The human spindle and kinetochore associated complex is required for proper mitotic progression. Extensive studies have demonstrated its important functions in both stable kinetochore-microtubule interactions and spindle checkpoint silencing. We suggest a model to explain how various Ska functions might be fulfilled by distinct pools of Ska at kinetochores. The Ndc80-loop pool of Ska is recruited by the Ndc80 loop, or together with some of its flanking sequences, and the recruitment is also dependent on Cdk1-mediated Ska3 phosphorylation. This pool seems (...) to play a more important role in silencing the spindle checkpoint than stabilizing kinetochore-microtubule interactions. In contrast, the Ndc80-N-terminus pool of Ska is recruited by the N-terminal domains of Ndc80 and appears to be more important for stabilizing kinetochore-microtubule interactions. Here, we review and discuss the evidence that supports this model and suggest further experiments to test the functioning mechanisms of the Ska complex. The human spindle and kinetochore associated complex plays essential functions in proper mitotic progression by promoting stable kinetochore-microtubule interactions and spindle checkpoint silencing. We propose that “distinct pools” of Ska—the Ndc80-loop and Ndc80-N-terminus pools—might fulfill these various functions. (shrink)

Typology of perpetrators of domestic violence The objective of the research conducted by the author was to obtain an answer to the question: could we distinguish different types of intrafamily violence perpetrators considering a specified profile of personality factors and temperament traits and how domestic violence perpetrators cope with stressful situations? The research was conducted on a group of 325 men who were convicted pursuant to article 207§1 & 2 of harassment over family members. In terms of a gender the (...) group was homogenous. On the basis of the literature on the subject, the following personality traits of violence perpetrators were categorised: locus of control, self-acceptance, aggressiveness, hostility, intelligent quotient and temperament traits. The following research techniques were employed in the study: the Wechsler Intelligence Scale, Berger's Self-Acceptance Scale, the Delta Questionnaire by R. Drwal, the SABD Questionnaire - Buss-Durkee, Formal Characteristics of Behaviour - Temperament Inventory by J. Strelau, the WCQ questionnaire by R.S. Lazarus and S. Folkman, a categorised interview and an analysis of court records. As a result of the analysis conducted on a group of the studied sample of violence perpetrators, four subgroups, differing in terms of selected personality traits, were specified. They are reactively aggressive perpetrators, perpetrators of low preventive competences, psychopathic and retaliatory perpetrators and perpetrators with a big adaptive potential. Further on, four distinguished groups have been characterised in terms of stress-coping strategies, and psychological processes of coping with stress proceeded differently in the research group. (shrink)

I sitt berömda bevis för tidens overklighet påstod McTaggart att det sätt händelser tycks skifta position i tiden från framtid till nutid och till förfluten tid, innebär en motsägelse. Vad McTaggart egentligen menade har varit föremål för en livlig debatt ända sedan beviset först publicerades 1908. Beviset består av två delar. I den första argumenterar McTaggart för att ingenting kan förändras förutom genom att övergå från framtid till förfluten tid. I den andra argumenterar han för att en sådan övergång innebär (...) en motsägelse och att det därför inte kan finnas någon förändring överhuvudtaget, vilket i sin tur innebär att det heller inte finns någon tid. De flesta filosofer är i dag eniga om att McTaggart har fel, men oeniga om på vilket sätt han har fel. Olika filosofer förkastar olika delar av beviset, beroende på om de har vad som kallas en A- eller B-uppfattning av tiden. De som har en A-uppfattning förnekar att tid förstådd som övergång från framtid till förfluten tid är motsägelsefull. De som har en B-uppfattning förnekar att en övergång från framtid till förfluten tid är nödvändig för förändring, men håller med om att sådan övergång är motsägelsefull. Det är min uppfattning att denna oenighet beror på att McTaggarts argument från första början blivit missuppfattat, av både A- och B-teoretiker. Av någon anledning har det alltid betraktats som ett självständigt argument, ett som är oberoende av det ontologiska system McTaggart förespråkade. Jag föreslår ett nytt sätt att förstå hur han menade att tiden är motsägelsefull. Ett sätt som tar hans ontologiska system som utgångspunkt. (shrink)

