Results for 'Databases, Nucleic Acid ethics'

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  1.  15
    Human Genetic Biobanks in Asia: Politics of Trust and Scientific Advancement.Margaret Sleeboom-Faulkner (ed.) - 2009 - Routledge.
    This volume investigates human genetic biobanking and its regulation in various Asian countries and areas, including Japan, Mainland China, Taiwan, Hong Kong, ...
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  2.  1
    Variation, Differential Reproduction and Oscillation: The Evolution of Nucleic Acid Hybridization.Edna Suárez-Díaz - 2012 - History and Philosophy of the Life Sciences 35 (1):39-44.
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  3.  33
    Corrosive Effects: Environmental Ethics and the Metaphysics of Acid Mine Drainage.Robert Frodeman - 2001 - Research in Phenomenology 31 (1):156-172.
    Environmentally we seem to be both the victims and the perpetrators of a type of bait and switch: lured into the discussion by one set of intuitions, our interests become redescribed in terms that are intellectually more respectable. Our deepest concerns with the environment are converted into foreign discourses, as we strain to make the languages of science, economics, and interest group politics express our intuitions. The circumscription of environmental philosophy within environmental ethics is one manifestation of this process (...)
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  4. Production of Mutants of Tobacco Mosaic Virus by Chemical Alteration of its Nucleic Acid in Vitro.Alfred Gierer & K. W. Mundry - 1958 - Nature 182:1457-1458.
    The generation of viral mutants in vitro was demonstrated by treatment of the isolated RNA of Tobacco Mosaic Virus by nitrous acid. This agent causes deaminations converting cytosine into uracil, and adenine into hypoxanthine. Our assay for mutagenesis was the production of local lesions on a tobacco variety on which the untreated strain produces systemic infections only. A variety of different mutants are generated in this way. Quantitative analysis of the kinetics of mutagenesis leads to the conclusion that alteration (...)
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  5. Structural and Functional Properties of the Evolutionarily Ancient Y‐Box Family of Nucleic Acid Binding Proteins.Alan P. Wolffe - 1994 - Bioessays 16 (4):245-251.
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  6.  2
    A Case of Convergent Evolution of Nucleic Acid Binding Modules.Peter Graumann & Moharned A. Marahiel - 1996 - Bioessays 18 (4):309-315.
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  7.  12
    Multiple but Dissectible Functions of FEN‐1 Nucleases in Nucleic Acid Processing, Genome Stability and Diseases.Binghui Shen, Purnima Singh, Ren Liu, Junzhuan Qiu, Li Zheng, L. David Finger & Steve Alas - 2005 - Bioessays 27 (7):717-729.
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  8.  2
    Common Structural Features of Nucleic Acid Polymerases.P. Cramer - 2002 - Bioessays 24 (8):724-729.
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  9.  1
    Genetic Nucleic Acid: Key Material in the Origin of Life.H. J. Muller - 1961 - Perspectives in Biology and Medicine 5 (1):1-23.
  10.  1
    Nucleic Acid‐Mediated Inflammatory Diseases.Rachel E. Rigby, Andrea Leitch & Andrew P. Jackson - 2008 - Bioessays 30 (9):833-842.
  11. A Guide to Nucleic Acid Hybridization Nucleic Acid Hybridization: A Practical Approach, Ed. By B. D. Hames and S. J. Higgins. Irl Press. 1985. Pp. 245. £22, $40 Hardback; £14. $25 Paperback. [REVIEW]David A. Gillespie - 1986 - Bioessays 5 (4):187-188.
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  12. Stereochemical Recognition in Nucleic Acid-Amino Acid Interactions and its Implications in Biological Coding: A Model Approach.Lawrence B. Hendry & Francis H. Witham - 1979 - Perspectives in Biology and Medicine 22 (3):333-345.
  13. Reviews of Macromolecular Structure: A Needed Compendium? Protein and Nucleic Acid Structure and Dynamics, Edited by J. KING, Annual Reviews Special Collections Programme. Benjamin/Cummings. 1985. Pp. 587. £29.95. [REVIEW]E. James Milner‐White - 1988 - Bioessays 8 (2‐3):92-93.
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  14. Non-Radioactive Nucleic Acid Probes for the Diagnosis of Virus Infections.H. G. Pereira - 1986 - Bioessays 4 (3):110-113.
