Bidirectional deep brain stimulation platforms have enabled a surge in hours of recordings in naturalistic environments, allowing further insight into neurological and psychiatric disease states. However, high amplitude, high frequency stimulation generates artifacts that contaminate neural signals and hinder our ability to interpret the data. This is especially true in psychiatric disorders, for which high amplitude stimulation is commonly applied to deep brain structures where the native neural activity is miniscule in comparison. Here, we characterized artifact sources in recordings from (...) a bidirectional DBS platform, the Medtronic Summit RC + S, with the goal of optimizing recording configurations to improve signal to noise ratio. Data were collected from three subjects in a clinical trial of DBS for obsessive-compulsive disorder. Stimulation was provided bilaterally to the ventral capsule/ventral striatum using two independent implantable neurostimulators. We first manipulated DBS amplitude within safe limits to characterize the impact of stimulation artifacts on neural recordings. We found that high amplitude stimulation produces slew overflow, defined as exceeding the rate of change that the analog to digital converter can accurately measure. Overflow led to expanded spectral distortion of the stimulation artifact, with a six fold increase in the bandwidth of the 150.6 Hz stimulation artifact from 147–153 to 140–180 Hz. By increasing sense blank values during high amplitude stimulation, we reduced overflow by as much as 30% and improved artifact distortion, reducing the bandwidth from 140–180 Hz artifact to 147–153 Hz. We also identified artifacts that shifted in frequency through modulation of telemetry parameters. We found that telemetry ratio changes led to predictable shifts in the center-frequencies of the associated artifacts, allowing us to proactively shift the artifacts outside of our frequency range of interest. Overall, the artifact characterization methods and results described here enable increased data interpretability and unconstrained biomarker exploration using data collected from bidirectional DBS devices. (shrink)

Recent advances in wireless data transmission technology have the potential to revolutionize clinical neuroscience. Today sensing-capable electrical stimulators, known as “bidirectional devices”, are used to acquire chronic brain activity from humans in natural environments. However, with wireless transmission come potential failures in data transmission, and not all available devices correctly account for missing data or provide precise timing for when data losses occur. Our inability to precisely reconstruct time-domain neural signals makes it difficult to apply subsequent neural signal processing techniques (...) and analyses. Here, our goal was to accurately reconstruct time-domain neural signals impacted by data loss during wireless transmission. Towards this end, we developed a method termed Periodic Estimation of Lost Packets. PELP leverages the highly periodic nature of stimulation artifacts to precisely determine when data losses occur. Using simulated stimulation waveforms added to human EEG data, we show that PELP is robust to a range of stimulation waveforms and noise characteristics. Then, we applied PELP to local field potential recordings collected using an implantable, bidirectional DBS platform operating at various telemetry bandwidths. By effectively accounting for the timing of missing data, PELP enables the analysis of neural time series data collected via wireless transmission—a prerequisite for better understanding the brain-behavior relationships underlying neurological and psychiatric disorders. (shrink)

In his autobiographical-biographical study, Father and Son, Edmund Gosse describes how one evening, during his childhood, while his father was praying at - or, rather, over - his bed, a rather large insect dark and flat, with more legs than a self-respecting insect ought to need, appeared at the bottom of the counterpane, and slowly advanced… I bore it in silent fascination till it almost tickled my chin, and then I screamed ‘Papa! Papa!’. My Father rose in great dudgeon, removed (...) the insect and then gave me a tremendous lecture. 1. (shrink)

There is a very interesting phenomenon which takes place in philosophy. Theories which appeared ten or fifteen years ago in the literature of, say, the philosophy of language or the philosophy of mind, often make a reappearance in current discussions of problems in the philosophy of religion. As Yogi Berra once remarked, ‘It's déjà vu all over again’. However, there is always a possibility that the transition from the earlier context to the later one will be less than smooth. For (...) sometimes the theory reappears in a slightly distorted form, and, as a result, its bearing on the current discussion is somewhat misconceived. In this paper, an example of this phenomenon, and its potential problems, will be considered. Our purpose is not, of course, to discourage such intra-disciplinary dialogue in philosophy of religion, but rather to recommend that it be undertaken with a considerable measure of care. (shrink)