The Polish society has perceived privatization as an issue of special importance which enables a free market economy in a short time. Privatization has always raised hopes and expectations. It is the lack of experience in the field of ownership transformations, the level of their complexity and the economic, legal, psychological and other conditionings that have confronted those transformations with many hindrances. They have also raised numerous moral and ethical dilemmas among the staff of privatized companies and founding organs including (...) the staff of the Voivodship Council of Łódź. The decisions of the Working Board of one company about the future path of privatization have raised concerns among the staff uncertain of the fate of their place of work. In such cases the voice of the staff, which previously contributed to the company’s financial status, has always been decisive when choosing the path of privatization; this concerns mostly workers’ partnerships. It was John Paul II’s words about people of conscience who are needed in Poland, which were said in Skoczów, that were crucial for privatization decisions by the Voivodship Council of Łódź. (shrink)

Since the Supreme Court of New Jersey decided the Quinlan case a quarter of a century ago, three American Supreme Court decisions and a host of state appellate decisions have addressed end-of-life issues. These decisions, as well as legislation addressing the same issues, have prompted a torrent of law journal articles analyzing every aspect of end-of-life law. In recent years, moreover, a number of law review articles, many published in this journal, have also specifically addressed legal issues raised by palliative (...) care. Much less is known in the United States, however, as to how other countries address these issues. Reflection on the experience and analysis of other nations may give Americans a better understanding of their own experience, as well as suggest improvements to their present way of dealing with the difficult problems in this area.This article offers a conceptual and comparative analysis of major legal issues relating to end-of-life treatment and to the treatment of pain in a number of countries. In particular, it focuses on the law of Australia, Canada, the United Kingdom, Poland, France, the Netherlands, Germany, and Japan. (shrink)

Since the Supreme Court of New Jersey decided the Quinlan case a quarter of a century ago, three American Supreme Court decisions and a host of state appellate decisions have addressed end-of-life issues. These decisions, as well as legislation addressing the same issues, have prompted a torrent of law journal articles analyzing every aspect of end-of-life law. In recent years, moreover, a number of law review articles, many published in this journal, have also specifically addressed legal issues raised by palliative (...) care. Much less is known in the United States, however, as to how other countries address these issues. Reflection on the experience and analysis of other nations may give Americans a better understanding of their own experience, as well as suggest improvements to their present way of dealing with the difficult problems in this area.This article offers a conceptual and comparative analysis of major legal issues relating to end-of-life treatment and to the treatment of pain in a number of countries. In particular, it focuses on the law of Australia, Canada, the United Kingdom, Poland, France, the Netherlands, Germany, and Japan. (shrink)

Interactive media create a space conducive to development of participatory culture, in which media content recipients become its active creators. Participant activities are not limited to commenting on online articles or being active on social media. They want to influence reality through their actions and to participate in creating and spreading information. The willingness and readiness of Internet users to co-create content is becoming increasingly important also in scientific projects, where success depends on the involvement of many volunteers who undertake (...) specific tasks. Although such projects are often time-consuming, they usually do not require advanced skills from the people involved. The only payoff for their efforts is the satisfaction that comes from participating, as well as the recognition in their community. The purpose of this paper is to attempt to evaluate the phenomenon of crowdsourcing in humanities, especially in the context of the new reality created by the Covid-19 pandemic. It is based on the literature which addresses the importance of crowdsourcing in projects in a variety of areas, on top of an analysis of examples in which this method is used. The selection of presented examples is strongly intended to demonstrate the enormous possibilities and resulting benefits of involving willing volunteers in humanities projects. Their role is not diminished by the fact that they do not have competencies related to project topics. It can be assumed that crowsrourcing will be more and more widely used by researchers, especially in times when increasing numbers of people undertake online activities. (shrink)

J. Such first introduced the notion of „complementary experiments”, referring to the decisive situations in science. The similar notions appears in the discussions of new experimentalists. For example, I. Hacking writes about complementarity of different types of microscopy, A. Franklin distinguishes technically good and conceptually important experiments, and P. Galison analyses examples of complementarity of two different approaches to the problem of cosmic radiation. In the article the notion of „complementarity” is extended as to cover the cases of complementarity of (...) method, complementarity of scientific teams etc. As an illustration it is used the case of discovering new type of carbon - called „fulleren”. (shrink)