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  15. Ethical Issues of Human Genetic Databases: A Challenge to Classical Health Research Ethics (Review).Tamra Lysaght - 2011 - Asian Bioethics Review 3 (2):170-174.
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  16.  8
    Gene Patents—A Pharmaceutical Perspective.Jack L. Tribble - 1998 - Cambridge Quarterly of Healthcare Ethics 7 (4):429-432.
    The decade-long debate over ownership of living human materials has recently intensified with the ability of biomedical research to isolate, purify, and use human genes and gene products as therapeutics, factories for the production of therapeutics, and targets for the identification of therapeutic pharmaceuticals. Indeed, advances in genomic research have resulted in the identification of hundreds of thousands of DNA fragments and hundreds of genes. Many within the scientific and business communities believe genes and gene fragments have commercial value and (...)
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  17.  6
    The Long and Winding Road of Molecular Data in Phylogenetic Analysis.Edna Suárez-Díaz - 2014 - Journal of the History of Biology 47 (3):443-478.
    The use of molecules and reactions as evidence, markers and/or traits for evolutionary processes has a history more than a century long. Molecules have been used in studies of intra-specific variation and studies of similarity among species that do not necessarily result in the analysis of phylogenetic relations. Promoters of the use of molecular data have sustained the need for quantification as the main argument to make use of them. Moreover, quantification has allowed intensive statistical analysis, as a condition and (...)
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  18.  13
    Retracted Article: Modern Business Ethics Research: Concepts, Theories, and Relationships. [REVIEW]Hsing-Chau Tseng, Chi-Hsiang Duan, Hui-Lien Tung & Hsiang-Jui Kung - 2010 - Journal of Business Ethics 91 (4):587-597.
    The main purpose of this study is to explore and map the intellectual structure of business ethics studies during 1997–2006 by analyzing 85,000 cited references of 3,059 articles from three business ethics related journals in SSCI and SCI databases. In this article, co-citation analysis and social network analysis techniques are used to research intellectual structure of the business ethics literature. We are able to identify the important publications and the influential scholars as well as the correlations among (...)
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  19.  16
    Organization Ethics From a Perspective of Praxis.Richard P. Nielsen - 1993 - Business Ethics Quarterly 3 (2):131-151.
    Organization ethics praxis is theory and method of appropriate action for addressing ethics issues and developing ethical organizations. The perspective of praxis (theory and method of action) is important and different from the perspectives of theoria (theory of understanding), epistemology (ways of knowing), and ontology (ways of being/existing). Praxis is the least developed area within the field of organization ethics. Differences between theoria and praxis are considered within the context of Kohlberg-Gilligan developmental ethics where part of (...)
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  20.  59
    Infectivity of Ribonucleic Acid From Tobacco Mosaic Virus.Alfred Gierer & Gerhard Schramm - 1956 - Nature 177:702-703.
    Upon separation of the protein from the nucleic acid component of tobacco mosaic virus by phenol, using a fast and gentle procedure, the nucleic acid is infective in assays on tobacco leaves. A series of qualitative and quantitative control experiments demonstrates that the biological activity cannot depend on residual proteins in the preparation, but is a property of isolated nucleic acid which is thus the genetic material of the virus.
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  21.  10
    Accountability, Governance and Biobanks: The Ethics and Governance Committee as Guardian or as Toothless Tiger? [REVIEW]Jean V. McHale - 2011 - Health Care Analysis 19 (3):231-246.
    The huge potential of biobanks/genetic databases for the research community has been recognised across jurisdictions in both publicly funded and commercial sectors. But although there is tremendous potential there are likewise potential difficulties. The long-term storage of personal health information and samples poses major challenges. This is an area is fraught with ethical and legal uncertainties. Biobanks raise many questions of the control of rights, of consent, of privacy and confidentiality and of property in human material. It is thus unsurprising (...)
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  22.  19
    A Quantitative Analysis of Authors, Schools and Themes in Virtue Ethics Articles in Business Ethics and Management Journals. [REVIEW]Ignacio Ferrero & Alejo José G. Sison - 2014 - Business Ethics: A European Review 23 (4):375-400.