Ethical reflection on the practice of war stands in a long tradition in Western philosophy and theology, a tradition which begins with the writings of Plato and Augustine and encompasses accounts of justified warfare offered by writers from the Medieval period to the present. Ethical reflection on nuclear war is of necessity a more recent theme. The past few years have seen an enormous increase in popular as well as scholarly concern with nuclear issues, and philosophers have joined theologians in (...) exploring the moral issues surrounding the harnessing of atomic forces in the service of war. (shrink)

Although the basic ideas of the ontological argument can be found in Aristotle and Philo Judaeus, the argument received its classical formulation in Anselm's Proslogion and his Reply to the objections raised by Gaunilo. During the succeeding nine centuries the argument has had a chequered career. It was supported by some scholastic theologians but rejected by Aquinas. Descartes and Leibniz offered their own versions of the proof but Kant's refutation of the argument has generally been accepted as conclusive during the (...) past century and a half. Nevertheless, interest in the proof has never completely disappeared—perhaps provoked by Aquinas' suggestion that the proof may be valid for God even though it cannot be valid for us because of the inadequacy of our knowledge of God. Recently there has been a revival of interest in the ontological argument. J. N. Findlay put the argument into reverse to show the necessary non-existence of God in an article in 1948 but in later writings he has suggested that the argument may have positive significance. In 1960 Norman Malcolm published a paper in which he distinguished two basically different forms of the ontological argument in the Proslogion and defended the possible validity of the second of them. (shrink)

Towards the end of Way to Wisdom , after noting how specialization has fragmented modern thought, Karl Jaspers writes that One might wish for a philosophy that would encompass and assimilate the whole tradition, that would be equal to the intellectual situation of our time, that would express the contents common to all of us, and this both in sublime intellectual constructions and in simple propositions capable of finding resonance in every man.

Philosophers and theologians from around the world and throughout history have grappled with such fundamental issues as the nature of the world and man's relation to it, as well as the optimal forms of human perception, language and behaviour. Yet it has always been difficult to compare the works of thinkers from different eras and cultures. In this work of systematic philosophy, David Dilworth places the major texts of ancient and modern, and Western and Oriental philosphy and religion into (...) one comparative framework. His study reveals affinities between thinkers who lived centuries and continents apart and produces numerous insights by bringing together the greatest philosophical texts into a single scheme. (shrink)

Professor MacKinnon, in an essay on Philosophy and Christology , remarks that Christology confronts theology with difficult but ‘inescapable problems’ because logically ‘it is unique; and yet it overlaps here, there and everywhere’. The complexity of the task, however, does not excuse the theologian from the need to determine the logical nature of the concept of ‘incarnation’ if he wishes to use it in his work—and, as I hope to show, any theology which attempts to describe the actual nature of (...) God probably cannot avoid using this concept in some form or other. Only by appreciating the logic of this concept can the theologian be confident that he understands its proper content and implications and that he offers appropriate justification for his claims about it. In this paper I want to suggest one possible way of viewing the logic of incarnational talk in theology which is based upon the attempt to treat such talk in terms of the notion of ‘revelation’. (shrink)

How do we know when we are investing wisely in security? Answering this question requires investigating what things are worth securing ; what threatens them; how best to protect them; and how to think about it. Is it possible to protect them? How best go about protecting them? What trade-offs are involved in allocating resources to security problems? This book responds to these questions by stripping down our preconceptions and rebuilding an understanding of security from the ground up on the (...) basis of a common-sense ontology and an explicit theory of value. It argues for a clear distinction between objective and subjective security threats, a non-anthropocentric understanding of security, and a particular hierarchy of security referents, looking closely at four in particular-the ecosphere, the state, culture, and individual human beings. The analysis will be of interest not only to students and scholars of International Relations, but also to practitioners. David A. Welch is University Research Chair and Professor of Political Science at the Balsillie School of International Affairs, University of Waterloo. His previous books include Justice and the Genesis of War, which won the 1994 Edgar S. Furniss Award for an Outstanding Contribution to National Security Studies, and Painful Choices: A Theory of Foreign Policy Change, which was the inaugural winner of the International Studies Association International Security Studies Section Best Book Award. He is currently co-editor of the Cambridge University Press journal, International Theory. (shrink)

