BackgroundBiobanks are considered to be key infrastructures for research development and have generated a lot of debate about their ethical, legal and social implications. While the focus has been on human genomic research, rapid advances in human microbiome research further complicate the debate.DiscussionWe draw on two cystic fibrosis biobanks in Toronto, Canada, to illustrate our points. The biobanks have been established to facilitate sample and data sharing for research into the link between disease progression and microbial dynamics in the lungs (...) of pediatric and adult patients. We begin by providing an overview of some of the ELSI associated with human microbiome research, particularly on the implications for the broader society. We then discuss ethical considerations regarding the identifiability of samples biobanked for human microbiome research, and examine the issue of return of results and incidental findings. We argue that, for the purposes of research ethics oversight, human microbiome research samples should be treated with the same privacy considerations as human tissues samples. We also suggest that returning individual microbiome-related findings could provide a powerful clinical tool for care management, but highlight the need for a more grounded understanding of contextual factors that may be unique to human microbiome research.ConclusionsWe revisit the ELSI of biobanking and consider the impact that human microbiome research might have. Our discussion focuses on identifiability of human microbiome research samples, and return of research results and incidental findings for clinical management. (shrink)
Selections from Hume's major writings are grouped under the headings: Reason and Experience, Reason and Sentiment, and Reason and Religion. There is also a short conclusion entitled "Skepticism." A Treatise on Human Nature, An Enquiry Concerning the Human Understanding, and An Enquiry Concerning the Principles of Morals are from the 1962 and 1947 translations by André Leroy. The Dialogues on Natural Religion were translated in 1912 by Maxime David. Part I gives Hume's account of impressions, ideas, and their relations. (...) Also covered are the crucial arguments on causality from the Treatise and the Enquiry Concerning Understanding--including the role of experience of constant conjunction and the role of instinct in our construction and use of the notion of causality. Part II contains the famous statement from the Treatise that moral matters are "more rightly felt than judged of" and a treatment of the natural and artificial virtues. Considering its central place in recent ethics, the English-speaking reader would miss the familiar lines remarking the passage from "is" to "ought." Part III and the Conclusion are drawn entirely from the Dialogues on Natural Religion.--M. B. M. (shrink)
F. A. Hayek is uniquely responsible for his fellow economists grasping the importance of the decentralization of knowledge: as Hayek shows in his pathbreaking “The Use of Knowledge in Society,” knowledge nowhere exists as a coherent whole and to pretend otherwise is a most serious error. Hayek also shares responsibility for the popularity of a strong form of the methodological individualist research program which asserts that since collectives as such have no impact on the choices of individuals, investigators ought to (...) purge any reliance on collectives from our analysis. (shrink)
It used to be that a book on utopia that did not quote Oscar Wilde's homily about a map of the world without utopia was itself not worth glancing at, for it left out the one thing we thought we could all agree on. But what if the world map only serves to reinforce the systems of domination inherent to colonialism, racism, capitalism, and patriarchy? And why should the quest for utopia take us to the high seas anyway, rather than (...) surveying those existing social formations that resist oppression?For David Bell, Wilde was wrong. Utopia is on the world map, but it lies neither in the unexplored place on the horizon for which humanity is forever setting sail nor in some nonexistent linear future: following Tom Moylan's... (shrink)
Wittgenstein's Method: Neglected Aspects By Gordon Baker. Oxford: Blackwell, 2004 pp. 328. £40.00 HB.. Wittgenstein's Copernican Revolution: The Question of Linguistic Idealism By Ilham Dilman. Basingstoke: Palgrave, 2002. pp. 240. £52.50 HB. Wittgenstein: Connections and Controversies By P. M. S. Hacker. Oxford: Oxford University Press,. pp. 400. £45.00 HB; £19.99 PB. Wittgenstein's Philosophical Investigations: An Introduction By David G. Stern. Cambridge: Cambridge University Press, 2004. pp. 224. £40.00 HB; £10.99 PB.
Getting over systematics Content Type Journal Article Category Book Review Pages 1-4 DOI 10.1007/s11016-012-9662-5 Authors John S. Wilkins, University of Sydney, Sydney, NSW 2009, Australia Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.