    Virtue ethics is generally recognized as one of the three major schools of ethics, but is often waylaid by utilitarianism and deontology in business and management literature. EBSCO and ABI databases were used to look for articles in the Journal of Citation Reports publications between 1980 and 2011 containing the keywords ‘virtue ethics’, ‘virtue theory’, or ‘virtuousness’ in the abstract and ‘business’ or ‘management’ in the text. The search was refined to draw lists of the most prolific (...)
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  23.  4
    Unesco's Global Ethics Observatory.H. ten Have & T. W. Ang - 2007 - Journal of Medical Ethics 33 (1):15-16.
    The Global Ethics Observatory, launched by the United Nations Educational, Scientific, and Cultural Organization in December 2005, is a system of databases in the ethics of science and technology. It presents data on experts in ethics, on institutions and on teaching programmes in ethics. It has a global coverage and will be available in six major languages. Its aim is to facilitate the establishment of ethical infrastructures and international cooperation all around the world.
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  24.  33
    Modern Business Ethics Research: Concepts, Theories, and Relationships.Hsing-Chau Tseng, Chi-Hsiang Duan, Hui-Lien Tung & Hsiang-Jui Kung - 2010 - Journal of Business Ethics 91 (4):587 - 597.
    The main purpose of this study is to explore and map the intellectual structure of business ethics studies during 1997–2006 by analyzing 85,000 cited references of 3,059 articles from three business ethics related journals in SSCI and SCI databases. In this article, co-citation analysis and social network analysis techniques are used to research intellectual structure of the business ethics literature. We are able to identify the important publications and the influential scholars as well as the correlations among (...)
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  25.  14
    Organizational Ethics: A Literature Review.Riitta Suhonen, Minna Stolt, Heli Virtanen & Helena Leino-Kilpi - 2011 - Nursing Ethics 18 (3):285-303.
    The aim of the study was to report the results of a systematically conducted literature review of empirical studies about healthcare organizations’ ethics and management or leadership issues. Electronic databases MEDLINE and CINAHL yielded 909 citations. After a two stage application of the inclusion and exclusion criteria 56 full-text articles were included in the review. No large research programs were identified. Most of the studies were in acute hospital settings from the 1990s onwards. The studies focused on ethical challenges, (...)
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  26.  17
    Forensic DNA Databases: Genetic Testing as a Societal Choice.A. Patyn & K. Dierickx - 2010 - Journal of Medical Ethics 36 (5):319-320.
    In this brief report, the authors argue that while a lot of concerns about forensic DNA databases have been raised using arguments from biomedical ethics, these databases are used in a complete different context from other biomedical tools. Because they are used in the struggle against crime, the decision to create or store a genetic profile cannot be left to the individual. Instead, this decision is made by officials of a society. These decisions have to be based on a (...)
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  27.  18
    Bioethics, Business Ethics, and Science: Bioinformatics and the Future of Healthcare.Kenneth W. Goodman & Anita Cava - 2008 - Cambridge Quarterly of Healthcare Ethics 17 (4):361-372.
    The intersection of ethics, computing, and genetics plots a space not yet adequately mapped, despite its importance, indeed, its rapidly growing importance. Its subdomains are well-enough known: or the study of ethical issues in genetics and genomics, is part of core curricula everywhere. Ethics and computing is an established subfield. Computing and geneticshas in little more than a decade progressed from subsubspecialty to the sine qua non of contemporary biomedical research, and it bids fair to transform clinical practice. (...)
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  28.  4
    The Ethics of Community-Based Research with People Who Use Drugs: Results of a Scoping Review.Rusty Souleymanov, Dario Kuzmanović, Zack Marshall, Ayden I. Scheim, Mikiki Mikiki, Catherine Worthington & Margaret Millson - 2016 - BMC Medical Ethics 17 (1):25.
    BackgroundDrug user networks and community-based organizations advocate for greater, meaningful involvement of people with lived experience of drug use in research, programs and services, and policy initiatives. Community-based approaches to research provide an opportunity to engage people who use drugs in all stages of the research process. Conducting community-based participatory research with people who use drugs has its own ethical challenges that are not necessarily acknowledged or supported by institutional ethics review boards. We conducted a scoping review to identify (...)
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  29.  14
    Publishing Ethics in Paediatric Research: A Cross-Cultural Comparative Review.I. Brannstrom - 2012 - Nursing Ethics 19 (2):268-278.
