou aux liens entre le tragique et la capacité d'institution politique chez Aristote. Se dégage alors une longue tradition : celle d'une humanité dénuée de toute prétention à l'innocence, rendue au mal de sa liberté.

Historical studies suggest that all ideas, including the philosophical, scientific, and religious, are relative to the culture in which they are formulated. After clarifying the concept of relativism, and exploring the epistemological reasons why knowledge is relative, Kaufman argues that these admissions are not fatal to the achievement of valid knowledge in philosophy and theology.--D. D. O.

D’Oro asks whether Collingwood’s metaphysics of absolute presuppositions leads to the belief-system relativism that is the target of Boghossian’s sustained criticism in his Fear of Knowledge. She argues that Collingwood’s metaphysics of absolute presuppositions aims to defend a form of epistemic pluralism which is not reducible to the kind of epistemic relativism Boghossian critiques. The decoupling of epistemic pluralism from epistemic relativism rests on a reading of absolute presuppositions as epistemic “hinges” which give rise to the characteristic complexes of questions (...) and answers operative in different contexts of inquiry. The task of the metaphysician, D’Oro argues, is to show that the questions asked in different contexts of inquiry are entailed by the absolute presuppositions constitutive of those forms of knowing. Since epistemic pluralism is not a form of epistemic relativism, it is not vulnerable to the stock objections raised against relativism. (shrink)

A study was carried out in a large teaching hospital to ascertain the current view of members of ten ward teams in regard to certain problems in the field of medical ethics. The investigator accompanied each team on their morning rounds and sat in on their discussions. At the end of each week he interviewed the faculty member, residents, intern, and medical students who comprised that team. Responses to these fifty open-ended interviews were grouped into categories that seemed natural to (...) the data. These were tabulated and commented upon. The conclusions drawn were that there is an urgent need for ethical discourse in medical education, but that there are certain built-in difficulties in bringing this about in a significant way. Focus of attention upon critical incidents that come up in the normal cycle of ward rounds appeared to be the optimum approach to take. (shrink)

This book is the second volume of a critical edition of the writings of Thomas Reid, an edition that will include many of his manuscript remains as well as his previously published works. These volumes are intended to displace the heretofore standard 8th edition of Reid’s works edited by Sir William Hamilton. Hamilton’s edition is marred by his numerous, often intrusive, and obtuse footnotes. Reid’s spelling and punctuation were also sometimes “corrected” by Hamilton, so his edition does not present a (...) fully accurate version of the original editions whose publication was superintended by Reid. The type in the Hamilton edition is also archaic and very small, making reading the text excessively difficult. The present and subsequent volumes are intended to present canonical texts free of the flaws in the Hamilton text. This volume succeeds admirably in that project. (shrink)

What happened in the aftermath of Caligula's assassination in January A.d. 41 in relation to the client kings of the period has been the subject of a stimulating note by A. A. Barrett. He has argued that a rescission of Caligula's acta invalidated the legal position of the client kings appointed by Caligula, and that Claudius’ regularising of their position has been misunderstood by the ancient literary sources and has given rise to several apparent inconsistencies in their accounts.

D E Cooper; Is Language Learned?1, Journal of Philosophy of Education, Volume 9, Issue 1, 30 May 2006, Pages 93–104, https://doi.org/10.1111/j.1467-9752.1975.tb.

This essay is about experience, and not only about ideas. I have been drawn to write about John Cameron Mitchell’s Shortbus for a number of reasons: First, I find his work to be part of a new turn in LGBT art and media that take queer lives as a point of departure, and not only as narrative focus, for their work. These areworks that are not just about being queer, but cross the line into being queer works. Of those who (...) can be said to be a part of this recent turn, I find Mitchell’s work to be both especially philosophical and formally interesting. Not only does his work take up philosophical questions over what it means to be human, and the nature of love and sex, but also his works are produced through an organic, cooperative process that re-frames what it could mean to queer representation, political or otherwise. (shrink)

Study on the philosophy of Cārvāka, classical Indian materialist.

What is the meaning of numerosa? From the fifteenth-century commentaries of Valla and Mancinelli to the most recent translation of Juvenal into English, by Peter Green, interpreters are in nearly unanimous agreement that numerosa describes a particular annoyance of the rhetor's unrewarding life, namely, the large size of his classes. A few commentaries, however, touch upon another interpretation, although without defending it. Pearson and Strong, after translating numerosa as ‘overgrown’, continue: numerosa might mean “in rhythmical cadence”, referring to the sing-song (...) implied in cantabit. H. P. Wright too sees a possibility that the adjective might describe a musical or sing-song style of declaiming. A brief examination of Juvenal's purpose here and a consideration of some passages from other writers will show that ‘sing-song’ is certainly the primary meaning intended here and probably the only one. (shrink)

Ne vers 1180 a Aurillac, mort le 30 mars 1249, Guillaume d'Auvergne est nomme eveque de Paris des 1228. Son oeuvre est contemporaine de la querelle de l'aristotelisme qui gagne la faculte de theologie, et du bouleversement de l'histoire theorique qui l'accompagne. Quelle est la cause efficiente de la pensee? D'ou vient l'intelligible necessairement present dans l'ame qui pense? C'est a cela que repondent les neuf premieres parties du chapitre sept du De anima, ecrit vers 1240. La noetique de Guillaume (...) d'Auvergne, complexe, s'y deploie et sensiblement se demarque de l' augustinisme avicennisant qui traditionnellement la caracterise. L'ame, dans son rapport au sensible, est principium agens, lectrice, en tant qu'elle pense, d'un livre dont elle-meme est l'auteur, et dont la verite se passe en partie de l'illumination divine. (shrink)