Using 94 published empirical articles in academic journals as a data base, this paper provides a critical review of the methodology employed in the study of ethical beliefs and behavior of organizational members. The review revealed that full methodological detail was provided in less than one half of the articles. Further, the majority of empirical research articles expressed no concern for the reliability or validity of measures, were characterized by low response rates, used convenience samples, and did not offer a (...) theoretic framework, hypotheses, or a definition of ethics. Several recommendations, including a reviewer rating form addressing methodological decisions and inclusion of methodologists on the review panel, are offered to improve methodological rigor in published ethics research. (shrink)

Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and replicated at PRSS1-PRSS2 and X-linked CLDN2 through a two-stage genome-wide study. The PRSS1 variant likely affects disease susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is (...) associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men. © 2012 Nature America, Inc. All rights reserved. (shrink)

© 2015 Elsevier Inc.Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within an intracellular parasitophorous vacuole that is selectively permeable to small molecules through unidentified mechanisms. We have identified GRA17 as a Toxoplasma-secreted protein that localizes to the parasitophorous vacuole membrane and mediates passive transport of small molecules across the PVM. GRA17 is related to the putative Plasmodium translocon protein EXP2 and conserved across PV-residing Apicomplexa. The PVs of GRA17-deficient parasites have aberrant morphology, reduced permeability to (...) small molecules, and structural instability. GRA17-deficient parasites proliferate slowly and are avirulent in mice. These GRA17-deficient phenotypes are rescued by complementation with Plasmodium EXP2. GRA17 functions synergistically with a related protein, GRA23. Exogenous expression of GRA17 or GRA23 alters the membrane conductance properties of Xenopus oocytes in a manner consistent with a large non-selective pore. Thus, GRA17 and GRA23 provide a molecular basis for PVM permeability and nutrient access. (shrink)

The Blackwell Companion and Blackwell Guide to the philosophy of education, edited respectively by Randall Curren and by Nigel Blake, Paul Smeyers, Richard Smith and Paul Standish, are potentially field-defining volumes. The present essay moves back and forth between the two books to assess the overall impression they provide of the ‘state of the art’. Whilst both texts can be criticised for failing to engage sufficiently with non-philosophical work on education, these are otherwise estimable volumes, containing many fine essays (...) that can be read with profit. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:F. H. Bradley and the Working-out of Absolute Idealism* JOHN HERMAN RANDALL, JR. FRANCIS HERBERTBRADLEY (1846-1924) 1 agreed with the other English idealists that the real world is the experienced world. But he started with the fundamental conviction that "experience" is more than "thought," as Green had maintained. Bradley's basic drive is the refusal to abolish "feeling" in favor of knowledge and intelligibility. "Feeling" is a fundamental and (...) ineradicable aspect of "reality"m more fundamental, in fact, than thinking. In the immediately experienced world, all intelligible distinctions and relations are merged in a "whole of feeling" which is the ultimate subject-matter of philosophy. "Thought" arises out of feeling, out of "immediacy," as an interpretation of immediate experience by distinguishing relations and aspects in it. "Knowledge " is only one aspect of the experienced world; it needs blending with "feeling" and will to include all the experienced aspects. "Feeling" starts for Bradley, in his Principles of Logic (1883), in pretty much the empiricist sense, as isolated sensations, and as subjective (in flavor at least). It then becomes neutral: "feeling" is identified with "the felt"; and it grows richer, attempting to include the whole wealth of immediate experience. Thus Bradley gets very close to Dewey's conception of "direct experience," "non-reflective experience," without, however, Dewey's biological analysis. It is through this conception of experience that Bradley approaches the naturalism to which his thinking almost arrived at the end. Thought, that is, has a setting in experience " it is relational, and by its analysis it breaks up experienced and felt wholes. There is a double insistence in Bradley. On the one hand, reality is experienced, but is not adequately expressed in thought. On the other, reality/s accessible to knowledge. What has often been called Bradley's "skepticism" is really an objective relativism. Thought, logical structure, is not ultimate. In Appearance and *This study of F. It. Bradley is based on one of five chapters on post-ttegehan philosophical Ideahsm in Britain and America to be included in my forthcoming Career oJ Philosophy in Modem Times, Vol.III: The Hundred Years Since Darwin. ISee Bradley ed. of Mind, XXXIV (1925); A. E. Taylor, "F. H. Bradley"; J. H. Muirhead, "Bradley's Place in Philosophy." See also T. M. Forsyth, English Philosophy (London: 1910), chap. VII, 2rid part; Rudolf Kagey, F. H. Bradley's Logic (New York: 1931). The best philosophical analyses of Bradley are Robert D. Mack, The Appeal to Immediate Experience (New York: 1945),and Richard Wollheim,F. H. Bradley (Pelican Books, 1959). [245] 246 HISTORY OF PHILOSOPHY Reality, he insists it is really self-contradictory; then later he emphasizes rather that it is always relative to its particular subiect-matter. The real, experienced world is never identical with the intelligible world, yet it is also never "extraneous " to it. The relation of the two can be said to be, in Aristotelian terms, that of substance to form, that of what is to its intelligible aspect. The intelligible world, the system of science and knowledge, thus fundamentally needs criticism in the light of its setting in the experienced world. This is not only the entire drive of Dewey's Experience and Nature; it is the expression of that whole current of thought on the Continent which began with the criticism of Hegel's "panlogism" in the 1840's and is today called "Existentialism." Bradley is the British counterpart of all those who have criticized philosophies of logical structure like T. H. Green's, or like the other contemporary forms of Neo-Kantianism in Germany and France. The "known world" is a world of relations distingflished in the richer "real world." These distinctions are ultimately relative to their particular setting, but in that setting they are valid enough. Bradley's celebrated doctrine of the "degrees of truth and reality" means that practically knowledge is "true"; any idea which fulfills its purpose of rendering some portion or aspect of experience intelligible and significant and meaningful, and which is not ousted by a better idea, Bradley is willing to say is "so far true." It is valid, in its own sphere and purpose, despite its ultimate inconsistency; the wave-theory... (shrink)