    The present article aims to scrutinize publishing ethics in the fields of paediatrics and paediatric nursing. Full-text readings of all original research articles in paediatrics from a high-income economy, i.e. Sweden, and from all low-income economies in Sub-Saharan Africa, were reviewed as they were indexed and stored in Web of Science for the search period from 1 January 2007 to 7 October 2009. The application of quantitative and qualitative content analysis revealed a marked discrepancy in publishing frequencies between the (...)
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  30.  6
    Research on Ethics in Nursing Care for Older People: A Literature Review.Riitta Suhonen, Minna Stolt, Veikko Launis & Helena Leino-Kilpi - 2010 - Nursing Ethics 17 (3):337-352.
    The aim of this review was to analyse the empirical studies that focus on ethics in nursing care for older people, scoping the need and areas for further study. A search of the MEDLINE and CINAHL databases (earliest to August 2009) was conducted using the the keywords: ethic* and nursing or care or caring and elderly or aged or older. After a four-stage process, 71 empirical articles were included in the review, with informants ranging from elderly people to relatives, (...)
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  31.  6
    Ethics Support in Institutional Elderly Care: A Review of the Literature. [REVIEW]S. van der Dam, B. Molewijk, G. A. M. Widdershoven & T. A. Abma - 2014 - Journal of Medical Ethics 40 (9):625-631.
    Clinical ethics support mechanisms in healthcare are increasing but little is known about the specific developments in elderly care. The aim of this paper is to present a systematic literature review on the characteristics of existing ethics support mechanisms in institutional elderly care. A review was performed in three electronic databases . Sixty papers were included in the review. The ethics support mechanisms are classified in four categories: ‘institutional bodies’ ; ‘frameworks’ ; ‘educational programmes and moral case (...)
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  32.  8
    Healthcare Ethics in Finland: A Follow-Up.Pekka Louhiala & Tuija Takala - 2004 - Cambridge Quarterly of Healthcare Ethics 13 (3):236-240.
    Last year we reported that there are no professorships in medical ethics in Finland. This year we are happy to report that a chair in medical ethics has now been advertised at the University of Turku. We also gave details about the attempts to come up with a law on assisted reproduction. As predicted, there were problems, and eventually the proposal was withdrawn, leaving Finland still without a law on assisted reproduction. The talk on large-scale genetic databases has (...)
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  33.  4
    UNESCO Global Ethics Observatory: Database on Ethics Related Legislation and Guidelines.T. W. Ang, H. T. Have, J. H. Solbakk & H. Nys - 2008 - Journal of Medical Ethics 34 (10):738-741.
    The Database on Ethics Related Legislation and Guidelines was launched in March 2007 as the fourth database of the UNESCO Global Ethics Observatory system of databases in ethics of science and technology. The database offers a collection of legal instruments searchable by region, country, bioethical themes, legal categories and applicability to specific articles of the UNESCO Universal Declaration on Bioethics and Human Rights and International Declaration on Human Genetic Data. This paper discusses the background and rationale for (...)
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  34. UNESCO Global Ethics Observatory: Database on Ethics Related Legislation and Guidelines.T. W. Ang, Hamj ten Have, J. H. Solbakk & Herman Nys - 2008 - Journal of Medical Ethics 34 (10):738-741.
    The Database on Ethics Related Legislation and Guidelines was launched in March 2007 as the fourth database of the UNESCO Global Ethics Observatory system of databases in ethics of science and technology. The database offers a collection of legal instruments searchable by region, country, bioethical themes, legal categories and applicability to specific articles of the UNESCO Universal Declaration on Bioethics and Human Rights and International Declaration on Human Genetic Data. This paper discusses the background and rationale for (...)
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  35.  48
    Bioethics and Large-Scale Biobanking: Individualistic Ethics and Collective Projects.Garrath Williams - 2005 - Genomics, Society and Policy 1 (2):50-66.
    Like most bioethical discussion, examination of human biobanks has been largely framed in terms of research subjects’ rights, principally informed consent, with some gestures toward public benefits. However, informed consent is for the competent, rights-bearing individual: focussing on the individual, it thus neglects social, economic and even political matters; focussing on the competent rights-bearer, it does not serve situations where consent is plainly inappropriate (eg, the young child) or where coercion can obviously be justified (the criminal). Using the British experience (...)
