BackgroundBiobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social implications. While the focus has been on human genomic research, rapid advances in human microbiome research further complicate the debate.DiscussionWe draw on two cystic fibrosis biobanks in Toronto, Canada, to illustrate our points. The biobanks have been established to facilitate sample and data sharing for research into the link between disease progression and microbial dynamics in the lungs (...) of pediatric and adult patients. We begin by providing an overview of some of the ELSI associated with human microbiome research, particularly on the implications for the broader society. We then discuss ethical considerations regarding the identifiability of samples biobanked for human microbiome research, and examine the issue of return of results and incidental findings. We argue that, for the purposes of research ethics oversight, human microbiome research samples should be treated with the same privacy considerations as human tissues samples. We also suggest that returning individual microbiome-related findings could provide a powerful clinical tool for care management, but highlight the need for a more grounded understanding of contextual factors that may be unique to human microbiome research.ConclusionsWe revisit the ELSI of biobanking and consider the impact that human microbiome research might have. Our discussion focuses on identifiability of human microbiome research samples, and return of research results and incidental findings for clinical management. (shrink)
An examination of the contemporary Italian movement associated with M. P. Sciacca, and the serious application of dialectical and phenomenological methods to unveil the structure of "intentionality" or "spirit." An appraisal of Sciacca together with a sample critique of Dante follows a competent summary of the prevailing positions.--D. B. B.
Dans ce beau livre, superbement édité, sont reproduites pour la première fois depuis leur récente restauration les peintures de l'église du monastère de Saint-Antoine, décor du XIIIe siècle qui est non seulement le plus complet et le mieux conservé d'Égypte, mais qui est aussi l'un des rares à être précisément daté. Il ne s'agit pas d'une monographie traditionnelle, mais d'un ouvrage collectif réunissant autour d'Elizabeth Bolman, maître d'œuvre de l'entreprise, une série d'auteurs venus d'horizons divers, dont les regards croisés (...) et complémentaires contribuent à la richesse et à l'intérêt du volume. (shrink)
Elizabeth Jennings was one of the most popular, prolific, and widely anthologized lyric poets in the second half of the twentieth century. This first biography, based on extensive archival research and interviews with Jennings's contemporaries, integrates her life and work and explores the 'inward war' the poet experienced as a result of her gender, religion, and mental fragility. Originally associated with the Movement, Jennings was sui generis, believing poetry was 'communication' and 'communion.' She wrote of nature, friendship, childhood, religion, (...) love, and art, endearing her to a wide audience. Yet lifelong depression, unbearable loneliness, unrelenting fears, poverty, and physical illness plagued her. These were exacerbated by her gender in a male-dominated literary world and an inherited Catholic worldview which initially inculcated guilt and shame. However, a tenacious drive to be a poet made her, 'the most unconditionally loved writer of her generation.' Although her claim was that the poem is not the poet, her life is tracked in her voluminous published and unpublished poetry and prose. The themes of mental illness, the importance of place, the problems associated with being an unmarried woman artist, her relationship with literary mentors and younger poets, her non-feminist feminism, and her marginality and sympathy for the outcast are all explored. It was poetry which saved her; it helped her push back darkness and discover order in the midst of chaos. Poetry was her raison d'etre. It was her life. (shrink)
Elizabeth H. Blackburn, Ph.D., is a leader in the area of telomere and telomerase research—in fact, in 1984 she codiscovered the ribonucleoprotein enzyme telomerase, opening up new potentials in cancer research and therapy. This and subsequent work has earned her numerous honors, not the least of which are the National Academy of Science Award in Molecular Biology, an Honorary Doctorate of Science from Yale University, the American Cancer Society Medal of Honor, and many more awards. Dr. Blackburn is a (...) Fellow of the American Academy of Arts and Sciences, the Royal Society of London, the American Academy of Microbiology, and the American Association for the Advancement of Science. She was elected to the National Academy of Sciences, and is a Member of the Institute of Medicine. (shrink)
There are calls to expand the schema “ S knows that p ” to accommodate ways of knowing that are socially important but neglected in recent epistemology. A wider, more adequate conception of human knowing is needed that will include interested or motivated inquirers as “S,” and personal traits of persons as “ p .” Historically important treatments of knowing that accommodate these features deserve examination as part of the effort to create a broader epistemology. We find such a treatment (...) of knowing in Plato's Apology , 20 d-24 b, in which Socrates claims a bit of wisdom. We attend more carefully than others have to the concrete aspects of Socrates' encounters with interlocutors. (shrink)
Much has been written on the relative merits of different readings of Wittgenstein's Tractatus Logico-Philosophicus. The recent renewal of the debate has almost exclusively been concerned with variants of the ineffabilist (metaphysical) reading of TL-P - notable such readings have been advanced by Elizabeth Anscombe, P. M. S. Hacker and H. O. Mounce - and the recently advanced variants of therapeutic (resolute) readings - notable advocates of which are James Conant, Cora Diamond, Juliet Floyd and Michael Kremer. During this (...) debate, there have been a number of writers who have tried to develop a third way, incorporating what they see as insights and avoiding what they see as flaws in both the ineffabilist and resolute readings. The most prominent advocates of these elucidatory readings of TL-P are Dan Hutto (2003) and Marie McGinn (1999). In this paper we subject Hutto's and McGinn's readings of TL-P to critical scrutiny. We find that in seeking to occupy the middle ground they ultimately find themselves committed to (and in the process commit Wittgenstein to) the very ineffabilism they (and Wittgenstein) are seeking to overcome. (shrink)
Since everything which enters into the human understanding comes there through the senses, man's first reason is a reason of the senses; this sensual reason serves as the basis of intellectual reason. Our first masters of philosophy are our feet, our hands, our eyes. Emile, 125.