Abstract (for the combined three Parts) This paper presents the simplest known theory of processes involved in a person’s unconscious and conscious achievements such as intending, perceiving, reacting and thinking. The basic principle is that an individual has mental states which possess quantitative causal powers and are susceptible to influences from other mental states. Mental performance discriminates the present level of a situational feature from its level in an individually acquired, multiple featured norm (exemplar, template, standard). The effect on output (...) of a moderate disparity between input and norm is scaled in a universal unit of discrimination (Weber’s fraction), with the norm’s level being zero. When one process converts separate sources of input into an output, their discriminative distances from norm are summated. Distinct processes converging on an output combine their discriminations from norm orthogonally. An output may be influenced by the constructs of other outputs as well as by inputs. Descriptive performance is the influence of one category of input on a verbal output. Reasoning is minimally the effect of one verbal process on another. In deeper mental processing, the influence on a response comes from a response construct modulating a description: this process gives the meaning to an emotion or a motive. Descriptive modulation of stimulation corresponds to a bodily sensation or other conceptualized percept. When an output is explained solely by sources of input, that response to the stimulation may be mediated unconsciously. Development of a person within physical and communal environments embodies such mental causation within material causation and acculturates that mind to social causation. (shrink)

_Comparative Education: A Field in Discussion_ is a personal reflection on the field of comparative education from the perspective of one scholar who has been active in the field since the 1980s.

Poverty, inequality, violence, environmental degradation, and tyranny continue to afflict the world. Ethics of Global Development offers a moral reflection on the ends and means of local, national, and global efforts to overcome these five scourges. After emphasizing the role of ethics in development studies, policy-making, and practice, David A. Crocker analyzes and evaluates Amartya Sen's philosophy of development in relation to alternative ethical outlooks. He argues that Sen's turn to robust ideals of human agency and democracy improves on (...) both Sen's earlier emphasis on 'capabilities and functionings' and Martha Nussbaum's version of the capability orientation. This agency-focused capability approach is then extended and strengthened by applying it to the challenges of consumerism and hunger, the development responsibilities of affluent individuals and nations, and the dilemmas of globalization. Throughout the book the author argues for the importance of more inclusive and deliberative democratic institutions. (shrink)

A thoroughly updated introduction to the concepts, methods, and standards of critical thinking, _A Practical Guide to Critical Thinking: Deciding What to Do and Believe, Second Edition_ is a unique presentation of the formal strategies used when thinking through reasons and arguments in many areas of expertise. Pursuing an interdisciplinary approach to critical thinking, the book offers a broad conception of critical thinking and explores the practical relevance to conducting research across fields such as, business, education, and the biological sciences. (...) Applying rigor when necessary, the _Second Edition_ maintains an informal approach to the fundamental core concepts of critical thinking. With practical strategies for defining, analyzing, and evaluating reasons and arguments, the book illustrates how the concept of an argument extends beyond philosophical roots into experimentation, testing, measurement, and policy development and assessment. Featuring plenty of updated exercises for a wide range of subject areas, _A Practical Guide to Critical Thinking Deciding What to Do and Believe, Second Edition_ also includes: Numerous real-world examples from many fields of research, which reflect the applicability of critical thinking in everyday life New topical coverage, including the nature of reasons, assertion and supposing, narrow and broad definitions, circumstantial reasons, and reasoning about causal claims Selected answers to various exercises to provide readers with instantaneous feedback to support and extend the lessons _A Practical Guide to Critical Thinking Deciding What to Do and Believe, Second Edition_ is an excellent textbook for courses on critical thinking and logic at the undergraduate and graduate levels as well as an appropriate reference for anyone with a general interest in critical thinking skills. (shrink)

This book is intended as a contribution to the philosophy of history. The scope of this contribution--uncovering the awareness of the historical past as a part of human experience--is laid out in an extensive introduction drawing upon both contemporary analytic and phenomenological thought. In chapter 1, Carr presents an account of the temporal structure of experience based primarily on Husserl and, relevant themes in analytic philosophy. Chapter 2 describes the concept of narration and relates this concept to the account of (...) experience and action offered in chapter 1. In chapter 3, Carr draws upon Dilthey and the early Heidegger's use of Dilthey to develop the restricted descriptions of the first chapter into an account of the self as a unity. (shrink)