The Blackwell Companion and Blackwell Guide to the philosophy of education, edited respectively by Randall Curren and by Nigel Blake, Paul Smeyers, Richard Smith and Paul Standish, are potentially field-defining volumes. The present essay moves back and forth between the two books to assess the overall impression they provide of the ‘state of the art’. Whilst both texts can be criticised for failing to engage sufficiently with non-philosophical work on education, these are otherwise estimable volumes, containing many fine essays (...) that can be read with profit. (shrink)

It is now some years since Professor D. Daiches Raphael published his interesting book, The Paradox of Tragedy , which represented one of the first serious attempts made by a British philosopher to assess the significance of tragic drama for ethical, and indeed metaphysical theory. Since then we have had a variety of books touching on related topics: for instance, Dr George Steiner's Death of Tragedy and Mr Raymond Williams’ most recent, elusive and interesting essay, Modern Tragedy. To entitle an (...) essay Theology and Tragedy might be thought to invite needless trouble for oneself; to indulge to a dangerous degree the human intellectual obsession of supposing that ‘the meaning of a word is an object’. After all, if one confines one's regard to the Greeks, one has to recognise that between the treatments of their common theme of Electra , Sophocles and Euripides are in fact doing very different things. There is no gainsaying the significance for Euripides of the postponement of the murder of Clytemnestra till after that of Aegisthus, still less of his introduction into the play of the morally upright peasant, who has had the banished Electra in his keeping, and whose simple integrity contrasts both with the corruption of the court and the obsessive preoccupation with a dreadful, supposed duty of brother and sister. The element of propaganda is unmistakable; while in Sophocles’ Electra it is altogether absent, although Dr Victor Ehrenberg in his very interesting monograph on Sophocles and Pericles has argued strongly for an element of subtle political commentary in the treatment of Oedipus in the Oedipus Tyrannus , and of Pocreon in the Antigone. These remarks may serve to show that the title does not express a blind indifference to the multiple complexity of those works which we class together as tragedies. They are inherently complex, and various in emphasis; at best we can discern a family resemblance between them, and, in an essay like this, the author runs the risk not only of selecting examples tailor-made to his thesis, but also of imposing an appearance of similarity of conception where it is at least equally important to stress differences. (shrink)

The purpose of this article should become plain during the reading of it, but perhaps some prior explanation is needed. Almost from the beginning of my study of the paṭiccasamuppāda I have had the notion that it could not have come into existence in the form the usual twelvefold formulation takes. For reasons which I try to make clear this twelvefold formulation is not a satisfactory statement of what it is supposed to explain, namely the reasons for each individual's continued (...) rebirths. I feel - and sadly I have to emphasize, before someone else does it for me, that in the final analysis I am relying more or less on intuition for my attitude towards the twelvefold formulation - that if one person alone had been responsible for the usually referred to formulation, and especially if that one person had been the Buddha, then those anomalies that now prevail would never have existed. (shrink)