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  36.  13
    The Hypothesis of a Genetic Protolanguage: An Epistemological Investigation. [REVIEW]Gregory Katz - 2008 - Biosemiotics 1 (1):57-73.
    Progress in molecular biology has revealed profound relations between linguistic and genomic sciences, mainly through advances in bioinformatics. The structural symmetries between biochemical and verbal syntaxes raise the question of their origins: did they emerge independently, or did one arise from the other? Does the genetic code contain the traces of a protolanguage, a universal grammar whose gradual evolution and successive mutations progressively led to the polymorphism of natural languages? To explore this question, we review the isomorphism of the genetic (...)
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  37.  5
    A Well Placed Trust? Public Perceptions of the Governance of DNA Databases.Mairi Levitt & Sue Weldon - unknown
    Biobanks that are run on an opt-in basis depend on people having the motivation to give and to trust in those who control their samples. Yet in the UK trust in the healthcare system has been in decline and there have been a number of health-related scandals that have received widespread media and public attention. Given this background, and the previous public consultations on UK Biobank, the paper explores the way people express their trust and mistrust in the area of (...)
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  38.  6
    Acid Brothers: Henry Beecher, Timothy Leary, and the Psychedelic of the Century.Jonathan D. Moreno - 2016 - Perspectives in Biology and Medicine 59 (1):107-121.
    Henry Knowles Beecher, an icon of human research ethics, and Timothy Francis Leary, a guru of the counterculture, are bound together in history by the synthetic hallucinogen lysergic acid diethylamide. Beecher was a U.S. Army Lieutenant Colonel who received five battle stars, was inducted into the Legion of Merit, held the first endowed chair in his discipline, wrote at least three path-breaking papers, and is honored by two prestigious ethics awards in his name. Leary was a West (...)
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  39.  5
    Researchers and Subpoenas: The Troubling Precedent of the Selikoff Case.A. R. Holder - 1988 - IRB: Ethics & Human Research 11 (6):8-10.
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  40.  4
    Broad Data Sharing in Genetic Research: Views of Institutional Review Board Professionals.A. A. Lemke, M. E. Smith, W. A. Wolf & S. B. Trinidad - 2011 - IRB: Ethics & Human Research 33 (3):1-5.
    Genome-wide association studies raise important ethical and regulatory issues. This is particularly true of the current move toward broad sharing of genomic and phenotypic data. Our survey study examined the opinions of professionals involved in human subjects protection regarding genetic research review. The majority indicated that it is important for their institutional review board to offer guidance about developing and using a data repository or biobank that includes genetic data, and also about sharing this data with other investigators. Only one-third (...)
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  41.  3
    The Informed Consent Aftermath of the Genetic Revolution. An Italian Example of Implementation.Federica Artizzu - 2008 - Medicine, Health Care and Philosophy 11 (2):181-190.
    A great part of human genetics research is carried out collecting data and building large databases of biological samples that are in a non-anonymous format. These constitute a valuable resource for future research. The construction of such databases and tissue banks facilitates important scientific progress. However, biobanks have been recognized as ethically problematic because they contain thousands of data that could expose individuals and populations to discrimination, stigmatization and psychological stress if misused. Informed consent is regarded as a cornerstone in (...)
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  42.  1
    Application of Molecular Dynamics Computer Simulations in the Design of a Minimal Self-Replicating Molecular Machine.Paweł Weroński, Yi Jiang & Steen Rasmussen - 2008 - Complexity 13 (4):10-17.
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  43. Clinical Ethics Support for Healthcare Personnel: An Integrative Literature Review.Dara Rasoal, Kirsti Skovdahl, Mervyn Gifford & Annica Kihlgren - 2017 - HEC Forum 29 (4):313-346.
    This study describes which clinical ethics approaches are available to support healthcare personnel in clinical practice in terms of their construction, functions and goals. Healthcare personnel frequently face ethically difficult situations in the course of their work and these issues cover a wide range of areas from prenatal care to end-of-life care. Although various forms of clinical ethics support have been developed, to our knowledge there is a lack of review studies describing which ethics support approaches are (...)
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  44.  6
    The Double Helix 50 Years On: Models, Metaphors, and Reductionism.R. E. Ashcroft - 2003 - Journal of Medical Ethics 29 (2):63-64.