A detailed treatment regarding the diverse properties and uses of evidence and the judgmental tasks they entail. Examines various processes by which evidence may be developed or discovered. Considers the construction of arguments made in defense of the relevance and credibility of individual items and masses of evidence as well as the task of assessing the inferential force of evidence. Includes over 100 numerical examples to illustrate the workings of diverse probabilistic expressions for the inferential force of evidence and the (...) subtleties they reveal. (shrink)

Available from UMI in association with The British Library. Requires signed TDF. ;This work examines some of the epistemological and ontological conditions of the deep self-knowledge that is demanded by the Delphic motto gnothi seauton . The guiding questions are: what is the 'self' that deep self-knowledge is of? What are we such that we can ask deep and puzzling questions about our life-plans, our self-conceptions and the meaning of our lives? Can we know ourselves as we really are, or (...) only under a certain description which conceals as much as it reveals? What is the nature of the relation between self-knowledge and reality? ;The central thesis that is defended is that a person is to a certain extent a self-defining and self-forming being by virtue of his self-knowledge; fundamental changes in how he knows himself, and conceives his way of life, his life-history, emotions, final ends, death etc.--particularly in light of fundamental practical questions --necessarily occasion changes in what he is. What he is at any one moment in his life is in part constituted by his self-knowledge. ;To account for the complex 'inter-relation' between self-knowledge and its object, and the possibility of self-formation, a broadly Kantian theory of constituting activity is developed, as well as a theory of the empirical 'under-determination' of self-knowledge. The peculiarity of self-knowledge is that the knower is the known, and that he is active with respect to the object known ; the object of knowledge and the knowing subject change and extend their range together. This complicates some of the claims of realism and the correspondence theory of truth: self-knowledge is not a matter of the strict conformity of beliefs or conceptions to an independent, determinate and unchanging reality. In Kantian terms, the object of self-knowledge conforms to the conditions of knowledge. ;This broadly Kantian approach is brought to the analysis of Hampshire and Sartre's theories, which are studied as illustrations of the general ontological and epistemological conditions of self-knowledge. Other issues that are discussed include the problem of truth conditions in deep self-knowledge, the agent-observer dualism in self-inquiry, the relational model of the self, and Iris Murdoch's critique of Hampshire and Sartre. (shrink)

On the evolution of mind Harry J. Jerison Most of us think of mind as a little person in the head, the 'knower' of reality (cf. Attneave,). ...

The thesis that anything conceivable is possible plays a central role in philosophical debates about the self. Discussions about free will have focused, at least in the last hundred years, on whether a free yet determined action is conceivable. If it is, and if anything conceivable is possible, then a deterministic physics would by itself pose no obstacle to human freedom. Current debates about the nature and value of personal survival turn on whether it is conceivable for a person to (...) move from one body to another. Discussions about the topic of John Perry’s impressive book, the relation between a person’s mental and physical states, has recently centered on whether it is conceivable for physically identical beings to differ in their conscious experiences. Some claim that zombies, beings physically just like us but without any conscious experiences at all, are conceivable. If they are, and if anything conceivable is possible, then it would seem to follow that facts about conscious experience are not physical. In short, some form of mind-body dualism would have to be right after all. (shrink)

Wide ranging and up to date, this is the single most comprehensive treatment of the most influential political philosopher of the 20th century, John Rawls. An unprecedented survey that reflects the surge of Rawls scholarship since his death, and the lively debates that have emerged from his work Features an outstanding list of contributors, including senior as well as “next generation” Rawls scholars Provides careful, textually informed exegesis and well-developed critical commentary across all areas of his work, including non-Rawlsian perspectives (...) Includes discussion of new material, covering Rawls’s work from the newly published undergraduate thesis to the final writings on public reason and the law of peoples Covers Rawls’s moral and political philosophy, his distinctive methodological commitments, and his relationships to the history of moral and political philosophy and to jurisprudence and the social sciences Includes discussion of his monumental 1971 book, A Theory of Justice, which is often credited as having revitalized political philosophy. (shrink)