This paper described a formal theory of type judgments for propositional logic notations of PM; I felt the need of my own automated type checker to check their examples. The type checker I wrote did indeed serve to help me referee the paper, but also took a rather different approach to notation and typing for propositional functions of PM, which proved worth writing up independently in our own paper: Holmes, M. Randall, “Polymorphic type– checking for the ramified theory of (...) types of Principia Mathematica”, in Fairouz Kamareddine, ed., Thirty–five Years of Automating Mathematics, Kluwer, 2003, pp. 173-215. (shrink)

The central insight of Darwin's Origin of Species is that evolution is an ecological phenomenon, arising from the activities of organisms in the 'struggle for life'. By contrast, the Modern Synthesis theory of evolution, which rose to prominence in the twentieth century, presents evolution as a fundamentally molecular phenomenon, occurring in populations of sub-organismal entities - genes. After nearly a century of success, the Modern Synthesis theory is now being challenged by empirical advances in the study of organismal development and (...) inheritance. In this important study, D. M. Walsh shows that the principal defect of the Modern Synthesis resides in its rejection of Darwin's organismal perspective, and argues for 'situated Darwinism': an alternative, organism-centred conception of evolution that prioritises organisms as adaptive agents. His book will be of interest to scholars and advanced students of evolutionary biology and the philosophy of biology. (shrink)

Related Works: Original Paper: M. Randall Holmes. Strong Axioms of Infinity in NFU. J. Symbolic Logic, Volume 66, Issue 1 , 87--116. Project Euclid: euclid.jsl/1183746361.

This is a brief report on results reported at length in our paper [2], made for the purpose of a presentation at the workshop to be held in November 2011 in Cambridge on the Principia Mathematica of Russell and Whitehead ([?], hereinafter referred to briefly as PM ). That paper grew out of a reading of the paper [3] of Kamareddine, Nederpelt, and Laan. We refereed this paper and found it useful for checking their examples to write our own independent (...) computer type-checker for the type system of PM ([1]), which led us to think carefully about formalization of the language and the type system of PM A modern mathematical logician reading PM finds that it is not completely formalized in a modern sense. The type theory in particular is inarguably not formalized, as no notation for types is given at all! In PM itself, the only type annotations which appear are occasional numerical indices indicating order; the type notation we use here extends one introduced later by Ramsey. The authors of PM regard the absence of explicit indications of type as a virtue of their system: they call it “systematic ambiguity”; modern computer scientists refer to this as “polymorphism”. The language of PM is also not completely formalized, and it is typographically inconvenient for computer software to which ASCII input is to be given. The notation of PM for abstractions (propositional functions) does not use head binders; the order of the arguments of a complex expression is determined by the alphabetical order of the bound variables. For example ˆa < ˆb is the “less than” relation while ˆb < ˆa is the “greater than” relation (this is indicated by the alphabetical order of the variables). In PM , the fact that a variable is bound in a propositional function is indicated by circumflexing it. Variables bound by quantifiers are not circumflexed. A feature of the notation of [3], carried over into ours, is that no circumflexes are used: notations for propositions and the corresponding propositional functions are identical.. (shrink)

We analyze the representation of binary relations in general, and in particular of functions and of total antisymmetric relations, in monadic third order logic, that is, the simple typed theory of sets with three types. We show that there is no general representation of functions or of total antisymmetric relations in this theory. We present partial representations of functions and of total antisymmetric relations which work for large classes of these relations, and show that there is an adequate representation of (...) cardinality in this theory. The relation of our work to similar work by Henrard and Allen Hazen is discussed. This work can be understood as part of a program of assessing the capabilities of weak logical frameworks: our results are applicable for example, to the framework in David Lewis’s Parts of Classes. (shrink)

An ω-model (a model in which all natural numbers are standard) of the predicative fragment of Quine's set theory "New Foundations" (NF) is constructed. Marcel Crabbe has shown that a theory NFI extending predicative NF is consistent, and the model constructed is actually a model of NFI as well. The construction follows the construction of ω-models of NFU (NF with urelements) by R. B. Jensen, and, like the construction of Jensen for NFU, it can be used to construct α-models for (...) any ordinal α. The construction proceeds via a model of a type theory of a peculiar kind; we first discuss such "tangled type theories" in general, exhibiting a "tangled type theory" (and also an extension of Zermelo set theory with Δ 0 comprehension) which is equiconsistent with NF (for which the consistency problem seems no easier than the corresponding problem for NF (still open)), and pointing out that "tangled type theory with urelements" has a quite natural interpretation, which seems to provide an explanation for the more natural behaviour of NFU relative to the other set theories of this kind, and can be seen anachronistically as underlying Jensen's consistency proof for NFU. (shrink)