    Bioethics should update its conception of the geneThe 25th of April marks the 50th anniversary of the publication in Nature of the letter by James Watson and Francis Crick announcing their solution to the structure of deoxyribose nucleic acid .1 By that time, much was known about the role of chromosomes in inheritance, the contribution of DNA to chromosome structure, and the chemistry of DNA.2 The gene concept itself was also well established by then; the principal scientific problem (...)
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  45.  1
    A Theoretical Foundation for the Ethical Distribution of Authorship in Multidisciplinary Publications.Smith Elise - 2017 - Kennedy Institute of Ethics Journal 27 (3):371-411.
    In 1953, James Watson and Francis Crick were named as the authors of the publication “Molecular Structure of Nucleic Acids; a Structure for Deoxyribose Nucleic Acid” in the journal Nature. While historians have debated the relevance and importance of various discoveries in molecular science, there is little dispute as to the major significance of the discovery of the double-helix structure of deoxyribose nucleic acid. But what of Rosalind Franklin? There is little mention in science manuals (...)
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  46. Governing Biobanks: Understanding the Interplay Between Law and Practice.Jane Kaye (ed.) - 2012 - Hart.
     
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  47.  1
    Family Tree and Ancestry Inference: Is There a Need for a ‘Generational’ Consent?Susan E. Wallace, Elli G. Gourna, Viktoriya Nikolova & Nuala A. Sheehan - 2015 - BMC Medical Ethics 16 (1):1-9.
    BackgroundGenealogical research and ancestry testing are popular recreational activities but little is known about the impact of the use of these services on clients’ biological and social families. Ancestry databases are being enriched with self-reported data and data from deoxyribonucleic acid analyses, but also are being linked to other direct-to-consumer genetic testing and research databases. As both family history data and DNA can provide information on more than just the individual, we asked whether companies, as a part of the (...)
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  48. Protein Ontology: A Controlled Structured Network of Protein Entities.A. Natale Darren, N. Arighi Cecilia, A. Blake Judith, J. Bult Carol, R. Christie Karen, Cowart Julie, D’Eustachio Peter, D. Diehl Alexander, J. Drabkin Harold, Helfer Olivia, Barry Smith & Others - 2013 - Nucleic Acids Research 42 (1):D415-21..
    The Protein Ontology (PRO; http://proconsortium.org) formally defines protein entities and explicitly represents their major forms and interrelations. Protein entities represented in PRO corresponding to single amino acid chains are categorized by level of specificity into family, gene, sequence and modification metaclasses, and there is a separate metaclass for protein complexes. All metaclasses also have organism-specific derivatives. PRO complements established sequence databases such as UniProtKB, and interoperates with other biomedical and biological ontologies such as the Gene Ontology (GO). PRO relates (...)
     
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  49.  3
    Plagiarism Allegations Account for Most Retractions in Major Latin American/Caribbean Databases.Renan Moritz V. R. Almeida, Karina de Albuquerque Rocha, Fernanda Catelani, Aldo José Fontes-Pereira & Sonia M. R. Vasconcelos - 2016 - Science and Engineering Ethics 22 (5):1447-1456.
    This study focuses on retraction notices from two major Latin American/Caribbean indexing databases: SciELO and LILACS. SciELO includes open scientific journals published mostly in Latin America/the Caribbean, from which 10 % are also indexed by Thomson Reuters Web of Knowledge Journal of Citation Reports. LILACS has a similar geographical coverage and includes dissertations and conference/symposia proceedings, but it is limited to publications in the health sciences. A search for retraction notices was performed in these two databases using the keywords “retracted”, (...)
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  50.  10
    Plagiarism Allegations Account for Most Retractions in Major Latin American/Caribbean Databases.Renan Moritz V. R. Almeida, Karina de Albuquerque Rocha, Fernanda Catelani, Aldo José Fontes-Pereira & Sonia M. R. Vasconcelos - forthcoming - Science and Engineering Ethics:1-10.
    This study focuses on retraction notices from two major Latin American/Caribbean indexing databases: SciELO and LILACS. SciELO includes open scientific journals published mostly in Latin America/the Caribbean, from which 10 % are also indexed by Thomson Reuters Web of Knowledge Journal of Citation Reports. LILACS has a similar geographical coverage and includes dissertations and conference/symposia proceedings, but it is limited to publications in the health sciences. A search for retraction notices was performed in these two databases using the keywords “retracted”, (...)
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