In this remarkable study, David A. J. Richards combines an interpretive history of culture and law, political philosophy, and constitutional analysis to explain the background, development, and growing impact of two of the most important and challenging human rights movements of our time, feminism and gay rights. Richards argues that both movements are extensions of rights-based dissent, rooted in antebellum abolitionist feminism that condemned both American racism and sexism. He sees the progressive role of such radical dissent as an (...) emancipated moral voice in the American constitutional tradition. He examines the role of dissident African Americans, Jews, women, and homosexuals in forging alternative visions of rights-based democracy. He also draws special attention to Walt Whitman's visionary poetry, showing how it made space for the silenced and subjugated voices of homosexuals in public and private culture. According to Richards, contemporary feminism rediscovers and elaborates this earlier tradition. And, similarly, the movement for gay rights builds upon an interpretation of abolitionist feminism developed by Whitman in his defense, both in poetry and prose, of love between men. Richards explores Whitman's impact on pro-gay advocates, including John Addington Symonds, Havelock Ellis, Edward Carpenter, Oscar Wilde, and André Gide. He also discusses other diverse writers and reformers such as Margaret Sanger, Franz Boas, Elizabeth Stanton, W. E. B. DuBois, and Adrienne Rich. Richards addresses current controversies such as the exclusion of homosexuals from the military and from the right to marriage and concludes with a powerful defense of the struggle for such constitutional rights in terms of the principles of rights-based feminism. (shrink)

Correspondence should be addressed to David A. Leopold david[email protected] the viewing of certain patterns, widely known as ambiguous or puzzle figures, perception lapses into a sequence of spontaneous alternations, switching every few seconds between two or more visual interpretations of the stimulus. Although their nature and origin remain topics of debate, these stochastic switches are generally thought to be the automatic and inevitable consequence of viewing a pattern without a unique solution. We report here that in humans such (...) perceptual alternations can be slowed, and even brought to a standstill, if the visual stimulus is periodically removed from view. We also show, with a visual illusion, that this stabilizing effect hinges on perceptual disappearance rather than on actual removal of the stimulus. These findings indicate that uninterrupted subjective perception of an ambiguous pattern is required for the initiation of the brain-state changes underlying multistable vision.Visual perception involves coordination between sensory sampling of the world and active interpretation of the sensory data. Human perception of objects and scenes is normally stable and robust, but it falters when one is presented with patterns that are inherently ambiguous or contradictory. Under such conditions, vision lapses into a chain of continually alternating percepts, whereby a viable visual interpretation dominates for a few seconds and is then replaced by a rival interpretation. This multistable vision, or 'multistability', is thought to result from destabilization of fundamental visual mechanisms, and has offered valuable insights into how sensory patterns are actively organized and interpreted in the brain1, 2. Despite a great deal of recent research and interest in multistable perception, however, its neurophysiological underpinnings remain poorly understood. Physiological studies have suggested that disambiguation of ambiguous patterns. (shrink)

Monogenesis of language is widely accepted, but the conventional argument seems to be mistaken; a simple probabilistic model shows that polygenesis is likely. Other prehistoric inventions are discussed, as are problems in tracing linguistic lineages. Language is a system of representations; within such a system, words can evoke complex and systematic responses. Along with its social functions, language is important to humans as a mental instrument. Indeed, the invention of language,that is the accumulation of symbols to represent emotions, objects, and (...) acts may be the most important event in human evolution, because so many developments follow from it. For example, Edward Sapir speculated that some embryonic form of language must have been available to early man to help him fashion tools from stone (Sapir,1921). Sophisticated biface stone tools date to early Homo erectus some 1.5 million years ago, suggesting a similar age for language. This paper considers whether the invention of language occurred at only one pre-historic site or at several sites. In other words, did language emerge by monogenesis or polygenesis? Early thinkers believed in monogenesis, against a background of divine creation. Perhaps the best known account is the biblical story of Adam giving names to plants and animals in the Garden of Eden. Similar legends are found among many peoples. Modern linguists too assume monogenesis, but on probabilistic grounds (see, for instance, Southworth and Daswani, 1974, p.314). The argument seems to be that the invention of language is an extremely unlikely event, because symbolization involves abstraction and requires synchronized insight by several individuals; therefore, the probability of occurrence at more than one site must be vanishingly small. We have found no explicit quantitative treatment of this question in the literature, but the underlying logic has to be the multiplication of probabilities. If p is small at one site,then p.p for two sites is smaller still, and so on. This reasoning is false, as we show here. The fallacy lies in the focus on two particular sites rather than consideration of all pairs of sites. (shrink)