This paper presents an exposition of subsystems and of Quine's , originally defined and shown to be consistent by Crabbé, along with related systems and of type theory. A proof that (and so ) interpret the ramified theory of types is presented (this is a simplified exposition of a result of Crabbé). The new result that the consistency strength of is the same as that of is demonstrated. It will also be shown that cannot be finitely axiomatized (as can and (...) ). (shrink)

Systems TRC and TRCU of illative combinatory logic are introduced and shown to be equivalent in consistency strength and expressive power to Quine's set theory ‘New Foundations’ and the fragment NFU + Infinity of NF described by Jensen, respectively. Jensen demonstrated the consistency of NFU + Infinity relative to ZFC; the question of the consistency of NF remains open. TRC and TRCU are presented here as classical first-order theories, although they can be presented as equational theories; they are not constructive.

The usual construction of models of NFU (New Foundations with urelements, introduced by Jensen) is due to Maurice Boffa. A Boffa model is obtained from a model of (a fragment of) Zermelo–Fraenkel with Choice (ZFC) with an automorphism which moves a rank: the domain of the Boffa model is a rank that is moved. “Most” elements of the domain of the Boffa model are urelements in terms of the interpreted NFU. The main result of this paper is that the restriction (...) of the membership relation of the original model of set theory with automorphism to the domain of the Boffa model is first-order definable in the language of NFU. In particular, all information about the extensions in the original model of the urelements of the model of NFU is definable in terms of NFU. A corollary (answering a question of Thomas Forster) is that the urelements in a Boffa model are not homogeneous. (shrink)

Three systems of double extension set theory have been proposed by Andrzej Kisielewicz in two papers. In this paper, it is shown that the two stronger systems are inconsistent, and that the third, weakest system does not admit extensionality for general sets or the use of general sets as parameters in its comprehension scheme. The parameter-free version of the comprehension principle of double extension set theory is also shown to be inconsistent with extensionality. The definitions of the systems and a (...) self-contained exposition of their properties is given, sufficient to develop the inconsistency proofs. (shrink)

Andrzej Kisielewicz has proposed three systems of double extension set theory of which we have shown two to be inconsistent in an earlier paper. Kisielewicz presented an argument that the remaining system interprets ZF, which is defective: it actually shows that the surviving possibly consistent system of double extension set theory interprets ZF with Separation and Comprehension restricted to 0 formulas. We show that this system does interpret ZF, using an analysis of the structure of the ordinals.

This paper extends the results of an earlier paper by the author . New subsystems of the combinatory logic TRC shown in that paper to be equivalent to NF are introduced; these systems are analogous to subsystems of NF with predicativity restrictions on set comprehension introduced and shown to be consistent by Crabbé. For one of these systems, an exact equivalence in consistency strength and expressive power with the analogous subsystem of NF is established.

In this important study D. M. Armstrong offers a comprehensive system of analytical metaphysics that synthesises but also develops his thinking over the last twenty years. Armstrong's analysis, which acknowledges the 'logical atomism' of Russell and Wittgenstein, makes facts the fundamental constituents of the world, examining properties, relations, numbers, classes, possibility and necessity, dispositions, causes and laws. All these, it is argued, find their place and can be understood inside a scheme of states of affairs. This is a comprehensive and (...) rigorously this-worldly account of the most general features of reality, argued from a distinctive philosophical perspective, and it will appeal to a wide readership in analytical philosophy. (shrink)

A common objection to Quine’s set theory “New Foundations” is that it is inadequately motivated because the restriction on comprehension which appears to avert paradox is a syntactical trick. We present a semantic criterion for determining whether a class is a set (a kind of symmetry) which motivates NF.

A common objection to Quine's set theory "New Foundations" is that it is inadequately motivated because the restriction on comprehension which appears to avert paradox is a syntactical trick. We present a semantic criterion for determining whether a class is a set which motivates NF.

This is a study of a crucial and controversial topic in metaphysics and the philosophy of science: the status of the laws of nature. D. M. Armstrong works out clearly and in comprehensive detail a largely original view that laws are relations between properties or universals. The theory is continuous with the views on universals and more generally with the scientific realism that Professor Armstrong has advanced in earlier publications. He begins here by mounting an attack on the orthodox and (...) sceptical view deriving from Hume that laws assert no more than a regularity of coincidence between instances of properties. In doing so he presents what may become the definitive statement of the case against this position. Professor Armstrong then goes on to establish his own theory in a systematic manner defending it against the most likely objections, and extending both it and the related theory of universals to cover functional and statistical laws. This treatment of the subject is refreshingly concise and vivid: it will both stimulate vigorous professional debate and make an excellent student text. (shrink)